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compositionComposition:CEFOTAXIME-250MG
prescription
Prescription Medicine
info
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Synthotox 250mg Injection is an antibiotic used in treating bacterial infections. This medicine stops the growth of bacteria and thereby helps reduce various bacterial infections like lung, skin, soft tissue, urinary tract, genital tract, heart valves, spine, brain, abdomen and blood infections. It helps by inhibiting the bacterial cell synthesis and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

CEFOTAXIME-250MG

Manufacturer/Marketer :

Salud Care India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Synthotox 250mg Injection

Synthotox 250mg Injection is an injectable antibiotic used to treat a wide variety of severe bacterial infections. It is prescribed for serious, deep-seated conditions such as infections of the brain (meningitis), lungs (pneumonia), abdomen, skin, and urinary tract.

Since this medicine is given as an injection, a healthcare provider will typically inject it at regular intervals throughout the day to keep a steady level in your body. It is vital to complete your full treatment course exactly as prescribed, regardless of food intake, to ensure the infection is completely cleared. Getting plenty of rest and staying well-hydrated are helpful lifestyle practices that support your body's recovery.

Common side effects of this medication include pain or swelling at the injection site, mild diarrhoea, and feeling sick to your stomach. You should contact your doctor immediately if you experience severe, watery diarrhoea, skin rashes, or sudden difficulty breathing.

Before you begin treatment, tell your doctor if you have kidney disease, stomach disorders like colitis, or a history of drug allergies. Do not take this if you have ever had a life-threatening allergic reaction to similar cephalosporin or penicillin antibiotics.

Some medications, such as strong water pills, can increase the risk of kidney damage when used alongside Synthotox 250mg Injection. Speak with your healthcare provider if you are pregnant, breastfeeding, or managing health conditions as an older adult, as your dose may need to be carefully adjusted.

Uses of Synthotox 250mg Injection

Synthotox 250mg Injection helps treat serious bacterial infections by stopping the growth of harmful bacteria throughout the body. Your doctor may recommend it for the following conditions:

  • Brain infections (Meningitis): Synthotox 250mg Injection helps by crossing into the brain and spinal fluids to eliminate the bacteria causing dangerous inflammation.
  • Lung infections (Pneumonia): Synthotox 250mg Injection fights severe respiratory tract infections by stopping the growth of bacteria in the lungs.
  • Abdominal infections (Peritonitis): Synthotox 250mg Injection helps treat peritonitis, an infection inside the abdomen, by targeting the bacteria causing the infection.
  • Urinary tract infections (UTIs): Synthotox 250mg Injection clears complicated infections in the kidneys and bladder by eliminating the causative bacteria.
  • Skin and soft tissue infections: Synthotox 250mg Injection stops the spread of bacteria in deep skin layers, muscles, and surgical wounds.
  • Bloodstream infections (Sepsis): Synthotox 250mg Injection works rapidly throughout the body to clear bacteria from the blood, preventing life-threatening complications.

Key Benefits

Because Synthotox 250mg Injection is injected directly into a vein or muscle, it enters your bloodstream immediately. This rapid delivery helps control severe, fast-spreading infections much quicker than oral antibiotics can. Key benefits of this treatment include:

  • Rapid symptom relief: Patients often notice a significant reduction in fever, pain, and inflammation within the first few days of treatment.
  • High effectiveness: It successfully treats complex bacterial strains that may be resistant to other common medicines.
  • Surgical protection: When used before certain surgeries, it helps prevent infections from developing at the surgical site.
Side effects of Synthotox 250mg Injection
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Eosinophil levels can be lowered by eating fruits and vegetables, avoiding smoking, and consuming alcohol in moderation.
  • Several foods, such as ginger, garlic, pepper, turmeric, and honey, might boost immunity.
  • Avoid dairy products, including cheese, yoghurt, and milk.
  • Drink water and keep yourself hydrated.
  • Manage the symptoms with medications as prescribed, and consult your doctor if symptoms persist.
  • Stay away from painkillers like NSAIDs (nonsteroidal anti-inflammatory drugs) and some antibiotics, as they can worsen the symptoms.
  • Make sure to have regular check-ups with your doctor, especially during flare-ups, and get immediate help if you have serious symptoms like dehydration or blood in your stool.
  • Avoid eating fried foods and foods high in fibre, as they can make your symptoms worse.
  • Practice stress-reduction techniques, like meditation or exercise.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Synthotox 250mg Injection will be administered by the doctor.
  • Do not self-administer.

