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  3. Symbiva 400 mcg Inhaler 1's

Symbiva 400 mcg Inhaler 1's, Pack of 1 Inhaler
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Symbiva 400 mcg Inhaler is used to treat asthma and chronic obstructive pulmonary disease (COPD). It contains Budesonide and Formoterol, which work by reducing the swelling and relaxing air passages in the lungs, making it easier to breathe. Some people may experience side effects such as fungal infection in the mouth, headache, sore throat, hoarse voice, upper respiratory tract infection, flu, cough, back pain, increased heart rate, and trembling. Before starting this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

BUDESONIDE-400MCG + FORMOTEROL-6MCG

Consume Type :

INHALATION

Return Policy :

Not Returnable

Expires on or after :

About Symbiva 400 mcg Inhaler

Symbiva 400 mcg Inhaler is used to treat asthma and chronic obstructive pulmonary diseases (COPD). It helps prevent and treat difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness associated with asthma and COPD.

Symbiva 400 mcg Inhaler contains Budesonide and Formoterol. Budesonide reduces the swelling of the airways, and Formoterol works by relaxing and opening air passages in the lungs, making it easier to breathe.

Some people may experience fungal infection in the mouth, headache, sore throat, hoarse voice, upper respiratory tract infection, flu, cough, back pain, increased heart rate, and trembling. If the side effects persist or worsen, please consult your doctor.

Do not take Symbiva 400 mcg Inhaler if you are allergic to any of its components. If you are pregnant or breastfeeding, consult your doctor before using Symbiva 400 mcg Inhaler. Keep your doctor informed about your medications and medical conditions to prevent any potential interactions.

Uses of Symbiva 400 mcg Inhaler

Symbiva 400 mcg Inhaler is used in the treatment of Asthma and Chronic Obstructive Pulmonary Disease (COPD). The detailed uses of Symbiva 400 mcg Inhaler are as follows:

  • Asthma management: Symbiva 400 mcg Inhaler is widely prescribed for asthma patients to reduce inflammation and prevent asthma attacks. It works by relaxing airway muscles, easing breathing and providing effective relief.
  • COPD treatment: Symbiva 400 mcg Inhaler is highly effective in managing chronic obstructive pulmonary disease (COPD), a progressive lung condition. It helps alleviate symptoms like breathlessness and wheezing, ensuring better respiratory function.
  • Maintenance therapy: It is used as regular maintenance therapy and as needed in response to symptoms.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Hold Symbiva 400 mcg Inhaler with the mouthpiece downwards. Put the mouthpiece between your teeth and seal the lips around it. Then, press down on the inhaler once to release the medication. Breathe in slowly and hold your breath for 5 to 10 seconds. Breathe out slowly. Repeat the process until you have inhaled the number of puffs prescribed by the doctor.
  • Rinse your mouth with water and spit it out after using Symbiva 400 mcg Inhaler to avoid fungal infections in the mouth and throat.

Medicinal Benefits

  • Symbiva 400 mcg Inhaler is a combination inhalation therapy that contains Budesonide (an inhaled corticosteroid) and Formoterol (a long-acting beta-2 adrenergic agonist).
  • This combination offers both anti-inflammatory and bronchodilator actions, providing comprehensive control over respiratory conditions such as Asthma and Chronic Obstructive Pulmonary Disease (COPD).
  • Budesonide reduces airway inflammation, while Formoterol helps to relax the airway muscles, leading to improved airflow and reduced breathlessness.
  • Symbiva 400 mcg Inhaler is used as a regular maintenance therapy for individuals with asthma where the use of inhaled corticosteroids and long-acting beta-agonists (LABA) is appropriate.
  • It reduces airway inflammation and prevents bronchospasm, thereby minimising the frequency and severity of asthma attacks.
  • Helps maintain long-term asthma control, improves lung function, and enhances quality of life.
  • Symbiva 400 mcg Inhaler is also indicated for the regular treatment of moderate to severe COPD in patients who experience frequent symptoms and have a history of exacerbation.
  • Symbiva 400 mcg Inhaler decreases the rate and severity of COPD exacerbations and maintains day-to-day function.

How Symbiva 400 mcg Inhaler Works

Symbiva 400 mcg Inhaler contains budesonide (corticosteroid) and formoterol (bronchodilator). Budesonide prevents the release of certain chemicals responsible for causing inflammatory reactions. Formoterol fumarate relaxes and widens the respiratory airway muscles, making it easier to breathe. Together, Symbiva 400 mcg Inhaler helps treat asthma and COPD.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Symbiva 400 mcg Inhaler
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.

