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compositionComposition:SEVELAMER-400MG
prescription
Prescription Medicine
info
Sevneph-400 Tablet 10's
Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

SEVELAMER-400MG

Manufacturer/Marketer :

Enphamed Biotech Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Sevneph-400 Tablet

Sevneph-400 Tablet is a medication prescribed to lower high phosphorus levels in the blood of adults with chronic kidney disease who are on dialysis. When kidney function declines, the body cannot remove excess phosphorus, which can lead to severe health complications. This medicine helps manage this buildup by targeting the phosphorus in your digestive tract.

To get the best results, you must take Sevneph-400 Tablet consistently with every meal or snack. Taking it with food is essential because it works directly on the phosphorus present in your meals. Along with taking this medicine, your doctor will likely recommend a low-phosphorus diet and other lifestyle adjustments to help control your levels.

Most people tolerate this medicine well, but it can cause common digestive side effects like nausea, vomiting, bloating, or mild constipation. If you experience severe stomach pain, persistent constipation, or difficulty swallowing, you should stop taking it and contact your doctor immediately.

Before starting this medication, tell your doctor if you have a history of bowel blockages, severe constipation, swallowing difficulties, or major stomach surgery. Do not take this if you have a known bowel obstruction or naturally low levels of phosphorus in your blood.

This medicine can interact with several other oral drugs by preventing your body from absorbing them properly. Talk to your doctor or pharmacist if you are taking antibiotics, thyroid hormones, or heart medications, as you may need to space them apart from Sevneph-400 Tablet . If you are pregnant, breastfeeding, or an older adult, consult your doctor for personalised advice before starting treatment.

Uses of Sevneph-400 Tablet

Sevneph-400 Tablet is used to lower high phosphorus levels in the blood. The detailed uses of Sevneph-400 Tablet are as follows:

  • High blood phosphorus levels (hyperphosphatemia) in kidney disease patients on dialysis: Sevneph-400 Tablet helps control blood phosphorus levels in adults with chronic kidney disease who are receiving haemodialysis or peritoneal dialysis.
     

Key Benefits

Sevneph-400 Tablet helps manage elevated phosphorus levels in people with chronic kidney disease, particularly those undergoing dialysis. By reducing the absorption of phosphorus from food, it helps maintain healthier mineral balance in the body and supports long-term bone and cardiovascular health. This medicine offers several key benefits:

  • Supports Stronger and Healthier Bones: By helping keep phosphorus levels within the recommended range, Sevneph-400 Tablet reduces the risk of mineral imbalances that can weaken bones over time. This supports bone strength and may help reduce the likelihood of bone pain, fractures, and other complications associated with chronic kidney disease.
  • Helps Maintain Healthy Blood Vessel Function: Excess phosphorus can contribute to the formation of calcium-phosphate deposits in blood vessels and soft tissues. By controlling phosphorus levels, Sevneph-400 Tablet helps reduce the risk of these deposits, supporting healthier blood vessel function and overall cardiovascular health.
  • Promotes Long-Term Health in Dialysis Patients: Regular use of Sevneph-400 Tablet as prescribed helps manage one of the key complications of chronic kidney disease. By maintaining healthier phosphorus levels, it supports better overall health and may help reduce the risk of long-term complications related to mineral and bone disorders.
     
Side effects of Sevneph-400 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Directions for Use

To get the full benefit of Sevneph-400 Tablet and minimise side effects, follow these simple guidelines:

  • Swallow the tablets whole with a glass of water during your meals or snacks.
  • Do not chew, crush, or break the tablets, as they can expand rapidly in your throat and cause choking.
  • If you are taking the oral suspension powder form, mix the exact prescribed amount with the recommended amount of water, stir thoroughly, and drink the entire mixture immediately. Do not leave the mixture sitting.
  • Always follow your doctor's exact instructions regarding how and when to take this medicine.
  • Your healthcare provider may need to adjust your dosage over time based on your routine blood test results.
     

How Sevneph-400 Tablet Works

When you eat, your food naturally contains phosphorus, which enters your digestive tract. Sevneph-400 Tablet acts like a sponge in your stomach and intestines. Once you take it with a meal, it binds tightly to the dietary phosphorus in your food before your body has a chance to absorb it. Because Sevneph-400 Tablet itself is not absorbed into your bloodstream, it remains in your digestive tract. The bound phosphorus is then carried safely out of your body through your stool. This direct binding action successfully lowers the amount of phosphorus that enters your blood.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Sevneph-400 Tablet to avoid unpleasant side effects.

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Pregnancy

Consult your doctor

Sevneph-400 Tablet is not absorbed by the body and is not expected to reach the baby. If you are pregnant or planning to become pregnant, tell your doctor. They will advise you whether you should take Sevneph-400 Tablet during this time.

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Breast Feeding

Consult your doctor

Sevneph-400 Tablet is not absorbed by the body and is not expected to pass into breast milk. If you are breastfeeding or plan to breastfeed, tell your doctor. They will advise you if you should take Sevneph-400 Tablet while breastfeeding.