How Synthotox 250mg Injection Works

Synthotox 250mg Injection contains cefotaxime; it is a third-generation cephalosporin antibiotic with activity against a wide range of bacteria, particularly many gram-negative bacteria, as well as some gram-positive bacteria. Doctors may choose it when a serious bacterial infection requires an injectable antibiotic with broad coverage, especially when the specific bacteria causing the infection are not yet known. Synthotox 250mg Injection works by preventing bacteria from forming their protective cell walls. Without a strong cell wall, the bacteria become weak, rupture, and die. This action specifically targets bacterial cells without harming human cells, as human cells do not have cell walls. By eliminating the bacteria causing the infection, Synthotox 250mg Injection helps your body's immune system clear the remaining infection and supports the healing process.
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Alcohol

Caution

It is unknown whether alcohol affects Synthotox 250mg Injection. However, it is best to avoid or limit alcohol consumption as a precaution.

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Pregnancy

Caution

Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Synthotox 250mg Injection.

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Breast Feeding

Caution

Inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Synthotox 250mg Injection.

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Driving

Caution

Synthotox 250mg Injection may cause a reduction in mental awareness; thus, avoid using machinery or driving unless you are alert.

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Liver

Caution

Synthotox 250mg Injection to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Synthotox 250mg Injection to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Synthotox 250mg Injection should be used in children only if recommended by a child specialist.

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Heart

Caution

Synthotox 250mg Injection is generally safe for heart patients but should be given with caution. Rapid IV administration may affect heart rhythm, so medical supervision is essential.

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Geriatrics

Caution

Geriatric patients can receive Synthotox 250mg Injection, but with careful monitoring. Older adults may have reduced kidney function, so dosage adjustments and supervision are important to avoid side effects.

What if I have taken an overdose of Synthotox 250mg Injection

Because this medication is usually administered by a healthcare professional, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe muscle twitching or seizures, seek immediate emergency medical care.

Diet & Lifestyle Advise

  • Support your gut: Consider eating probiotic-rich foods like yoghurt or taking a probiotic supplement a few hours after your injection to help restore healthy gut bacteria.
  • Drink plenty of water: Stay well-hydrated to help your kidneys process and safely clear the medication from your body.
  • Prioritise rest: Allow your body time to heal by avoiding strenuous activities and getting 7–9 hours of sleep each night.
  • Eat balanced meals: Focus on nutrient-dense foods, including lean proteins, fruits, and vegetables, to help rebuild your immune strength.
health query

Have a query?

How Soon It Starts Working

The time required for Synthotox 250mg Injection to start to work: The time required for Synthotox 250mg Injection to show its action is unknown. The time for which the effects of Synthotox 250mg Injection last: The effect of Synthotox 250mg Injection lasts for 24 hours.

What if you forget to take Synthotox 250mg Injection

If you miss a dose of Synthotox 250mg Injection, contact your healthcare provider immediately for instructions. Do not receive a double dose to make up for a missed one.

Storage

•Store the dry powder vials of Synthotox 250mg Injection at 20°C to 25°C, protected from direct light and moisture.•Keep out of the reach of children and pets.

Drug Warnings

  • Inspect the liquid: Always check the mixed solution before injecting; do not use it if it is cloudy, discoloured, or contains visible particles.
  • Rotate injection sites: Change the exact spot where you inject each time to prevent pain, hard lumps, or tissue damage.
  • Never reuse needles: Use a sterile needle and syringe for every single injection, and discard them immediately in a sharps container.
  • Do not stop early: Complete the full course of treatment even if you feel completely recovered, as stopping early can cause the infection to return and resist future treatments.
  • Avoid self-treating diarrhoea: If you develop severe, watery diarrhoea, do not take over-the-counter anti-diarrhoeal medicines. Contact your doctor immediately.

Drug-Drug Interactions

verifiedApollotooltip
  • Aminoglycoside antibiotics: Combining these with Synthotox 250mg Injection may increase the risk of kidney damage.
  • Strong diuretics (water pills like furosemide): May increase the likelihood of kidney problems.
  • Probenecid: Can slow down how quickly your kidneys remove Synthotox 250mg Injection from your body, raising the levels of the medicine in your blood.
  • Typhoid vaccine: This antibiotic may decrease the effectiveness of live bacterial vaccines.

 

CefotaximeCholera, live attenuated
Severe

Drug-Drug Interactions

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CefotaximeCholera, live attenuated
Severe
How does the drug interact with Synthotox 250mg Injection:
Taking the cholera vaccine after or along with Synthotox 250mg Injection may reduce the activity of the vaccine.

