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compositionComposition:TENOFOVIR DISOPROXIL FUMARATE-300MG
prescription
Prescription Medicine
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Synfovir Tablet is used to treat HIV and chronic hepatitis B infection. It contains Tenofovir disoproxil fumarate which works by preventing the development of the virus in the human body. In some cases, this medicine may cause side effects such as diarrhoea, rash, nausea, pain, weakness, and stomach pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TENOFOVIR DISOPROXIL FUMARATE-300MG

Manufacturer/Marketer :

Synmedic Laboratories

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Synfovir Tablet

Synfovir Tablet is a prescription antiviral medicine used to treat chronic hepatitis B and human immunodeficiency virus type 1 (HIV-1) infection in adults and certain children. It works by slowing the growth of the virus, helping protect the immune system, reduce liver damage, and lower the amount of virus in the body. Although it does not cure HIV or hepatitis B, it plays an important role in their long-term management.

For Synfovir Tablet to work effectively, it must be taken exactly as prescribed, usually once daily at the same time each day. Missing doses can make the treatment less effective and increase the risk of the virus becoming resistant to Synfovir Tablet. You can take Synfovir Tablet with or without food, although taking it with food may help reduce stomach discomfort. Eating a balanced diet, staying well hydrated, avoiding alcohol, and following your doctor's advice can also help support your overall health during treatment.

While taking Synfovir Tablet, some people may experience mild side effects such as nausea, diarrhea, headache, or tiredness. These side effects are usually manageable, but seek medical attention immediately if you develop severe muscle pain, unusual weakness, difficulty breathing, persistent vomiting, yellowing of the skin or eyes, or signs of kidney problems such as reduced urination or swelling of the legs.

Before starting Synfovir Tablet, tell your doctor if you have kidney disease, liver disease, osteoporosis or other bone problems, or if you have both HIV and hepatitis B infection. Do not stop taking Synfovir Tablet without your doctor's advice, especially if you have hepatitis B, as this may cause a serious worsening of your liver disease. Do not take Synfovir Tablet if you are allergic to Synfovir Tablet or any of its ingredients.

Synfovir Tablet can interact with medicines that may affect kidney function, including certain pain relievers, antivirals, and some antibiotics, so always tell your doctor about all prescription medicines, over-the-counter medicines, and herbal supplements you are taking. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, discuss the benefits and risks of treatment with your healthcare provider before starting Synfovir Tablet.

Uses of Synfovir Tablet

Synfovir Tablet is used in the treatment of HIV (Human Immunodeficiency Virus) infection and Chronic Hepatitis B. The detailed uses of Synfovir Tablet are as follows:

  • HIV-1 Infection: Synfovir Tablet helps manage HIV-1 by keeping the virus from multiplying, which protects your immune cells and helps lower the overall amount of virus in your body.
  • Chronic Hepatitis B: Synfovir Tablet helps control the hepatitis B virus, preventing it from damaging your liver cells and reducing the risk of long-term liver scarring or liver failure.

Key Benefits

Synfovir Tablet helps manage certain viral infections by reducing the amount of virus in the body and supporting long-term immune and liver health. When taken regularly as prescribed, it helps control the infection and improves overall health outcomes.
Benefits may include:

  •  Helps reduce viral activity and supports long-term control of HIV or chronic hepatitis B infection.
  • Supports immune system health by helping keep viral levels low.
  • Helps protect liver health in people with chronic hepatitis B.
  • Reduces the risk of disease progression and virus-related complications.
  • Provides convenient once-daily dosing to support consistent treatment.
  • Promotes long-term health and improved quality of life when taken as prescribed.
Side effects of Synfovir Tablet
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Directions for Use

  • Synfovir Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Synfovir Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Synfovir Tablet Works

Synfovir Tablet control viral infections by preventing the virus from making copies of itself. This reduces the amount of virus in the body, supports the immune system, and helps protect the liver from further damage.
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Alcohol

Caution

Avoid drinking alcohol. Consuming alcohol while using Synfovir Tablet may worsen the condition.

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Pregnancy

Caution

Synfovir Tablet is a category B medicine. It should be used with caution in pregnant women because it may cause side effects to the unborn baby.

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Breast Feeding

Unsafe

The active part of Synfovir Tablet may pass with breast milk. Women who are HIV-positive must not breast-feed, because HIV infection can be passed on to the baby in breast milk.

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Driving

Caution

Synfovir Tablet may cause dizziness. So, avoid driving or refrain from any activities that require you to alert mentally.

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Liver

Caution

Synfovir Tablet should be used with caution in patients with liver diseases. Dose adjustments may be necessary. Patients with liver disease, who are treated with Synfovir Tablet, have a higher risk of serious and possibly fatal liver complications.

