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  3. SOLIAN 400MG TABLET

SOLIAN 400MG TABLET, Pack of 10 TABLETS
SOLIAN 400MG TABLET, Pack of 10 TABLETS
SOLIAN 400MG TABLET, Pack of 10 TABLETS
SOLIAN 400MG TABLET, Pack of 10 TABLETS
SOLIAN 400MG TABLET, Pack of 10 TABLETS
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Composition :

AMISULPRIDE-400MG

Manufacturer/Marketer :

Aventis Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About SOLIAN 400MG TABLET

SOLIAN 400MG TABLET belongs to a group of medicines called 'antipsychotics' primarily used to treat long term (chronic) schizophrenia and postoperative nausea/vomiting. Schizophrenia is characterized by hallucinations symptoms (seeing or hearing things that are not real) and delusions (wrong beliefs). In schizophrenic disorders, there are positive symptoms (like delusions, hallucinations and thought disorders) along with negative symptoms (like blunted effect, emotional and social withdrawal). Nausea is an uneasy feeling in which the person feels an urge to vomit, whereas vomiting is an uncontrollable reflex that expels the stomach's contents through the mouth.

SOLIAN 400MG TABLET contains Amisulpride, which helps restore the balance of certain natural substances in the brain. The key action of SOLIAN 400MG TABLET is to block some of the dopamine receptors in the brain and correct dopamine's overactivity. On the other hand, it also affects other brain neurotransmitters such as serotonin (5-HT), which may also lead to its beneficial effects. SOLIAN 400MG TABLET also stops the sensation of vomiting/nausea by blocking the D2 receptors located in the chemoreceptor trigger zone - CTZ of the brain responsible for inducing vomiting.

SOLIAN 400MG TABLET can be taken with or without food as prescribed by your doctor. You are advised to take SOLIAN 400MG TABLET for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain side effects such as dryness in the mouth, constipation, weight gain, decreased blood pressure, dystonia (involuntary muscle contractions), akathisia (inability to stay still), parkinsonism, increased prolactin level in blood. Most of these side effects of SOLIAN 400MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist for a longer duration, consult your doctor immediately.

SOLIAN 400MG TABLET should be avoided if you are allergic to it or any other medicines. SOLIAN 400MG TABLET is not recommended for children below 18 years of age. If you are pregnant or breastfeeding, inform your doctor before taking SOLIAN 400MG TABLET. Use SOLIAN 400MG TABLET with extreme caution in elderly patients above 65 years of age as there is an increased risk of severe adverse effects.  If you have breast cancer, pheochromocytoma (tumor of the adrenal gland), pituitary gland prolactinoma (tumor of the pituitary gland), fits, Parkinson’s disease, kidney or heart problems, inform your doctor before taking SOLIAN 400MG TABLET. Avoid driving and op taking SOLIAN 400MG TABLET as it may cause drowsiness or dizziness.

Uses of SOLIAN 400MG TABLET

SOLIAN 400MG TABLET is used in the treatment of schizophrenia, postoperative nausea and vomiting (PONV). The detailed uses of SOLIAN 400MG TABLET are as follows:<br/>• Schizophrenia: SOLIAN 400MG TABLET is used in the treatment of both acute and chronic schizophrenia, helping to manage symptoms like hallucinations, delusions, and disorganized thinking, and improving quality of life and social functioning.<br/>• Preventing Postoperative Nausea: SOLIAN 400MG TABLET helps to prevent nausea that occurs after surgery, reducing patient discomfort and promoting smoother recovery.<br/>• Treating Postoperative Vomiting: SOLIAN 400MG TABLET helps treat vomiting that occurs after surgery, minimizing complications and supporting patient well-being. <br/>

Directions for Use

• SOLIAN 400MG TABLET can be taken before meals or as advised by your doctor.• Take SOLIAN 400MG TABLET twice daily; however, follow your doctor’s recommendation regarding the dosage and duration.• Swallow the medicines as a whole with a glass of water. • Do not crush, chew or break it.

