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  3. SIMVAS 5MG TABLET

SIMVAS 5MG TABLET, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
SIMVAS 5MG TABLET is used to treat high cholesterol. It contains Simvastatin which works by lowering the levels of bad cholesterol, and triglycerides and raising the levels of good cholesterol. In some cases, this medicine may cause side effects such as headache, stomach pain, constipation, and nausea. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

SIMVASTATIN-5MG

Manufacturer/Marketer :

Micro Labs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About SIMVAS 5MG TABLET

SIMVAS 5MG TABLET is used to lower the levels of increased cholesterol in the body. Additionally, SIMVAS 5MG TABLET is also used to lower the risk of heart diseases such as heart attack or stroke. High cholesterol levels might cause a build-up of cholesterol on the artery walls, leading to blockage of blood flow to the heart and other body parts that could cause heart disease, heart attack or stroke.

SIMVAS 5MG TABLET contains 'Simvastatin' that works by blocking HMG-CoA reductase, an enzyme necessary for cholesterol production in the body. SIMVAS 5MG TABLET helps lower the levels of LDL (bad) cholesterol, and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, SIMVAS 5MG TABLET lowers the raised levels of fats, triglycerides and cholesterol, which lowers the risk of heart attack or stroke. 

You are advised to take SIMVAS 5MG TABLET as long as your doctor has prescribed it for you, depending on your medical condition. You may experience certain common side effects, such as headache, stomach pain, constipation, and nausea in some cases. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take SIMVAS 5MG TABLET if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Stop taking SIMVAS 5MG TABLET and consult a doctor immediately if you become pregnant while taking SIMVAS 5MG TABLET. SIMVAS 5MG TABLET may cause dizziness, so be cautious while driving. Avoid consuming alcohol with SIMVAS 5MG TABLET as it could lead to increased dizziness. SIMVAS 5MG TABLET is not recommended for children below 10 years as safety and effectiveness have not been established. Inform your doctor regarding your health condition and the medicines you are taking to rule out any side effects or interactions.

Uses of SIMVAS 5MG TABLET

Treatment of Hyperlipidaemia (high cholesterol)

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Directions for Use

• SIMVAS 5MG TABLET can be taken with or without food as advised by your doctor.• SIMVAS 5MG TABLET is usually taken once a day, or as prescribed by your doctor.• Swallow SIMVAS 5MG TABLET as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

SIMVAS 5MG TABLET contains 'Simvastatin', which belongs to a group of lipid-lowering agents called HMG-CoA reductase inhibitors to lower the increased levels of cholesterol or fat. SIMVAS 5MG TABLET works by blocking the HMG-CoA reductase enzyme, which is necessary for cholesterol production in the body. SIMVAS 5MG TABLET helps lower the levels of LDL (bad) cholesterol and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, SIMVAS 5MG TABLET lowers the blood level of fats and cholesterol and helps prevent a heart attack or stroke. SIMVAS 5MG TABLET as an adjunct to dietary measures is used to reduce the risk of having a heart event due to cardiovascular diseases, the incidence of non-fatal heart attack or stroke, the need for revascularisation procedures (restoration of blood flow to the heart), people with diabetes, pre-existing heart disease, and peripheral vascular disease.  

How SIMVAS 5MG TABLET Works

SIMVAS 5MG TABLET contains 'Simvastatin' that works by blocking HMG-CoA reductase, an enzyme necessary for cholesterol production in the body. SIMVAS 5MG TABLET helps lower the levels of LDL (bad) cholesterol, and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, SIMVAS 5MG TABLET lowers the raised levels of fats, triglycerides and cholesterol, which lowers the risk of heart attack or stroke.

Storage

Keep SIMVAS 5MG TABLET out of reach and sight of children.
Side effects of Simvas 5mg Tablet
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.

What if I have taken an overdose of SIMVAS 5MG TABLET

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take SIMVAS 5MG TABLET if you are allergic to any of its contents; if you are taking fusidic acid or have taken it in the past 7 days. Inform your doctor if you are due to have surgery, drink large amounts of alcohol; if you have liver or kidney problems. Do not take SIMVAS 5MG TABLET if you are pregnant, breastfeeding, think you may be pregnant or if you are trying for pregnancy. Stop taking SIMVAS 5MG TABLET and consult a doctor immediately if you become pregnant while taking SIMVAS 5MG TABLET. SIMVAS 5MG TABLET may cause dizziness, so be cautious while driving. Avoid consuming alcohol with SIMVAS 5MG TABLET as it could lead to increased dizziness. SIMVAS 5MG TABLET is not recommended for children below 10 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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SimvastatinItraconazole
Critical
SimvastatinNefazodone
Critical

Drug-Drug Interactions

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SimvastatinItraconazole
Critical
How does the drug interact with Simvas 5mg Tablet:
Simvas 5mg Tablet's blood levels and effects may be greatly increased when combined with itraconazole.