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Kidney

Unsafe

Synfovir Tablet should not be used in adolescents with kidney disease. In other people with severe kidney diseases, Synfovir Tablet is given only if clinically needed.

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Children

Unsafe

Synfovir Tablet should not be used in children below 12 years of age.

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Heart

Consult your doctor

It is unknown whether Synfovir Tablet is safe for use in heart patients or not. Please consult your physician.

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Geriatrics

Caution

Synfovir Tablet can be given in elderly patients with extreme caution, due to the cause of adverse effects like liver/kidney problems.

What if I have taken an overdose of Synfovir Tablet

If you take more than your prescribed dose, seek emergency medical attention or call a poison control center immediately.

Diet & Lifestyle Advise

  • Drink plenty of water: Stay well-hydrated throughout the day to support your kidney function while your body processes this medication.
  • Avoid alcohol: Do not drink alcohol, as it can put extra stress on your liver and worsen existing liver conditions.
  • Support your bones: Ensure your diet includes adequate calcium and Vitamin D, or speak with your doctor about supplements, as Synfovir Tablet can sometimes cause bone thinning.
  • Eat balanced meals: Maintain a nutrient-rich diet to help support your immune system and overall energy levels.
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How Soon It Starts Working

The time required for Synfovir Tablet to start to work: Synfovir Tablet ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Synfovir Tablet last: The effect of Synfovir Tablet lasts for 17 hours.

What if you forget to take Synfovir Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 12 hours away, skip the missed dose entirely and return to your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Synfovir Tablet tablets at room temperature, strictly between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect Synfovir Tablet before use: Do not take the tablets if they are discolored, cracked, damaged, or if the packaging shows signs of tampering.
  • Do not stop treatment abruptly: Do not stop taking Synfovir Tablet suddenly, especially if you have hepatitis B, as this may cause a severe flare-up of your liver infection. Always consult your doctor before stopping treatment.
  • Attend regular monitoring appointments: Keep all scheduled blood and urine test appointments so your doctor can monitor your kidney function, liver function, and overall response to treatment.
  • Keep an updated medication list: Maintain a current list of all prescription medicines, over-the-counter products, vitamins, and herbal supplements you take, and share it with your doctor, dentist, or any other healthcare professional involved in your care.

Drug-Drug Interactions

verifiedApollotooltip
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen, diclofenac): Taking these medicines alongside Synfovir Tablet may increase the risk of kidney damage.
  • Other antiviral medicines (for HIV or hepatitis C): Certain antiviral medicines may increase the amount of Synfovir Tablet in the body, raising the risk of side effects.
  • Anti-viral medicine (e.g., Adefovir dipivoxil): Do not take Synfovir Tablet alongside Synfovir Tablet, as using both together may increase the risk of serious side effects.
Tenofovir disoproxilStreptozocin
Critical
Tenofovir disoproxilDidanosine
Critical

Drug-Drug Interactions

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Tenofovir disoproxilStreptozocin
Critical
How does the drug interact with Synfovir Tablet:
Combining Synfovir Tablet and Streptozocin can increase the risk of kidney problems.

How to manage the interaction:
Taking Synfovir Tablet with Streptozocin is not recommended, as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
Tenofovir disoproxilDidanosine
Critical
How does the drug interact with Synfovir Tablet:
Coadministration of Didanosine with Synfovir Tablet can increase the levels and risk of Didanosine side effects.

How to manage the interaction:
Taking Didanosine with Synfovir Tablet is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. However, if you experience severe headaches, confusion, weakness, trouble walking, muscle pain, or high fever, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilSulfasalazine
Severe
How does the drug interact with Synfovir Tablet:
Coadministration of Sulfasalazine and Synfovir Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Sulfasalazine and Synfovir Tablet together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilPhenylbutazone
Severe
How does the drug interact with Synfovir Tablet:
Coadministration of Phenylbutazone and Synfovir Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Phenylbutazone and Synfovir Tablet can lead to an interaction, it can be taken when your doctor advises. However, if you experience any symptoms like vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilPhenytoin
Severe
How does the drug interact with Synfovir Tablet:
Coadministration of Phenytoin and Synfovir Tablet can reduce the levels of Synfovir Tablet, which can lead to low treatment outcomes.

How to manage the interaction:
Taking Synfovir Tablet and Phenytoin together can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilAmikacin
Severe
How does the drug interact with Synfovir Tablet:
Coadministration of Synfovir Tablet with Amikacin can increase the risk of developing kidney problems.

