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  1. Home
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  3. SYNCLAR 250MG TABLET

Prescription drug
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SYNCLAR 250MG TABLET, Pack of 4 TABLETS
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Extra 15% Off with Bank Offers

Composition :

CLARITHROMYCIN-250MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About SYNCLAR 250MG TABLET

SYNCLAR 250MG TABLET is used to treat bacterial infections, including chest infections such as bronchitis and pneumonia, skin problems such as cellulitis, and ear infections. Besides this, SYNCLAR 250MG TABLET is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori.

SYNCLAR 250MG TABLET contains Clarithromycin (antibiotic). It inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Thus, SYNCLAR 250MG TABLET helps treat infections.

SYNCLAR 250MG TABLET may cause side effects, including nausea, diarrhoea, vomiting, loss of appetite, bloating, indigestion, headaches, and difficulty sleeping. These side effects are temporary and may resolve after some time; however, if they persist, let your doctor know.

Do not take SYNCLAR 250MG TABLET if you are allergic to any of its components. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your health condition and medications to prevent any interactions.

Uses of SYNCLAR 250MG TABLET

SYNCLAR 250MG TABLET is used in the treatment of Bacterial infections. The detailed uses of SYNCLAR 250MG TABLET are as follows:

  • Treatment of Respiratory Infections: SYNCLAR 250MG TABLET is commonly prescribed to treat respiratory infections such as bronchitis and pneumonia caused by susceptible bacteria.
  • Skin Infections: SYNCLAR 250MG TABLET effectively treats skin infections like cellulitis or impetigo, caused by bacterial pathogens.
  • Sinusitis: SYNCLAR 250MG TABLET is used to manage acute bacterial sinusitis, relieving symptoms like nasal congestion and facial pain caused by bacterial infections.
  • Otitis Media: SYNCLAR 250MG TABLET is frequently utilised to treat middle ear infections (otitis media), providing relief from ear pain and inflammation.

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Directions for Use

  • SYNCLAR 250MG TABLET can be taken with or without food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow SYNCLAR 250MG TABLET as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • SYNCLAR 250MG TABLET is a macrolide class antibiotic used to treat a wide range of bacterial infections.
  • It is effective against both gram-positive and gram-negative bacteria, certain anaerobic organisms, and some parasites such as Balantidium coli and Entamoeba species.
  • It is commonly prescribed for chest and lung infections like bronchitis and pneumonia.
  • It helps treat bacterial skin infections such as cellulitis.
  • It is beneficial in treating middle ear infections and throat infections caused by susceptible bacteria.
  • When used in combination with other drugs, SYNCLAR 250MG TABLET aids in eradicating Helicobacter pylori, the bacteria responsible for duodenal ulcers.
  • By stopping the growth and multiplication of bacteria, SYNCLAR 250MG TABLET helps clear infections and promotes faster recovery.

How SYNCLAR 250MG TABLET Works

SYNCLAR 250MG TABLET contains Clarithromycin (antibiotic). It inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Thus, SYNCLAR 250MG TABLET helps prevent infections.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Synclar 250mg Tablet
  • Drink plenty of fluids and consider oral rehydration solutions.
  • Eat bland, easily digestible foods like bananas, rice, toast, and applesauce.
  • Avoid trigger foods like greasy, spicy, fatty, acidic, and caffeinated foods.
  • Gradually reintroduce fiber-rich foods as symptoms improve.
  • Get adequate sleep and rest.
  • Practice relaxation techniques to manage stress.
  • Maintain regular bowel habits.
  • Avoid overexertion and take breaks when needed.
  • Consult a doctor if your gastrointestinal symptoms are severe, persistent, or accompanied by fever, bloody stools, dehydration, or last for more than a few days.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of SYNCLAR 250MG TABLET

Do not take more than the prescribed dose of SYNCLAR 250MG TABLET as it may cause overdose. The symptoms of overdose include diarrhoea, vomiting, nausea and stomach pain. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Avoid taking SYNCLAR 250MG TABLET if you are allergic to any of the components present in it.
  • In some cases, the use of SYNCLAR 250MG TABLET causes antibiotic-associated diarrhoea.
  • SYNCLAR 250MG TABLET may cause sensitive skin to react to sunlight and ultraviolet rays, leading to an exaggerated sunburn reaction. Hence, it is advisable to apply sunscreen before going outside.
  • Consult your doctor if you are pregnant or breastfeeding.
  • Let your doctor know if you are taking any other medicines, including supplements or herbal products.

Drug-Drug Interactions

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ClarithromycinAlfuzosin
Critical
ClarithromycinRanolazine
Critical

Drug-Drug Interactions

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ClarithromycinAlfuzosin
Critical
How does the drug interact with Synclar 250mg Tablet:
When Alfuzosin and Synclar 250mg Tablet can increase the risk or severity of side effects like low blood pressure or irregular heart rates.

How to manage the interaction:
Taking Synclar 250mg Tablet with alfuzosin is not recommended as it can result in an interaction; it should be taken only if your doctor has advised it. However, if you experience dizziness, headache, palpitations, or chest discomfort, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinRanolazine
Critical
How does the drug interact with Synclar 250mg Tablet:
When Ranolazine and Synclar 250mg Tablet are taken together, significantly increases the blood levels and effects of Ranolazine.

