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compositionComposition:AZTREONAM-1000MG
prescription
Prescription Medicine
info
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Synernam 1 gm Injection is used to treat bacterial infections. It contains Aztreonam which works by killing the infection-causing bacteria. In some cases, this medicine may cause side effects such as dizziness, headache, sneezing, high temperature, and double vision. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AZTREONAM-1000MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Synernam 1 gm Injection

Synernam 1 gm Injection is a prescription antibiotic injection used to treat severe infections caused by bacteria. It is commonly prescribed for serious conditions like deep lung infections, urinary tract infections, blood infections, and abdominal infections. Your healthcare provider will determine the exact schedule for your treatment, which is delivered directly into a vein or muscle.

To ensure the infection is completely cleared, this medication must be injected at regular intervals as directed by your doctor. Even if you start feeling better after a few days, it is vital to complete the entire course of treatment to prevent the bacteria from returning and becoming resistant. While undergoing treatment, staying well-hydrated and getting plenty of rest can help your body recover more efficiently.

While using Synernam 1 gm Injection, you may experience mild side effects like redness or pain at the injection site, nausea, or mild diarrhoea. However, you must contact your doctor immediately if you develop severe watery diarrhoea, a skin rash, yellowing of your skin or eyes, or difficulty breathing.

Before starting treatment with Synernam 1 gm Injection, tell your doctor if you have kidney or liver disease, or if you have ever had an allergic reaction to antibiotics. You should not take this medicine if you have a known severe allergy to it. Your doctor will carefully evaluate your medical history to ensure this treatment is safe for you.

It is important to inform your doctor about all other medicines you are taking, as some drugs can affect how your kidneys process this medication. While there is no direct interaction with alcohol, avoiding alcohol and smoking can support your immune system during recovery. If you are pregnant, breastfeeding, or an older adult, discuss the risks and benefits with your healthcare provider before starting treatment.

Uses of Synernam 1 gm Injection

The following are the common conditions for which Synernam 1 gm Injection is prescribed:

  • Severe lung infections: Synernam 1 gm Injection helps clear deep chest infections, such as serious pneumonia, by targeting and destroying the bacteria causing the illness.
  • Urinary tract infections: It effectively treats complicated bladder and kidney infections by stopping the growth of harmful bacteria in the urinary system.
  • Abdominal and gynecological infections: This medication helps cure complex infections inside the stomach area and reproductive organs by eliminating the responsible bacteria.
  • Blood infections: For serious, widespread infections in the bloodstream, Synernam 1 gm Injection works quickly to clear the bacteria and prevent life-threatening complications.
  • Skin and bone infections: It treats deep-seated bacterial infections in the skin, soft tissues, and joints, promoting proper healing.

Key Benefits

The following benefits highlight how Synernam 1 gm Injection helps treat severe bacterial infections and supports recovery:

  • Rapid control of bacterial infections: It begins fighting susceptible bacteria soon after administration, helping prevent the infection from spreading further.
  • Relieves infection-related symptoms: By eliminating the bacteria causing the illness, it helps reduce fever, pain, swelling, and inflammation as the infection resolves.
  • Treats a wide range of serious infections: It is effective against several severe Gram-negative bacterial infections affecting different parts of the body, including the lungs, urinary tract, abdomen, bloodstream, skin, and bones.
  • Suitable for selected patients with penicillin allergies: Because Synernam 1 gm Injection has a unique antibiotic structure, it may be an appropriate alternative for many patients with penicillin allergies, although it should still be used with caution in people with a history of severe beta-lactam allergies.
Side effects of Synernam 1 gm Injection
  • A blocked nose can be relieved by drinking more water, which helps clear fluids.
  • Use saline nasal spray available over the counter to relieve blockage or blow harder to remove the mucus.
  • Use nasal strips that can be placed on the nose to widen nostrils and increase airflow.
  • Keep a humidifier around to moisten air at home/workplace.
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
Here are the steps to manage angioedema (Swelling Under The Skin) as a side effect of medication:
  • If you experience angioedema, inform your doctor immediately. Treatment can help keep the swelling under control.
  • Seek medical attention if symptoms are severe, such as difficulty breathing or swallowing.
  • Follow your doctor's instructions to manage symptoms, which may include stopping or adjusting the medication that triggered angioedema.
  • Your doctor may also recommend antihistamines, steroids, or other treatments to reduce swelling and inflammation.
  • Make dietary and lifestyle changes as recommended, such as avoiding trigger foods or reducing stress.
  • Monitor your condition closely and track your symptoms to report them to your doctor.
  • Consult your doctor again if symptoms worsen or do not improve or if you experience any new or concerning symptoms.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Synernam 1 gm Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Synernam 1 gm Injection Works

