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compositionComposition:ESTRADIOL-2MG
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Prescription Medicine
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ESTRADIOL-2MG

Manufacturer/Marketer :

Serum Institute Of India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About SII Evatone-2 Tablet

SII Evatone-2 Tablet is an oral hormone replacement therapy prescribed primarily to relieve moderate to severe symptoms of menopause, such as hot flashes and night sweats. It is also used to treat estrogen deficiency caused by ovarian conditions or to help prevent osteoporosis in postmenopausal individuals. By supplementing the body's declining hormone levels, this medication helps restore systemic hormonal balance.

You should take SII Evatone-2 Tablet consistently at the same time every day to maintain steady hormone levels in your body. It can be taken with or without food, though taking your daily tablet with a meal may help prevent mild stomach upset. Combining this treatment with a balanced diet rich in calcium and regular weight-bearing exercise can help support your overall results and bone health.

While many people tolerate SII Evatone-2 Tablet well, some may experience mild side effects such as nausea, breast tenderness, or occasional headaches. If you experience severe side effects, such as unusual vaginal bleeding, chest pain, or sudden severe headaches, you must contact your doctor immediately. Regular check-ups are essential to ensure the medication continues to be safe for you.

Before starting SII Evatone-2 Tablet , discuss your medical history with your doctor, especially if you have a history of high blood pressure, diabetes, gallbladder disease, or liver damage. Do not take this medicine if you are pregnant, have undiagnosed vaginal bleeding, or have a history of blood clots, stroke, or estrogen-sensitive cancers, such as breast or uterine cancer.

Certain medicines, such as those used for thyroid conditions or seizures, can change how SII Evatone-2 Tablet works, while smoking significantly increases your risk of serious side effects like blood clots and stroke. Pregnant and breastfeeding women should not use this medication, and elderly individuals should use it with caution under close medical supervision. Always consult your doctor or pharmacist before combining this therapy with other treatments or supplements.

Uses of SII Evatone-2 Tablet

SII Evatone-2 Tablet is used in the treatment of hormone replacement therapy, osteoporosis and hypoestrogenism. The detailed uses of SII Evatone-2 Tablet are as follows:

  • Menopause symptoms: SII Evatone-2 Tablet helps by replacing the natural estrogen that your body stops making, which reduces hot flashes, night sweats, and vaginal dryness.
  • Estrogen deficiency (hypogonadism or ovarian failure): SII Evatone-2 Tablet provides the necessary estrogen that your body is unable to produce naturally due to ovarian conditions or surgical removal of the ovaries.
  • Osteoporosis prevention: SII Evatone-2 Tablet helps preserve bone density and reduce the risk of fractures in postmenopausal individuals who are at high risk of bone loss.

Key Benefits

SII Evatone-2 Tablet offers significant relief from the disruptive symptoms of menopause and provides crucial long-term health protection, helping improve your daily comfort and overall quality of life.

Benefits may include:

  • Effectively reduces the frequency and intensity of sudden hot flashes and night sweats, allowing for more comfortable days and restful nights.
  • It helps control night sweats, which aids in achieving deeper, more restorative sleep, leading to reduced daytime fatigue and increased energy levels.
  • Restores vaginal tissue by relieving dryness, itching, and discomfort, which can make intimacy more comfortable and help maintain urinary health.
  • Helps prevent postmenopausal osteoporosis by preserving bone density, significantly lowering your long-term risk of painful fractures.
  • Helps to even out mood fluctuations and reduce the irritability often associated with the hormonal changes of menopause.
Side effects of SII Evatone-2 Tablet
  • Mild physical activity can increase blood flow and lessen pain from tense or irritated muscles.
  • Pain might be reduced with a supportive, properly fitting bra, particularly when exercising.
  • Limit or stay away from items that can cause breast pain, like spicy and caffeine-containing foods.
  • vitamin E medication which could ease breast pain and encourage rest.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Wash the vulva with warm water and a mild, unscented soap, avoiding harsh soaps or scrubbing.
  • Do not douche as it can disrupt the natural balance of bacteria in the vagina.
  • After bathing, pat the vulva completely dry with a soft towel.
  • Wear loose-fitting cotton underwear to allow air circulation.
  • Change wet or sweaty clothing regularly.
  • Avoid using scented products like feminine hygiene sprays, lotions, and toilet paper.
  • Wear loose-fitting pants and skirts.
  • Stress can increase itching, so practice relaxation techniques like meditation and yoga.

