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Sitadex-DM 1000 Tablet 10's is an antidiabetic medicine used to treat Type II Diabetes as an adjunct to diet and exercise. It contains Dapagliflozin (which removes excess sugar from the body via urine), Sitagliptin (which works by increasing the amounts of certain natural substances that lower blood sugar when it is high) and Metformin (which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines).

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DAPAGLIFLOZIN-10MG+METFORMIN-1000MG+SITAGLIPTIN-100MG

Manufacturer/Marketer :

Biochemix Health Care Pvt Ltd

Consume Type :

Oral

Return Policy :

Not Returnable

About Sitadex-DM 1000 Tablet 10's

Sitadex-DM 1000 Tablet 10's is a prescription medication used to manage blood sugar levels in adults with type 2 diabetes. It is prescribed alongside a healthy diet and regular physical activity to improve overall control of your blood sugar. By keeping blood sugar levels within a target range, this medication helps prevent long-term complications associated with diabetes.

This medication is typically taken daily, and it is highly important to take it consistently at the same time each day. For the best results and to reduce stomach upset, you should take this tablet with food. To support the effectiveness of your treatment, you should also adopt common lifestyle changes, such as eating a balanced diet lower in simple sugars and participating in regular exercise.

While taking Sitadex-DM 1000 Tablet 10's, you may experience mild side effects like nausea, a runny nose, or a headache. However, if you develop serious side effects, such as persistent, severe stomach pain or signs of severe dehydration, you must contact your doctor immediately. Seeking prompt medical advice ensures that any rare but serious complications are managed safely.

Before starting this medication, talk to your doctor if you have a history of kidney disease, liver damage, heart failure, or pancreatitis. Do not take this if you have type 1 diabetes, diabetic ketoacidosis, or severe kidney failure. Your doctor will evaluate your medical history to ensure this medication is safe for your specific condition.

This medicine can interact with substances like alcohol, which increases the risk of a rare but serious condition called lactic acidosis. If you are pregnant, breastfeeding, or are an elderly individual, you must consult your doctor before starting this treatment to discuss potential risks and appropriate care.

Uses of Sitadex-DM 1000 Tablet 10's

Sitadex-DM 1000 Tablet 10's is used to treat Type 2 diabetes mellitus. The detailed uses of Sitadex-DM 1000 Tablet 10's are as follows:

  • Type 2 Diabetes Mellitus: Sitadex-DM 1000 Tablet 10's helps lower blood sugar levels in adults when diet, exercise, and other single-ingredient medications do not provide enough control.
  • Prevention of cardiovascular complications: In patients with type 2 diabetes who also have established heart disease, this medication helps reduce the risk of hospitalisation for heart failure.
     

Key Benefits

Sitadex-DM 1000 Tablet 10's helps manage type 2 diabetes by improving blood sugar control through multiple complementary mechanisms. With regular use as prescribed, it helps maintain stable glucose levels, supports overall metabolic health, and reduces the risk of diabetes-related complications.

  • Provides Comprehensive Blood Sugar Control: By improving the body's response to insulin, increasing insulin release after meals, and helping the kidneys remove excess glucose through urine, this medicine helps maintain stable blood sugar levels throughout the day.
  • Reduces the Risk of Diabetes Complications: Consistent blood sugar control helps protect the kidneys, nerves, eyes, heart, and blood vessels, lowering the risk of long-term complications associated with diabetes.
  • Supports Overall Metabolic Health: In addition to improving blood sugar control, this medicine may help with modest weight loss and a slight reduction in blood pressure, providing added benefits for overall health in appropriate patients.

Directions for Use

  • Take Sitadex-DM 1000 Tablet 10's with food to reduce stomach upset or gastrointestinal side effects.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Sitadex-DM 1000 Tablet 10's Works

Sitadex-DM 1000 Tablet 10's is a combination of three active components that work together in harmony to lower blood sugar levels. The first component, dapagliflozin, works in your kidneys, blocking the absorption of glucose so that excess sugar is flushed out of your body when you urinate. The second component, sitagliptin, works on your pancreas and liver by increasing the levels of natural hormones that stimulate insulin production after you eat. This component also signals your liver to produce less sugar, keeping your baseline glucose levels steady. The third component, metformin, works directly on your body's cells, helping them become more sensitive to insulin so they can use sugar for energy more efficiently. It also slows down the absorption of sugar from the food you eat, preventing sudden spikes after meals.
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Alcohol

Unsafe

Alcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Sitadex-DM 1000 Tablet 10's.

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Pregnancy

Consult your doctor

There are no adequate studies on the effect of Sitadex-DM 1000 Tablet 10's in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Sitadex-DM 1000 Tablet 10's.

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Breast Feeding

Caution

Sitadex-DM 1000 Tablet 10's is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Sitadex-DM 1000 Tablet 10's.

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Driving

Safe

Sitadex-DM 1000 Tablet 10's usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Use Sitadex-DM 1000 Tablet 10's with caution, as lactic acidosis can occur due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Renal impairment also increases the risk of lactic acidosis. Hence, Sitadex-DM 1000 Tablet 10's should be used with caution if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Sitadex-DM 1000 Tablet 10's is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Sitadex-DM 1000 Tablet 10's if you have pre-existing heart problems. Your doctor will prescribe Sitadex-DM 1000 Tablet 10's if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Sitadex-DM 1000 Tablet 10's to geriatric patients. Your doctor will prescribe Sitadex-DM 1000 Tablet 10's if the benefits outweigh the risks.