Synernam 1 gm Injection belongs to a class of medicines known as monobactam antibiotics. It works by interfering with the bacteria's ability to build their protective outer walls. Without a strong cell wall, the bacteria cannot survive, eventually bursting and dying off. This medication is highly specific, meaning it selectively targets certain types of bacteria while leaving other human cells unharmed. Because it resists many of the protective enzymes that bacteria use to defend themselves, it remains highly effective even against some hard-to-treat bacterial strains.
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Alcohol

Caution

The interaction of alcohol with Synernam 1 gm Injection is unknown. Please consult a doctor before consuming alcohol while using Synernam 1 gm Injection.

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Pregnancy

Caution

The safety of Synernam 1 gm Injection in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

Synernam 1 gm Injection is excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Caution

Synernam 1 gm Injection cause double vision, dizziness as a side effect. So, avoid driving after receiving Synernam 1 gm Injection.

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Liver

Caution

Take Synernam 1 gm Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Synernam 1 gm Injection with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Synernam 1 gm Injection can be given safely to children, dose to be adjusted and recommended by a child specialist only.

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Heart

Caution

Synernam 1 gm Injection should be administered with caution, especially if you have a history of heart problems. Please inform your doctor about any existing heart problems before using Synernam 1 gm Injection.

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Geriatrics

Caution

Synernam 1 gm Injection should be administered with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Synernam 1 gm Injection

In case of an accidental overdose, seek immediate medical attention or call your local poison control centre. Symptoms of an overdose can include severe dizziness, seizures, or breathing difficulties, which require urgent medical evaluation.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of fluids, such as water or clear broths, to help your kidneys flush out the medication and support your body's recovery.
  • Support gut health: Since antibiotics can affect the natural balance of your gut bacteria, consider eating probiotic-rich foods like yogurt or kefir after finishing your treatment course.
  • Get adequate rest: Give your body ample time to heal by resting and avoiding strenuous physical activity while fighting off the infection.
  • Eat nutrient-dense meals: Focus on a balanced diet rich in vitamins and minerals to help rebuild your immune system and boost your strength.
health query

Have a query?

How Soon It Starts Working

The time required for Synernam 1 gm Injection to start to work: Synernam 1 gm Injection ideally shows its action within 1 hour after administration. The time for which the effects of Synernam 1 gm Injection last: The effect of Synernam 1 gm Injection lasts for 4 to 6 hours.

What if you forget to take Synernam 1 gm Injection

If you miss a dose of Synernam 1 gm Injection, contact your healthcare provider or pharmacist immediately for instructions. Do not inject a double dose to make up for a forgotten one, as this can increase the risk of side effects.

Storage

•Store the dry powder vials of Synernam 1 gm Injection at controlled room temperature, between 15°C and 30°C (59°F to 86°F). •Keep the medicine in its original outer carton to protect it from direct light, and do not freeze it.

Drug Warnings

  • Inspect the solution: Always check the liquid before injecting. It should be clear and colourless to pale yellow; discard it immediately if you see cloudiness, particles, or discolouration.
  • Rotate injection sites: If you are receiving muscle injections, change the injection spot each time to reduce muscle soreness and prevent tissue damage.
  • Never reuse needles: Use a brand-new, sterile needle and syringe for every single injection to prevent serious blood infections.
  • Complete the full course: Finish the entire prescribed treatment, even if you feel completely better, to ensure the bacteria are fully eliminated.
  • Monitor kidney health: Since this drug is cleared by the kidneys, your doctor may perform regular blood tests to check your kidney function during treatment.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Synernam 1 gm Injection and affect its safety or effectiveness:

  • Aminoglycosides: Combining this medicine with aminoglycoside antibiotics may increase the risk of kidney damage.
  • Strong Diuretics: Taking powerful water pills (such as furosemide) at the same time may put extra strain on your kidneys.
  • Oral Anticoagulants (Blood Thinners): This medicine may enhance the effect of blood thinners like warfarin, increasing the risk of bleeding. Your doctor may need to monitor your blood clotting times more closely.
AztreonamCholera, live attenuated
Severe
AztreonamBCG vaccine
Severe

Drug-Drug Interactions

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AztreonamCholera, live attenuated
Severe
How does the drug interact with Synernam 1 gm Injection:
Coadministration of Synernam 1 gm Injection with Cholera vaccine can reduce the effects of Cholera vaccine.

