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Tazocef 1000 mg/125 mg Injection is used to treat bacterial infections. It contains Ceftriaxone and Tazobactum which work by damaging the bacterial cell wall and killing bacteria. In some cases, this medicine may cause side effects such as diarrhoea, rash, abnormal white blood cells and platelets. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Medley Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tazocef 1000 mg/125 mg Injection

Tazocef 1000 mg/125 mg Injection is a prescription antibiotic injection used to treat a wide range of serious bacterial infections, including infections of the lungs, urinary tract, abdomen, skin, and other parts of the body. This combination is available as a brand-specific or regionally approved formulation in some countries and is not a universally approved fixed-dose combination. Its availability and approved uses may vary depending on local regulatory authorities. It combines an antibiotic with a beta-lactamase inhibitor to help treat susceptible bacterial infections. Because it is given by injection, it is generally reserved for infections that require prompt and reliable treatment.

Because Tazocef 1000 mg/125 mg Injection is given as an injection, it is typically administered by a healthcare professional once or twice daily, depending on the severity of the infection. It is crucial to receive every scheduled dose at the same time each day to maintain a steady level of medicine in your body. Drinking plenty of fluids and getting adequate rest during your treatment helps your body recover faster from the infection.

While using Tazocef 1000 mg/125 mg Injection, you may experience mild side effects such as temporary pain or swelling at the injection site, or mild diarrhea. However, you must contact your doctor immediately if you experience severe watery diarrhea, yellowing of your skin or eyes, or a sudden rash with breathing difficulties.

Tell your doctor about your complete medical history, especially if you have a history of gallbladder disease, kidney problems, or bowel inflammation. Do not receive this medicine if you have had a severe allergic reaction to cephalosporin or penicillin antibiotics in the past.

This medicine can interact with certain blood thinners, some other antibiotics, and calcium-containing intravenous solutions. Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, and herbal products you are taking before starting treatment. If you are pregnant, planning to become pregnant, breastfeeding, or managing health conditions in an elderly patient, discuss the risks and benefits thoroughly with your doctor.

Uses of Tazocef 1000 mg/125 mg Injection

Tazocef 1000 mg/125 mg Injection is used in the treatment of bacterial infections. The detailed uses of Tazocef 1000 mg/125 mg Injection are as follows:

  • Severe lung infections: Tazocef 1000 mg/125 mg Injection helps clear bacterial pneumonia and other deep chest infections by destroying the bacteria causing the illness.
  • Complicated urinary tract infections: It targets and eliminates bacteria in the kidneys and bladder, reducing painful urination and fever.
  • Skin and soft tissue infections: It stops the spread of bacteria in deep skin wounds, ulcers, or surgical sites, promoting proper healing.
  • Abdominal infections: It treats serious infections within the stomach and intestines, such as peritonitis, by clearing harmful bacteria.
  • Meningitis: Ceftriaxone is well known for reaching the fluid around the brain and spinal cord, making it useful in treating bacterial meningitis. The role of the tazobactam component in central nervous system infections is less clearly established, so treatment depends on your doctor's assessment and local treatment guidelines.

Key Benefits

Tazocef 1000 mg/125 mg Injection helps treat serious bacterial infections by combining an antibiotic with a beta-lactamase inhibitor. This combination helps fight susceptible bacteria effectively, supports faster recovery, and reduces the risk of the infection spreading when used as prescribed. Benefits may include:

  • Fast-acting treatment: As an injectable medicine, it reaches the bloodstream quickly and begins acting against susceptible bacteria soon after administration.
  • Helps overcome certain resistant bacteria: Tazobactam protects ceftriaxone from beta-lactamase enzymes produced by some bacteria, helping the antibiotic remain effective against susceptible strains.
  • Broad antibacterial coverage: It is active against many Gram-positive and Gram-negative bacteria, making it useful for treating a variety of serious bacterial infections as determined by your doctor.
  • Supports recovery: By controlling the infection, it helps reduce symptoms such as fever, pain, and inflammation, allowing your body to heal more effectively.
  • Helps prevent complications: Prompt and effective treatment can reduce the risk of the infection worsening or spreading to other parts of the body.
Side effects of Tazocef 1000 mg/125 mg Injection

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Tazocef 1000 mg/125 mg Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Tazocef 1000 mg/125 mg Injection Works