Directions for Use

  • Swallow the tablet whole with a full glass of water. Do not chew, crush, or break the tablet, as this can affect how the medicine is absorbed.
  • Take your tablet at the same time every day to keep a steady amount of medicine in your body.
  • You can take this medicine with or without food. If you experience mild nausea, taking it with a meal may help.
  • Always follow your doctor's exact instructions regarding how long to take this medication. Never adjust your dose or stop taking it without consulting your healthcare provider first.

How SII Evatone-2 Tablet Works

As individuals approach menopause, or if they have had their ovaries surgically removed, natural estrogen levels drop significantly. This drop triggers symptoms like hot flashes, mood changes, and thinning bones. SII Evatone-2 Tablet works by mimicking the natural estrogen hormones produced by the ovaries.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with SII Evatone-2 Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

SII Evatone-2 Tablet is not recommended during pregnancy, as it may harm the foetus and cause serious complications for the baby and mother.

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Breast Feeding

Unsafe

SII Evatone-2 Tablet is not recommended for breastfeeding mothers as it is known to cause harm to the baby.

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Driving

Safe if prescribed

It is not known to cause any side effects which may affect driving.

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Liver

Caution

SII Evatone-2 Tablet should be taken with caution, especially if you have a history of liver disease.

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Kidney

Caution

SII Evatone-2 Tablet should be taken with caution, especially if you have a history of kidney disease.

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Children

Unsafe

SII Evatone-2 Tablet is not recommended for children below 12 years of age.

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Heart

Caution

Please consult your doctor if you have any concerns regarding the use of SII Evatone-2 Tablet in heart patients.

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Geriatrics

Safe if prescribed

Please consult your doctor if you have any concerns regarding the use of SII Evatone-2 Tablet in elderly patients.

What if I have taken an overdose of SII Evatone-2 Tablet

In case of an accidental overdose, seek immediate medical attention or contact a poison control centre right away. Symptoms of an overdose may include severe nausea, vomiting, or unusual vaginal bleeding.

Diet & Lifestyle Advise

  • Boost calcium and vitamin D: Increase your intake of calcium and vitamin D through foods like leafy greens, dairy, or fortified products to support your bone health.
  • Support bone strength: Engage in regular weight-bearing and muscle-strengthening exercises, such as walking or light strength training, to keep your bones strong and reduce the risk of osteoporosis.
  • Avoid smoking: Stop smoking, as tobacco use significantly increases your risk of developing blood clots, stroke, and heart issues while taking oral SII Evatone-2 Tablet .
  • Limit alcohol: Reduce your alcohol intake to protect your liver, as both alcohol and oral hormones are processed by the liver.
  • Manage hot flashes: Stay cool by wearing layered clothing and avoiding triggers like spicy foods, caffeine, and hot beverages, which can worsen hot flashes.

Have a query?

How Soon It Starts Working

  • The time required for SII Evatone-2 Tablet to start to work: The time required for SII Evatone-2 Tablet to start to work is 3 to 6 hours after administration.
  • The time for which the effects of SII Evatone-2 Tablet last: The effect of SII Evatone-2 Tablet lasts for 4 to 5 days.

