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Sitared-MD XR 500 Tablet is an antidiabetic medicine used to treat Type II Diabetes as an adjunct to diet and exercise. It contains Dapagliflozin (which removes excess sugar from the body via urine), Sitagliptin (which works by increasing the amounts of certain natural substances that lower blood sugar when it is high) and Metformin (which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines).

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DAPAGLIFLOZIN-10MG+METFORMIN-500MG+SITAGLIPTIN-100MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Sitared-MD XR 500 Tablet

Sitared-MD XR 500 Tablet is a prescription medication used to manage blood sugar levels in adults with type 2 diabetes. It is prescribed alongside a healthy diet and regular physical activity to improve overall control of your blood sugar. By keeping blood sugar levels within a target range, this medication helps prevent long-term complications associated with diabetes.

This medication is typically taken daily, and it is highly important to take it consistently at the same time each day. For the best results and to reduce stomach upset, you should take this tablet with food. To support the effectiveness of your treatment, you should also adopt common lifestyle changes, such as eating a balanced diet lower in simple sugars and participating in regular exercise.

While taking Sitared-MD XR 500 Tablet, you may experience mild side effects like nausea, a runny nose, or a headache. However, if you develop serious side effects, such as persistent, severe stomach pain or signs of severe dehydration, you must contact your doctor immediately. Seeking prompt medical advice ensures that any rare but serious complications are managed safely.

Before starting this medication, talk to your doctor if you have a history of kidney disease, liver damage, heart failure, or pancreatitis. Do not take this if you have type 1 diabetes, diabetic ketoacidosis, or severe kidney failure. Your doctor will evaluate your medical history to ensure this medication is safe for your specific condition.

This medicine can interact with substances like alcohol, which increases the risk of a rare but serious condition called lactic acidosis. If you are pregnant, breastfeeding, or are an elderly individual, you must consult your doctor before starting this treatment to discuss potential risks and appropriate care.

Uses of Sitared-MD XR 500 Tablet

Sitared-MD XR 500 Tablet is used to treat Type 2 diabetes mellitus. The detailed uses of Sitared-MD XR 500 Tablet are as follows:

  • Type 2 Diabetes Mellitus: Sitared-MD XR 500 Tablet helps lower blood sugar levels in adults when diet, exercise, and other single-ingredient medications do not provide enough control.
  • Prevention of cardiovascular complications: In patients with type 2 diabetes who also have established heart disease, this medication helps reduce the risk of hospitalisation for heart failure.
     

Key Benefits

Sitared-MD XR 500 Tablet helps manage type 2 diabetes by improving blood sugar control through multiple complementary mechanisms. With regular use as prescribed, it helps maintain stable glucose levels, supports overall metabolic health, and reduces the risk of diabetes-related complications.

  • Provides Comprehensive Blood Sugar Control: By improving the body's response to insulin, increasing insulin release after meals, and helping the kidneys remove excess glucose through urine, this medicine helps maintain stable blood sugar levels throughout the day.
  • Reduces the Risk of Diabetes Complications: Consistent blood sugar control helps protect the kidneys, nerves, eyes, heart, and blood vessels, lowering the risk of long-term complications associated with diabetes.
  • Supports Overall Metabolic Health: In addition to improving blood sugar control, this medicine may help with modest weight loss and a slight reduction in blood pressure, providing added benefits for overall health in appropriate patients.
Side effects of Sitared-MD XR 500 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Take Sitared-MD XR 500 Tablet with food to reduce stomach upset or gastrointestinal side effects.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Sitared-MD XR 500 Tablet Works

Sitared-MD XR 500 Tablet is a combination of three active components that work together in harmony to lower blood sugar levels. The first component, dapagliflozin, works in your kidneys, blocking the absorption of glucose so that excess sugar is flushed out of your body when you urinate. The second component, sitagliptin, works on your pancreas and liver by increasing the levels of natural hormones that stimulate insulin production after you eat. This component also signals your liver to produce less sugar, keeping your baseline glucose levels steady. The third component, metformin, works directly on your body's cells, helping them become more sensitive to insulin so they can use sugar for energy more efficiently. It also slows down the absorption of sugar from the food you eat, preventing sudden spikes after meals.
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Alcohol

Unsafe

Alcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Sitared-MD XR 500 Tablet.

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Pregnancy

Consult your doctor

There are no adequate studies on the effect of Sitared-MD XR 500 Tablet in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Sitared-MD XR 500 Tablet.

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Breast Feeding

Caution

Sitared-MD XR 500 Tablet is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Sitared-MD XR 500 Tablet.

