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  3. Stresnil 0.5 Tablet 10's

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Stresnil 0.5 Tablet 10's, Pack of 10 TABLETS
Stresnil 0.5 Tablet 10's, Pack of 10 TABLETS
Stresnil 0.5 Tablet 10's, Pack of 10 TABLETS
Stresnil 0.5 Tablet 10's, Pack of 10 TABLETS
Stresnil 0.5 Tablet 10's, Pack of 10 TABLETS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Stresnil 0.5 Tablet is used to treat sleeplessness (insomnia). Besides this, it also helps to provide a calming effect on anxiety disorder and panic disorder. It contains Alprazolam and Melatonin, which reduces the abnormal and overactivity of brain cells (neurons), which in turn relaxes the brain and promotes sleep. Melatonin is a natural hormone that activates the ON-OFF mechanism of a person's sleeping-waking cycle (circadian cycle), thereby inducing sleep during the night time. It may cause common side effects such as drowsiness, tiredness, headache, depressed mood, daytime drowsiness, stomach pain, and dizziness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ALPRAZOLAM-0.5MG + MELATONIN-3MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Stresnil 0.5 Tablet

Stresnil 0.5 Tablet is used to treat sleeplessness (insomnia). Besides this, it also helps to provide a calming effect on anxiety disorder and panic disorder. Insomnia is a sleeping disorder in which a person finds difficulty falling asleep or staying asleep. Due to anxiety and panic disorder, a person cannot sleep due to disturbances in their circadian cycle and hormonal imbalances in the brain, like melatonin. 

Stresnil 0.5 Tablet is a combination of two medicines, Alprazolam and Melatonin, which help a person fall asleep faster and stay asleep during the night. Alprazolam is a benzodiazepine (BZD) that increases the activity of a chemical messenger in the brain known as GABA, reducing the abnormal and overactivity of brain cells (neurons), which in turn relaxes the brain and promotes sleep. On the other hand, Melatonin is a natural hormone that activates the ON-OFF mechanism of a person's sleeping-waking cycle (circadian cycle), thereby inducing sleep during the nighttime. 

Take Stresnil 0.5 Tablet with or without food and swallow whole with a glass of water. Do not break, crush, or chew it. Your doctor will advise you how often you take Stresnil 0.5 Tablet based on your medical condition. The most common side effects of Stresnil 0.5 Tablet include drowsiness, tiredness, headache, depressed mood, daytime drowsiness, stomach pain, and dizziness. Most of these side effects of Stresnil 0.5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Tell your doctor if you have an ongoing medical condition, including depression, diabetes, an autoimmune disorder, or high blood pressure. If you are known to be allergic to Stresnil 0.5 Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, inform your doctor before taking Stresnil 0.5 Tablet . Stresnil 0.5 Tablet should be used with caution in elderly patients as there is an increased risk of adverse reactions such as dizziness, muscle weakness, and drowsiness.

Uses of Stresnil 0.5 Tablet

Stresnil 0.5 Tablet is used in the treatment of Insomnia (sleeplessness). The detailed uses of Stresnil 0.5 Tablet are as follows:<br/>• Sleep Enhancement: Stresnil 0.5 Tablet is used to treat sleeplessness (insomnia), promoting a restful night's sleep and helping to regulate sleep patterns.<br/>• Anxiety and Calming Effects: Stresnil 0.5 Tablet provides a calming effect on anxiety disorders and panic disorders, helping individuals manage stress and achieve improved mental well-being.<br/>

Directions for Use

• Stresnil 0.5 Tablet can be taken with or without food as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow Stresnil 0.5 Tablet as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Stresnil 0.5 Tablet belongs to a class of sedatives and hypnotics, primarily used to treat insomnia (difficulty in falling asleep or staying asleep). Stresnil 0.5 Tablet is a combination of two medicines: 'Alprazolam' and  'Melatonin', which helps a person fall asleep faster and stay asleep during the night, which has been disturbed due to anxiety or panic disorder. Stresnil 0.5 Tablet helps relax the brain's exciting chemicals (GABA), allowing a person to sleep easily and stay asleep during the whole night without any disturbance.  

How Stresnil 0.5 Tablet Works

Stresnil 0.5 Tablet is a combination of two medicines, Alprazolam and Melatonin, which help a person fall asleep faster and stay asleep during the night. Alprazolam is a benzodiazepine (BZD) that increases the activity of a chemical messenger in the brain known as GABA, reducing the abnormal and overactivity of brain cells (neurons), which in turn relaxes the brain and promotes sleep. On the other hand, Melatonin is a natural hormone that activates the ON-OFF mechanism of a person's sleeping-waking cycle (circadian cycle), thereby inducing sleep during the nighttime.