What if I have taken an overdose of Symbiva 400 mcg Inhaler

Do not use Symbiva 400 mcg Inhaler in more doses or more often than prescribed. Symptoms of overdose include tremor, headache, and tachycardia (fast heartbeat). If you experience any of these symptoms or suspect an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not use Symbiva 400 mcg Inhaler if you are allergic to any of its components.
  • If you are pregnant or breastfeeding, it is advised to inform your doctor before using Symbiva 400 mcg Inhaler.
  • Symbiva 400 mcg Inhaler is not recommended for children below 6 years of age.
  • If your breathing worsens or you often wake up at night with asthma, experience chest tightness in the morning that lasts longer than usual, please consult a doctor immediately, as these might be signs indicating that your asthma is not controlled properly and requires an alternate or additional treatment.
  • Regular monitoring of potassium levels is recommended while taking Symbiva 400 mcg Inhaler, as it may cause low potassium levels in the blood.
  • Avoid contact with people who have infections or who are sick, as Symbiva 400 mcg Inhaler may weaken the immune system, causing infections to be easily contracted.
  • If you have high blood pressure, diabetes, hypokalaemia (low potassium levels in the blood), glaucoma, cataracts, osteoporosis (weak bones), fits, immune system problems, chickenpox, measles, thyroid, lung, heart, liver or adrenal gland problems, inform your doctor before using Symbiva 400 mcg Inhaler.

Drug-Drug Interactions

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BudesonideMifepristone
Critical
BudesonideRibociclib
Critical

Drug-Drug Interactions

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BudesonideMifepristone
Critical
How does the drug interact with Symbiva 400 mcg Inhaler:
Using mifepristone together with Symbiva 400 mcg Inhaler may significantly reduce the effects of Symbiva 400 mcg Inhaler.

How to manage the interaction:
Taking Symbiva 400 mcg Inhaler with Mifepristone is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
BudesonideRibociclib
Critical
How does the drug interact with Symbiva 400 mcg Inhaler:
Coadministration of Symbiva 400 mcg Inhaler and Ribociclib may increase the absorption of the medication from Symbiva 400 mcg Inhaler into the blood stream.

How to manage the interaction:
Taking Ribociclib with Symbiva 400 mcg Inhaler can cause an interaction, consult a doctor before taking it. Consult a doctor if experience swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Do not stop using any medications without talking to a doctor.
FormoterolPenbutolol
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Using Symbiva 400 mcg Inhaler together with penbutolol can reduce the effect of both medications.

How to manage the interaction:
There may be a possibility of interaction between Penbutolol and Symbiva 400 mcg Inhaler, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FormoterolCarteolol
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Taking carteolol with Symbiva 400 mcg Inhaler can reduce the effects of both drugs.

How to manage the interaction:
Although there is an interaction between Carteolol and Symbiva 400 mcg Inhaler, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FormoterolEpinephrine
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Using epinephrine together with Symbiva 400 mcg Inhaler may increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Symbiva 400 mcg Inhaler and Epinephrine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FormoterolRibociclib
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Taking ribociclib together with Symbiva 400 mcg Inhaler can increase the risk of an irregular heart rhythm

How to manage the interaction:
Co-administration of Symbiva 400 mcg Inhaler with Ribociclib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath, contact your doctor right away. Do not stop using any medications without first talking to your doctor.
FormoterolPropranolol
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Coadministration of propranolol with Symbiva 400 mcg Inhaler can reduce the effects of both medications.

How to manage the interaction:
Although taking propranolol and Symbiva 400 mcg Inhaler together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FormoterolSotalol
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Taking sotalol with Symbiva 400 mcg Inhaler could reduce the benefits of both medications because they have opposite effects on the body.

How to manage the interaction:
Although there is an interaction between Sotalol and Symbiva 400 mcg Inhaler, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FormoterolLabetalol
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Co-administration of labetalol and Symbiva 400 mcg Inhaler together could decrease the effects of both medications.

How to manage the interaction:
Although taking Labetalol and Symbiva 400 mcg Inhaler together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FormoterolCarvedilol
Severe
How does the drug interact with Symbiva 400 mcg Inhaler:
Using Symbiva 400 mcg Inhaler and Carvedilol together may reduce the effects of both medications.

How to manage the interaction:
Although there is an interaction between Symbiva 400 mcg Inhaler and Carvedilol, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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BUDESONIDE-400MCG+FORMOTEROL-6MCGFruit juices, Fruits
Moderate

Drug-Food Interactions

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BUDESONIDE-400MCG+FORMOTEROL-6MCGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Symbiva 400 mcg Inhaler levels in your body can grow due to grapefruit, which will result in more side effects. While using Symbiva 400 mcg Inhaler, you must stay away from consuming grapefruits and grapefruit juice. In case of any unusual side effects, consult a doctor. Do not discontinue any medication without consulting a doctor.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
  • Avoid foods such as cabbage, beans, garlic, onions, shrimp, pickled food, dried fruits, fried foods, carbonated drinks, wine, and bottled lemon and lime juice as they may worsen asthma symptoms.
  • Do meditation, deep breathing, regular exercise, and try progressive muscle relaxation techniques to get relief from stress and reduce the risk of an asthma attack.
  • Quit smoking as it may reduce the effectiveness of the Symbiva 400 mcg Inhaler and irritate the lungs, worsening breathing problems.
  • Learning breathing exercises will help you move more air in and out of your lungs.

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

Symbiva 400 mcg Inhaler Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of Symbiva 400 mcg Inhaler with alcohol is unknown. Please consult a doctor before consuming alcohol with Symbiva 400 mcg Inhaler.

