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compositionComposition:CLOMIPHENE-50MG
prescription
Prescription Medicine
info
Siphene Tablet 5's
Siphene Tablet 5's

Siphene Tablet is used to treat infertility in women who are not ovulating (producing an egg) properly or have irregular or no menstrual cycle. It contains Clomiphene, which induces ovulation (egg production) in a woman who has problems with ovulation and wishes to get pregnant. This medicine works by stimulating the production of hormones that are responsible for the ovulation process. It may cause common side effects such as flushing (reddening of the skin, especially the face), vasomotor symptoms (night sweats and hot flushes), abdominal bloating or discomfort, nausea, vomiting, headache, vision problems and breast pain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CLOMIPHENE-50MG

Manufacturer/Marketer :

Serum Institute Of India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Siphene Tablet

Siphene Tablet is an oral prescription medication primarily used to treat female infertility. It helps trigger ovulation (the release of a mature egg) in women who do not ovulate regularly or at all, such as those with polycystic ovary syndrome (PCOS).

Siphene Tablet is taken as a short oral course, usually for a few consecutive days during a specific window of your menstrual cycle. It can be taken with or without food, but taking it at the same time each day helps maintain steady levels in your body. Making positive lifestyle changes, such as managing stress, maintaining a healthy weight, and eating a balanced diet, can support the treatment's success.

While taking Siphene Tablet, some individuals may experience mild side effects like hot flashes, abdominal bloating, or breast tenderness. However, if you experience visual disturbances, severe pelvic pain, or sudden weight gain, you must contact your healthcare provider immediately.

Before starting Siphene Tablet, speak with your doctor if you have liver disease, unusual vaginal bleeding of unknown cause, ovarian cysts (unrelated to PCOS), or thyroid disorders. Do not take this medicine if you are already pregnant, have active liver damage, or have hormone-dependent tumours.

Certain medications can interact with Siphene Tablet, potentially reducing its effectiveness or increasing side effects, so share a full list of your current medicines with your pharmacist. Avoid drinking alcohol during treatment as it can worsen dizziness or hot flashes. This medicine is not intended for pregnant or breastfeeding women, nor is it typically prescribed for elderly individuals.

Uses of Siphene Tablet

Siphene Tablet is used to treat female infertility. The detailed uses of Siphene Tablet are as follows:

  • Infertility due to lack of ovulation: Siphene Tablet helps stimulate the ovaries to mature and release an egg, allowing women who do not ovulate regularly to have a chance at conception.
  • Polycystic Ovary Syndrome (PCOS)-associated infertility: It acts on the pituitary gland to trigger the hormones needed to prompt egg development in women with PCOS.

 

Key Benefits

Siphene Tablet helps support ovulation in women with certain ovulatory disorders, improving the chances of conception. By stimulating the body's natural hormonal processes, it promotes regular ovulation and supports fertility treatment.

  • Provides a non-invasive fertility option: Unlike injectable fertility treatments, Siphene Tablet is taken orally, offering a straightforward, widely utilised first-line treatment for ovulatory issues.
  • Establishes a predictable ovulation cycle: By regulating the hormonal signals that control egg release, this medication helps couples better plan intercourse or clinical procedures.
  • Addresses the root cause of certain ovulatory delays: It works directly with your body's natural hormone systems to restore ovulation without requiring continuous daily use throughout the entire month.
     
Side effects of Siphene Tablet
  • Schedule a comprehensive medical evaluation with a specialized women's health expert.
  • Adhere to a personalized medication regimen to alleviate symptoms and promote ovarian health.
  • Embrace a holistic approach to wellness, incorporating nutritious eating habits and consistent physical activity.
  • Refrain from engaging in physically demanding tasks that may exacerbate discomfort.
  • Prioritize rejuvenation and relaxation, ensuring adequate sleep and downtime.
  • Explore complementary therapies, like acupuncture or botanical supplements, under the guidance of a qualified medical professional.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Use hot or cold packs on your breasts to help alleviate discomfort.
  • Choose a supportive, well-fitting bra, preferably one that has been professionally fitted.
  • Practice relaxation techniques to manage stress and anxiety that may accompany severe breast pain.
  • Limit or avoid caffeine consumption.
  • Eat a low-fat diet and focus on foods rich in complex carbohydrates.
  • Rubbing evening primrose oil on your breasts may help balance fatty acids in the cells and reduce pain.
  • Keep track of when your breast pain occurs and any other symptoms to determine if the pain is regular or not.
  • Vitamin E supplements may help reduce pain for women who experience pain linked to their menstrual cycle.
  • Over-the-counter pain relievers like acetaminophen or ibuprofen can provide relief, but be sure to consult your doctor for the correct dosage, as prolonged use may cause side effects.
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Call and consult your doctor if you observe prolonged and unusual bleeding during menstruation cycle.
  • Drink more fluids and your doctor may prescribe a suitable medication to reduce the bleeding.
  • Ensure to use the right hygiene products to prevent leakage and discomfort.
  • Talk to your doctor to know the cause, severity and appropriate treatment options.
  • Try pain relievers like ibuprofen or naproxen to relieve mild pelvic pain.
  • Consider pelvic floor exercises as it helps to strengthen muscles in the pelvic region and relieve pain.
  • Try relaxation techniques like deep breathing, meditation or gentle stretching.
  • Vaginal bleeding can be abnormal if it is not related to menstruation, and needs immediate attention and cannot be ignored.
  • Get a physical examination and follow your doctor's instructions to get relief from bleeding.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Prefer practicing yoga and meditation to reduce stress and anxiety, as it can worsen vaginal bleeding.
  • Take a balanced diet and manage your weight.

