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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Simponi 50mg Injection is primarily used in treating moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders. It consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive; this helps reduce inflammation and pain caused by various autoimmune diseases.

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Whats That

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Composition :

GOLIMUMAB-50MG

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Simponi 50mg Injection

Simponi 50mg Injection belongs to the Anti-monoclonal TNF (Tumor necrosis factor) class of medicines that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders.

Simponi 50mg Injection consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Simponi 50mg Injection may cause certain side effects such as nausea, headache, upper respiratory tract infections, dizziness, constipation, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor. A trained healthcare doctor will administer Simponi 50mg Injection. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Simponi 50mg Injection should be avoided if you are allergic to any of its components. Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. If you are pregnant or breastfeeding, consult your doctor before taking Simponi 50mg Injection.

Uses of Simponi 50mg Injection

Treatment of Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis

Directions for Use

Simponi 50mg Injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Simponi 50mg Injection contains Golimumab, as an active ingredient that belongs to the class of monoclonal TNF inhibitors. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation, pain and redness caused by various autoimmune diseases.

How Simponi 50mg Injection Works

Simponi 50mg Injection consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Simponi 50mg Injection

Since Simponi 50mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Simponi 50mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, blood disorders, nervous system problems, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. It is not known whether Simponi 50mg Injection can be given to pregnant and breastfeeding women. Hence, consult your doctor if you are pregnant, planning to become pregnant or are breastfeeding. Do not take live vaccines while being treated with Simponi 50mg Injection to prevent any serious consequences.

Drug-Drug Interactions

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GolimumabMitomycin
Severe
GolimumabDeflazacort
Severe

Drug-Drug Interactions

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GolimumabMitomycin
Severe
How does the drug interact with Simponi 50mg Injection:
Using mitomycin together with Simponi 50mg Injection may increase the risk of serious infections.

How to manage the interaction:
Although taking Mitomycin and Simponi 50mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination call your doctor right away. Do not discontinue any medications without first consulting a doctor.
GolimumabDeflazacort
Severe
How does the drug interact with Simponi 50mg Injection:
Simponi 50mg Injection can cause tendinitis (inflammation of the thick fibrous cords that attach muscle to bone) and tendon rupture (injury to the soft tissue that connect muscle to bone), and the risk may be increased when combined with other drugs such as deflazacort.

How to manage the interaction:
Although there is an interaction, Simponi 50mg Injection can be taken with deflazacort if prescribed by the doctor. However, if you experience pain, swelling at the back of the ankle, biceps, shoulder, hand, or thumb, consult a doctor immediately. Avoid exercise or use of the affected area until further instruction from your doctor. Do not stop using any medications without first talking to your doctor.
GolimumabPrednisolone
Severe
How does the drug interact with Simponi 50mg Injection:
Co-administration of Simponi 50mg Injection with Prednisolone could increase the risk of severe infections.

How to manage the interaction:
Although taking Simponi 50mg Injection with Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Simponi 50mg Injection:
The combined use of Simponi 50mg Injection and valganciclovir can increase the risk of infections.

How to manage the interaction:
Although taking Valganciclovir and Simponi 50mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of the following symptoms - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - contact your doctor right away. Do not stop using any medications without talking to your doctor.
Severe
How does the drug interact with Simponi 50mg Injection:
Co-administration of Mercaptopurine with Simponi 50mg Injection together can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Mercaptopurine and Simponi 50mg Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms, contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not discontinue any medications without consulting a doctor.
GolimumabBusulfan
Severe
How does the drug interact with Simponi 50mg Injection:
Coadministration of Simponi 50mg Injection with Busulfan may increase the risk of developing infections.

How to manage the interaction:
Taking Busulfan with Simponi 50mg Injection together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, diarrhea, sore throat, muscle aches, difficulty breathing, or burning when you pee, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
GolimumabBetamethasone
Severe
How does the drug interact with Simponi 50mg Injection:
Co-administration of Betamethasone with Simponi 50mg Injection can increase the risk or severity of side effects.

How to manage the interaction:
Taking Betamethasone with Simponi 50mg Injection together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
GolimumabGemcitabine
Severe
How does the drug interact with Simponi 50mg Injection:
Combining Gemcitabine with Simponi 50mg Injection can increase the risk of infections.

How to manage the interaction:
Taking Gemcitabine with Simponi 50mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain/burning when you urinate. Do not stop using any medications without a doctor's advice.
GolimumabPazopanib
Severe
How does the drug interact with Simponi 50mg Injection:
Combining Simponi 50mg Injection with Pazopanib can increase the risk of infections.

How to manage the interaction:
There may be a possibility of interaction between Pazopanib and Simponi 50mg Injection, but it can be taken if prescribed by a doctor. Do not discontinue any medications without first consulting your doctor.
GolimumabPrimaquine
Severe
How does the drug interact with Simponi 50mg Injection:
When Primaquine is taken with Simponi 50mg Injection, it can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Primaquine and Simponi 50mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • Stay hydrated; drink plenty of water.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS
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Alcohol

Unsafe

It is not known if alcohol interacts with Simponi 50mg Injection. Please consult the doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Simponi 50mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is not known whether Simponi 50mg Injection passes into human milk. Hence, if you are breastfeeding, inform your doctor before receiving Simponi 50mg Injection.

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Driving

Caution

Simponi 50mg Injection will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

Simponi 50mg Injection may cause liver disease. Inform your doctor if you have a poor appetite, yellow discolouration of the skin or eyes, and abdominal pain. If you have pre-existing or a history of liver problems, let your doctor know, as this medicine may worsen your condition.

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Kidney

Consult your doctor

Limited data on the effects of Simponi 50mg Injection in patients with kidney impairment is available. If you have a pre-existing or a history of kidney disease, inform your doctor before taking Simponi 50mg Injection.

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Children

Unsafe

Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established.

Have a query?

FAQs

Simponi 50mg Injection is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis.

Simponi 50mg Injection contains Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.

Simponi 50mg Injection affects your immune system and makes you more susceptible to infections. It is not recommended in people with active infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, or weak immune system. Hence, inform your doctor if you have any history of these conditions beforehand.

Country of origin

Switzerland
Other Info - SI17953

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