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compositionComposition:PIPERACILLIN-4000MG+TAZOBACTAM-500MG
prescription
Prescription Medicine
info
Synpep T Injection 1's

Synpep T Injection is used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. It contains Piperacillin and Tazobactam, which kills bacteria. It may cause side effects such as nausea, constipation, diarrhoea, headache, and trouble sleeping. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PIPERACILLIN-4000MG+TAZOBACTAM-500MG

Manufacturer/Marketer :

Syndicate Life Sciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Synpep T Injection

Synpep T Injection is a prescription antibiotic injection used to treat a wide range of serious bacterial infections. It is commonly prescribed in hospital settings for moderate to severe infections of the lungs, skin, abdomen, and female reproductive organs. This medicine works by targeting and destroying the bacteria responsible for these illnesses, helping you recover safely.

Because this medicine must be injected directly into a vein, it is given at regular, scheduled times to keep a steady level of the treatment in your body. Since it is not taken by mouth, you do not need to worry about taking it with or without food. Staying well-hydrated and resting during your treatment will help your body heal more effectively.

While taking Synpep T Injection, you may experience some common side effects, such as mild diarrhea, nausea, headache, or trouble sleeping. However, you must contact your doctor immediately if you experience severe, watery, or bloody diarrhea, a high fever, or skin rashes. These can be signs of a more serious reaction that requires prompt medical attention.

Before you begin treatment, tell your doctor if you have kidney disease, cystic fibrosis, or a history of bleeding disorders. Do not take this medicine if you have ever had a severe allergic reaction to penicillin or similar antibiotic medications, as you may experience a serious reaction.

This medicine can interact with blood thinners, certain gout medications, and other antibiotics, which may affect how they work or increase your risk of side effects. Avoid drinking alcohol during treatment, as it can worsen stomach upset and cause dehydration. If you are pregnant, breastfeeding, or managing health conditions as an older adult, consult your healthcare provider to ensure this treatment is safe for you.

Uses of Synpep T Injection

Synpep T Injection is used to treat bacterial infections. The detailed uses of Synpep T Injection are as follows:

  • Pneumonia: Synpep T Injection helps clear severe bacterial infections in the lungs, making it easier to breathe and reducing fever and cough.
  • Stomach and abdominal infections: It targets and eliminates bacteria causing deep-seated infections inside the abdominal cavity, promoting healing.
  • Skin and soft tissue infections: It treats deep, severe bacterial infections of the skin, reducing painful swelling, redness, and heat.
  • Gynecological infections: It clears bacterial infections in the female reproductive organs, preventing further complications or spread.

Key Benefits

Synpep T Injection helps treat serious bacterial infections by eliminating the bacteria responsible for the infection. By providing effective infection control, it supports faster recovery and helps restore overall health. Benefits may include:

  • Helps treat a wide range of serious bacterial infections.
  • Supports rapid reduction of infection-related symptoms such as fever, pain, and inflammation.
  • Helps prevent the spread of infection to other parts of the body.
  • Reduces the risk of complications associated with severe bacterial infections.
  • Supports faster recovery and return to normal daily activities.
  • Helps improve overall health by effectively controlling bacterial growth.
Side effects of Synpep T Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Synpep T Injection will be administered by a healthcare professional in a medical setting.
  • Do not self-administer.

How Synpep T Injection Works

Synpep T Injection contains Piperacillin and Tazobactam. • Piperacillin: It is an antibiotic that helps treat bacterial infections by stopping the growth of bacteria and destroying them, helping the body fight the infection. • Tazobactam: It helps protect Piperacillin from being broken down by certain bacteria. This allows the antibiotic to work more effectively against resistant bacterial infections.
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Alcohol

Caution

Avoid alcohol consumption while taking Synpep T Injection to prevent unpleasant side-effects, such as nausea and vomiting.

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Pregnancy

Caution

Synpep T Injection should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking Synpep T Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

There is limited data on how Synpep T Injection affects breastfed infants. Synpep T Injection is excreted into breast milk. Please consult your doctor before taking Synpep T Injection if you are breastfeeding.

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Driving

Caution

It is unknown whether Synpep T Injection affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking Synpep T Injection, do not drive or operate any machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Synpep T Injection. Your doctor will prescribe Synpep T Injection only if the benefits outweigh the risk.

