About SEVELAMER
SEVELAMER belongs to a group of medications called phosphate binder (which decreases the level of phosphate in the body). It is primarily used to control high phosphate levels in the body (hyperphosphataemia) in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine), and patients with chronic kidney disease. It is also used for the treatment of bone disease.
SEVELAMER contains sevelamer that works by binding phosphate in the gastrointestinal tract and decreasing absorption. It effectively reduces excess phosphate levels in the blood, prevents the unsafe build-up of phosphate in your body, helps keep your bones strong, and decreases the risk of heart disease and strokes.
Take SEVELAMER exactly as directed by your doctor. The most common side effects of SEVELAMER are vomiting, upper abdominal pain, nausea, diarrhoea, stomach ache, indigestion, and flatulence. However, if the side effects persist, contact your doctor.
The use of SEVELAMER is restricted in persons with a known history of allergic to any of the ingredients present in this medicine, have low levels of phosphate in their blood, and have a bowel obstruction. SEVELAMER contains lactose (milk sugar). If you have an intolerance to some sugars, contact your doctor before taking SEVELAMER. Tell your doctor if you are facing swallowing problems, motility (movement) in your stomach and bowel, being sick frequently, active inflammation of the bowel, have undergone major surgery on your stomach or bowel, or have serious inflammatory bowel disease. If you are pregnant or breastfeeding, please consult your doctor before taking SEVELAMER.
Uses of SEVELAMER
Hyperphosphatemia (high phosphorus level in blood)
Medicinal Benefits
SEVELAMER belongs to a group of medications called phosphate binder, which works by binding phosphate in the gastrointestinal tract and decreasing its absorption. This lowers the phosphate concentration in the body. It effectively reduces excess phosphate levels in the blood, prevents the unsafe buildup of phosphate in your body, helps keep your bones strong, and decreases the risk of heart disease and strokes. SEVELAMER controls hyperphosphataemia (high blood phosphate levels) in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine) or peritoneal dialysis (where the fluid is pumped into the abdomen and an internal body membrane filters the blood), and patients with chronic kidney disease.
Directions for Use
Storage
Side Effects of SEVELAMER
- Headache
- Diarrhoea
- Stomach upset
- Constipation
In-Depth Precautions and Warning
Drug Warnings
You should avoid taking SEVELAMER if you are allergic to SEVELAMER. Speak to your doctor if you have swallowing disorders, digestive tract surgery, severe constipation, have undergone major surgery on your stomach or bowel, or have serious inflammatory bowel disease. It should be used with caution if you are pregnant or planning to become pregnant. SEVELAMER should not be recommended for breastfeeding mothers as it passes into breast milk. Avoid alcohol consumption while taking SEVELAMER as it might cause unpleasant side effects. The safety and effectiveness of children under six years of age have not been established, so a SEVELAMER should not be given to them. SEVELAMER contains lactose (milk sugar). If you have an intolerance to some sugars, contact your doctor before taking SEVELAMER. Regular monitoring of serum phosphate levels, vitamin D, A, E, K, and folic acid is advised while taking SEVELAMER.
Drug Interactions
Drug-Drug Interactions: SEVELAMER interacts with antibiotics (ciprofloxacin), immunosuppressive agents (mycophenolate), thyroid medications (levothyroxine), and medication used to treat bladder cancer (erdafitinib).
Drug-Food Interactions: Avoid taking high-phosphate additives and alcohol as this makes it harder for your body to absorb SEVELAMER and increases side effects. Using SEVELAMER together with multivitamins with minerals may decrease the effects of multivitamins with minerals. So, Multivitamins with minerals should be administered at least 4 hours before SEVELAMER.
Drug-Disease Interactions: The use of SEVELAMER is restricted in people with hypophosphatemia (low phosphate level in blood), bowel obstruction and perforation, and severe liver disease.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are recommended to avoid alcohol consumption while taking SEVELAMER to avoid unpleasant side effects.
Pregnancy
cautionSEVELAMER is Category C pregnancy medicine. Please consult your doctor if you have any concerns; your doctor will prescribe you SEVELAMER only if the benefits outweigh the risks.
Breast Feeding
cautionThe safety of SEVELAMER has not been established in breastfeeding women. Please consult your doctor if you have any concerns regarding this; your doctor will decide whether the SEVELAMER can be given to breastfeeding mothers or not.
Driving
safe if prescribedSEVELAMER has no or negligible influence on the ability to drive or operate any machinery.
Liver
cautionSEVELAMER should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
safe if prescribedDose adjustment may be needed. SEVELAMER should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
cautionFor children, SEVELAMER is available in pouches for oral suspension. Please consult your paediatrician for further information. The paediatrician will decide the dose of this medicine.
Habit Forming
Diet & Lifestyle Advise
- Take fresh fruits, vegetables, rice, milk, un-enriched corn and rice cereals, and soda without phosphate additives in your regular diet.
- Avoid or limit high phosphorus addictive foods (processed meats, instant puddings, sauces, spreadable cheeses, and beverage products).
- Avoid intake of alcoholic beverages with SEVELAMER as it can make you dehydrated and may increase the side effects.
- Make sure you drink plenty of fluids. This will help you clear out the extra phosphate and will help you overcome some.
- SEVELAMER is preferably taken with meals as it can bind to dietary phosphate and prevent its absorption into the bloodstream. Drink it with a full glass of water.
- Do not stop taking the SEVELAMER dose until your doctor says so.
- Do not use SEVELAMER if you have a history of bowel obstruction.
Special Advise
- Regular monitoring of serum phosphate levels, vitamin D, A, E, K, and folic acid is recommended while taking SEVELAMER.
Patients Concern
Disease/Condition Glossary
Hyperphosphatemia: Hyperphosphatemia is defined as an increased phosphate level in the blood. This condition is often a complication of chronic kidney disease. Phosphate is an important electrolyte. It strengthens your bones and teeth and produces energy. When phosphate levels increase in the blood due to kidney impairment (the kidney does not remove extra phosphate out of the body), this can cause muscle problems and increase the risk of weak bones, heart attacks, and strokes. It is more common in people with chronic kidney disease and people on dialysis. Symptoms may include itchy skin, red eyes, bone pain, and fractures.
