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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Sitared M 50/1000 Tablet is used to treat Type 2 diabetes. It contains Sitagliptin and Metformin, which work by increasing the amounts of certain natural substances that lower blood sugar when it is high. Additionally, it reduces glucose production in the liver, slows glucose absorption from the intestines, and enhances the body's sensitivity to insulin. Thus, it controls blood glucose levels from rising to very high after meals. The most common side effect is hypoglycemia (low blood glucose levels), characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth, and skin, among others. To avoid hypoglycemia, it is essential to eat regularly and carry a source of sugar with you. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Sitared M 50/1000 Tablet

Sitared M 50/1000 Tablet is a combination drug used in the treatment of type 2 diabetes mellitus. Type 2 diabetes develops when the body does not produce enough insulin or when the body's insulin does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance which helps to lower the level of sugar in your blood, especially after meals.

Sitared M 50/1000 Tablet contains metformin and vildagliptin, which help control blood sugar levels. It works by causing the pancreas to produce more insulin and less glucagon (the effect of vildagliptin) and also by helping the body utilise insulin more effectively (the effect of metformin).

Not everyone who is taking Sitared M 50/1000 Tablet will get these side effects. The most common side effect of Sitared M 50/1000 Tablet is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, hunger pangs, dry mouth and skin, etc. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Sitared M 50/1000 Tablet should be taken with food to avoid an upset stomach. It is advised to take it at the same time each day for best results. For better advice, your doctor will determine the appropriate dose, which can change quickly depending on your condition. Do not skip your meals, and also carry a form of sugar with you to prevent low blood sugar levels.

Avoid taking Sitared M 50/1000 Tablet if you are allergic to it. Sitared M 50/1000 Tablet should not be stopped even if you feel better without consulting your doctor, as sugar levels may change. If you stop taking Sitared M 50/1000 Tablet abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney damage and nerve damage. Sitared M 50/1000 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or are planning to get pregnant or breastfeed. You must continue following the diet and exercise recommended for you while on treatment with Sitared M 50/1000 Tablet .

Uses of Sitared M 50/1000 Tablet

Sitared M 50/1000 Tablet is used in the treatment of Type 2 Diabetes Mellitus. The detailed uses of Sitared M 50/1000 Tablet are as follows:
• Management of Diabetes: Sitared M 50/1000 Tablet is commonly prescribed to help regulate blood sugar levels in patients with type 2 diabetes, particularly those who may require additional medication alongside lifestyle changes.
• Improvement of Glycemic Control: Sitared M 50/1000 Tablet aids in improving overall glycemic control by enhancing insulin sensitivity and decreasing hepatic glucose production.
• Weight Management: In some cases, Sitared M 50/1000 Tablet can assist in weight management for diabetic patients, as it may help reduce appetite or modify fat metabolism.
• Prevention of Diabetes Complications: Regular use of Sitared M 50/1000 Tablet can contribute to the prevention of long-term complications associated with diabetes, such as neuropathy, nephropathy, and retinopathy.

Directions for Use

• Sitared M 50/1000 Tablet should be taken with meals to avoid stomach upset. • It is usually taken twice daily; however, your doctor may adjust the dosage based on your blood sugar levels. • Swallow Sitared M 50/1000 Tablet as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

  • Sitared M 50/1000 Tablet helps your pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar that your liver makes.
  • It helps control the rise of blood sugar levels in your body after a meal. 
  • Sitared M 50/1000 Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

How Sitared M 50/1000 Tablet Works

Sitared M 50/1000 Tablet is a combination of Sitagliptin and Metformin. Metformin slows the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that cause the pancreas to release more insulin, which helps regulate blood sugar levels. Thus, Sitared M 50/1000 Tablet controls blood glucose levels from rising to very high after meals.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Sitared M 50/1000 Tablet

Do not take more than the prescribed dose of Sitared M 50/1000 Tablet as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

Inform your doctor if you are allergic to Sitared M 50/1000 Tablet . This medicine should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Sitared M 50/1000 Tablet , might develop a rare but serious condition called lactic acidosis (too much lactic acid accumulated in the blood) that can damage the working of your liver and kidneys, which are required for the elimination of excess lactic acid from the blood. Before you start taking Sitared M 50/1000 Tablet , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, or a low vitamin B12 level. Sitared M 50/1000 Tablet , when used with insulin, may extremely lower the blood sugar level, leading to a hypoglycemic condition, which can be fatal.

Inform your doctor if you are pregnant, planning for a pregnancy or breastfeeding before starting the treatment. Prolonged intake of Sitared M 50/1000 Tablet may lower your thyroid-stimulating hormone (TSH); hence, an annual checkup of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. The use of Sitared M 50/1000 Tablet should be stopped for a short time before having an X-ray procedure.