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Pregnancy

Consult your doctor

The safety of Symbiva 400 mcg Inhaler in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Symbiva 400 mcg Inhaler is excreted in human milk. It is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Safe if prescribed

Symbiva 400 mcg Inhaler usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Use Symbiva 400 mcg Inhaler with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Symbiva 400 mcg Inhaler in patients with Kidney problems, please consult a doctor.

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Children

Consult your doctor

Symbiva 400 mcg Inhaler is not recommended for children below 6 years as the safety and effectiveness were not established. However, please consult a doctor before giving Symbiva 400 mcg Inhaler to children.

Have a query?

FAQs

Symbiva 400 mcg Inhaler is used to treat asthma and chronic obstructive pulmonary disease (COPD).

Yes, Symbiva 400 mcg Inhaler may cause fungal infection in the mouth (oral thrush) as a common side effect. It is not necessary for everyone taking Symbiva 400 mcg Inhaler to experience this side effect. However, to avoid such side effects, brush your teeth or rinse your mouth with water after using Symbiva 400 mcg Inhaler every time.

Symbiva 400 mcg Inhaler should be used with caution in osteoporosis (low bone density resulting in weak and brittle bones) patients, as it may worsen the condition. Therefore, inform your doctor if you have osteoporosis before taking Symbiva 400 mcg Inhaler so that the dose may be adjusted or an alternate medicine may be prescribed.

No, you are not recommended to take ketoconazole or other antifungal drugs such as itraconazole, posaconazole and voriconazole with Symbiva 400 mcg Inhaler as co-administration of these medicines may increase the absorption of Symbiva 400 mcg Inhaler into the bloodstream and increase the risk of adverse effects such as high blood pressure, weight gain, depression, muscle weakness, swelling, acne, skin thinning, cataracts, excessive growth of facial or body hair, stretch marks, high blood glucose levels, menstrual irregularities, loss of bone density, easy bruising and abnormal distribution of body fat, especially in the waist, back, neck and face, neck. However, please consult a doctor before using other medicines with Symbiva 400 mcg Inhaler.

You are not recommended to take more than the prescribed dose of Symbiva 400 mcg Inhaler as it may cause adverse effects such as a fast heartbeat, trembling or headache. However, if you experience any of these symptoms while taking Symbiva 400 mcg Inhaler, please consult a doctor immediately.

You are not recommended to stop taking Symbiva 400 mcg Inhaler without consulting your doctor, as it may worsen the condition or cause recurring symptoms. Therefore, take Symbiva 400 mcg Inhaler for as long as your doctor has prescribed it, and if you experience any difficulty while taking Symbiva 400 mcg Inhaler, please consult your doctor.

Symbiva 400 mcg Inhaler does not relieve a sudden asthma attack. Therefore, it is advised to carry a rescue inhaler always to treat sudden asthma symptoms.

Throat irritation or pain, oral thrush (fungal infection), respiratory tract infections, low potassium level and sinusitis (sinus inflammation) are some of the common side effects of Symbiva 400 mcg Inhaler, which might occur in some patients.

In rare cases, Symbiva 400 mcg Inhaler may cause a low potassium level. So if you experience tiredness, muscle cramps, weakness, abnormal heart rhythms (arrhythmias) and constipation, contact a doctor for advice.

People with heart problems (including high blood pressure, chest pain, fast heartbeat, fits (seizures), thyroid problems, diabetes, immune system problems, weak bones or osteoporosis, eye problems (glaucoma, cataracts) and liver problems should consult a doctor before using Symbiva 400 mcg Inhaler.

Yes, Symbiva 400 mcg Inhaler is a combination of two drugs: Budesonide (a corticosteroid) and Formoterol (LABA—long-acting beta-agonists or bronchodilators).

No, taking more than the prescribed dose may not be more effective; it may raise the possibility of experiencing severe adverse reactions.

Rinse your mouth with water after each dose to help prevent infection. Do not swallow the water after rinsing.

Before taking the Symbiva 400 mcg Inhaler, let your doctor know about all your medical conditions, sensitivities, and all the medications you are using. And inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

You may start to feel better after a couple of weeks. But it can take a month or more to work fully.

It's possible that your immune system is not strong enough to receive a live vaccine while you're taking Symbiva 400 mcg Inhaler. If you need vaccinations, inform the healthcare professional that you're taking Symbiva 400 mcg Inhaler.

It depends on your health condition. As directed by your physician, you will need to use it for longer to keep symptoms under control.

The safety of Symbiva 400 mcg Inhaler in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

Store it at room temperature and away from sunlight, excess heat and moisture (not in the bathroom). Please dispose of the inhaler three months after you remove it from the foil overwrap or when the dose indicator reads 0), whichever comes first.

Asthma is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty breathing. Symptoms include wheezing (a whistling sound while breathing), shortness of breath, chest tightness, and cough, especially at night.

Country of origin

India

Manufacturer/Marketer address

SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - SYM0020

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 1, 2025 | 6:20 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021929s013lbl.pdf
  2. https://www.drugs.com/cdi/budesonide-and-formoterol.html

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