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  3. Serocit-46.7% Injection 5 ml

Serocit-46.7% Injection 5 ml, Pack of 1 Injection
Serocit-46.7% Injection 5 ml, Pack of 1 Injection
Serocit-46.7% Injection 5 ml, Pack of 1 Injection
Serocit-46.7% Injection 5 ml, Pack of 1 Injection
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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy

Serocit-46.7% Injection 5 ml is used as a locking solution for catheters to prevent blood coagulation in various types of intravenous catheters. It works by preventing clot formation in the catheter lumen, ensuring the catheter remains open for future use. Serocit-46.7% Injection 5 ml is not recommended for use in patients allergic to polyhexanide or chlorhexidine, as it may trigger an anaphylactic reaction.

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Composition :

TRISODIUM CITRATE-467MG

Manufacturer/Marketer :

La Renon Healthcare Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Serocit-46.7% Injection 5 ml

Serocit-46.7% Injection 5 ml is used as an anticoagulant solution to reduce the risk of infection and prevent the formation of thrombus within the catheter. It is recommended for patients with central venous catheters. Central venous catheters are thin tubes inserted into large veins to administer medications, fluids, or blood, and they are often used for long-term treatment.

Serocit-46.7% Injection 5 ml contains Trisodium Citrate (TSC). It prevents coagulation by chelation of ionized calcium in the extracorporeal circuit, which stops the activation of coagulation factors and fibrin formation. It does not cause systemic anticoagulation and also helps reduce biofilms by binding to calcium.

A healthcare professional will administer Serocit-46.7% Injection 5 ml. Serocit-46.7% Injection 5 ml is not known to cause any side effects when used as a catheter lock. However, if the solution accidentally enters the intravenous line, it may result in paresthesia (numbness) or dysgenesis. These effects are usually linked to accidental exposure and should be monitored closely.

Serocit-46.7% Injection 5 ml is only for use as a catheter lock solution. It is contraindicated in patients who are allergic to polyhexanide or chlorhexidine, as it may trigger an anaphylactic reaction. If patients are receiving drugs through the catheter and there are known interactions with citrate or PHMA (like coagulation factor treatments), the catheter should be flushed with isotonic saline before the catheter lock procedure.

Uses of Serocit-46.7% Injection 5 ml

Serocit-46.7% Injection 5 ml is used to prevent blood clotting during granulocytapheresis procedures (granulocyte collection by apheresis). The detailed uses of Serocit-46.7% Injection 5 ml are as follows:

  • Anticoagulant for apheresis:Serocit-46.7% Injection 5 ml helps maintain blood fluidity during granulocyte collection by preventing clot formation.Ensures safe cell separation:Serocit-46.7% Injection 5 ml supports effective separation and collection of granulocytes by reducing clotting risks during the procedure.

Directions for Use

  • Serocit-46.7% Injection 5 ml is administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

Medicinal Benefits

Serocit-46.7% Injection 5 ml is a catheter locking solution that prevents blood clots in any type of intravenous catheter. It contains Trisodium Citrate (TSC), which acts as an anticoagulant by chelating ionized calcium in the extracorporeal circuit, forming a soluble complex. Calcium plays an essential role in the coagulation process, and its removal by citrate prevents the activation of coagulation factors like factor X and prothrombin, thus inhibiting fibrin formation. This process does not cause systemic anticoagulation. Additionally, TSC helps reduce biofilms by binding and neutralizing calcium (Ca2+) in the surroundings.

How Serocit-46.7% Injection 5 ml Works

Serocit-46.7% Injection 5 ml contains Trisodium Citrate (TSC). It prevents coagulation by binding ionized calcium in the extracorporeal circuit, which stops the activation of coagulation factors and fibrin formation. It does not cause systemic anticoagulation and also helps reduce biofilms by binding calcium in the surrounding.

Storage

• Store in a cool and dry place away from sunlight.• Keep Serocit-46.7% Injection 5 ml out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Serocit-46.7% Injection 5 ml

Serocit-46.7% Injection 5 ml is administered in a controlled medical setting by a healthcare professional, and the likelihood of an overdose is much less. However, if you suspect an overdose or experience any adverse effects, seek medical attention immediately.

Drug Warnings

Serocit-46.7% Injection 5 ml should be administered only by trained personnel. It should not be injected directly into the intravenous route or mixed with an infusion. Always verify the correct catheter volume according to the manufacturer's guidelines. Do not exceed the recommended catheter volume. Avoid contact with eyes or open wounds. It is contraindicated in patients who are allergic to polyhexanide or chlorhexidine, as it may trigger an anaphylactic reaction. Serocit-46.7% Injection 5 ml should not be re-sterilized or used after its expiration date. Always use proper aseptic techniques when applying the locking solution to prevent introducing infection into the catheter.

Drug-Drug Interactions

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Sodium citrateDoxycycline
Severe
Sodium citrateAluminium hydroxide
Severe

Drug-Drug Interactions

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Sodium citrateDoxycycline
Severe
How does the drug interact with Serocit-46.7% Injection 5 ml:
Coadministration of Serocit-46.7% Injection 5 ml with Doxycycline can reduce the effectiveness of Doxycycline.