Storage

Keep Stresnil 0.5 Tablet out of the sight and reach of children.
Side effects of Stresnil 0.5 Tablet
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Limit stimulants like tea, coffee and alcohol.
  • Identify triggers and try managing them.
  • Take a break by scheduling time for yourself.
  • Try creative activities like writing, dancing or painting as it helps release tension.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

What if I have taken an overdose of Stresnil 0.5 Tablet

Do not take more than the prescribed dose of Stresnil 0.5 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Before your doctor prescribes your Stresnil 0.5 Tablet , you should tell your doctor if you have allergies or not. With it, also tell if you are pregnant or breastfeeding as the use of this medication is restricted to be used in pregnancy and breastfeeding. Elderly people are more responsive to the side effects of the drug, so they should tell every product, including the herbal ones to their doctor so that doctor can decide the dosage for them. Inform your doctor about myasthenia gravis (muscle weakness), drug addiction, chronic pulmonary insufficiency, narrow-angle glaucoma, and kidney/liver problem before taking Stresnil 0.5 Tablet . Do not take Stresnil 0.5 Tablet with opioids as it may cause breathing problems, drowsiness and coma.

Drug-Drug Interactions

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AlprazolamKetoconazole
Critical
AlprazolamCobicistat
Critical

Drug-Drug Interactions

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AlprazolamKetoconazole
Critical
How does the drug interact with Stresnil 0.5 Tablet:
Co-administration of Stresnil 0.5 Tablet with Ketoconazole may considerably increase the blood levels of Stresnil 0.5 Tablet, which may result in side effects.

How to manage the interaction:
Although there is an interaction between Stresnil 0.5 Tablet and Ketoconazole, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
AlprazolamCobicistat
Critical
How does the drug interact with Stresnil 0.5 Tablet:
Co-administration of Stresnil 0.5 Tablet with Cobicistat may considerably increase the blood levels and effects of Stresnil 0.5 Tablet.

How to manage the interaction:
Despite the fact that there is an interaction between Stresnil 0.5 Tablet and Cobicistat, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
AlprazolamClarithromycin
Critical
How does the drug interact with Stresnil 0.5 Tablet:
The combination of Stresnil 0.5 Tablet and clarithromycin may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Stresnil 0.5 Tablet and clarithromycin, it can be used if prescribed by a doctor. Consult a doctor if you have excessive drowsiness, problems with movement, memory loss, anxiety, hallucinations (illogical thoughts), or breathing issues (particularly if you have asthma or obstructive sleep apnea). Do not discontinue any medications without consulting a doctor.
AlprazolamIndinavir
Critical
How does the drug interact with Stresnil 0.5 Tablet:
The combination of Stresnil 0.5 Tablet and Indinavir may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Stresnil 0.5 Tablet and Indinavir, it can be used if prescribed by a doctor. Consult a doctor if you have drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
AlprazolamItraconazole
Critical
How does the drug interact with Stresnil 0.5 Tablet:
Stresnil 0.5 Tablet's blood levels may be significantly raised when combined with itraconazole.

How to manage the interaction:
Although combining Stresnil 0.5 Tablet and Itraconazole may lead to an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you get extremely drowsy and your breathing becomes slow. Without consulting a doctor, never stop taking any medication.
AlprazolamSodium oxybate
Critical
How does the drug interact with Stresnil 0.5 Tablet:
Co-administration of Stresnil 0.5 Tablet with Sodium Oxybate may increase Sodium Oxybate's adverse effects (respiratory depression, low blood pressure, fainting).

How to manage the interaction:
Although the combination of Stresnil 0.5 Tablet and sodium oxybate may cause an interaction, they can be used if prescribed by a doctor. Consult a doctor if you suffer any of the following symptoms: breathing difficulties, low blood pressure, being severely drowsy, or fainting. Avoid driving or operating hazardous machinery or performing other hazardous activities for at least 6 hours after taking a dose. Do not discontinue any medications without consulting a doctor.
AlprazolamDelavirdine
Critical
How does the drug interact with Stresnil 0.5 Tablet:
The combination of Stresnil 0.5 Tablet and Delavirdine may considerably increase the risk of side effects.