How to manage the interaction:
Although taking Synthotox 250mg Injection and Cholera, live attenuated together can evidently cause an interaction, it can be taken if your doctor has suggested it. Make sure to inform the doctor if you are on Cholera vaccine dose or you have already taken it. You should wait at least 14 days after finishing your antibiotic treatment before receiving the cholera vaccine in order to ensure an appropriate immune response. In case of any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

There are no known major interactions between Synthotox 250mg Injection and specific foods, as this medication is injected and bypasses the digestive system.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Synthotox 250mg Injection belongs to a class of drugs known as cephalosporin antibiotics used to treat various bacterial infections such as lung, skin, soft tissue, urinary tract, genital tract, heart valves, spine, brain, abdomen and blood infections. Apart from that, it may also be used to prevent infection before surgery, as well as during and after a caesarean section to prevent infections.
Synthotox 250mg Injection exerts its bactericidal action by inhibiting bacterial cell wall synthesis, thus killing the bacteria. As a result, it treats bacterial infections.
Inform the doctor if you do not feel better after completing the whole course of treatment. You must also notify your doctor if your symptoms worsen while using this medication.
Synthotox 250mg Injection is an antibiotic used to treat bacterial infections only. Synthotox 250mg Injection does not treat a viral infection like the flu or a common cold.
Synthotox 250mg Injection may cause diarrhoea as a side effect. If you have diarrhoea or soft stools, consult your doctor. Do not use anti-diarrheal medicine unless the doctor tells you to.
You are recommended to take Synthotox 250mg Injection for as long as it is advised by your doctor for effective results. If your symptoms continue or worsen, seek further advice from your doctor.
Inappropriate use of antibiotics means using them when they are not necessary, such as for viral infections (like colds or the flu), stopping the treatment early, or using the wrong antibiotic for a specific infection. This can lead to antibiotic resistance.
Antibiotic resistance occurs when bacteria change in a way that reduces the effectiveness of antibiotics. As a result, the drugs no longer kill the bacteria, making infections more difficult to treat. This resistance can develop from overusing or misusing antibiotics, like taking them unnecessarily or not finishing the prescribed course.
No, Synthotox 250mg Injection is not the same as penicillin. Synthotox 250mg Injection contains ceftriaxone, a cephalosporin antibiotic, while penicillin belongs to a different class of antibiotics. Both treat bacterial infections, but they work in different ways.
Synthotox 250mg Injection is effective when taken as per the dose advised by your doctor for the recommended duration. Even if you start feeling better, do not stop the treatment early. Stopping it early may cause the symptoms to return or worsen.
Synthotox 250mg Injection will only be administered by a healthcare professional. Do not self-administer.
Synthotox 250mg Injection usually begins to work shortly after you start taking it. However, it may take few days to eliminate all harmful bacteria and improve your symptoms.
Synthotox 250mg Injection causes side fever, nausea, vomiting, dizziness, soft stools or diarrhoea, skin rash, swelling, tenderness, or pain at the site of injection. These do not require any medical treatment as they will gradually reduce over time. However, please contact a doctor if these side effects persist or worsen.
While alcohol does not directly stop Synthotox 250mg Injection from working, it can dehydrate your body and strain your organs while you are fighting an infection. It is best to avoid alcohol during treatment. Talk to your doctor.
Synthotox 250mg Injection is generally used during pregnancy only when clearly needed and prescribed by a physician. Your doctor will weigh the benefits against any potential risks to the baby. Talk to your doctor.
Yes, like many strong antibiotics, Synthotox 250mg Injection can disrupt the natural balance of bacteria in your body, which may lead to oral thrush or a vaginal yeast infection. Talk to your doctor if you notice unusual white patches in your mouth or itching.
Yes, Synthotox 250mg Injection may be used in newborns, including premature infants, and children to treat serious bacterial infections such as sepsis and meningitis. In neonates and premature infants, the dose and dosing interval are carefully determined by the doctor based on the baby's age, weight, kidney function, and severity of infection. Talk to your doctor for specific advice about your child's treatment.
If you are receiving Synthotox 250mg Injection for an extended period, your doctor may order regular blood and kidney function tests to monitor how your body is handling the medication. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.12713 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A682765 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Cefotaxime Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Cefotaxime Cefotaxime. 2015. [Accessed on 29 Mar. 2019]Check here
  6. Cefotaxime 500mg, 1g Powder for solution for injection or infusion PL 29831/0030 — Summary of Product Characteristics (SmPC) — (emc) [Internet]. Medicines.org.uk; 2025 [Accessed on 29 September 2025]Check here
  7. CP Pharmaceuticals Ltd; Electronic Medicines Compendium (EMC) [Revised on March 2024] [Accessed on 18th May 2026]Check here

Manufacturer/Marketer address

HALBERD PHARMACEUTICALS, OLD NO 7/2, NEW NO: 33, PARTHASARATHY PURAM, T NAGAR, CHENNAI, TAMILNADU -600022
Other Info - SY22536
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