Directions for Use

  • Siphene Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.

Swallow Siphene Tablet as a whole with a glass of water.

  • Do not chew, crush, or break it.

How Siphene Tablet Works

Siphene Tablet contains clomiphene, which belongs to a class of medications called selective oestrogen receptor modulators. It works by blocking oestrogen receptors in the brain, specifically in the hypothalamus. This action tricks your brain into thinking that oestrogen levels in the body are very low. In response, the brain releases more follicle-stimulating hormone (FSH) and luteinising hormone (LH). These hormones signal the ovaries to develop, mature, and eventually release one or more eggs during the menstrual cycle.
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Alcohol

Caution

Alcohol consumption may worsen your condition and increase the risk of side-effects.

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Pregnancy

Unsafe

Siphene Tablet is a category X drug. It should not be given to pregnant women as Siphene Tablet doesn't benefit this population and may also cause birth defects/congenital disabilities in the unborn baby.

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Breast Feeding

Caution

Siphene Tablet decreases the supply of breast milk. So, it should be used with caution in breastfeeding mothers.

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Driving

Caution

Siphene Tablet may cause vision problems, so do not drive or operate heavy machinery after taking Siphene Tablet until your vision gets normal.

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Liver

Caution

Siphene Tablet should be used with extreme caution in patients with liver disease as the liver metabolizes this medicine. Dose adjustments may be necessary.

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Kidney

Caution

Siphene Tablet can be used in patients with kidney diseases if clinically required.

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Children

Unsafe

Siphene Tablet is not recommended for use in children.

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Heart

Caution

Siphene Tablet is used with caution in cardiac patients and regular monitoring is required.

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Geriatrics

Caution

Siphene Tablet is contraindicated for use in elderly women. For elderly men, this medicine should be used with caution.

What if I have taken an overdose of Siphene Tablet

If you suspect you have taken more than the prescribed amount, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Maintain a balanced, nutrient-rich diet focusing on whole grains, lean proteins, and healthy fats, which can help support hormone balance.
  • If you have PCOS, managing insulin levels by limiting refined sugars and processed carbohydrates can improve your overall response to fertility treatments.
  • Incorporate moderate, low-impact exercise like walking, swimming, or yoga while avoiding extreme, exhausting workouts which can sometimes disrupt ovulation.
  • Track your basal body temperature or use ovulation predictor kits as advised by your healthcare provider to help identify your most fertile days.
     

Health Queries

Have a query?

How Soon It Starts Working

The time required for Siphene Tablet to start to work: The time required for Siphene Tablet to show its action is unknown. The time for which the effects of Siphene Tablet last: The duration of action for Siphene Tablet is unknown.

What if you forget to take Siphene Tablet

If you miss a dose of Siphene Tablet, talk to your doctor or pharmacist immediately for guidance on how to adjust your cycle timing. Do not take a double dose to make up for the missed one.

Storage

•Store Siphene Tablet oral tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture

Drug Warnings

  • Check your vision regularly: Stop taking the medication and call your doctor immediately if you experience any blurry vision or visual flashes.
  • Monitor for signs of multiple births: Be aware that taking Siphene Tablet increases the chance of having a multiple pregnancy (such as twins or triplets).
  • Do not share your medication: This treatment is strictly customized to your body's hormone profile; sharing it can cause serious medical complications.
  • Avoid driving or operating machinery: This medicine can cause dizziness or temporary vision changes, so exercise extreme caution before performing activities that require clear sight and alertness.
  • Limit treatment cycles: Most medical guidelines recommend not using this medication for more than 3 to 6 cycles; talk to your doctor if pregnancy is not achieved within this timeframe.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Other fertility medications (such as gonadotropins): Combining these can significantly increase the risk of overstimulating the ovaries.
     
clomipheneOspemifene
Critical
clomipheneBexarotene
Severe

Drug-Drug Interactions

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clomipheneOspemifene
Critical
How does the drug interact with Siphene Tablet:
Co-administration of Clomifene with Ospemifene can increase the seriousness of side effects.