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Kidney

Caution

Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of Synpep T Injection may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking Synpep T Injection. Your doctor will prescribe Synpep T Injection only if the benefits outweigh the risk.

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Children

Caution

Safety and efficacy of Synpep T Injection in children less than two months of age have not been established.

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Heart

Caution

Exercise caution while taking Synpep T Injection in heart patients.

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Geriatrics

Safe if prescribed

Synpep T Injection can be safely given in elderly patients if recommended by the physician.

What if I have taken an overdose of Synpep T Injection

Since this medication is usually injected by a healthcare professional, an overdose is highly unlikely. However, if you suspect an overdose or experience severe muscle spasms, agitation, or seizures, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear fluids while receiving this medication to support your kidneys and help flush the medicine out of your system.
  • Support your gut: Talk to your doctor about eating yogurt or taking a high-quality probiotic supplement after your antibiotic course is finished to help rebuild healthy bacteria in your gut.
  • Prioritize rest: Give your body plenty of time to rest and recover, which helps your immune system fight off the infection more efficiently.
  • Avoid alcohol: Do not consume alcohol during your treatment, as it can cause dehydration and worsen stomach-related side effects like nausea and diarrhea.

Have a query?

How Soon It Starts Working

  • The time required for Synpep T Injection to start to work: The time required for Synpep T Injection to show its action is unknown.
  • The time for which the effects of Synpep T Injection last: The effect of Synpep T Injection lasts for 4 to 7 hours.

What if you forget to take Synpep T Injection

If you miss a scheduled injection, contact your doctor or home health nurse immediately for instructions on when to receive your next dose. Do not inject a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inspect the liquid: Always check the mixed liquid before injecting. It should be clear and colorless to pale yellow. Do not use the solution if you notice particles, cloudiness, or unusual discoloration.
  • Monitor the injection site: Regularly check your IV line site for redness, warmth, swelling, or pain, and tell your nurse or doctor if you notice any changes.
  • Complete the full course: Finish the entire prescribed course of treatment, even if your symptoms improve. Stopping too early can cause the infection to return and make the bacteria harder to treat in the future.
  • Expect regular blood tests: If you are receiving this treatment for a prolonged period, your doctor may require regular blood tests to check your kidney and liver health.
  • Practice needle safety: If injecting at home, always use a new, sterile needle and syringe for every injection, and discard them immediately in an approved sharps container.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Blood thinners: Taking Synpep T Injection with blood-thinning medications may increase your risk of bleeding or alter your clotting times.
  • Gout medications: Certain gout medicines can slow down how fast your kidneys clear Synpep T Injection, leading to higher levels of the antibiotic in your body and increasing the risk of side effects.
  • Muscle relaxants: This antibiotic can prolong the muscle-relaxing effects of certain medications used during surgical procedures.
  • Other antibiotics: Combining this medicine with specific types of antibiotics can strain your kidneys or reduce the effectiveness of either drug.

Drug-Food Interactions

  • Alcohol: Avoid consuming alcohol while taking Synpep T Injection, as it may increase the risk of stomach irritation, dehydration, and related side effects.

Drug-Disease Interactions

  • Kidney disease: Your doctor may need to lower your dose, as damaged kidneys cannot clear this medicine from your system as quickly.
  • Seizure disorders: This medicine can occasionally trigger seizures, especially in patients with a history of epilepsy or underlying kidney issues.
  • Cystic fibrosis: People with cystic fibrosis may have a higher risk of developing fever and skin rashes when using this medication.
  • Sodium-restricted diets: This medication contains sodium, which may affect individuals managing high blood pressure or heart failure.
Piperacillin + TazobactamBCG vaccine
Severe
Piperacillin + TazobactamVancomycin
Severe

Drug-Drug Interactions

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Piperacillin + TazobactamBCG vaccine
Severe
How does the drug interact with Synpep T Injection:
Co-administration of BCG vaccine with Piperacillin may reduce the BCG vaccine activity.

How to manage the interaction:
Taking Piperacillin and BCG vaccine together can result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamVancomycin
Severe
How does the drug interact with Synpep T Injection:
Co-administration of Vancomycin with Piperacillin can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Piperacillin may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
Piperacillin + TazobactamArgatroban
Severe
How does the drug interact with Synpep T Injection:
Co-administration of Piperacillin with Argatroban will increase the level or effect of Argatroban.

