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compositionComposition:TRIFLUOPERAZINE-5MG
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Prescription Medicine
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Talecalm-5 Tablet is used to treat schizophrenia. It may also be used to treat anxiety and depression. It contains Trifluoperazine which works by inhibiting the chemical messenger (dopamine) that regulates mood, behaviour, and emotions. In some cases, this medicine may cause side effects such as restlessness, weakness, drowsiness, dizziness, dry mouth, loss of appetite, and blurred vision. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

TRIFLUOPERAZINE-5MG

Manufacturer/Marketer :

Talent India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Talecalm-5 Tablet

Talecalm-5 Tablet is a prescription tablet used to treat schizophrenia and manage short-term symptoms of severe anxiety. It belongs to a class of medicines that help balance natural chemicals in the brain, helping you feel calmer and more in control of your thoughts.

To get the best results, you must take Talecalm-5 Tablet consistently at the same times each day as directed by your doctor. You can take this tablet with or without food, but taking it with a meal can help if you experience an upset stomach. Making simple lifestyle adjustments, such as drinking plenty of fluids and avoiding extreme heat, can also support your treatment.

While taking Talecalm-5 Tablet , some people may experience common side effects like drowsiness, dry mouth, or blurred vision. If you notice any serious issues, such as uncontrolled muscle movements, a high fever, or severe muscle stiffness, you should contact your doctor right away.

Do not take this if you are in a coma, have severe central nervous system depression, or have bone marrow depression. Before starting this medicine, talk to your doctor if you have a history of liver damage, heart conditions, blood disorders, or glaucoma.

This medicine can interact with alcohol, which can cause severe drowsiness, and certain other drugs like sleeping pills or blood pressure medications. If you are pregnant, breastfeeding, or an older adult, consult your healthcare provider to discuss whether this treatment is safe for you.

Uses of Talecalm-5 Tablet

Here are the common uses of Talecalm-5 Tablet :

  • Schizophrenia: Talecalm-5 Tablet helps manage severe mental symptoms such as hearing or seeing things that are not there, strong false beliefs, and disorganized thinking.
  • Short-term management of severe non-psychotic anxiety: Talecalm-5 Tablet may be prescribed for the short-term relief of severe anxiety when your doctor considers it appropriate. It is not intended for long-term treatment of anxiety.

Key Benefits

Talecalm-5 Tablet offers significant support for individuals dealing with severe mental health challenges. By helping to stabilise brain chemistry, it allows you to regain control over your daily life and thoughts. Here are the key benefits of Talecalm-5 Tablet :

  • Clearer thinking: It helps reduce disturbing thoughts, hallucinations, and confusion, making it easier to focus and communicate.
  • Reduced anxiety: It calms excessive worry and physical tension, helping you feel more relaxed in your daily environment.
  • Improved daily routine: By managing distressing symptoms, this medicine supports your ability to participate in social, work, and family activities.

Directions for Use

  • Take Talecalm-5 Tablet with or without food as advised by your doctor.
  • Adhere to your doctor’s guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Talecalm-5 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Talecalm-5 Tablet Works

Talecalm-5 Tablet contains trifluoperazine, an antipsychotic medicine that helps treat schizophrenia and provides short-term relief from severe anxiety when other treatments have not been effective. Talecalm-5 Tablet mainly works by blocking dopamine receptors in the brain. Dopamine is a chemical messenger involved in regulating thoughts, emotions, and behaviour. In conditions such as schizophrenia and severe anxiety, excessive dopamine activity can contribute to hallucinations, delusions, disorganised thinking, and agitation. Talecalm-5 Tablet also affects other brain receptors, including histamine and muscarinic receptors. These additional effects may contribute to some of its common side effects, such as drowsiness, dry mouth, and blurred vision. By reducing the effects of excess dopamine, Talecalm-5 Tablet helps restore the balance of chemical messengers in the brain. This helps control psychotic symptoms, reduces severe anxiety and agitation, promotes clearer thinking, and improves overall mental stability.
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Alcohol

Unsafe

Avoid consumption of alcohol with Talecalm-5 Tablet as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

Talecalm-5 Tablet is not recommended for use during pregnancy, especially in the third trimesters as it may cause adverse effects in the baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Talecalm-5 Tablet may be unsafe to use during breastfeeding. Please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Talecalm-5 Tablet may cause dizziness, double vision or drowsiness in some people. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking Talecalm-5 Tablet .

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Liver

Unsafe

Talecalm-5 Tablet is not recommended for patients suffering from Liver diseases/conditions. Please consult a doctor if you have any concerns regarding this.