Medicinal Benefits

SOLIAN 400MG TABLET contains Amisulpride, a group of medicines called antipsychotics used to treat a mental illness called schizophrenia and bipolar disorder. Additionally, SOLIAN 400MG TABLET has anti-emetics properties used either in monotherapy or in combination with other antiemetic drugs to prevent nausea and vomiting, which might occur after surgery. The key action of SOLIAN 400MG TABLET is to block some of the brain's dopamine receptors and correct dopamine's overactivity, thereby producing a calming effect in the brain. Altogether, SOLIAN 400MG TABLET may help decrease hallucinations and help you think more clearly and positively about yourself, feel less agitated and take a more active part in everyday life. 

How SOLIAN 400MG TABLET Works

SOLIAN 400MG TABLET contains Amisulpride, which helps restore the balance of certain natural substances in the brain. The key action of SOLIAN 400MG TABLET is to block some of the dopamine receptors in the brain and correct dopamine's overactivity. On the other hand, it also affects other brain neurotransmitters such as serotonin (5-HT), which may also lead to its beneficial effects. SOLIAN 400MG TABLET also stops the sensation of vomiting/nausea by blocking the D2 receptors located in the chemoreceptor trigger zone - CTZ of the brain responsible for inducing vomiting.

Storage

Store in a cool and dry place away from sunlight
Side effects of Solian 400mg Tablet
  • Stretching and walking are examples of mild exercises that can improve mobility and reduce muscle stiffness.
  • Improving posture, mobility, and muscle coordination through physical therapy can help manage slowness or stiffness.
  • Maintain healthy weight and advance general health depend on eating a balanced diet.
  • Reducing symptoms like tremors or muscle spasms requires adequate sleep and rest.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Regularly brush your tongue and teeth to prevent Excessive Saliva Production.
  • Avoid eating foods high in sugar or acid since these foods might increase saliva production, which increases the Excessive Saliva Production.
  • Keep your head up straight and maintain proper posture to prevent saliva from collecting in your mouth.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.

What if I have taken an overdose of SOLIAN 400MG TABLET

Take SOLIAN 400MG TABLET only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include tremors, slow heartbeats, seizures, involuntary muscle movement, and fainting. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take SOLIAN 400MG TABLET if you are allergic (hypersensitive) to amisulpride or any other ingredients present in this medicine or have a medical history of prolactin-dependent tumor or breast cancer, phaeochromocytoma (a tumor on the adrenal gland), pituitary tumor.

  • SOLIAN 400MG TABLET should not be given to children as safety has not been established.

  • Use SOLIAN 400MG TABLET with extreme caution in elderly patients above 65 years of age as there is an increased risk of severe adverse effects.

  • If you are pregnant or breastfeeding, please consult a doctor before taking SOLIAN 400MG TABLET. SOLIAN 400MG TABLET may impair fertility, so inform your doctor if you are planning for pregnancy.

  • Inform your doctor if you are previously diagnosed with kidney disease, liver disease epilepsy or seizures (fits), Parkinson's disease, unusual heart rate (rhythm), slow heartbeat (less than 55 beats per minute), low potassium levels in your blood, prolonged QT interval (heart conduction problem), if you or someone else in your family has a history of blood clots, heart problems, stroke, diabetes, have a low number of white blood cells (agranulocytosis), leucopenia (blood disorder).

  • SOLIAN 400MG TABLET may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with SOLIAN 400MG TABLET as it could lead to increased drowsiness and dizziness.  

Drug-Drug Interactions

verifiedApollotooltip
AmisulprideCisapride
Critical
AmisulprideGrepafloxacin
Critical