What if you forget to take SII Evatone-2 Tablet

If you miss a dose of SII Evatone-2 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed tablet and resume your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently forget to take your medication.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Schedule routine screenings: Schedule regular physical exams, including pelvic exams and mammograms, as directed by your doctor to monitor your health while on hormone therapy.
  • Perform breast self-exams: Perform monthly breast self-exams and report any new lumps, changes, or unusual discharge to your healthcare provider immediately.
  • Plan for surgeries or bed rest: If you need major surgery or will be on prolonged bed rest, inform your doctor well in advance, as you may need to temporarily stop taking SII Evatone-2 Tablet to reduce blood clot risks.
  • Monitor blood pressure: Check your blood pressure regularly, as oral estrogens can sometimes cause blood pressure levels to rise.
  • Watch for contact lens changes: If you wear contact lenses, notify your doctor if you experience changes in your vision or feel discomfort while wearing them.

Drug-Drug Interactions

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Drug-Drug Interaction:

  • Thyroid medications: SII Evatone-2 Tablet may decrease the effectiveness of thyroid hormone replacements, meaning your doctor may need to adjust your thyroid dose.
  • Anti-seizure medications (such as carbamazepine or phenobarbital): These can speed up how your liver processes SII Evatone-2 Tablet , making it less effective.
  • Certain antibiotics or antifungals (such as rifampin or ketoconazole): These can alter the levels of SII Evatone-2 Tablet in your blood, either reducing its effect or increasing side effects.

Drug-Food Interaction:

  • Grapefruit juice: Grapefruit and grapefruit juice can interfere with how your body processes this medicine, which may increase the risk of side effects.

Drug-Disease Interaction:

  • Liver disease: Do not take SII Evatone-2 Tablet if you have active liver damage, as the liver processes this medication, and damaged tissue cannot metabolise it safely.
  • Blood clotting disorders: Taking SII Evatone-2 Tablet can worsen or trigger blood clotting events in individuals with a history of deep vein thrombosis or pulmonary embolism.
  • Estrogen-sensitive cancers: SII Evatone-2 Tablet must be avoided if you have a history of breast cancer or uterine cancer, as estrogen can stimulate the growth of these cancer cells.
EstradiolDantrolene
Severe

Drug-Drug Interactions

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How does the drug interact with SII Evatone-2 Tablet:
When Etodolac is taken with Bivalirudin, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Bivalirudin with SII Evatone-2 Tablet can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
EstradiolDantrolene
Severe
How does the drug interact with SII Evatone-2 Tablet:
The usage of SII Evatone-2 Tablet with dantrolene might have significant adverse effects on your liver.

How to manage the interaction:
Taking SII Evatone-2 Tablet with Dantrolene together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, severe fatigue or weakness, unusual bleeding or bruising, skin rash or itching, lack of appetite, nausea, vomiting, or yellowing of the skin or whites of your eyes, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with SII Evatone-2 Tablet:
Co-administration of SII Evatone-2 Tablet with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking SII Evatone-2 Tablet with Tranexamic acid can lead to an interaction; however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with SII Evatone-2 Tablet:
Coadministration of SII Evatone-2 Tablet and Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and SII Evatone-2 Tablet, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with SII Evatone-2 Tablet:
Taking thalidomide together with SII Evatone-2 Tablet may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking SII Evatone-2 Tablet and thalidomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with SII Evatone-2 Tablet:
Letrozole may have a negative effect when used with SII Evatone-2 Tablet, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letrozole and SII Evatone-2 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with SII Evatone-2 Tablet:
Using SII Evatone-2 Tablet with Exemestane may interfere with Exemestane's activity and make it less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Exemestane and SII Evatone-2 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with SII Evatone-2 Tablet:
SII Evatone-2 Tablet may interfere with anastrozole's function and make it less effective in treating your condition.

How to manage the interaction:
Co-administration of Anastrozole with SII Evatone-2 Tablet can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
How does the drug interact with SII Evatone-2 Tablet:
Carfilzomib can cause serious blood clots and taking it alongside SII Evatone-2 Tablet may enhance the risk.