Tazocef 1000 mg/125 mg Injection is a combination of Ceftriaxone and Tazobactam. Ceftriaxone is a cephalosporin antibiotic. It works by preventing bacteria from building their protective cell wall. Without this wall, the bacteria break apart and die. Tazobactam is a beta-lactamase inhibitor. Some bacteria produce enzymes called beta-lactamases that can break down certain antibiotics. Tazobactam blocks these enzymes, helping protect ceftriaxone so it can work more effectively against susceptible bacteria. Together, these medicines help treat a broad range of susceptible bacterial infections. They are not effective against viral infections such as the common cold or flu. Your doctor may also use culture and sensitivity test results to confirm that this antibiotic is appropriate for your infection.
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Alcohol

Caution

Interaction of Tazocef 1000 mg/125 mg Injection with alcohol is unknown. Please consult a doctor before consuming alcohol while using Tazocef 1000 mg/125 mg Injection.

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Pregnancy

Caution

Please consult a doctor if you are pregnant or planning for pregnancy. Tazocef 1000 mg/125 mg Injection is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

It is unknown whether Tazocef 1000 mg/125 mg Injection is excreted in human milk. Tazocef 1000 mg/125 mg Injection is given to breastfeeding mothers if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Tazocef 1000 mg/125 mg Injection may cause dizziness in some people. Therefore, avoid driving if you feel dizzy after taking Tazocef 1000 mg/125 mg Injection.

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Liver

Caution

Take Tazocef 1000 mg/125 mg Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Tazocef 1000 mg/125 mg Injection with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Tazocef 1000 mg/125 mg Injection is not recommended for premature and new-born babies up to 28 days who has jaundice or certain blood problems. However, Tazocef 1000 mg/125 mg Injection is given to children only if prescribed by a doctor.

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Heart

Consult your doctor

Tazocef 1000 mg/125 mg Injection will be administered by the physician if it is safe for your condition.

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Geriatrics

Safe if prescribed

Tazocef 1000 mg/125 mg Injection can be safely administered in elderly patients if recommended.

What if I have taken an overdose of Tazocef 1000 mg/125 mg Injection

Because this medication is usually injected by a medical professional, an overdose is highly unlikely. However, if you receive too much of this medicine or experience severe muscle twitching, seizures, or breathing issues, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water and clear broths while receiving Tazocef 1000 mg/125 mg Injection to help support kidney function and flush bacterial toxins from your body.
  • Support your gut health: Antibiotics can disrupt your natural gut bacteria. Ask your doctor if taking a probiotic or eating fermented foods like yogurt after finishing your course of treatment would be beneficial for your digestion.
  • Limit or avoid alcohol during treatment: Although there is no known direct alcohol interaction with this medicine, alcohol may contribute to dehydration, worsen side effects such as nausea or dizziness, and slow your recovery from infection. It is generally best to avoid or limit alcohol until you have recovered.
  • Rest and limit physical strain: Allow your body to direct its energy toward healing by getting at least 7-8 hours of sleep and avoiding strenuous physical activities until your infection has fully cleared.
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How Soon It Starts Working

The time required for Tazocef 1000 mg/125 mg Injection to start to work: Tazocef 1000 mg/125 mg Injection ideally shows its action within 10 to 15 minutes after administration. The time for which the effects of Tazocef 1000 mg/125 mg Injection last: The effect of Tazocef 1000 mg/125 mg Injection lasts for 24 hours.

What if you forget to take Tazocef 1000 mg/125 mg Injection

If you miss an appointment to receive your injection, contact your healthcare provider or clinic immediately to reschedule. It is important to receive each dose on time to keep the infection from returning.

Storage

• Store Tazocef 1000 mg/125 mg Injection dry powder vials according to the manufacturer's instructions, typically at room temperature (around 20°C to 25°C), unless otherwise directed by the manufacturer or your pharmacist.