How to manage the interaction:
Simvas 5mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you have side effects such unexplained pain in the muscles or tenderness, muscle weakness, fever or flu-like symptoms, or dark urine. Without consulting a doctor, never stop taking any medication.
SimvastatinNefazodone
Critical
How does the drug interact with Simvas 5mg Tablet:
Combining Nefazodone and Simvas 5mg Tablet can increase the blood levels and effects of Simvas 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nefazodone and Simvas 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinPosaconazole
Critical
How does the drug interact with Simvas 5mg Tablet:
Taking Posaconazole with Simvas 5mg Tablet can increase the blood levels and effects of Simvas 5mg Tablet. This can increase the risk of side effects such as liver problems and rhabdomyolysis (which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Posaconazole and Simvas 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by a doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinAmprenavir
Critical
How does the drug interact with Simvas 5mg Tablet:
Combining Amprenavir and Simvas 5mg Tablet can increase the blood levels and effects of Simvas 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Amprenavir and Simvas 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinCeritinib
Critical
How does the drug interact with Simvas 5mg Tablet:
Combining Ceritinib and Simvas 5mg Tablet can increase the blood levels and effects of Simvas 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Ceritinib and Simvas 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinClarithromycin
Critical
How does the drug interact with Simvas 5mg Tablet:
Co-administration of Clarithromycin and Simvas 5mg Tablet can increase the blood levels and effects of Simvas 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis(which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Clarithromycin and Simvas 5mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinMifepristone
Critical
How does the drug interact with Simvas 5mg Tablet:
Combining Mifepristone with Simvas 5mg Tablet can increase the blood levels of Simvas 5mg Tablet, which may increase the risk of side effects.

How to manage the interaction:
Taking Simvas 5mg Tablet with Mifepristone is not recommended, but can be taken if prescribed by the doctor. If you experience any symptoms, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinVoriconazole
Critical
How does the drug interact with Simvas 5mg Tablet:
Taking Voriconazole and Simvas 5mg Tablet can increase the blood levels and effects of Simvas 5mg Tablet. This can increase the risk of side effects (liver damage and rhabdomyolysis - involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Voriconazole and Simvas 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if a doctor advises. However, if you experience muscle pain, fever or dark-colored urine, vomiting, and yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinRitonavir
Critical
How does the drug interact with Simvas 5mg Tablet:
Taking Ritonavir and Simvas 5mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Simvas 5mg Tablet with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, contact a doctor. Do not discontinue any medications without consulting a doctor.
SimvastatinTroleandomycin
Critical
How does the drug interact with Simvas 5mg Tablet:
Combining Troleandomycin and Simvas 5mg Tablet can increase the blood levels and effects of Simvas 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Troleandomycin and Simvas 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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SIMVASTATIN-5MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe

Drug-Food Interactions

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SIMVASTATIN-5MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, Green Tea

How to manage the interaction:
Taking grapefruit or grape juice and green tea or green tea extracts can increase the blood levels of Simvas 5mg Tablet and can increase the risk of liver damage and rhabdomyolysis (breakdown of skeletal muscle tissue). Taking grapefruit or grape juice and green tea or green tea extracts can lead to an interaction. However, if you experience any symptoms like muscle pain, tenderness, or weakness during treatment, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, consult the doctor immediately. Avoid taking grapefruit or grape juice and green tea or green tea extracts.

Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.

  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.

  • Limit salt and sugar intake.

  • Avoid smoking and alcohol consumption. 

  • Choose healthy fats and cut down on trans-fat.

  • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.

  • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS

SIMVAS 5MG TABLET Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking SIMVAS 5MG TABLET as it may cause increased dizziness.

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Pregnancy

Unsafe

SIMVAS 5MG TABLET belongs to pregnancy category X. Do not take SIMVAS 5MG TABLET if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Stop taking SIMVAS 5MG TABLET and consult a doctor immediately if you become pregnant while taking SIMVAS 5MG TABLET.