What if I have taken an overdose of Sitadex-DM 1000 Tablet 10's

cIf you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Diet & Lifestyle Advise

  • Monitor carbohydrate intake: Focus on complex carbohydrates like whole grains, vegetables, and legumes, which help prevent sudden spikes in your blood sugar levels.
  • Stay well-hydrated: Because this medicine removes sugar through your urine, you may urinate more frequently. Drink plenty of water throughout the day to avoid dehydration.
  • Engage in regular physical activity: Aim for at least 150 minutes of moderate exercise, like brisk walking, per week to improve your body's sensitivity to insulin.
  • Perform regular foot checks: People with diabetes are at a higher risk of foot complications. Inspect your feet daily for cuts, sores, or redness.
  • Check your blood sugar levels regularly: Keep a log of your daily readings as directed by your doctor to track how well your treatment plan is working.
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How Soon It Starts Working

The time required for Sitadex-DM 1000 Tablet 10's to start to work: The time required for Sitadex-DM 1000 Tablet 10's to show its action is not clinically established. The time for which the effects of Sitadex-DM 1000 Tablet 10's last: The duration of action for Sitadex-DM 1000 Tablet 10's is not clinically established.

What if you forget to take Sitadex-DM 1000 Tablet 10's

If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Sitadex-DM 1000 Tablet 10's tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Be aware of low blood sugar symptoms: Learn to recognise signs of low blood sugar, such as sweating, shaking, fast heartbeat, and confusion. Keep a fast-acting source of sugar, like fruit juice or glucose tablets, nearby.
  • Watch for signs of dehydration: If you experience severe vomiting, diarrhoea, or cannot drink enough fluids, contact your doctor, as you may need to temporarily pause this medicine to prevent kidney issues.
  • Limit alcohol intake: Drinking alcohol while taking this medicine increases the risk of a rare but serious condition called lactic acidosis.
  • Schedule regular kidney function tests: Your doctor will need to monitor your kidney health through blood tests before and during your treatment with Sitadex-DM 1000 Tablet 10's.
  • Inform surgeons before procedures: If you are scheduled for surgery or any medical imaging that requires contrast dye, tell your doctor, as you may need to stop taking this medicine temporarily.

verifiedApollotooltip
  • Insulin or sulfonylureas: Combining these medications with Sitadex-DM 1000 Tablet 10's may increase the risk of low blood sugar. Your doctor may need to adjust your doses.
  • Diuretics (water pills): May increase the risk of dehydration and low blood pressure when taken together.
  • NSAIDs (like ibuprofen) and certain blood pressure medicines (ACE inhibitors): May increase the risk of kidney problems when used alongside Sitadex-DM 1000 Tablet 10's.

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verifiedApollotooltip
  • Alcohol: Significantly increases the risk of lactic acidosis and low blood sugar. Avoid excessive alcohol consumption while on this therapy.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Sitadex-DM 1000 Tablet 10's is used to treat type II diabetes mellitus, a condition wherein the body doesn't use insulin effectively, which causes unusual blood glucose levels.
Sitadex-DM 1000 Tablet 10's is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin helps remove excess sugar from the body via urine. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines.
If you forget to take Sitadex-DM 1000 Tablet 10's, take it as soon as you remember. However, if it's time for the next dose, avoid taking it and do not double-dose to make up the missed dose. Taking an overdose might cause your sugar level to fall rapidly.
Sitadex-DM 1000 Tablet 10's may cause certain side effects such as vomiting, nausea, abdominal pain, headache and allergic reactions. If these side effects persist or worsen, please consult your doctor.
No, this medicine is generally not recommended during pregnancy, particularly in the second and third trimesters, as it may harm the unborn baby. Talk to your doctor if you are planning to become pregnant or suspect you might be.
Yes, some people may experience modest weight loss while taking this medicine due to the way it helps the kidneys excrete excess sugar and calories. Talk to your doctor for personalised dietary advice.
Stop taking the medicine and contact your doctor immediately, as severe and persistent abdominal pain that radiates to your back can be a sign of pancreatitis.
You should avoid excessive alcohol intake while taking this medicine. Alcohol increases the risk of a rare but life-threatening side effect called lactic acidosis, as well as low blood sugar. Talk to your doctor about safe limits.
Yes. This medication works best when paired with a healthy, balanced diet and regular physical activity. Talk to your doctor or a dietitian to create a plan that works for you.
Yes, because the medicine removes excess sugar through your urine, it can create an environment that promotes yeast growth in the genital area. Maintain good hygiene and talk to your doctor if you notice symptoms like itching or discharge.
You must inform your surgeon or doctor that you are taking this medication well in advance. You may need to stop taking it temporarily before and after your procedure. Talk to your doctor for specific instructions.

Disclaimer

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Reference

  1. U.S. Food and Drug Administration (FDA). 022044S022Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A606023 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 202293S020Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Metformin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, and James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 12th July 2024]Check here
  6. Dapagliflozin+Metformin+Sitagliptin [Prescribing Information]. 2022. [Accessed on 30 Mar. 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Dsco 54, Tau Devilal Market, Near Kanhaiya Sahib Chowk, Yamunanagar - 135001, Haryana, India
Other Info - SIT1312
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