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  3. Tasigna 200 mg Capsule 4's

Tasigna 200 mg Capsule 4's, Pack of 1 TABLET
Tasigna 200 mg Capsule 4's, Pack of 1 TABLET
Tasigna 200 mg Capsule 4's, Pack of 1 TABLET
Tasigna 200 mg Capsule 4's, Pack of 1 TABLET
Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tasigna 200 mg Capsule is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia (a type of blood cancer). It contains Nilotinib, which works by blocking the action of an abnormal protein produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thus, it stops the multiplication, inhibits the growth of cancerous cells, and then causes their death.

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Composition :

NILOTINIB-200MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tasigna 200 mg Capsule

Tasigna 200 mg Capsule belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.

Tasigna 200 mg Capsule contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Take Tasigna 200 mg Capsule as prescribed. You are recommended to take Tasigna 200 mg Capsule for as long as your doctor has advised it for you based on your medical condition. Sometimes, Tasigna 200 mg Capsule may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Tasigna 200 mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Tasigna 200 mg Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Tasigna 200 mg Capsule and for two weeks after completing the course of Tasigna 200 mg Capsule. Tasigna 200 mg Capsule is not recommended for children below one year of age. Drive only if you are alert as Tasigna 200 mg Capsule may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Tasigna 200 mg Capsule, contact your doctor immediately, as these might be symptoms of liver problems. 

Uses of Tasigna 200 mg Capsule

Treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)

Directions for Use

Take this medicine on an empty stomach or as advised by the doctor. Avoid eating food for at least 2 hours before taking Tasigna 200 mg Capsule and avoid eating for at least 1 hour after taking Tasigna 200 mg Capsule. Swallow it as a whole with a glass of water. If you are unable to swallow it, open the capsule and sprinkle the contents in 1 teaspoon of applesauce and take it right away (within 15 minutes). Do not use more than one teaspoon of apple sauce for each capsule, and do not use any food other than apple sauce.

Medicinal Benefits

Tasigna 200 mg Capsule contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Tasigna 200 mg Capsule is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib. 

How Tasigna 200 mg Capsule Works

Tasigna 200 mg Capsule contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tasigna 200 mg Capsule
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Tasigna 200 mg Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Tasigna 200 mg Capsule may include drowsiness and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Tasigna 200 mg Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Tasigna 200 mg Capsule and for two weeks after completing the course of Tasigna 200 mg Capsule. Tasigna 200 mg Capsule is not recommended for children below one year of age. Tasigna 200 mg Capsule may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Tasigna 200 mg Capsule. Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Tasigna 200 mg Capsule may cause dizziness or visual disorders as side effects in some people. Tasigna 200 mg Capsule may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Tasigna 200 mg Capsule, contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Tasigna 200 mg Capsule may contain lactose. Most people who have mild or moderate lactose intolerance can take Tasigna 200 mg Capsule. Avoid taking Tasigna 200 mg Capsule if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Tasigna 200 mg Capsule.

Drug-Drug Interactions

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NilotinibMesoridazine
Critical
NilotinibSaquinavir
Critical

Drug-Drug Interactions

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NilotinibMesoridazine
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Combining Mesoridazine and Tasigna 200 mg Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine and Tasigna 200 mg Capsule together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibSaquinavir
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Combining Saquinavir and Tasigna 200 mg Capsule can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Saquinavir and Tasigna 200 mg Capsule together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibGrepafloxacin
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Coadministration of Grepafloxacin with Tasigna 200 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Tasigna 200 mg Capsule with Grepafloxacin is not recommended, please consult your doctor before taking it. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
NilotinibBCG vaccine
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Combining BCG vaccine with Tasigna 200 mg Capsule can increase the risk of infection.

How to manage the interaction:
Taking Tasigna 200 mg Capsule with BCG vaccine is not recommended, please consult your doctor before taking it. if you experience any symptoms , contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibYellow fever vaccine
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Combining Yellow fever vaccine with Tasigna 200 mg Capsule can increase the risk of infection.

How to manage the interaction:
Taking Tasigna 200 mg Capsule with Yellow fever vaccine is not recommended, please consult your doctor before taking it. if you experience any symptoms , contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibLeuprorelin
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Using Tasigna 200 mg Capsule together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Leuprorelin with Tasigna 200 mg Capsule is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
NilotinibSparfloxacin
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Coadministration of Sparfloxacin with Tasigna 200 mg Capsule can prolong the QT interval.