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Breast Feeding

Unsafe

It is not known if SIMVAS 5MG TABLET passes into breastmilk. Do not take SIMVAS 5MG TABLET if you are breastfeeding.

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Driving

Caution

Usually, SIMVAS 5MG TABLET does not interfere with your ability to drive or usage of machinery. However, SIMVAS 5MG TABLET may cause dizziness in some people. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

SIMVAS 5MG TABLET is not recommended for children below 10years as the safety and effectiveness have not been established.

FAQs

SIMVAS 5MG TABLET is used to lower the levels of increased cholesterol in the body. Additionally, SIMVAS 5MG TABLET is also used to lower the risk of heart diseases such as heart attack or stroke.

SIMVAS 5MG TABLET works by blocking HMG-CoA reductase, an enzyme necessary for the production of cholesterol in the body. SIMVAS 5MG TABLET helps lower the levels of LDL (bad) cholesterol and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, SIMVAS 5MG TABLET lowers the blood level of raised fats and cholesterol and helps prevent a heart attack or stroke.

Do not discontinue SIMVAS 5MG TABLET without consulting your doctor as it could lead to the rise of cholesterol. To treat your condition effectually, continue taking SIMVAS 5MG TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking SIMVAS 5MG TABLET.

Constipation could be a side-effect of SIMVAS 5MG TABLET. Drink plenty of fluids and eat fibre-rich food if you experience constipation. Consult your doctor if you have severe constipation.

SIMVAS 5MG TABLET can be taken by diabetes patients if prescribed by the doctor. Your doctor will monitor your condition closely if you have diabetes. Regular monitoring of blood sugar levels is advised.

SIMVAS 5MG TABLET should not be taken with antibiotics such as fusidic acid as it could lead to a serious muscle problem called rhabdomyolysis (the breakdown of muscle tissue). Inform the doctor that you are taking SIMVAS 5MG TABLET if your doctor has prescribed fusidic acid, the doctor may ask you to temporarily stop taking SIMVAS 5MG TABLET to treat your infection. Your doctor will decide when it is safe to restart treatment with SIMVAS 5MG TABLET.

SIMVAS 5MG TABLET might cause muscle problems, particularly when taken at high doses. In rare conditions, SIMVAS 5MG TABLET might cause serious muscle problems such as rhabdomyolysis (muscle tissue breakdown). Consult your doctor immediately if you experience muscle pain, weakness, and tenderness, especially if associated with fever or tiredness.

SIMVAS 5MG TABLET may cause side effects such as nausea, headache, stomach pain, and constipation. If these side effects persist or worsen, please consult your doctor.

Swallow SIMVAS 5MG TABLET as a whole. Do not crush or break while taking SIMVAS 5MG TABLET.

You are recommended to avoid alcohol consumption while taking SIMVAS 5MG TABLET as it may increase dizziness and also increase the risk of muscle breakdown. If you have still have any concerns regarding this, please discuss with your doctor.

Take SIMVAS 5MG TABLET as advised by your doctor. It is usually taken once a day mostly after dinner. Try to take SIMVAS 5MG TABLET at the same time every day for effective results and to remember taking it.

You should take SIMVAS 5MG TABLET for as long as it is advised by your doctor. You might need to take it lifelong as cholesterol levels will be maintained only while you are taking SIMVAS 5MG TABLET. If you stop SIMVAS 5MG TABLET without starting other treatment, your cholesterol levels may increase again. Therefore, do not stop taking it without first consulting your doctor.

You should avoid foods rich in calories like junk food and fried food. It is recommended to eat a low-cholesterol diet and a low-fat. Make sure to follow all the exercise and dietary recommendations made by your dietician or doctor.

Yes, SIMVAS 5MG TABLET can make you feel tired. Additionally, SIMVAS 5MG TABLET may cause muscle damage which further worsens the tiredness. Therefore, if you feel tired while taking SIMVAS 5MG TABLET, consult your doctor.

Yes, SIMVAS 5MG TABLET is safe to take in prescribed dose and duration. The patient should follow doctor’s recommendations. Do not exceed the recommended daily dose.

Country of origin

India

Manufacturer/Marketer address

No. 28 Sundar Industrial Estate,N.T.Y Layout Mysore Road , Bangalore - 560026, India
Other Info - SIM0010

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:48 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.542.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019766s085lbl.pdf
  3. https://www.nhs.uk/medicines/simvastatin/
  4. https://www.drugs.com/simvastatin.html

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