Drug-Drug Interactions

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AmisulprideCisapride
Critical
How does the drug interact with Solian 400mg Tablet:
Taking Solian 400mg Tablet with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Solian 400mg Tablet with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AmisulprideGrepafloxacin
Critical
How does the drug interact with Solian 400mg Tablet:
Taking Solian 400mg Tablet with Grepafloxacin can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking Solian 400mg Tablet with Grepafloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
AmisulprideSaquinavir
Critical
How does the drug interact with Solian 400mg Tablet:
Taking Saquinavir with Solian 400mg Tablet can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking Solian 400mg Tablet with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AmisulprideMesoridazine
Critical
How does the drug interact with Solian 400mg Tablet:
Taking Solian 400mg Tablet with Mesoridazine can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking Solian 400mg Tablet with Mesoridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AmisulprideDronedarone
Critical
How does the drug interact with Solian 400mg Tablet:
Taking Solian 400mg Tablet with Dronedarone can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking Solian 400mg Tablet with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AmisulprideZiprasidone
Critical
How does the drug interact with Solian 400mg Tablet:
Co-administration of Ziprasidone with Solian 400mg Tablet can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Ziprasidone and Solian 400mg Tablet but can be taken together if prescribed by a doctor. Contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
AmisulpridePimozide
Critical
How does the drug interact with Solian 400mg Tablet:
Taking Pimozide with Solian 400mg Tablet can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking Pimozide with Solian 400mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AmisulprideMetoclopramide
Critical
How does the drug interact with Solian 400mg Tablet:
Taking Metoclopramide with Solian 400mg Tablet may increase the risk or severity of side effects.

How to manage the interaction:
Taking Solian 400mg Tablet with Metoclopramide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AmisulprideTetrabenazine
Severe
How does the drug interact with Solian 400mg Tablet:
Using tetrabenazine together with Solian 400mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Solian 400mg Tablet with Tetrabenazine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience fever, extreme sweating, stiffness, trouble moving or swallowing, abrupt disorientation, lightheadedness, faintings, rapid or pounding heartbeat, muscle spasms or uncontrollable movements, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, or restlessness, consult a doctor immediately. You should avoid activities requiring mental alertness, such as driving or operating equipment.
AmisulprideTamoxifen
Severe
How does the drug interact with Solian 400mg Tablet:
Taking Solian 400mg Tablet together with tamoxifen can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Solian 400mg Tablet and tamoxifen together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Mental illness:

  • Monitor your mood. Keep track of your mood regularly, including factors such as sleep, medicine and activities that can impact your mood. 

  • Exercise daily. Exercise is nice to relieve tension. It can also avoid the weight gain that can be a side effect of your bipolar medication.

  • You may also practice calming techniques such as meditation and deep breathing exercises.

  • Get some normal sleep. Having enough sleep will help to stabilize your mood.

  • Eat a healthy diet. Certain foods may affect your mood more than others. Consider keeping a food log to track what you eat and how certain foods make you feel. Talk to your doctor or nutritionist about foods that may help stabilize your mood.

  • Stay optimistic. It will take time for your symptoms to improve after you start bipolar therapy, but you will feel relaxed knowing that you will get better and that the worst is most definitely behind you.

 

Nausea/Vomiting:

  • Eat smaller meals more often.

  • Drink fluids to stay hydrated. Use oral rehydration solutions (ORS) to replace lost electrolytes.

  • Avoid solid foods until vomiting stops.

  • Avoid foods that might cause stomach upset.

  • Take ample rest. Avoid any activity immediately after eating.

  • Consume plain, light foods such as bread and biscuits.

  • Avoid food with strong flavours and fried food.

  • Ginger tea might help in proper digestion.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

SOLIAN 400MG TABLET Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Unsafe

Avoid consumption of alcohol while taking SOLIAN 400MG TABLET as it may lead to increased dizziness and drowsiness.

bannner image

Pregnancy

Caution

SOLIAN 400MG TABLET should be used in pregnant women only when prescribed by a doctor. Consult your doctor before taking SOLIAN 400MG TABLET if you are pregnant, your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Breast Feeding

Unsafe

SOLIAN 400MG TABLET is unsafe and should not be taken by breastfeeding mothers. Consult your doctor for further advice.

bannner image

Driving

Caution

SOLIAN 400MG TABLET may cause dizziness, drowsiness and uncontrolled movements. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Take SOLIAN 400MG TABLET with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. However, SOLIAN 400MG TABLET is not recommended for patients with severe liver disease. Inform your doctor immediately if you experience fatigue, loss of appetite, nausea, vomiting, abdominal pain or yellow discoloration of the eyes or skin.

bannner image

Kidney

Caution

SOLIAN 400MG TABLET should be used in patients with kidney diseases only when prescribed by a doctor. Dose adjustments and regular monitoring of electrolytes may be required as it may alter electrolyte levels in the body.

bannner image

Children

Unsafe

SOLIAN 400MG TABLET should not be given to children as the safety and effectiveness were not established.

