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  1. Home
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  3. Syncapone 50 Tablet 10's

Prescription drug
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Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
Syncapone 50 Tablet 10's, Pack of 10 TABLETS
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Extra 15% Off with Bank Offers

Composition :

CARBIDOPA-12.5MG + ENTACAPONE-200MG + LEVODOPA-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Syncapone 50 Tablet

Syncapone 50 Tablet is used in treating Parkinson's disease and its symptoms, including tremors, spasms, muscle stiffness and poor muscle control. Parkinson's disease is a disorder of the central nervous system that affects movement and locomotion.

Syncapone 50 Tablet contains Carbidopa, Levodopa, and Entacapone, which work by maintaining the levels of dopamine in the brain. Thereby, it helps reduce symptoms of Parkinson's disease, such as tremors and stiffness.

The most common side effects of Syncapone 50 Tablet are nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (uncontrolled/involuntary muscle movement). If the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to any of the components in Syncapone 50 Tablet , please tell your doctor. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your medicines and health condition to rule out any side effects.

Uses of Syncapone 50 Tablet

Syncapone 50 Tablet is used in the treatment of Parkinson's disease. The detailed use of Syncapone 50 Tablet is as follows:

  • Treatment of Parkinson’s disease: Syncapone 50 Tablet is used in the treatment of Parkinson's disease. It improves motor function and enhances mobility.

Have a query?

Directions for Use

  • Take Syncapone 50 Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Syncapone 50 Tablet is used to treat Parkinson’s disease. It contains Carbidopa, Levodopa, and Entacapone.
  • Levodopa converts into dopamine in the brain, helping control movement and motor functions.
  • Carbidopa prevents the breakdown of Levodopa in the bloodstream, ensuring more reaches the brain for effective symptom relief.
  • Entacapone inhibits the enzyme COMT, prolonging the action of Levodopa and maintaining sustained dopamine levels.
  • Syncapone 50 Tablet reduces symptoms of Parkinson’s disease, including tremors, rigidity, stiffness, and slow movement.
  • It enhances overall mobility and quality of life by improving the effectiveness and duration of Levodopa therapy.
  • It supports overall neurological health, helping maintain a better quality of life for patients.

How Syncapone 50 Tablet Works

Syncapone 50 Tablet contains Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the central nervous system agents, while Carbidopa is a decarboxylase inhibitor. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. Carbidopa prevents the breakdown of Levodopa in the bloodstream so that more Levodopa can reach the brain. On the other hand, Entacapone belongs to a class of COMT (catechol-o-methyltransferase enzyme) inhibitors, which cause higher and more sustained levels of Levodopa in the blood, so that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson's disease.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Syncapone 50 Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Talk to your doctor about identifying the cause of the discoloration, adjusting your dose, or switching to a different medication.
  • Keep an eye on your urine colour and let your doctor know if you notice any unusual changes.
  • Increase your intake of water or other liquids to dilute your urine and restore its normal colour.
  • Avoid foods that can change your urine colour, such as beets, rhubarb, and berries.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.

What if I have taken an overdose of Syncapone 50 Tablet

An overdose of Syncapone 50 Tablet may cause unpleasant side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Syncapone 50 Tablet if you are allergic to any of its ingredients.
  • The use of Syncapone 50 Tablet is not recommended if a person takes monoamine oxidase inhibitors (MAOs) or antidepressant drugs like isocarboxazid, phenelzine, selegiline, and tranylcypromine because it can lead to a high blood pressure (hypertension) crisis.
  • Do not stop taking Syncapone 50 Tablet suddenly without talking to your doctor. It may result in a serious neuroleptic malignant syndrome (NMS) that causes fever, muscle cramps or stiffness, unusual body movements, fast heartbeat, sweating, change in thinking, and confusion.
  • Tell your doctor if you have/had diabetes, a heart attack, a mental illness, stomach ulcers, heart disease, or have recently undergone a surgical procedure.
  • Syncapone 50 Tablet may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, especially when you start taking Syncapone 50 Tablet , so please get up gradually.
  • Prolonged intake of Syncapone 50 Tablet may lead to greater chances of neuropathy (nerve damage).
  • Syncapone 50 Tablet should be used with caution in patients with eye problems (narrow-angle glaucoma), irregular heartbeat (arrhythmia), gastrointestinal bleeding, and psychosis.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
EntacaponeIsocarboxazid
Critical

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Phenelzine can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Syncapone 50 Tablet with Phenelzine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeIsocarboxazid
Critical
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Isocarboxazid can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Syncapone 50 Tablet with Isocarboxazid is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, Contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeLinezolid
Critical
How does the drug interact with Syncapone 50 Tablet:
Coadministration of Syncapone 50 Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Syncapone 50 Tablet with Linezolid is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeTranylcypromine
Critical
How does the drug interact with Syncapone 50 Tablet:
Coadministration of Syncapone 50 Tablet with Tranylcypromine can increase the risk of high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Syncapone 50 Tablet with Tranylcypromine can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
LevodopaTranylcypromine
Critical
How does the drug interact with Syncapone 50 Tablet:
Taking Tranylcypromine with Syncapone 50 Tablet can increase the risk of high blood pressure