How to manage the interaction:
Although taking Amikacin and Synfovir Tablet together can result in an interaction, it can be taken when a doctor has prescribed it. Consult the doctor if you experience vomiting, loss of appetite, irregular urination, sudden weight gain or loss, shortness of breath, weakness, or dizziness. Do not discontinue any medications without a doctor's advice.
Tenofovir disoproxilGanciclovir
Severe
How does the drug interact with Synfovir Tablet:
coadministration of Synfovir Tablet with Ganciclovir can increase the risk or severity of side effects like kidney damage.

How to manage the interaction:
Although taking Ganciclovir and Synfovir Tablet together can cause an interaction, it can be taken if your doctor has suggested it. If you have symptoms like feeling sick, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, swelling, trouble breathing, bone or muscle pain, feeling weak or dizzy, feeling confused, or having an irregular heartbeat -contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilKanamycin
Severe
How does the drug interact with Synfovir Tablet:
Coadministration of Kanamycin and Synfovir Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Taking Kanamycin and Synfovir Tablet together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, dizziness, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilDeferoxamine
Severe
How does the drug interact with Synfovir Tablet:
Coadministration of Deferoxamine with Synfovir Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Deferoxamine and Synfovir Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tenofovir disoproxilKetoconazole
Severe
How does the drug interact with Synfovir Tablet:
Coadministration of Ketoconazole and Synfovir Tablet may increase the risk of developing liver damage.

How to manage the interaction:
Although taking Ketoconazole and Synfovir Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any symptoms like fever, chills, joint pain or swelling, unusual bleeding, fatigue, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Synfovir Tablet when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Synfovir Tablet is used to treat HIV and chronic hepatitis B infection.
In the case of HIV infection, Synfovir Tablet may decrease the risk of spreading the virus to others, but the risks of infecting others still continue. Although, in the case of hepatitis B virus infection, Synfovir Tablet has not proven to decrease the risk of transferring the virus to others. Thereby, the patients of both HIV infection and hepatitis B virus (HBV) infection should not share needles and should practice safe sex.
Synfovir Tablet is safe if used in the dose and duration recommended by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.
Duration of treatment will depend on the seriousness of hepatitis B virus infection. You will require to take regular blood tests to keep a check on the viral load. Your doctor will then decide the duration of the Synfovir Tablet appropriately. In a few cases, treatment is needed lifelong.
Synfovir Tablet works by prevents the development of viruses in human cells. This prevents the virus from producing new viruses and cleans up your infection. It can effectively reduce the symptoms associated with HIV and chronic hepatitis B infection.
The main symptoms include yellowing of eyes and skin, flu-like symptoms, pale stools and dark-colored urine.
Synfovir Tablet does not prevent the chance of transmission of new virus infection. Therefore, always take necessary precautions as per national guidelines for the prevention of transmission of new virus infection.
If you have Tuberculosis, HIV-1 virus infection or any other medical condition, you are recommended to inform your doctor before taking Synfovir Tablet.
You should take Synfovir Tablet in the dose and duration prescribed by your doctor. Take Synfovir Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.
If you vomit within 1 hour of taking Synfovir Tablet, take another one. However, you need not take another tablet if you vomit after more than an hour of taking Synfovir Tablet. If you experience vomiting whenever you take Synfovir Tablet or if the vomiting persists for a longer duration, consult your doctor.
If you forget to take Synfovir Tablet within 12 hours of your usual dosing time, you should take it with food as soon as possible and go back to the normal dosing schedule. If you miss a dose of Synfovir Tablet by more than 12 hours and it is almost time for your next dose, you should skip the missed dose and simply resume the regular dosing schedule.
The side effects of Synfovir Tablet include nausea, diarrhoea, rash, weakness, and stomach pain. If any of these side effects persist or worsen, please consult your doctor.
Unexplained muscle weakness, especially when accompanied by deep, rapid breathing or extreme tiredness, can be a sign of a serious condition called lactic acidosis. Stop taking Synfovir Tablet and seek immediate emergency medical care if you experience these symptoms.
It is highly recommended to avoid or strictly limit alcohol while taking this medication. Alcohol increases stress on your liver, which can worsen liver damage, especially if you are being treated for hepatitis B. Talk to your doctor or pharmacist for personalized advice.
Yes, some people experience a decrease in bone mineral density while taking this medication. Your doctor may monitor your bone health or suggest calcium and vitamin D supplements. Talk to your doctor or pharmacist if you have concerns about your bone health.
You should avoid taking pain relievers known as NSAIDs (like ibuprofen or naproxen) regularly while taking Synfovir Tablet, as they can increase the risk of kidney damage. Speak to your doctor or pharmacist to find a safer pain relief alternative.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India
Other Info - SY84805
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