Store Sitared M 50/1000 Tablet at room temperature. You are advised not to chew, crush or break the medicine. Keep the medicine out of reach of children. Do not take more than the recommended dose of medicine, as it can cause undesirable effects. It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

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MetforminIoglicic acid
Critical
MetforminIobenzamic acid
Critical

Drug-Drug Interactions

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MetforminIoglicic acid
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Ioglicic acid with Sitared M 50 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobenzamic acid
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Sitared M 50 mg/1000 mg Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIocarmic acid
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Sitared M 50 mg/1000 mg Tablet and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.
MetforminIobitridol
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Sitared M 50 mg/1000 mg Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Iopamidol with Sitared M 50 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopanoic acid
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Iopanoic acid with Sitared M 50 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIocetamic acid
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Sitared M 50 mg/1000 mg Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopromide
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Iopromide with Sitared M 50 mg/1000 mg Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Sitared M 50 mg/1000 mg Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIofendylate
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Iofendylate with Sitared M 50 mg/1000 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Iofendylate is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminMetrizamide
Critical
How does the drug interact with Sitared M 50 mg/1000 mg Tablet:
Co-administration of Sitared M 50 mg/1000 mg Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Sitared M 50 mg/1000 mg Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include starchy veggies, proteins, and whole grains in your diet.
  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly.
  • If you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.
  • Invest in at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Unsafe

Avoid consumption of alcohol while on treatment with Sitared M 50/1000 Tablet .

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Pregnancy

Consult your doctor

Sitared M 50/1000 Tablet is only recommended during pregnancy when the benefit outweighs the risk. Please consult your doctor before starting Sitared M 50/1000 Tablet if you are pregnant or planning to conceive.

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Breast Feeding

Consult your doctor

Consult your doctor; Sitared M 50/1000 Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

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Liver

Consult your doctor

If you have or have a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

If you have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

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Children

Consult your doctor

It is advisable to consult a doctor before using it.

Have a query?

FAQs

Sitared M 50/1000 Tablet is used to treat Type 2 Diabetes Mellitus.

Sitagliptin and Metformin are combined to form $ name. Metformin slows down the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that stimulate the pancreas to release more insulin, thereby helping to regulate blood sugar levels. Thus, Sitared M 50/1000 Tablet controls blood glucose levels from rising to very high after meals.

Increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sore healing, and frequent infections are the signs of type 2 diabetes. Please consult your doctor if you notice such symptoms.

No. Sitared M 50/1000 Tablet is only prescribed for the treatment of type 2 diabetes, also called non-insulin-dependent diabetes.

Sitared M 50/1000 Tablet needs to be taken with food to avoid stomach upset. Take it as prescribed by your doctor.

Do not crush or chew Sitared M 50/1000 Tablet as it may release all of the medicine at once and cause side effects. It should be taken as a whole, with food, or as advised by your doctor.

Generally, Sitared M 50/1000 Tablet does not cause hypoglycemia. It can cause low blood sugar if taken along with other antidiabetic medications, especially when engaging in strenuous exercise or consuming low-calorie foods. Symptoms of low blood sugar include sudden sweating, blurred vision, shaking, hunger, increased heart rate, dizziness, or tingling sensations in the hands or feet. If you experience low blood sugar while taking Sitared M 50/1000 Tablet , consult your doctor.

To quickly increase your blood sugar, eat sugar, candy, honey, or drink fruit juice or non-diet soda if you have sudden sweating, blurry vision, shaking, dizziness, increased heartbeat, or hunger.

Long-term use of Sitared M 50/1000 Tablet can lead to Vitamin B12 deficiency. It interferes with the absorption of Vitamin B12 in the stomach. If left untreated, it may lead to anaemia and nerve problems, which can cause the patient to experience tingling sensations and numbness in the hands and feet, urinary problems, weakness, changes in mental status, and difficulty maintaining balance (ataxia). Some researchers recommend the intake of vitamin B12 from external sources at least once a year to avoid such problems.

Sitared M 50/1000 Tablet may cause side effects such as headache, nausea, vomiting, diarrhoea, low blood sugar, or upper respiratory tract infection. If these side effects persist or worsen, please consult your doctor.

Sitared M 50/1000 Tablet should be avoided in patients with known allergy to any of the components or excipients in it and in patients with severe liver impairment, kidney impairment, congestive heart failure, diabetic ketoacidosis or lactic acidosis.

No, it is not safe to take alcohol while using Sitared M 50/1000 Tablet as it may increase the chance of a life-threatening condition known as lactic acidosis.

Store Sitared M 50/1000 Tablet at room temperature. Protect from light and moisture. Keep it out of reach of children.

Yes, the use of Sitared M 50/1000 Tablet can lead to lactic acidosis. It is a life threatening condition caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect of metformin and thus, it is avoided in patients with underlying kidney disease, elderly patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, tiredness, dizziness, difficulty in breathing, feeling of cold in arms and legs, stomach pain, nausea, vomiting, or slow heart rate. If you have these symptoms, stop taking Sitared M 50/1000 Tablet and consult your doctor immediately.

Sitared M 50/1000 Tablet can lower the chance of severe complications such as nerve problems, kidney damage, blindness, limb amputations, and heart diseases by controlling high blood sugar.

You are recommended to consult your doctor before taking other medications with Sitared M 50/1000 Tablet to avoid drug interactions.

Avoid alcohol consumption while taking Sitared M 50/1000 Tablet and ensure regular monitoring of kidney function. Always take Sitared M 50/1000 Tablet as prescribed by your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - SIT0099

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