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Kidney

Caution

Take Talecalm-5 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Use Talecalm-5 Tablet in children in prescribed doses. Your doctor will determine the dose based on your child's condition, age, and body weight.

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Heart

Caution

Talecalm-5 Tablet should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Talecalm-5 Tablet .

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Geriatrics

Unsafe

Talecalm-5 Tablet is not safe for use in elderly patients due to its serious side effects.

What if I have taken an overdose of Talecalm-5 Tablet

If you suspect an overdose, seek immediate emergency medical attention or contact a poison control center. Symptoms of an overdose may include severe drowsiness, muscle tremors, rapid heart rate, or fainting.

Diet & Lifestyle Advise

  • Stay well-hydrated: This medication can make it harder for your body to cool down. Drink plenty of water, especially in hot weather or during exercise.
  • Stand up slowly: To prevent dizziness or fainting caused by a sudden drop in blood pressure, take your time when rising from a sitting or lying position.
  • Limit caffeine: Reduce your intake of coffee, tea, and energy drinks, as caffeine can worsen anxiety and interfere with the calming effects of Talecalm-5 Tablet .
  • Protect your skin: This medicine can make your skin more sensitive to sunlight. Wear protective clothing and apply a high-SPF sunscreen when spending time outdoors.
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How Soon It Starts Working

The time required for Talecalm-5 Tablet to start to work: Talecalm-5 Tablet ideally shows its action within 2 to 4 hours after administration. The time for which the effects of Talecalm-5 Tablet last: The effect of Talecalm-5 Tablet lasts for 4 to 6 hours.

What if you forget to take Talecalm-5 Tablet

If you miss a dose of Talecalm-5 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Talecalm-5 Tablet tablets at room temperature. An ideal storage temperature is between 20°C and 25°C (68°F to 77°F), although many products may be stored at temperatures up to 30°C. Follow the storage instructions provided on your medicine label.

Drug Warnings

  • Do Not Stop Suddenly: Do not stop taking Talecalm-5 Tablet suddenly, as doing so can cause withdrawal symptoms or make your condition return; talk to your doctor about gradually decreasing the dose.
  • Avoid Alcohol: Avoid drinking alcohol while taking this medicine, as it can severely increase drowsiness and lower your coordination.
  • Take Care While Driving: Be cautious when driving, operating machinery, or performing tasks that require mental alertness until you know how this medicine affects you.
  • Watch for Unusual Movements: Contact your doctor immediately if you notice any unusual, uncontrollable movements of your tongue, face, mouth, or limbs.
  • Inform Your Healthcare Providers: Inform all your healthcare providers, including dentists and surgeons, that you are taking Talecalm-5 Tablet before undergoing any procedures.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Talecalm-5 Tablet . Inform your doctor about all the medicines you are taking, including prescription medicines, over-the-counter products, and herbal supplements.

  • Sleep aids and sedatives: Taking Talecalm-5 Tablet with medicines that cause drowsiness, such as sleeping pills, anxiety medications, or opioid pain relievers, can cause severe sleepiness and breathing difficulties.
  • Blood pressure medicines: Combining this medicine with drugs that lower blood pressure may increase the risk of dizziness and fainting upon standing.
  • Medicines that affect heart rhythm: Certain medicines that prolong the QT interval, including some antiarrhythmic medicines, antibiotics, and other antipsychotics, may increase the risk of serious heart rhythm problems when taken with Talecalm-5 Tablet .
  • Heart rhythm disorders: Tell your doctor if you have a personal or family history of QT prolongation, irregular heartbeats, or sudden cardiac death, as this medicine may increase the risk of abnormal heart rhythms. 
TrifluoperazineZiprasidone
Critical
TrifluoperazineMetoclopramide
Critical

Drug-Drug Interactions

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TrifluoperazineZiprasidone
Critical
How does the drug interact with Talecalm-5 Tablet:
Co-administration of Talecalm-5 Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Talecalm-5 Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TrifluoperazineMetoclopramide
Critical
How does the drug interact with Talecalm-5 Tablet:
Co-administration of Metoclopramide with Talecalm-5 Tablet can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Metoclopramide with Talecalm-5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping., contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TrifluoperazineMoxifloxacin
Severe
How does the drug interact with Talecalm-5 Tablet:
Using moxifloxacin together with Talecalm-5 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Talecalm-5 Tablet, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - an irregular heart rhythm, severe or prolonged diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, or heart palpitations - call your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrifluoperazineDisopyramide
Severe
How does the drug interact with Talecalm-5 Tablet:
The combined use of Talecalm-5 Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Talecalm-5 Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TrifluoperazineSotalol
Severe
How does the drug interact with Talecalm-5 Tablet:
Using sotalol together with Talecalm-5 Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Talecalm-5 Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
TrifluoperazineMorphine
Severe
How does the drug interact with Talecalm-5 Tablet:
Using Morphine together with Talecalm-5 Tablet can increase the risk of central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Talecalm-5 Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Here are the important food and drink considerations while taking Talecalm-5 Tablet : 