How to manage the interaction:
Taking Synernam 1 gm Injection with Cholera vaccine together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
AztreonamBCG vaccine
Severe
How does the drug interact with Synernam 1 gm Injection:
When BCG vaccine is used together with Synernam 1 gm Injection, its effectiveness may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Synernam 1 gm Injection and BCG vaccine, but it can be taken if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Synernam 1 gm Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Synernam 1 gm Injection contains Aztreonam, an antibiotic that works by interfering with the formation of the bacterial cell wall (a protective covering) that is necessary for their survival. Thereby damages the bacterial cell wall and kills bacteria.
No. You should complete the full course of Synernam 1 gm Injection as prescribed by your doctor. After completing the full course of Synernam 1 gm Injection will work. It is important that you take Synernam 1 gm Injection at the right dose, right times, and for the right numbers of days.
Synernam 1 gm Injection is used to treat serious bacterial infections that require injectable antibiotic therapy. It may be used alone or in combination with other antibiotics depending on the type and severity of the infection. It does not work against viral infections such as the common cold, viral cough, or influenza, and should only be used when prescribed for a bacterial infection.
Synernam 1 gm Injection may cause dizziness and double vision. So, drive only if you are alert and avoid driving and operating machinery if you feel dizzy or experience vision changes.
Synernam 1 gm Injection causes side effects such as dizziness, chest pain, headache, double vision, bad breath, vaginal irritation, and a blocked nose. However, please contact a doctor if these side effects worsen or persist longer.
Synernam 1 gm Injection cannot be taken as an oral pill because it is not absorbed well through the stomach or intestines. It must be given as an injection, either directly into a vein (intravenously) or into a large muscle (intramuscularly), depending on your condition and your doctor's recommendation. It is usually administered by a doctor or nurse in a hospital or clinic, although some patients may receive it at home after appropriate training. Your healthcare provider will decide the most suitable method and dosage for your treatment.
Yes. Synernam 1 gm Injection is generally considered safe for most people with a penicillin allergy because it is a monobactam antibiotic with a different chemical structure from penicillins and has minimal cross-reactivity. However, you should always inform your doctor about any previous allergic reactions to antibiotics, especially severe reactions, so that appropriate precautions can be taken during treatment.
While there is no direct, dangerous interaction between Synernam 1 gm Injection and alcohol, it is best to avoid alcohol during treatment. Alcohol can dehydrate your body and weaken your immune system, making it harder for your body to fight off the infection. Talk to your doctor or pharmacist for personalised advice.
Synernam 1 gm Injection should only be used during pregnancy if it is clearly needed and prescribed by a doctor. Studies suggest it does not carry a high risk of birth defects, but your healthcare provider will weigh the benefits against any potential risks to your baby. Talk to your doctor if you are pregnant or planning to become pregnant.
It is very important to receive this medicine on a consistent schedule. If you miss a dose, contact your healthcare provider or clinic right away to find out when to receive your next injection. Talk to your doctor or pharmacist to help set up a reliable dosing schedule.
Mild diarrhoea can be a common side effect of antibiotics. However, if you develop severe, watery, or bloody diarrhoea along with stomach cramps, contact your healthcare provider immediately, as this could be a sign of a serious gut infection. Talk to your doctor before taking any anti-diarrhoea medications.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.3773 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Aztreonam [Prescribing Information]. [Accessed on 29 Mar. 2019]Check here
  3. Aztreonam [Product label]. 2022. [Accessed on 14 Mar. 2025]Check here
  4. Azactam 1g Powder for Solution for Injection or Infusion, vial - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 17 June 2022]Check here
  5. Azactam 1g Powder for Solution for Injection or Infusion, vial - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 17 June 2022]Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 28 Mar. 2019]Check here
  7. Chambers HF, Dech DH Beta-Lactam Antibiotics & Other Cell Wall Synthesis Inhibitors. In: Trevor AJ, Katzung BG, Kruidering-Hall M, eds. Katzung & Trevor's Pharmacology: Examination & Board Review. 11 th ed. McGraw-Hill Education: New York, New York; 2015Check here

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - SYN0402
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