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compositionComposition:ISONIAZID-300MG
prescriptionPrescription Medicine

Solonex Tablet is used to treat and prevent tuberculosis (TB). It contains isoniazid, an antibiotic that works by preventing bacteria from producing mycolic acids, an enzyme required for cell wall formation (protective coating). As a result of the disturbance in their metabolism, bacteria that lack a cell wall die and burst. Thus, it inhibits the spread of infection by acting against the bacteria Mycobacterium tuberculosis, which causes tuberculosis.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISONIAZID-300MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

Solonex Tablet is used to treat and prevent tuberculosis (TB). Solonex Tablet is used in combination with other anti-tuberculosis agents. Tuberculosis is an infectious bacterial disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Solonex Tablet does not work against infections caused by the virus.

Solonex Tablet contains isoniazid, an antibiotic that works by preventing bacteria from producing mycolic acids, an enzyme required for cell wall formation (protective coating). As a result of the disturbance in their metabolism, bacteria that lack a cell wall die and burst. Thus, Solonex Tablet inhibits the spread of infection by acting against the bacteria Mycobacterium tuberculosis, which causes tuberculosis.

Use Solonex Tablet as prescribed. Use Solonex Tablet for as long as your doctor has prescribed it for your child based on his/her medical condition. Sometimes, Solonex Tablet may cause side effects such as nausea, vomiting, constipation, difficulty passing urine, numbness, or tingling in the feet or hands. Most of these side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist or worsen, please consult your doctor.

If your child is allergic to Isoniazid, please inform your doctor. It is important that you complete the entire course of Solonex Tablet as prescribed by the doctor, even if your child feels better after taking a few doses, because stopping the drug abruptly may not kill bacteria and may result in a resurgence of tuberculosis.

Uses of Solonex Tablet

Solonex Tablet is used in the treatment of Tuberculosis (TB). The detailed uses of Solonex Tablet are as follows:

  • Treatment of Active Tuberculosis (TB): Solonex Tablet is a first-line antitubercular agent used in combination with other drugs to treat active TB infections in children. It works by inhibiting the synthesis of mycolic acids, essential components of the bacterial cell wall, thereby killing Mycobacterium tuberculosis.
  • Latent Tuberculosis Infection (LTBI): Solonex Tablet is used as a monotherapy for children who have been exposed to TB but do not show active symptoms. It helps prevent the progression from latent infection to active disease, especially in high-risk paediatric populations.
  • Tuberculous Meningitis: Solonex Tablet is included in combination regimens for treating TB meningitis in children. It penetrates the cerebrospinal fluid effectively, making it valuable in managing central nervous system TB infections.
  • Prophylaxis in High-Risk Children: Solonex Tablet may be used as a preventive measure for children who are immunocompromised or have been in close contact with TB-positive individuals, reducing the risk of developing active TB.

Key Benefits

Solonex Tablet contains isoniazid, an antibiotic used to treat and prevent tuberculosis. Solonex Tablet prevents bacteria from producing mycolic acids, which are required for the formation of cell walls (protective coating). Additionally, Solonex Tablet may combine with an enzyme that interferes with bacterial cell metabolism. Bacteria die as a result of the disruption in their metabolism and the lack of a cell wall. As a result, it kills Mycobacterium tuberculosis bacteria that causes tuberculosis (TB) and eliminates the infection. Solonex Tablet is used in combination with other anti-tuberculosis agents to treat all forms of tuberculosis caused by Mycobacterium tuberculosis.

Side effects of Solonex Tablet
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Solonex Tablet should be administered at least 30 minutes before a meal or 2 hours after a meal as directed by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Disperse the tablet in the suggested amount of water and give the mixture to your child using an oral syringe or measuring cup.
  • Do not store the mixture for later use.
Solonex Tablet contains isoniazid, an antibiotic that works by preventing bacteria from producing mycolic acids, an enzyme required for cell wall formation (protective coating). As a result of the disturbance in their metabolism, bacteria that lack a cell wall die and burst. Thus, Solonex Tablet inhibits the spread of infection by acting against the bacteria Mycobacterium tuberculosis, which causes tuberculosis.
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Alcohol

Not applicable

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Pregnancy

Not applicable

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Breast Feeding

Not applicable

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Driving

Not applicable

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Liver

Caution

If your child has liver problems, inform your doctor before using Solonex Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your child’s health condition.

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Kidney

Caution

If your child has kidney problems, inform your doctor before using Solonex Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your child’s health condition.

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Children

Safe if prescribed

Use Solonex Tablet for children as prescribed by the paediatrician.

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Heart

Consult your doctor

Please consult your doctor before giving Solonex Tablet to your child. Your doctor will prescribe Solonex Tablet if the benefits outweigh the risks.

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Geriatrics

Not applicable

Solonex Tablet is for paediatric patients only.