How to manage the interaction:
Co-administration of Synclar 250mg Tablet and Ranozaline can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
ClarithromycinSaquinavir
Critical
How does the drug interact with Synclar 250mg Tablet:
When Synclar 250mg Tablet is taken with Saquinavir, increases the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Synclar 250mg Tablet and Saquinavir can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinEplerenone
Critical
How does the drug interact with Synclar 250mg Tablet:
Co-administration of Eplerenone and Synclar 250mg Tablet may significantly increase the blood levels and effects of eplerenone.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Synclar 250mg Tablet with Eplerenone is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
ClarithromycinDihydroergotamine
Critical
How does the drug interact with Synclar 250mg Tablet:
When Dihydroergotamine is taken with Synclar 250mg Tablet, the amount of Dihydroergotamine in the blood can go up.

How to manage the interaction:
Taking Synclar 250mg Tablet with Dihydroergotamine can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinMethylergometrine
Critical
How does the drug interact with Synclar 250mg Tablet:
When Methylergometrine is taken with Synclar 250mg Tablet, the amount of Methylergometrine in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Synclar 250mg Tablet with Methylergometrine is generally avoided as it can lead to an interaction, it can be taken only when advised by a doctor. Do not stop using any medications without a doctor's advice.
ClarithromycinBepridil
Critical
How does the drug interact with Synclar 250mg Tablet:
Co-administration of Bepridil with Synclar 250mg Tablet may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Synclar 250mg Tablet with Bepridil is not recommended as it can result in an interaction, it should be taken only if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinRegorafenib
Critical
How does the drug interact with Synclar 250mg Tablet:
When Regorafenib is taken with Synclar 250mg Tablet, may alter the blood levels and effects of Regorafenib.

How to manage the interaction:
Co-administration of Synclar 250mg Tablet and Regorafenib can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
ClarithromycinPimozide
Critical
How does the drug interact with Synclar 250mg Tablet:
Combining Synclar 250mg Tablet with Pimozide can increase the risk of heart rhythm problems.

How to manage the interaction:
Co-administration of Synclar 250mg Tablet and Pimozide can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like irregular heartbeat, chest tightness, blurred vision or nausea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinZiprasidone
Critical
How does the drug interact with Synclar 250mg Tablet:
Taking Synclar 250mg Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Synclar 250mg Tablet and Ziprasidone can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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CLARITHROMYCIN-250MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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CLARITHROMYCIN-250MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may delay the gastrointestinal absorption of Synclar 250mg Tablet. Avoid grapefruit juice while on treatment with Synclar 250mg Tablet.

Diet & Lifestyle Advise

  • Probiotics and prebiotics can also help to reduce the side effects of antibiotics.
  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet.
  • Eating grapefruit during antibiotic treatment can prevent the body from utilising SYNCLAR 250MG TABLET properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic.
  • Avoid taking too much calcium, iron-enriched foods and drinks as it might affect the working of SYNCLAR 250MG TABLET.
  • Avoid the intake of alcoholic beverages, as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the medicine in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

SYNCLAR 250MG TABLET Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

Limited information is available. Keep your doctor informed if you drink alcohol.

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Pregnancy

Caution

SYNCLAR 250MG TABLET should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking SYNCLAR 250MG TABLET; your doctor will decide whether SYNCLAR 250MG TABLET can be taken by breastfeeding mothers or not.

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Driving

Consult your doctor

Not enough scientific data available, hence it is advised to consult your doctor.

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Liver

Caution

SYNCLAR 250MG TABLET to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

SYNCLAR 250MG TABLET to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Children

Safe if prescribed

SYNCLAR 250MG TABLET can be given safely to children above 6 months of age, with the dose to be adjusted and recommended by a child specialist only.

FAQs

SYNCLAR 250MG TABLET is used to treat bacterial infections, including chest infections, skin infections, and ear infections. Besides this, SYNCLAR 250MG TABLET is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori.

SYNCLAR 250MG TABLET contains Clarithromycin (antibiotic). It inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Thus, SYNCLAR 250MG TABLET helps in the prevention of infections.

You should avoid taking iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking SYNCLAR 250MG TABLET. Avoid taking any other antibiotics containing SYNCLAR 250MG TABLET unless your doctor has prescribed you.

After taking antibiotics such as SYNCLAR 250MG TABLET, some people get thrush, a fungal infection. This is due to the fact that antibiotics kill the regular, harmless bacteria that serve to protect you from thrush.

SYNCLAR 250MG TABLET treats only bacterial infections. It will not work for viral infections (such as the common cold, flu).

No, SYNCLAR 250MG TABLET is a macrolide antibiotic. It can be taken by people who are allergic to penicillin with a doctor's advice only.

Side effects are rare with SYNCLAR 250MG TABLET and do not usually last long. They will get better after a day or two. If any side effects persist, reach out to the doctor immediately.

No, SYNCLAR 250MG TABLET should not be stopped even if you feel better, as it is an antibiotic medication and completing the full course is very necessary; otherwise, the infection might reappear in a more severe form.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - SYN0038

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Oct 22, 2025 | 12:42 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/6094/smpc#gref
  2. https://www.medicines.org.uk/emc/files/pil.6094.pdf
  3. https://www.nhs.uk/medicines/clarithromycin/

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