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Driving

Safe if prescribed

Sevneph-400 Tablet has no or negligible influence on the ability to drive or operate any machinery.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Sevneph-400 Tablet is not recommended for children below 6 years as its safety and effectiveness are not known.

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Heart

Caution

Extreme caution should be exercised in cardiac patients while taking Sevneph-400 Tablet . The patient should be closely monitored for any changes.

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Geriatrics

Consult your doctor

Please consult a doctor before giving Sevneph-400 Tablet to geriatric patients. Your doctor will prescribe Sevneph-400 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Sevneph-400 Tablet

Do not take more than the prescribed dose of Sevneph-400 Tablet as it may cause serious adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Follow a low-phosphorus diet as recommended by your healthcare team or dietitian. Avoid or limit high-phosphorus foods such as dairy products, nuts, seeds, dark colas, beer, and processed meats containing phosphate additives.
  • Maintain a daily food and symptom journal to track your meals and monitor for any digestive changes like constipation.
  • Attend all scheduled blood tests. Your doctor will need to regularly check your phosphorus, calcium, bicarbonate, and chloride levels to ensure the treatment is working safely.
  • Stay hydrated by drinking the amount of fluids recommended by your doctor, which helps manage and prevent mild constipation.
     

Have a query?

How Soon It Starts Working

  • The time required for Sevneph-400 Tablet to start to work: The time required for Sevneph-400 Tablet to show its action is not clinically established.
  • The time for which the effects of Sevneph-400 Tablet last: The duration of action for Sevneph-400 Tablet is not clinically established.

What if you forget to take Sevneph-400 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

•Store Sevneph-400 Tablet at room temperature, between 20°C and 25°C (68°F and 77°F). •Keep the medicine in its original container, tightly closed, to protect it from moisture and humidity. Do not store it in damp areas like the bathroom

Drug Warnings

  • Always take this medicine with food to ensure it can bind to the phosphorus in your meals effectively.
  • Never split, crush, or chew the tablets, as they can swell and block your airway.
  • Keep a close watch on your bowel movements. If you experience severe constipation or do not have a bowel movement for several days, contact your healthcare provider immediately.
  • Separate your other oral medications carefully. Take other oral drugs at least 1 hour before or 3 hours after taking Sevneph-400 Tablet to prevent absorption issues.
  • Inform any healthcare provider you visit that you are taking this medicine, especially if you are scheduled for any stomach or bowel surgeries.
     

Drug-Drug Interactions

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Drug-Drug Interactions

  • Ciprofloxacin: Taking Sevneph-400 Tablet can lower the amount of this antibiotic your body absorbs. Take ciprofloxacin at least 2 hours before or 6 hours after taking this medicine.
  • Mycophenolate mofetil: This medicine may reduce the absorption of mycophenolate mofetil (an immunosuppressant), potentially lowering its effectiveness.
  • Levothyroxine: This thyroid medicine may not be absorbed properly if taken with Sevneph-400 Tablet . Take your thyroid medication at least 4 hours before taking this medicine.
  • Digoxin: Sevneph-400 Tablet may interfere with how your body absorbs digoxin, a medication used for heart conditions.

Drug-Food Interactions

  • There are no known direct interactions with specific foods, but taking this medicine without food prevents it from working, as it must bind to phosphorus in your meals.

Drug-Disease Interactions

  • Bowel obstruction: Do not take this medicine if you have a blocked bowel or severe slow motility, as it can worsen bowel complications.
  • Low blood phosphorus (hypophosphatemia): If your phosphorus levels are already too low, taking this medicine can decrease them further to unsafe levels.

 

SevelamerGemifloxacin
Severe
SevelamerEnoxacin
Severe

Drug-Drug Interactions

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SevelamerGemifloxacin
Severe
How does the drug interact with Sevneph-400 Tablet:
Gemifloxacin's efficiency can be decreased by Sevneph-400 Tablet if it prevents the drug from being absorbed into the bloodstream. this is caused by the combined use of gemifloxacin and Sevneph-400 Tablet.

How to manage the interaction:
Co-administration of enoxacin and Sevneph-400 Tablet can lead to an interaction, but it can be taken if your doctor advises. It has been advised to separate the dosing of these medications by at least 4 hours and consult the doctor if your symptoms do not improve. Do not stop using any medications without a doctor's advice.
SevelamerEnoxacin
Severe
How does the drug interact with Sevneph-400 Tablet:
Co-administration of Enoxacin and Sevneph-400 Tablet can decrease the blood levels and effectiveness of Enoxacin.

How to manage the interaction:
Co-administration of Enoxacin and Sevneph-400 Tablet can lead to an interaction, but it can be taken if advised by your doctor. Do not stop using any medications without a doctor's advice.
SevelamerErgocalciferol
Severe
How does the drug interact with Sevneph-400 Tablet:
Co-administration of Sevneph-400 Tablet with Ergocalciferol can decrease the effects of Ergocalciferol.