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Solonex Tablet may include ataxia, blurred vision, coma, dizziness, dysarthria, hyperreflexia, lactic acidosis, mydriasis, nausea, photophobia, rapid confusion, refractory seizures, tachycardia, and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Vitamin C-rich foods such as kiwi, broccoli, and bell pepper help in improving the immune system.
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from a cough.
  • Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.

Have a query?

Drug Warnings

If your child is allergic to Isoniazid, please inform your doctor. If your child feels thirsty all the time and has to go to the toilet often, contact your doctor, as they may have high blood sugar. You are recommended to complete the full course of Solonex Tablet as prescribed by the doctor even if your child feels better after 2 weeks of using Solonex Tablet as discontinuing the medicine suddenly may not kill bacteria and there might be a relapse of tuberculosis.

Drug-Drug Interactions

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IsoniazidLomitapide
Critical

Drug-Drug Interactions

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IsoniazidLomitapide
Critical
How does the drug interact with Solonex Tablet:
When Lomitapide is taken with Solonex Tablet, Solonex Tablet may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Solonex Tablet with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
How does the drug interact with Solonex Tablet:
When Solonex Tablet is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Solonex Tablet is not recommended, it taken can be taken if prescribed by the doctor.
How does the drug interact with Solonex Tablet:
When Lovastatin is taken with Solonex Tablet, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Solonex Tablet with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
IsoniazidHalofantrine
Severe
How does the drug interact with Solonex Tablet:
Co-administration of Solonex Tablet and Halofantrine together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Solonex Tablet and Halofantrine together can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Solonex Tablet:
When Omeprazole is taken with Solonex Tablet, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Omeprazole with Solonex Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without talking to a doctor.
IsoniazidAlfentanil
Severe
How does the drug interact with Solonex Tablet:
Co-administration of Solonex Tablet will enhance the amount or action of Alfentanil when taken together.

How to manage the interaction:
Taking Alfentanil with Solonex Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
IsoniazidBCG vaccine
Severe
How does the drug interact with Solonex Tablet:
When BCG vaccine is used with Solonex Tablet, its effectiveness may be reduced.

How to manage the interaction:
Although there is a possible interaction between Solonex Tablet and BCG vaccine, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Solonex Tablet:
Combining Solonex Tablet with Citalopram may raise Citalopram blood levels and increase the chance of certain adverse effects, including an abnormal heart rhythm.

How to manage the interaction:
Although taking Solonex Tablet and Citalopram together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like a fast or pounding heartbeat, feeling dizzy or lightheaded, or having trouble breathing, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Solonex Tablet:
Using Solonex Tablet with Teriflunomide can increase the risk and severity of the side effects of the liver.

How to manage the interaction:
Taking Solonex Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to consult a doctor: Fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, nausea, vomiting, abdominal pain, dark urine, light colored stool, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
How does the drug interact with Solonex Tablet:
Co-administration of Solonex Tablet may considerably enhance the blood levels of Tizanidine, which may result in side effects.

How to manage the interaction:
There may be a possibility of interaction between Tizanidine and Solonex Tablet, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience excessive drowsiness, dizziness, lightheadedness, fainting, and irregular heart rhythm. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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ISONIAZID-300MGCaffeine containing foods/drinks

Drug-Food Interactions

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ISONIAZID-300MGCaffeine containing foods/drinks
Common Foods to Avoid:
Dark Chocolate, Cocoa, Coffee, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking caffeine containing products including chocolates(which contains caffeine) during Solonex Tablet treatment may lead to an interaction. Avoid caffiene and its products during treatment with Solonex Tablet.

All Substitutes & Brand Comparisons

No
[ANTI- TUBERCULOSIS]

FAQs

Solonex Tablet is used to treat and prevent tuberculosis (TB). Solonex Tablet is used in combination with other anti-tuberculosis agents.

Solonex Tablet contains isoniazid, an antibiotic used to treat and prevent tuberculosis. Solonex Tablet prevents bacteria from producing mycolic acids, which are required for the formation of cell walls (protective coating). Additionally, Solonex Tablet may combine with an enzyme that interferes with bacterial cell metabolism. Bacteria die as a result of the disruption in their metabolism and the lack of a cell wall. As a result, it kills Mycobacterium tuberculosis bacteria that causes tuberculosis (TB) and eliminates the infection.

You are recommended to avoid giving foods containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, and mackerel to your child as they may interact with Solonex Tablet and cause adverse effects such as sweating, headache, dizziness, light-headedness, flushing (reddening of the skin), fainting due to low blood pressure, uneven, fast or forceful heartbeat.

Solonex Tablet is usually not recommended for children with severe liver impairment as it may worsen the condition. Therefore, please inform the doctor if your child has any liver problems before using Solonex Tablet .

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