How to manage the interaction:
Taking Siphene Tablet with Ospemifene is not recommended, please consult a doctor before taking it.
clomipheneBexarotene
Severe
How does the drug interact with Siphene Tablet:
Co-administration of Siphene Tablet with Bexarotene may increase the risk of pancreatitis, or inflammation of the pancreas.

How to manage the interaction:
Although there is an interaction, Siphene Tablet can be taken with Bexarotene if prescribed by the doctor. Consult the prescriber if you experience symptoms of pancreatitis such as persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, especially that which is made worse after eating or radiates to the back. Do not discontinue the medication without consulting a doctor.
clomipheneFluoroestradiol (18f)
Severe
How does the drug interact with Siphene Tablet:
Co-administration of Fluoroestradiol F 18 together with Siphene Tablet may reduce the action of Fluoroestradiol F 18.

How to manage the interaction:
Taking Siphene Tablet with Fluoroestradiol (18f) together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No major foods are known to directly interfere with Siphene Tablet, but it is best to avoid alcohol, as it can worsen side effects like dizziness and hot flashes.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Siphene Tablet is used to treat infertility in women who are not ovulating (producing an egg) properly or have irregular or no menstrual cycle.
Siphene Tablet contains 'clomiphene' which can induce ovulation in women who have problems with fertility. It enhances fertility by stimulating the production of hormones that are necessary for ovulation.
Siphene Tablet is not a cure to infertility. It can only enhance your chance of getting pregnant by inducing ovulation. In most of the cases, the women ovulate within 7 to 10 days after taking this medicine. So, ask your doctor if you have any questions regarding the benefits of Siphene Tablet.
Siphene Tablet is given to women who cannot become pregnant due to problems with ovulation. It is not recommended for children, adolescents, men, pregnant women and post-menopausal women.
Siphene Tablet can be taken with or without food. However, take this medicine at the same time every day for effective results.
After taking Siphene Tablet, this medicine may (1) induce ovulation, and you may get your period, or (2) induce ovulation, and you get pregnant and not have a period, or (3) fail to induce ovulation. So, if you have not had your period, take a pregnancy test at home or in the doctor's office to confirm pregnancy.
Siphene Tablet can only enhance your chances of fertility. The reason for not getting pregnant after taking this medicine may be low dosage, other underlying causes of infertility, or any comorbid conditions that interfere with Siphene Tablet action. Consult your doctor to know the exact reason.
Siphene Tablet is used in the treatment of infertility. It should not be used for any other condition without doctor’s advice. Do not self-medicate.
Siphene Tablet is used to treat infertility in women. It doesn’t increase the sperm count or quality. If you have any concerns about this, please consult a doctor.
Take it as per the dose advised by the doctor. Swallow it with a glass of water. Do not break or chew or crush it.
The common side effects of Siphene Tablet include flushing (reddening of the skin, especially the face), abdominal bloating or discomfort, nausea (feeling sick), vomiting (being sick), headache, vision problems and breast pain. Tell your doctor if any of these side effects persist or worsen.
Yes, Siphene Tablet stimulates the ovaries and can cause more than one egg to release, which increases the likelihood of a multiple pregnancy (most commonly twins). Talk to your doctor.
If ovulation does not occur during the first cycle, your doctor may adjust your treatment plan or explore alternative fertility options. Do not increase your dose on your own. Talk to your doctor.
You should not take Siphene Tablet if you have ovarian cysts that are not related to Polycystic Ovary Syndrome (PCOS), as the medicine can cause these cysts to enlarge. Talk to your doctor.
It is highly recommended to avoid alcohol while taking Siphene Tablet. Alcohol can intensify side effects like hot flashes, dizziness, and headaches and is not supportive of fertility goals. Talk to your doctor.
Yes, some women experience temporary mood changes, irritability, or mild anxiety while taking Siphene Tablet due to the shifts in oestrogen levels. Talk to your doctor.
Generally, it is not recommended to use Siphene Tablet for more than 3 to 6 treatment cycles. If pregnancy is not achieved by then, your doctor will likely recommend a different fertility path. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India
Other Info - SIP0002

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