How to manage the interaction:
Co-administration of SII Evatone-2 Tablet with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with SII Evatone-2 Tablet:
When taken in combination, clindamycin can lower the amount or action of SII Evatone-2 Tablet.

How to manage the interaction:
Co-administration of SII Evatone-2 Tablet with Clindamycin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ESTRADIOL-2MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ESTRADIOL-2MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
The rate of absorption of oral estrogens may be increased by coadministration with grapefruit juice. Avoid or restrict the consumption of grapefruit juice while taking SII Evatone-2 Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

SII Evatone-2 Tablet is used to treat hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). This medicine is prescribed when the body is not producing a sufficient amount of natural estrogen.

SII Evatone-2 Tablet works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause.

Do not use SII Evatone-2 Tablet if you are allergic to peanuts, have unusual vaginal bleeding, have/had any cancer (breast or uterus cancer), or undergoing any other estrogen treatment. Tell your doctor if you had a heart attack, stroke, blood clot, or liver problems, if you are pregnant, breastfeeding, or planning to get pregnant.

No, SII Evatone-2 Tablet should not be taken if you are undergoing surgery. You should inform your doctor, and he might ask you to stop hormone replacement therapy about 4 to 6 weeks before surgery to reduce the risk of blood clots.

SII Evatone-2 Tablet may cause weight gain or loss, a common side effect. Regular exercise and a healthy diet can help prevent weight gain.

Do not discontinue SII Evatone-2 Tablet without consulting your doctor as stopping the medicine can cause your symptoms to come back. Consult the doctor, he/she might reduce the dose gradually.

If you miss a dose of SII Evatone-2 Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

You may experience side effects like headaches, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding. Consult the doctor if the side effects persist or worsen.

Foods like flaxseeds, soy, peaches, garlic, sesame seeds, kale, broccoli, Brussels sprouts, peanuts, almonds, cashews, and pistachios can be included in your diet for oestrogen deficiency.

Do not take SII Evatone-2 Tablet if you are allergic to any of its components or if you had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina or have undiagnosed vaginal bleeding, liver disease, or a bleeding disorder.

SII Evatone-2 Tablet should be swallowed as a whole with water; do not crush or chew it. It can be taken with or without food; taking with food or after meals may help prevent stomach upset.

Yes. In fact, individuals who have had a hysterectomy (removal of the uterus) are often prescribed SII Evatone-2 Tablet alone. If you still have your uterus, your doctor will typically prescribe a second hormone (progestin) alongside SII Evatone-2 Tablet to protect the uterine lining. Talk to your doctor for personalised advice.

Many people begin to feel relief from hot flashes and other menopausal symptoms within a few weeks of starting treatment. However, it may take several weeks to experience the full benefits of the medication. Talk to your doctor if your symptoms do not improve.

Yes, you can take SII Evatone-2 Tablet with or without food. If you find that the medicine causes a mild upset stomach or nausea, taking your daily tablet with a meal or a light snack can help reduce this feeling. Talk to your doctor or pharmacist if stomach discomfort persists.

Take the missed tablet as soon as you remember. If your next dose is due within a few hours, skip the missed dose and resume your regular schedule. Do not take two tablets at once to make up for a missed dose. Talk to your doctor or pharmacist if you frequently miss doses.

Yes, smoking significantly increases the risk of serious cardiovascular side effects, including blood clots, stroke, and heart attacks, while taking oral estrogen. It is strongly advised to quit smoking before starting this medication. Talk to your doctor about smoking cessation resources.

No, SII Evatone-2 Tablet is not recommended for individuals who are breastfeeding. Estrogen can pass into breast milk and may also decrease the quantity and quality of breast milk produced. Talk to your doctor about alternative options for symptom relief.

Hormone therapy is generally recommended at the lowest effective dose for the shortest possible duration to manage symptoms. Your doctor will re-evaluate your treatment plan every 3 to 6 months to determine if you should continue. Talk to your doctor about your specific health needs.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India
Other Info - SII0002
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