How to manage the interaction:
Taking Syncapone 50 Tablet with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
LevodopaPhenelzine
Critical
How does the drug interact with Syncapone 50 Tablet:
Using Syncapone 50 Tablet together with phenelzine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Syncapone 50 Tablet with Phenelzine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
LevodopaProcarbazine
Critical
How does the drug interact with Syncapone 50 Tablet:
Using Syncapone 50 Tablet together with procarbazine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Procarbazine with Syncapone 50 Tablet together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
EntacaponeFurazolidone
Severe
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Furazolidone can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although there is a possible interaction between Syncapone 50 Tablet and Furazolidone, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling really unwell, confusion, seeing or hearing things that aren't there, having a seizure, a faster heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty moving, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeSodium oxybate
Severe
How does the drug interact with Syncapone 50 Tablet:
Taking Syncapone 50 Tablet with Sodium oxybate can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Syncapone 50 Tablet and Sodium oxybate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like fatigue, dizziness, lightheaded, drowsiness, confusion, shortness of breath, chest pain or tightness, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeMethylene blue
Severe
How does the drug interact with Syncapone 50 Tablet:
Combining Syncapone 50 Tablet with Methylene blue can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Syncapone 50 Tablet with Methylene blue together can result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling confused or hallucinating, having a seizure, a fast heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty coordinating movements, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Drink plenty of water to avoid headaches due to dehydration.
  • Limit the consumption of sugar-containing food or food with too many calories but few nutrients, as it may cause tooth decay.
  • Engaging in physical activity like dancing or exercising will boost the metabolism and make a person more energetic.
  • Avoid intake of alcoholic beverages with Syncapone 50 Tablet as it can make a person dehydrated and may affect their sleep. This can make it harder for a person’s body to aid the system in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Syncapone 50 Tablet Substitute

Substitutes safety advice
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Alcohol

Caution

Avoid consumption of alcohol with Syncapone 50 Tablet as it may increase the risk of adverse effects such as drowsiness, dizziness, or difficulty in concentrating.

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Pregnancy

Caution

Syncapone 50 Tablet is a pregnancy Category C medicine. It is unknown whether Syncapone 50 Tablet will affect pregnant women or the fetus. Hence, the intake of Syncapone 50 Tablet should be avoided if you are pregnant or planning to become pregnant, as it may harm the baby.

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Breast Feeding

Caution

Syncapone 50 Tablet is excreted in human milk, but the effect of Syncapone 50 Tablet on an infant is unknown. So, Syncapone 50 Tablet is given to a breastfeeding mother only if the doctor thinks the benefits outweigh the risks.

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Driving

Unsafe

Syncapone 50 Tablet may cause drowsiness and make you fall asleep suddenly. Therefore, avoid driving if you feel drowsy after taking Syncapone 50 Tablet .

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Liver

Caution

Take Syncapone 50 Tablet with caution if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Syncapone 50 Tablet with caution if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Syncapone 50 Tablet is not recommended for use in children, as safety and effectiveness have not been established.

FAQs

Syncapone 50 Tablet is used in the treatment of Parkinson's disease and helps relieve symptoms, including tremors, spasms, muscle stiffness and poor muscle control.

Syncapone 50 Tablet works by maintaining the levels of dopamine in the brain. Thereby, it helps reduce symptoms of Parkinson's disease, such as tremors and stiffness.

Take Syncapone 50 Tablet at the same time every day, as this will help you remember to take the medicine.

In some cases, prolonged intake of Syncapone 50 Tablet may lead to autoimmune haemolytic anaemia (red blood cells in the blood are destroyed earlier than normal). Levodopa in Syncapone 50 Tablet can cause the immune system to mistake your own red blood cells for foreign substances. The body responds by making antibodies to attack the body's own red blood cells. The antibodies attach to red blood cells and cause them to break down too early. So, your doctor might recommend regular blood tests while using Syncapone 50 Tablet .

You are recommended to avoid taking protein-rich food (such as chicken, beef, pork, eggs, meats, fish, dairy products, seeds, and nuts), iron supplements, or multivitamin tablets while taking Syncapone 50 Tablet as it may delay and reduce the absorption of levodopa. Thus, it reduces the effectiveness of Syncapone 50 Tablet . Please consult your doctor and do as advised for the best results.

Yes, orthostatic hypotension could be a side-effect of Syncapone 50 Tablet . Orthostatic hypotension is a sudden lowering of blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People taking Syncapone 50 Tablet are advised to regularly monitor their blood pressure levels to avoid unpleasant events.

Consult your doctor before taking Syncapone 50 Tablet if you have glaucoma. Syncapone 50 Tablet is contraindicated in patients with narrow-angle glaucoma. Syncapone 50 Tablet may cause blindness on long-term use in the case of patients with narrow-angle glaucoma.

Hallucination is a medical condition in which a person may feel, hear, or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. Syncapone 50 Tablet may cause hallucinations in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Syncapone 50 Tablet , please talk to your doctor immediately.

It is advised not to stop taking Syncapone 50 Tablet without consulting your doctor, as it may lead to a severe condition called withdrawal-emergent hyperpyrexia with symptoms such as confusion, fever, muscle stiffness, changes in heartbeat, and breathing. Therefore, take Syncapone 50 Tablet for as long as your doctor has prescribed it, and if you experience any of these symptoms while taking Syncapone 50 Tablet , please consult your doctor so that the dose may be gradually reduced.

Syncapone 50 Tablet can be taken with or without food as advised by your doctor. Stay away from protein meals as it can delay the action of Syncapone 50 Tablet .

Yes, Syncapone 50 Tablet can turn the colour of your urine, sweat and saliva dark (brown, red, or black). Although it not harmful, it can sometimes stain your bedding and clothes.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - SYN0015

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Oct 9, 2025 | 11:46 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/cdi/levodopa-carbidopa-and-entacapone.html
  2. https://www.medicines.org.uk/emc/files/pil.6518.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021485s028s029lbl.pdf

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