How to manage the interaction:
Despite the fact that there is an interaction between Stresnil 0.5 Tablet and Delavirdine, it can be used if prescribed by a doctor. Consult a doctor if you have sleepiness, dizziness, confusion, or weak or rapid breathing over a long duration of time. Do not discontinue any medications without consulting a doctor.
AlprazolamCeritinib
Critical
How does the drug interact with Stresnil 0.5 Tablet:
Co-administration of Stresnil 0.5 Tablet with Ceritinib may considerably increase the blood levels and effects of Stresnil 0.5 Tablet.

How to manage the interaction:
Although there is a interaction between Stresnil 0.5 Tablet and Ceritinib, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
AlprazolamMorphine
Severe
How does the drug interact with Stresnil 0.5 Tablet:
Using Stresnil 0.5 Tablet together with Morphine can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although the combination of Stresnil 0.5 Tablet and Morphine may cause an interaction, they can be used if prescribed by a doctor. Consult a doctor if you have any symptoms such as dizziness, drowsiness, difficulty concentrating, or impairment in judgment, reaction speed, or control of movements. Do not discontinue any medications without consulting a doctor.
AlprazolamTapentadol
Severe
How does the drug interact with Stresnil 0.5 Tablet:
Using Stresnil 0.5 Tablet together with Tapentadol can cause central nervous system depression can lead to serious side effects including respiratory distress.

How to manage the interaction:
Although the combination of Stresnil 0.5 Tablet and Tapentadol may cause an interaction, they can be used if prescribed by a doctor. Consult a doctor if you have any symptoms such as dizziness, drowsiness, difficulty concentrating, or impairment in judgment, reaction speed, or control of movements. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keeping a fixed time to go to bed and wake up consistently every day helps maintain a better sleeping and waking plan.

  • Engage yourself in workouts, dancing, and walking that help promote calmness in the body so that you can enjoy a good night's sleep.

  • Taking naps in a day can make it harder to fall asleep at night, so one should try to limit a nap to no more than half an hour and don't nap after 2 p.m. 

  • Limit caffeine and alcohol consumption as it will not let you sleep and causes frequent urination.

  • Avoid large, heavy meals before bed. One can have a light snack that helps to avoid heartburn.

  • Avoid consumption of alcohol as it may increase drowsiness.

  • Take less liquid before bedtime so that you won't have to urinate as often. One must keep their worries and planning aside and enjoy a warm bath or a massage before bedtime. It will help in having a good night's relaxing sleep.

Habit Forming

Yes

Therapeutic Class

SEDATIVE-HYPNOTIC DRUGS

Stresnil 0.5 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol is sedative in nature, so taking it with Stresnil 0.5 Tablet may interrupt the sleep cycle. Alcohol may worsen the effects of Stresnil 0.5 Tablet so one should not consume it with Stresnil 0.5 Tablet .

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Pregnancy

Unsafe

Stresnil 0.5 Tablet is a category D pregnancy drug. It is not recommended for use during pregnancy, especially in the second and third trimesters as it may cause harm to the unborn baby.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Stresnil 0.5 Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Stresnil 0.5 Tablet may cause dizziness, double vision, or drowsiness in some people. It is an offence to drive if Stresnil 0.5 Tablet affects you. Therefore, avoid driving if you feel drowsy, dizzy, or experience any vision problems after taking Stresnil 0.5 Tablet .

bannner image

Liver

Caution

Take Stresnil 0.5 Tablet with caution, especially if you have or had a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Stresnil 0.5 Tablet with caution, especially if you have or had a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Caution

Not enough scientific data available for Stresnil 0.5 Tablet , hence it is best to consult a child specialist.

Have a query?

FAQs

Stresnil 0.5 Tablet belongs to a class of medication called sedatives and hypnotics, primarily used to treat sleeplessness (insomnia). Besides this, it also helps to provide a calming effect on anxiety disorder and panic disorder.

Stresnil 0.5 Tablet is a combination of two medicines: Alprazolam and Melatonin, which helps a person fall asleep faster and stay asleep during the night. Alprazolam is a benzodiazepine (BZD) that increases the activity of a chemical messenger in the brain known as GABA, reducing the abnormal and overactivity of brain cells (neurons), which in turn relaxes the brain and promotes sleep. On the other hand, Melatonin is a natural hormone that activates the ON-OFF mechanism of a person&amp;#039;s sleeping-waking cycle (circadian cycle), thereby inducing sleep during the nighttime.