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Driving

Safe

Sitared-MD XR 500 Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Use Sitared-MD XR 500 Tablet with caution, as lactic acidosis can occur due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Renal impairment also increases the risk of lactic acidosis. Hence, Sitared-MD XR 500 Tablet should be used with caution if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Sitared-MD XR 500 Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Sitared-MD XR 500 Tablet if you have pre-existing heart problems. Your doctor will prescribe Sitared-MD XR 500 Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Sitared-MD XR 500 Tablet to geriatric patients. Your doctor will prescribe Sitared-MD XR 500 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Sitared-MD XR 500 Tablet

cIf you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Diet & Lifestyle Advise

  • Monitor carbohydrate intake: Focus on complex carbohydrates like whole grains, vegetables, and legumes, which help prevent sudden spikes in your blood sugar levels.
  • Stay well-hydrated: Because this medicine removes sugar through your urine, you may urinate more frequently. Drink plenty of water throughout the day to avoid dehydration.
  • Engage in regular physical activity: Aim for at least 150 minutes of moderate exercise, like brisk walking, per week to improve your body's sensitivity to insulin.
  • Perform regular foot checks: People with diabetes are at a higher risk of foot complications. Inspect your feet daily for cuts, sores, or redness.
  • Check your blood sugar levels regularly: Keep a log of your daily readings as directed by your doctor to track how well your treatment plan is working.
health query

Have a query?

How Soon It Starts Working

The time required for Sitared-MD XR 500 Tablet to start to work: The time required for Sitared-MD XR 500 Tablet to show its action is not clinically established. The time for which the effects of Sitared-MD XR 500 Tablet last: The duration of action for Sitared-MD XR 500 Tablet is not clinically established.

What if you forget to take Sitared-MD XR 500 Tablet

If you miss a dose, take it with food as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Sitared-MD XR 500 Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Be aware of low blood sugar symptoms: Learn to recognise signs of low blood sugar, such as sweating, shaking, fast heartbeat, and confusion. Keep a fast-acting source of sugar, like fruit juice or glucose tablets, nearby.
  • Watch for signs of dehydration: If you experience severe vomiting, diarrhoea, or cannot drink enough fluids, contact your doctor, as you may need to temporarily pause this medicine to prevent kidney issues.
  • Limit alcohol intake: Drinking alcohol while taking this medicine increases the risk of a rare but serious condition called lactic acidosis.
  • Schedule regular kidney function tests: Your doctor will need to monitor your kidney health through blood tests before and during your treatment with Sitared-MD XR 500 Tablet.
  • Inform surgeons before procedures: If you are scheduled for surgery or any medical imaging that requires contrast dye, tell your doctor, as you may need to stop taking this medicine temporarily.

Drug-Drug Interactions

verifiedApollotooltip
  • Insulin or sulfonylureas: Combining these medications with Sitared-MD XR 500 Tablet may increase the risk of low blood sugar. Your doctor may need to adjust your doses.
  • Diuretics (water pills): May increase the risk of dehydration and low blood pressure when taken together.
  • NSAIDs (like ibuprofen) and certain blood pressure medicines (ACE inhibitors): May increase the risk of kidney problems when used alongside Sitared-MD XR 500 Tablet.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Significantly increases the risk of lactic acidosis and low blood sugar. Avoid excessive alcohol consumption while on this therapy.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Sitared-MD XR 500 Tablet is used to treat type II diabetes mellitus, a condition wherein the body doesn't use insulin effectively, which causes unusual blood glucose levels.
Sitared-MD XR 500 Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin helps remove excess sugar from the body via urine. Metformin helps reduce the sugar production by cells in the liver and delays sugar absorption from the intestines.
If you forget to take Sitared-MD XR 500 Tablet, take it as soon as you remember. However, if it's time for the next dose, avoid taking it and do not double-dose to make up the missed dose. Taking an overdose might cause your sugar level to fall rapidly.
Sitared-MD XR 500 Tablet may cause certain side effects such as vomiting, nausea, abdominal pain, headache and allergic reactions. If these side effects persist or worsen, please consult your doctor.
No, this medicine is generally not recommended during pregnancy, particularly in the second and third trimesters, as it may harm the unborn baby. Talk to your doctor if you are planning to become pregnant or suspect you might be.
Yes, some people may experience modest weight loss while taking this medicine due to the way it helps the kidneys excrete excess sugar and calories. Talk to your doctor for personalised dietary advice.
Stop taking the medicine and contact your doctor immediately, as severe and persistent abdominal pain that radiates to your back can be a sign of pancreatitis.
You should avoid excessive alcohol intake while taking this medicine. Alcohol increases the risk of a rare but life-threatening side effect called lactic acidosis, as well as low blood sugar. Talk to your doctor about safe limits.
Yes. This medication works best when paired with a healthy, balanced diet and regular physical activity. Talk to your doctor or a dietitian to create a plan that works for you.
Yes, because the medicine removes excess sugar through your urine, it can create an environment that promotes yeast growth in the genital area. Maintain good hygiene and talk to your doctor if you notice symptoms like itching or discharge.
You must inform your surgeon or doctor that you are taking this medication well in advance. You may need to stop taking it temporarily before and after your procedure. Talk to your doctor for specific instructions.

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Reference

  1. U.S. Food and Drug Administration (FDA). 022044S022Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A606023 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 202293S020Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Metformin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, and James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on 12th July 2024]Check here
  6. Dapagliflozin+Metformin+Sitagliptin [Prescribing Information]. 2022. [Accessed on 30 Mar. 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - SIT0441
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