Have a query?

FAQs

SOLIAN 400MG TABLET is used to treat long-term (chronic) schizophrenia and postoperative nausea/vomiting. Additionally, SOLIAN 400MG TABLET is used either in monotherapy or in combination with other antiemetic drugs to prevent nausea and vomiting, which might occur after surgery. The key action of SOLIAN 400MG TABLET is to block some of the brain&amp;#039;s dopamine receptors and correct dopamine&amp;#039;s overactivity, thereby producing a calming effect in the brain.

SOLIAN 400MG TABLET contains Amisulpride, which works by modulating certain chemical messengers (dopamine D2) in the brain, which helps regulate mood, behaviour, nausea and vomiting.

SOLIAN 400MG TABLET can be used to treat psychotic disorders like schizophrenia, bipolar disorder and depression. However, you should not take this medication without a doctor’s advice.

SOLIAN 400MG TABLET may affect fertility as it may cause hyperprolactinemia (excessive levels of prolactin hormone in the blood) resulting in amenorrhea (absence of menstrual periods), anovulation (lack of egg release) and impaired fertility.

You are not recommended to stop taking SOLIAN 400MG TABLET without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take SOLIAN 400MG TABLET for as long as your doctor has prescribed it, and if you experience any difficulty while taking SOLIAN 400MG TABLET, please consult your doctor so that the dose may be gradually reduced.

SOLIAN 400MG TABLET is not recommended for dementia (loss of memory or other mental abilities) patients especially in elderly people as it may cause severe adverse effects including stroke. Therefore, it is advised to inform your doctor if you have dementia or history of stroke before taking SOLIAN 400MG TABLET.

Stopping SOLIAN 400MG TABLET abruptly can cause withdrawal symptoms and stopping it too early could make your illness come back. Please consult your doctor if you want to stop taking SOLIAN 400MG TABLET.

Take SOLIAN 400MG TABLET with caution in patients with diabetes as it may increase the risk of having diabetes. It is advised to monitor your blood sugar levels regularly while taking SOLIAN 400MG TABLET.

SOLIAN 400MG TABLET is not recommended for children as the safety and effectiveness have not been established.

SOLIAN 400MG TABLET should be used with caution and only if prescribed by the doctor in elderly patients due to the possible risk of low blood pressure and sedation.

SOLIAN 400MG TABLET should be used in patients with kidney diseases only when prescribed by a doctor. Dose adjustment and regular monitoring of electrolytes may be required as SOLIAN 400MG TABLET may alter electrolyte levels in the body.

SOLIAN 400MG TABLET may cause sleepiness and drowsiness. Do not drive or operate machinery unless you are alert.

SOLIAN 400MG TABLET should be taken at the same time daily or as prescribed by the doctor.

SOLIAN 400MG TABLET modulates certain chemical messengers (dopamine D2) in the brain, which helps regulate mood and behaviour.

No, SOLIAN 400MG TABLET is not indicated for anxiety. It is used to treat schizophrenia and postoperative nausea and vomiting.

Do not take SOLIAN 400MG TABLET if you are allergic (hypersensitive) to amisulpride or any other ingredients present in this medicine or have a medical history of prolactin-dependent tumour or breast cancer, phaeochromocytoma (a tumour on the adrenal gland), or pituitary tumour.

No, SOLIAN 400MG TABLET has no habit-forming tendency and is not addictive.

Withdrawal symptoms of SOLIAN 400MG TABLET are nausea, vomiting, difficulty sleeping, sweating, extreme restlessness, abnormal movements, or muscle stiffness.

SOLIAN 400MG TABLET may cause side effects like dryness in the mouth, constipation, weight gain, decreased blood pressure, dystonia (involuntary muscle contractions), akathisia (inability to stay still), parkinsonism, and increased prolactin level in blood. Most of these side effects of SOLIAN 400MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist for a longer duration, consult your doctor immediately.

Country of origin

India

Manufacturer/Marketer address

Behind HDFC Bank, Sai Nagar, Devendra Nagar Road, Raipur, Chhattisgarh (492001) - India
Other Info - SOL0194

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:49 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/amisulpride.html
  2. https://www.medicines.org.uk/emc/files/pil.548.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209510s000lb

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