Drug Warnings

  • Inspect the solution: Always look at the liquid in the syringe or IV bag before it is injected. It should be clear and pale yellow to amber; do not use it if you notice cloudiness, discoloration, or floating particles.
  • Rotate injection sites: If you are receiving intramuscular injections, make sure your healthcare provider rotates the injection site each time to prevent muscle soreness and tissue damage.
  • Never reuse needles: Use a sterile needle and syringe for every single injection if you are self-injecting at home. Dispose of them immediately in an approved puncture-resistant sharps container.
  • Complete the entire course: Even if your fever drops and you feel healthy, do not skip doses or stop the therapy early, as the infection could return stronger.
  • Attend follow-up appointments: If you are receiving this medicine for several days or longer, your doctor may recommend blood tests to monitor your blood cell counts and check how well your liver and kidneys are working.
  • Monitor for severe diarrhea: If you develop severe, watery diarrhea during your treatment or up to two months after finishing Tazocef 1000 mg/125 mg Injection, do not take any over-the-counter anti-diarrhea medicines; contact your doctor immediately.
  • Be aware of gallbladder effects: Ceftriaxone can sometimes cause temporary deposits in the gallbladder (called biliary sludge or pseudolithiasis), especially in children or during prolonged treatment. Contact your doctor if you develop severe pain in the upper right side of your abdomen, nausea, or vomiting.
  • Do not use Tazocef 1000 mg/125 mg Injection without medical advice if you have had a severe allergic reaction to ceftriaxone, other cephalosporin antibiotics, or any ingredient in this medicine, experienced a serious allergic reaction to penicillin or certain other beta-lactam antibiotics, as cross-reactivity may occur or are a premature newborn or a newborn with high bilirubin (jaundice), unless your doctor decides the benefits outweigh the risks.

Drug-Drug Interactions

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  • Blood thinners (e.g., warfarin): Using this medicine with blood-thinning medicines may increase the risk of bleeding in some people. Your doctor may recommend closer monitoring if both medicines are needed.
  • Other strong antibiotics (like aminoglycosides): Combining these can increase the risk of kidney damage.
  • Calcium-containing IV fluids: Injecting Tazocef 1000 mg/125 mg Injection along with calcium-containing solutions through the same IV line can cause dangerous particles to form in the lungs and kidneys, especially in newborns.

Drug-Drug Interactions

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How does the drug interact with Tazocef 1000 mg/125 mg Injection:
Co-administration of Calcium chloride with Ceftriaxone can increase the risk of side effects.

How to manage the interaction:
Taking Ceftriaxone with Calcium chloride is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tazocef 1000 mg/125 mg Injection:
Co-administration of Calcium gluconate with Ceftriaxone can increase the risk of adverse effects.

How to manage the interaction:
Taking Ceftriaxone with Calcium gluconate is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tazocef 1000 mg/125 mg Injection:
Taking mycophenolic acid and ceftriaxone together can reduce the blood levels and effects of mycophenolic acid.

How to manage the interaction:
Using mycophenolic acid Ceftriaxone together can lead to an interaction; it can be taken if your doctor has suggested it. If you experience any symptoms, like less urine output, shortness of breath, or swelling, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
Ceftriaxone + TazobactamCholera, live attenuated
Severe
How does the drug interact with Tazocef 1000 mg/125 mg Injection:
Taking the cholera vaccine after or along with ceftriaxone may reduce the activity of the vaccine.

How to manage the interaction:
Although taking Ceftriaxone and Cholera, live attenuated together can evidently cause an interaction, it can be taken if your doctor has suggested it. To ensure adequate vaccine response, you should not receive cholera vaccine, live until at least 14 days after you complete your antibiotic therapy. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Tazocef 1000 mg/125 mg Injection:
Taking ceftriaxone and the BCG vaccine can reduce the anti-tumor activity of BCG in the bladder.