How to manage the interaction:
Taking Piperacillin and Argatroban together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamBivalirudin
Severe
How does the drug interact with Synpep T Injection:
Co-administration of Piperacillin with Bivalirudin will increase the level or effect of Bivalirudin by anticoagulation.

How to manage the interaction:
Taking Piperacillin and Bivalirudin together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamCholera vaccines
Severe
How does the drug interact with Synpep T Injection:
Co-administration of the Cholera vaccine with Piperacillin may reduce the Cholera vaccine activity.

How to manage the interaction:
Taking the Cholera vaccine Piperacillin and together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Piperacillin + TazobactamHeparin
Severe
How does the drug interact with Synpep T Injection:
When used together Piperacillin will raise the amount of anticoagulant (blood thinners, are chemical substances that prevent or reduce clotting of blood) effect of Heparin.

How to manage the interaction:
Although there is a possible interaction between Piperacillin and Heparin, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTIC COMBINATION]

FAQs

Synpep T Injection is used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections.
Synpep T Injection contains Piperacillin and Tazobactam. Piperacillin inhibits bacterial cell wall synthesis, and Tazobactam prevents the bacteria from gaining resistance against Piperacillin. Thus Synpep T Injection helps in treating various bacterial infections.
Synpep T Injection should be used with proper caution and doctor consultation if you have any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, heart or liver diseases and undergoing dialysis.
Synpep T Injection can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Synpep T Injection if you are undergoing any vaccinations.
It is recommended to complete the course of Synpep T Injection even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections. Continue taking Synpep T Injection for as long as your doctor has prescribed to treat your condition effectually.
Synpep T Injection is used to treat bacterial infections, including hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.
Synpep T Injection should only be used during pregnancy if your doctor determines it is absolutely necessary. There is limited data on its safety for unborn babies, so your medical team will carefully weigh the benefits against the risks. Talk to your doctor if you are pregnant or planning to become pregnant.
It is highly recommended to avoid alcohol while receiving Synpep T Injection. Alcohol can dehydrate your body and worsen side effects like nausea, vomiting, and diarrhea, which can delay your overall recovery. Talk to your doctor for further guidance.
Because Synpep T Injection is injected directly into a vein, it begins fighting bacteria in your system immediately. While you may start to feel better within a few days, you must complete the entire course of treatment to ensure the infection is completely cleared. Talk to your doctor if your symptoms do not improve after a few days.
Yes, because Synpep T Injection is a broad-spectrum antibiotic, it can destroy the good bacteria in your body along with the bad. This can lead to an overgrowth of yeast, causing vaginal yeast infections or oral thrush. Talk to your doctor if you notice unusual vaginal discharge, itching, or white patches in your mouth.
If you develop severe, watery, or bloody diarrhea, contact your doctor immediately. Do not take any over-the-counter anti-diarrheal medications, as they can make the condition worse if it is caused by a serious bacterial overgrowth in your gut. Talk to your doctor to get a proper diagnosis.
Yes, Synpep T Injection belongs to the penicillin family of antibiotics. You must inform your healthcare provider before starting treatment if you have a known allergy to penicillins, cephalosporins, or any other antibiotics. Talk to your doctor to discuss safe alternative treatments if you have an allergy.
In some cases, especially at high doses or when used alongside other medications, Synpep T Injection can place strain on the kidneys. Your doctor will likely monitor your kidney health using blood tests if you are receiving this treatment for more than a few days. Talk to your doctor if you have a history of kidney problems.
Yes, in some cases, Synpep T Injection can be administered at home with the assistance of a home care nurse or after you have been properly trained on how to inject it safely. You must strictly follow all sterile techniques and disposal guidelines. Talk to your doctor to determine if home administration is a safe option for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 050684S88S89S90 050750S37S38S39Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Piperacillin Tazobactam Pregnancy and Lactation Reference Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Piperacillin/Tazobactam 4g/0.5g Powder for Solution for Infusion- Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 25 Feb 2026] Check here
  6. Tazobactam P. Piperacillin and Tazobactam [Internet]. Ncbi.nlm.nih.gov. 2025 [Accessed on 25 Feb 2026] Check here
  7. Wockhardt UK Ltd, Electronic Medicines Compendium (EMC) [Revised on May 2022] [Accessed on 25th May 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Sco-31,1St Floor, Sector 13 P, Hisar-125005, Haryana,
Other Info - SYN0329

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