How to manage the interaction:
Taking Tasigna 200 mg Capsule with Sparfloxacin is not recommended, please consult your doctor before taking it. If you experience any symptoms, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NilotinibZiprasidone
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Taking Tasigna 200 mg Capsule with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Tasigna 200 mg Capsule with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
NilotinibCisapride
Critical
How does the drug interact with Tasigna 200 mg Capsule:
Combining Cisapride and Tasigna 200 mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Cisapride and Tasigna 200 mg Capsule together is generally avoided as it can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
NilotinibDasatinib
Severe
How does the drug interact with Tasigna 200 mg Capsule:
Coadministration of Tasigna 200 mg Capsule with Dasatinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Dasatinib and Tasigna 200 mg Capsule, but it can be taken when advised by a doctor. If you experience dizziness, difficulty breathing, or heart palpitations, contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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NILOTINIB-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NILOTINIB-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the blood levels of Tasigna 200 mg Capsule, and increase the risk of an irregular heart rhythm. Consumption of grape juice and grape fruit should be avoided as is causes symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with Tasigna 200 mg Capsule. Food may also increase the blood levels of Tasigna 200 mg Capsule. Therefore, you should take Tasigna 200 mg Capsule on an empty stomach, meaning no food should be eaten for at least two hours before or one hour after taking Tasigna 200 mg Capsule.

Diet & Lifestyle Advise

  • Drink nutrient-rich liquids such as juices, shakes and soups if you have trouble swallowing solid food.
  • Eat frequently by opting for 4 to 6 smaller meals a day instead of 2 to 3 big meals.
  • Consume a variety of vegetables, including legumes.
  • Eat whole grains, whole fruits, and fat-free or low-fat dairy products.
  • Include a variety of proteins in the diet, such as lean meats, poultry, seafood, soy, beans, and eggs.
  • Use healthy oils such as olive oil.
  • Drink plenty of water to keep yourself hydrated.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Tasigna 200 mg Capsule Substitute

Substitutes safety advice

  • Nelova 200 mg Capsule 28's

    by Others

    ₹73.93per tablet

  • Nilocap 200 Capsule 4's

    by Others

    ₹33.30per tablet

  • Kylonib 200 mg Capsule 4's

    by Others

    ₹135.72per tablet

  • Knilonat 200 Capsule 10's

    by Others

    ₹108.00per tablet

  • Myelotib 200 mg Capsule 28's

    by Others

    ₹133.36per tablet

Product Substitutes

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Alcohol

Consult your doctor

The interaction of Tasigna 200 mg Capsule with alcohol is unknown. Please discuss with your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Tasigna 200 mg Capsule is not recommended for use during pregnancy as it may harm the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Tasigna 200 mg Capsule. Also, you are advised to use effective birth control measures during treatment with Tasigna 200 mg Capsule and for up to 2 weeks after the last dose of Tasigna 200 mg Capsule.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with Tasigna 200 mg Capsule and for two weeks after the final dose. Inform your doctor if you are breastfeeding.

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Driving

Caution

If you experience side effects such as dizziness or visual disorders, avoid driving or operating machinery until you are alert.

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Liver

Caution

Inform your doctor if you have liver problems before taking Tasigna 200 mg Capsule. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Consult your doctor

Limited information is available on the use of Tasigna 200 mg Capsule in patients with impaired kidney function. Therefore, if you have kidney problems, inform your doctor before taking Tasigna 200 mg Capsule.

bannner image

Children

Caution

Tasigna 200 mg Capsule is not recommended for children below 1 year of age as the safety and effectiveness were not established.

Have a query?

FAQs

Tasigna 200 mg Capsule is used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).

Tasigna 200 mg Capsule contains Nilotinib, an anticancer drug. In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells.

You are not recommended to take antacids and Tasigna 200 mg Capsule at the same time. You are advised to take antacids containing magnesium hydroxide, aluminium hydroxide, and simethicone about two hours before or two hours after taking Tasigna 200 mg Capsule. However, please consult a doctor before taking other medicines with Tasigna 200 mg Capsule.

You are recommended to avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Tasigna 200 mg Capsule as it may increase the amount of Nilotinib in the body and cause serious side effects.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - TAS0011

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:45 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.us.tasigna.com/patient-support/download-helpful-materials/
  2. https://www.hcp.novartis.com/siteassets/tasigna/pdf/tasigna-patient-guide.pdf
  3. https://www.hcp.novartis.com/siteassets/tasigna/pdf/tasigna-patient-guide.pdf
  4. https://www.medicines.org.uk/emc/files/pil.6251.pdf
  5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022068s004s005lbl.pdf
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