  • Alcohol: Avoid alcohol while taking this medicine, as it can severely increase drowsiness, impair coordination, and lower blood pressure.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Talecalm-5 Tablet is used to treat schizophrenia (a mental illness). Additionally, it may be used for anxiety, depression, nausea and vomiting.
Talecalm-5 Tablet contains Trifluoperazine, an antipsychotic that works by inhibiting the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour and emotions. Thereby, Talecalm-5 Tablet helps in relieving depression, lighten the mood and relieve anxiety symptoms such as fear and panic. Also, Talecalm-5 Tablet blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and inhibits transmission of messages to the vomiting centre. Thereby, it helps in controlling nausea and vomiting.
You are not recommended to take Talecalm-5 Tablet with levodopa (antiparkinson drug) as it may decrease the effectiveness of levodopa and increase the risk of adverse effects such as low blood pressure, drowsiness, light-headedness and dizziness. However, please consult your doctor before using Talecalm-5 Tablet with any other medicines.
Talecalm-5 Tablet should be avoided by dementia (decline in memory, behaviour, thinking and ability to do daily activities) patients as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you are suffering from dementia before taking Talecalm-5 Tablet .
Talecalm-5 Tablet may be used to treat nausea and vomiting. Talecalm-5 Tablet blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) in the brain and inhibits transmission of messages to vomiting centre. Thereby, it helps in controlling nausea and vomiting.
Talecalm-5 Tablet may cause dizziness, especially while standing up suddenly from a sitting or lying position. Therefore, to avoid such adverse effects, standing up slowly if you are sitting or lying down is advised. However, if the condition persists or worsens, please consult a doctor.
Talecalm-5 Tablet should be used cautiously in patients suffering from fits as it may worsen the condition. Therefore, inform your doctor if you have a history of fits before taking Talecalm-5 Tablet .
Talecalm-5 Tablet medication may cause face/muscle twitching and uncontrollable movements (tardive dyskinesia). In some cases, this condition may be permanent. Tell your doctor immediately if you develop any uncontrollable movements such as lip smacking, mouth puckering, tongue thrusting, chewing, or unusual arm/leg movements.
No, you should not stop taking Talecalm-5 Tablet suddenly. Stopping the medicine abruptly can cause your symptoms to return or lead to withdrawal effects. Talk to your doctor, who will guide you on gradually decreasing your dose safely.
Some people may experience mild changes in weight while taking Talecalm-5 Tablet . Maintaining a balanced diet and exercising regularly can help manage this. Talk to your doctor or pharmacist if you have concerns about weight changes.
You should only take Talecalm-5 Tablet during pregnancy if your doctor determines that the benefits outweigh the potential risks to the baby. If you are pregnant or planning to become pregnant, talk to your doctor immediately.
Yes, drowsiness is a common side effect of Talecalm-5 Tablet , especially when you first start taking it. Avoid driving or operating machinery until you know how this medicine affects your alertness.
It is best to limit your intake of caffeinated beverages like coffee and tea. Caffeine can increase anxiety and interfere with the calming effects of this medication. Talk to your doctor for personalised dietary advice.
No, Talecalm-5 Tablet is not considered addictive. However, stopping it suddenly can cause physical withdrawal symptoms, which is why any changes to your treatment should be managed gradually under a doctor's supervision.
Dry mouth is a common side effect. You can manage it by taking frequent sips of water, chewing sugarless gum, or sucking on sugar-free hard candies. If dry mouth persists or becomes severe, talk to your doctor or pharmacist.
The duration of treatment depends on why you are taking the medicine. For severe anxiety, Talecalm-5 Tablet is generally prescribed for short-term use. For schizophrenia, treatment may be needed for a longer period to help control symptoms and prevent relapse. Always continue treatment for as long as your doctor recommends.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.438 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.506 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Trifluoperazine Pregnancy and Lactation Reference Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 20 Feb. 2020]Check here
  5. Trifluoperazine [EMC Label]. 2018. [Accessed on 19 Mar. 2019]Check here
  6. Trifluoperazine [Prescribing Information]. 2024. [Accessed on 05 Feb. 2025]Check here
  7. Bethesda. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. NIH National Library of Medicine, National center for biotechnology information. July 2020 [Accessed on 1st June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

1601, Karnavati Estate, Gidc, Phase Iii, Vatva, Ahmedabad 382445, Gujarat, India.
Other Info - TAL0131

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