It is advised not to take Stresnil 0.5 Tablet if you have a bleeding disorder as taking this medicine may worsen the medical condition. The use of Stresnil 0.5 Tablet is restricted in patients dealing with diabetes and depression.

It is advised not to stop taking this medicine by yourself. If you are noticing an improvement in their condition, then you should first consult with their doctor. The doctor will gradually reduce the dose and then stop it to avoid withdrawal effects

It is suggested not to indulge in any heavy exercise like running or put up heavyweights as it can make you active and wake for a long time. However, you can practice some mindful activities like meditation to make yourself relax and sleep properly. Doing heavy workouts before bed increases blood circulation and body temperature of the body and creates difficulty sleeping. Your bedroom should be dark and should be mend for only sleep.

It has been reported in some patients that Stresnil 0.5 Tablet may cause drowsiness. Therefore, it is recommended to avoid driving or any other activities that require mental alertness after taking Stresnil 0.5 Tablet .

Yes, it has been observed in some persons that Stresnil 0.5 Tablet may cause mental or physical dependence if used for a prolonged time. Therefore, take Stresnil 0.5 Tablet only in dose and duration as advised by your doctor.

Stresnil 0.5 Tablet is habit-forming and should be used for a short duration in adults and should only be taken after discussing it with doctors. However, taking it for a longer time may cause extreme drowsiness the next day. Thus, one should always take this medication within the prescribed time limit.

Yes, Stresnil 0.5 Tablet is an addictive or habit-forming medication. Because it makes the brain feel calm and relaxed. So, prolonged usage or overdose may lead to addiction for the brain. Therefore it is important to follow as prescribed by your doctor, especially dose and duration.

Stresnil 0.5 Tablet is not used for pain relief. It is used to treat sleeplessness (insomnia) and also helps to provide a calming effect on anxiety and panic disorders.

Stresnil 0.5 Tablet is generally considered safe when used as prescribed by a doctor. However, like all medications, it can have side effects and potential interactions with other drugs. It is important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.

No, Stresnil 0.5 Tablet is not an opioid. It contains alprazolam a benzodiazepine and melatonin a hormone supplement.

Stresnil 0.5 Tablet has antidepressant properties. Alprazolam alleviates sadness and anxiety, while melatonin regulates sleep and stimulates neurogenesis. Please consult a doctor before using it to ensure safety.

No, Stresnil 0.5 Tablet is not a narcotic substance. Stresnil 0.5 Tablet contains alprazolam which is a benzodiazepine and melatonin is a hormone supplement.

Stresnil 0.5 Tablet is not used for treating a hangover. It is used for anxiety and panic disorders as well as helps to regulate sleep. For hangover relief stay hydrated, have some rest, and consider over-the-counter pain relievers if needed. If it persists or worsens consult a doctor for appropriate treatment.

Yes, you can take Stresnil 0.5 Tablet for anxiety under medical guidance. But make sure to follow your doctor's instructions strictly to avoid addiction or side effects and have optimal results.

Stresnil 0.5 Tablet can show the effect of reducing blood pressure through relaxation. But prolonged usage may lead to negative impact. Consult your doctor for personalized advice which is suitable to your condition without causing any side effects.

Generally, Stresnil 0.5 Tablet does not lead to weight gain. However, an increased or decreased appetite may cause weight gain or weight loss in some people depending on the individual response to the medication. Please talk to your doctor if you have any concerns about weight gain.

No, avoid taking Stresnil 0.5 Tablet with hydrocodone. As Stresnil 0.5 Tablet interacts with hydrocodone (a synthetic opioid derivative of codeine) and causes negative side effects. Therefore, it is a better idea to discuss with your doctor before taking any medication while on treatment with Stresnil 0.5 Tablet to ensure safety.

Generally, taking Stresnil 0.5 Tablet with paracetamol is safe. However, it is important to consult your doctor before combining medications to ensure there are no potential interactions or side effects specific to your health situation.

No, do not take Stresnil 0.5 Tablet for the rest of your life as it is a habit-forming or addictive medication.

The common side effects of Stresnil 0.5 Tablet that may occur in some individuals are drowsiness, tiredness, headache, depressed mood, daytime drowsiness, stomach pain, and dizziness. Most of these side effects of Stresnil 0.5 Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
Other Info - STR0002

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:36 AM IST

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Reference

  1. https://www.drugs.com/melatonin.html
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018276s052lbl.pdf

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