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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tacrograf 0.25 Tablet is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

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Composition :

TACROLIMUS-0.25MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tacrograf 0.25 Tablet

Tacrograf 0.25 Tablet is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Tacrograf 0.25 Tablet contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Tacrograf 0.25 Tablet as prescribed. You are advised to use Tacrograf 0.25 Tablet for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Tacrograf 0.25 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Tacrograf 0.25 Tablet . Avoid alcohol consumption with Tacrograf 0.25 Tablet . Drive only if you are alert, as Tacrograf 0.25 Tablet may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Tacrograf 0.25 Tablet . Tacrograf 0.25 Tablet may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Tacrograf 0.25 Tablet

Tacrograf 0.25 Tablet is used for prevention of transplanted organ rejection

Directions for Use

Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Tacrograf 0.25 Tablet contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Tacrograf 0.25 Tablet suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tacrograf 0.25 Tablet

  • Nausea
  • Diarrhoea
  • Headache
  • Kidney problems
  • Infection
  • Constipation
  • Fever
  • High blood pressure

What if I have taken an overdose of Tacrograf 0.25 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. This medicine may be harmful if swallowed. Seek emergency medical attention or call your doctor if you notice any unusual symptoms or if anyone has accidentally swallowed the medication.

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Tacrograf 0.25 Tablet . Avoid alcohol consumption with Tacrograf 0.25 Tablet . Drive only if you are alert, as Tacrograf 0.25 Tablet may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Tacrograf 0.25 Tablet . Tacrograf 0.25 Tablet may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Tacrograf 0.25 Tablet , you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension, as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Drug-Drug Interactions

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TacrolimusThioridazine
Critical
TacrolimusSaquinavir
Critical

Drug-Drug Interactions

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TacrolimusThioridazine
Critical
How does the drug interact with Tacrograf 0.25 Tablet:
Combining Tacrograf 0.25 Tablet with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.25 Tablet with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Tacrograf 0.25 Tablet:
Taking Tacrograf 0.25 Tablet with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.25 Tablet with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusCidofovir
Critical
How does the drug interact with Tacrograf 0.25 Tablet:
Taking cidofovir with Tacrograf 0.25 Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Tacrograf 0.25 Tablet with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Tacrograf 0.25 Tablet:
Taking Tacrograf 0.25 Tablet with Mifepristone may significantly increase the blood levels of Tacrograf 0.25 Tablet, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Tacrograf 0.25 Tablet with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Tacrograf 0.25 Tablet:
Taking Tacrograf 0.25 Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.25 Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusDronedarone
Critical
How does the drug interact with Tacrograf 0.25 Tablet:
Taking Tacrograf 0.25 Tablet with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tacrograf 0.25 Tablet with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusCarbamazepine
Severe
How does the drug interact with Tacrograf 0.25 Tablet:
Taking carbamazepine and Tacrograf 0.25 Tablet together may cause kidney problems.

How to manage the interaction:
Although taking carbamazepine and Tacrograf 0.25 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.
TacrolimusEnzalutamide
Severe
How does the drug interact with Tacrograf 0.25 Tablet:
Taking Tacrograf 0.25 Tablet with Enzalutamide may reduce the levels of Tacrograf 0.25 Tablet, which may make Tacrograf 0.25 Tablet less effective in treating your condition.

How to manage the interaction:
Although taking Tacrograf 0.25 Tablet and Enzalutamide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
TacrolimusBaricitinib
Severe
How does the drug interact with Tacrograf 0.25 Tablet:
Taking baricitinib and Tacrograf 0.25 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Tacrograf 0.25 Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your phlegm, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without first talking to your doctor.
TacrolimusLoperamide
Severe
How does the drug interact with Tacrograf 0.25 Tablet:
Taking Tacrograf 0.25 Tablet with loperamide may significantly increases the loperamide levels in the blood. This can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking loperamide with Tacrograf 0.25 Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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TACROLIMUS-0.25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-0.25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Tacrograf 0.25 Tablet treatment may lead to increased Tacrograf 0.25 Tablet levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Tacrograf 0.25 Tablet.

Diet & Lifestyle Advise

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Tacrograf 0.25 Tablet Substitute

Substitutes safety advice
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    14.45per tablet
  • Tacroren 0.25 Capsule 10's

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  • Biomus 0.25 mg Capsule 10's

    by Others

    13.23per tablet
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Alcohol

Unsafe

Avoid alcohol consumption with Tacrograf 0.25 Tablet as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Tacrograf 0.25 Tablet .

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Tacrograf 0.25 Tablet and if you are a woman of childbearing age, use effective contraceptive methods while using Tacrograf 0.25 Tablet .

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Breast Feeding

Consult your doctor

Tacrograf 0.25 Tablet may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Tacrograf 0.25 Tablet . You should avoid taking Tacrograf 0.25 Tablet during breastfeeding or avoid breastfeeding while on treatment with Tacrograf 0.25 Tablet .

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Driving

Caution

Tacrograf 0.25 Tablet may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Tacrograf 0.25 Tablet .

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Tacrograf 0.25 Tablet .

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Tacrograf 0.25 Tablet .

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Children

Safe if prescribed

Tacrograf 0.25 Tablet should be used in children in doses as advised by a doctor only.

FAQs

Tacrograf 0.25 Tablet is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart.

Tacrograf 0.25 Tablet contains Tacrolimus, an immunosuppressant that works by the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Tacrograf 0.25 Tablet may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as sore throat or fever.

Tacrograf 0.25 Tablet may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for a long time or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Tacrograf 0.25 Tablet because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.

Using Tacrograf 0.25 Tablet with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Tacrograf 0.25 Tablet with other medications.

Tacrograf 0.25 Tablet may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.

Tacrograf 0.25 Tablet is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.

Tacrograf 0.25 Tablet is a macrolide antibiotic with immunosuppressant properties.

Tacrograf 0.25 Tablet should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.

Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.

Tacrograf 0.25 Tablet decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).

No, Tacrograf 0.25 Tablet does not have an abuse potential as it is not a controlled substance.

Side effects of Tacrograf 0.25 Tablet include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - TAC0063

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