How to manage the interaction:
Although taking Serocit-46.7% Injection 5 ml with Doxycycline can possibly result in decreased efficacy, they can be taken together if prescribed by a doctor. It is advised to separate Serocit-46.7% Injection 5 ml and doxycycline by three to four hours. Do not stop using any medications without consulting a doctor.
Sodium citrateAluminium hydroxide
Severe
How does the drug interact with Serocit-46.7% Injection 5 ml:
Co-administration of Aluminium hydroxide and Serocit-46.7% Injection 5 ml may increase aluminum levels and risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Serocit-46.7% Injection 5 ml and Aluminium hydroxide, you can take these medicines together if prescribed by your doctor. However, if you experience symptoms like severe stomach pain, constipation, loss of appetite, pain when you urinate, muscle weakness, tiredness nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Sodium citrateLevofloxacin
Severe
How does the drug interact with Serocit-46.7% Injection 5 ml:
Co-administration of Levofloxacin and Serocit-46.7% Injection 5 ml together may increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Serocit-46.7% Injection 5 ml and Levofloxacin, you can take these medicines together if prescribed by a doctor. However, if you experience flank pain, painful urination, or blood in the urine, consult the doctor. It is advised to drink plenty of fluids during treatment with Levofloxacin. Do not stop using any medications without talking to a doctor.
Sodium citrateDihydroxialumini sodium carbonate
Severe
How does the drug interact with Serocit-46.7% Injection 5 ml:
Co-administration of Dihydroxialumini sodium carbonate and Serocit-46.7% Injection 5 ml may increase aluminum levels and risk of developing side effects.

How to manage the interaction:
Although taking Serocit-46.7% Injection 5 ml and Dihydroxialumini sodium carbonate together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience severe stomach pain, constipation, loss of appetite, pain when you urinate, tiredness, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

-

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Breast Feeding

Not applicable

-

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Driving

Not applicable

-

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Liver

Not applicable

-

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Kidney

Not applicable

-

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Children

Caution

The safety and effectiveness of Serocit-46.7% Injection 5 ml for children have not been established.

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Heart

Serocit-46.7% Injection 5 ml could be dangerous for those who have heart problems. Therefore, please inform your doctor if you have any pre-existing heart problems before prescribing Serocit-46.7% Injection 5 ml.

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Geriatrics

Caution

Serocit-46.7% Injection 5 ml should be used with caution in geriatric people due to increased risk of side effects. Therefore, please consult your doctor before using Serocit-46.7% Injection 5 ml.

Have a query?

FAQs

Serocit-46.7% Injection 5 ml is used as a catheter locking solution that prevents blood clots in any type of intravenous catheter. It helps keep the catheter clear by preventing clot formation inside the lumen, reducing the need for catheter replacement. It provides an effective locking mechanism without heparin, offering a safer option for patients at risk of heparin-induced thrombocytopenia (HIT).

Serocit-46.7% Injection 5 ml contains Trisodium Citrate (TSC). It prevents coagulation by binding ionized calcium in the extracorporeal circuit, which stops the activation of coagulation factors and fibrin formation. It does not cause systemic anticoagulation and also helps reduce biofilms by binding calcium in the surrounding.

Serocit-46.7% Injection 5 ml is generally used after each catheter use. However, your healthcare provider will decide the exact frequency based on your treatment requirements.

If you are allergic to sodium citrate or any other ingredient in the solution, it is important to consult your doctor. They will help identify an alternative treatment that is safe for you, ensuring that you receive appropriate care while avoiding any allergic reactions. Always tell your healthcare provider about any known allergies before starting a new medication.

Serocit-46.7% Injection 5 ml is suitable for central venous and dialysis catheters. It should not be used with arterial catheters or in situations not recommended by your healthcare provider.

If the catheter becomes blocked, contact your healthcare provider for assessment and possible treatment to restore its function. They may suggest alternative therapies or recommend catheter removal and replacement.

Serocit-46.7% Injection 5 ml is intended only for use as a catheter lock solution. It should not be administered through direct intravenous injection or mixed with an infusion. Proper use is essential to ensure the effectiveness and safety of the treatment.

Country of origin

India

Manufacturer/Marketer address

Behind Rajpath Club, Kensville Road, Opp. Infostretch Building, Off S.G. Highway, Ahmedabad- 380059, Gujarat- India
Other Info - SER0418

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Reference

  1. https://www.larenon.com/wp-content/uploads/2017/12/Serocit.pdf
  2. https://www.polifarma.com.tr/media/3775/catesyt-sodyum-sitrat-kateter-kapama-solusyonu-46-7-en.pdf
  3. https://www.zimmerbiomet.com/content/dam/zb-corporate/en/products/products/pharmaceuticals/tricitrasol-anticoagulant-sodium-citrate-concentrate/InstructionsforUseFL6030triCitrasol.pdf

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