How to manage the interaction:
Co-administration of Sevneph-400 Tablet with Ergocalciferol can lead to an interaction, but they can be taken if advised by your doctor. Consult the doctor if your symptoms worsen. Do not stop using any drugs without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HYPOPHOSPHATEMIC AGENT]

FAQs

Sevneph-400 Tablet is used to control high phosphate levels in the body (hyperphosphataemia)‚ in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine), and patients with chronic kidney disease. It is also used for the treatment of bone disease.

Sevneph-400 Tablet works by holding onto phosphate from the food so that it can pass out of your body. Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and possibly decrease the risk of heart disease and strokes that can result from high phosphate levels.

Yes, serum phosphate levels should be monitored regularly while you are taking Sevneph-400 Tablet . The use of Sevneph-400 Tablet may decrease the levels of vitamin D, A, E, K, and folic acid, and hence, the levels need to be monitored during the treatment.

No, do not stop taking Sevneph-400 Tablet on your own. If you stop taking Sevneph-400 Tablet , your phosphate levels may elevate again. Please consult your doctor.

The side effects of Sevneph-400 Tablet include diarrhoea, headache, stomach upset, and constipation. If these side effects persist or worsen, please consult your doctor.

Take Sevneph-400 Tablet for as long as it is prescribed by your doctor. The dose and duration will depend on the response to treatment. Follow your doctor's instructions and do not stop taking Sevneph-400 Tablet on your own.

No, Sevneph-400 Tablet does not contain a steroid. It contains Sevelamer, which belongs to the class of drugs called phosphate binders.

It is important to take Sevneph-400 Tablet as phosphate levels in the blood cannot be controlled in patients undergoing dialysis, especially after a meal. When the phosphate level exceeds the range in the blood, it may cause problems such as red eyes, itchy skin, high blood pressure, bone pain, and also increase the risk of fractures. Sevneph-400 Tablet lowers these increased serum phosphate levels by binding phosphate from food in the digestive tract.

Sevneph-400 Tablet should be avoided by patients who are allergic to it and who have low phosphate levels in blood. Additionally, patients having intestinal obstruction should also avoid taking Sevneph-400 Tablet .

Sevneph-400 Tablet can affect the absorption of certain medicines, including some antibiotics such as ciprofloxacin. In general, other oral medicines should be taken at least 1 hour before or 3 hours after Sevneph-400 Tablet unless your doctor advises otherwise. Always inform your doctor about all medicines you are taking.

If you miss a dose of Sevneph-400 Tablet , do not worry. Take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for the missed dose.

No. Sevneph-400 Tablet should always be taken with meals or snacks because it works by binding to phosphorus from food in the digestive tract. Taking it on an empty stomach makes it much less effective.

You must swallow the tablets whole because they can expand quickly if they are broken, crushed, or chewed. This can lead to choking or difficulty swallowing. If you have trouble swallowing tablets, talk to your doctor or pharmacist about other options.

Yes, constipation is a common side effect of Sevneph-400 Tablet , although not everyone experiences it. Drinking adequate fluids (within your prescribed fluid allowance), staying physically active, and following your doctor's dietary advice may help. Contact your doctor if constipation becomes severe, persistent, or is accompanied by severe stomach pain.

Generally, you should take your other oral medicines at least 1 hour before or 3 hours after taking Sevneph-400 Tablet . This prevents Sevneph-400 Tablet from binding to your other medications and reducing their effectiveness. Talk to your doctor or pharmacist for a personalized schedule.

There is limited information about the safety of this medicine during pregnancy. Because it is not absorbed into the bloodstream, it is unlikely to harm an unborn baby directly, but it can affect your absorption of vitamins. Talk to your doctor if you are pregnant or planning to become pregnant.

Yes, Sevneph-400 Tablet is meant to be used alongside a low-phosphorus diet, not as a replacement for it. Continuing to limit your intake of phosphorus-rich foods will help you achieve the best results. Talk to your doctor or dietitian for guidance on your diet.

If you develop severe, persistent stomach pain, cramping, bloating, or if you begin vomiting, contact your doctor immediately. These could be signs of a serious bowel complication that requires urgent medical attention.

You will not feel Sevneph-400 Tablet working directly, but your doctor will monitor its effectiveness through regular blood tests to check your phosphorus and calcium levels. Keep all your laboratory appointments so your healthcare team can track your progress.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.8784 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 022127S019,022318S021Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.3681 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Sevelamer Suspension Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Sevelamer hydrochloride. 2000. [Accessed on 30 Jan. 2019] Check here
  6. Sevelamer Sevelamer. 1998. [Accessed on 6 Apr. 2019] Check here
  7. National Center for Biotechnology Information. [Accessed on 06 Aug. 2023]Check here

Country of origin

India
Other Info - SEV0129

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