How to manage the interaction:
Using ceftriaxone and the BCG vaccine can lead to an interaction; it can be taken if your doctor has suggested it. To ensure an adequate response to your cancer treatment, you should not receive BCG until after you complete your antibiotic therapy. Contact the doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Tazocef 1000 mg/125 mg Injection when used as directed. 
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Tazocef 1000 mg/125 mg Injection is used to treat bacterial infections of the urinary tract, blood, bones and joints, heart, brain, chest, ears, skin, or soft tissues.
Tazocef 1000 mg/125 mg Injection contains Ceftriaxone and Tazobactum. Ceftriaxone is an antibiotic that works by interfering with the formation of the bacterial cell wall (a protective covering) that is necessary for their survival. Thereby damages the bacterial cell wall and kills bacteria. Tazobactum is a beta-lactamase inhibitor that enhances the activity of ceftriaxone and decreases resistance.
Tazocef 1000 mg/125 mg Injection may interfere with urine test (for sugar) and Coomb’s test (blood test) giving false-positive results. Therefore, if you are about to undergo any laboratory tests, inform your doctor or lab technician that you are taking Tazocef 1000 mg/125 mg Injection.
You are not recommended to take Tazocef 1000 mg/125 mg Injection with streptomycin as co-administration of these two medicines may increase the risk of kidney damage. However, please consult your doctor before taking Tazocef 1000 mg/125 mg Injection with other medicines to adjust the dose appropriately.
Tazocef 1000 mg/125 mg Injection should be used with caution in patients with kidney problems as it may increase the risk of adverse effects. Therefore, inform your doctor if you have any kidney problems before taking Tazocef 1000 mg/125 mg Injection so that the dose may be adjusted accordingly.
Inform your doctor if you don't get better after finishing the full course of treatment as prescribed by your doctor. Also, inform if your symptoms are getting worse while using Tazocef 1000 mg/125 mg Injection.
The common side effects of Tazocef 1000 mg/125 mg Injection are diarrhoea, rash, raised white blood cells, raised platelets, nausea, vomiting, stomach upset, blood clots, dizziness, headache, a lump where the medicine was injected and sweating. If any of these side effects persist or worsen, please consult your doctor.
No, Tazocef 1000 mg/125 mg Injection is not available as a tablet or liquid to be swallowed. It must be injected directly into a vein or a muscle so that it can bypass the digestive system and treat severe infections quickly. Talk to your doctor if you have questions about how this medicine is given.
Mild diarrhea can happen as your body adjusts to the medicine. However, if you develop severe, watery, or bloody diarrhea with stomach cramps, this could be a sign of a serious gut infection. Do not take over-the-counter anti-diarrheal medicines, and talk to your doctor immediately.
Tazocef 1000 mg/125 mg Injection should only be used during pregnancy if it is clearly needed and prescribed by a healthcare provider. There is limited research on its effects on unborn babies, so your doctor will weigh the benefits against any potential risks. Talk to your doctor if you are pregnant or planning to become pregnant.
It is best to avoid alcohol while being treated with Tazocef 1000 mg/125 mg Injection. Alcohol can cause dehydration, weaken your immune system, and increase your risk of experiencing side effects like headaches, nausea, or dizziness. Talk to your doctor for specific advice.
No, Tazocef 1000 mg/125 mg Injection is an antibiotic and is only effective against infections caused by bacteria. It will not work against viral infections like colds, flu, or Covid-19. Using antibiotics when they are not needed can make future bacterial infections harder to treat. Talk to your doctor if you are unsure about your diagnosis.
Stopping your treatment early, even if you feel completely healthy, allows the strongest bacteria to survive and multiply. This can cause your infection to return and make the bacteria resistant to future antibiotic treatments. Talk to your doctor before making any changes to your therapy.
Tazocef 1000 mg/125 mg Injection is generally avoided in premature newborns and newborns with high bilirubin levels unless a doctor decides it is necessary. It should also not be given together with calcium-containing IV solutions in newborns because of the risk of serious complications. Doctors carefully choose the safest antibiotic based on the baby's age, weight, and medical condition.
If you are receiving this medicine for several days or longer, your doctor may order blood tests to monitor your blood cell counts and check how well your liver and kidneys are functioning. These tests help ensure the treatment remains safe and effective throughout your course of therapy.
Small amounts of ceftriaxone may pass into breast milk, but it is generally considered compatible with breastfeeding in most cases. Information on the tazobactam component is more limited, so your doctor will consider the benefits and any potential risks before prescribing this medicine. Tell your doctor if you are breastfeeding so they can advise you appropriately. Seek medical advice if your baby develops diarrhea, thrush, or unusual symptoms.
Your doctor selects an antibiotic based on several factors, including the type and severity of your infection, the bacteria most likely to be causing it, local antibiotic resistance patterns, and your medical history. In some cases, Tazocef 1000 mg/125 mg Injection may be chosen because it can treat a broad range of susceptible bacteria, including some that produce enzymes capable of reducing the effectiveness of certain antibiotics.

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Country of origin

India

Manufacturer/Marketer address

Lane No. 3, Phase - 1, SIDCO Industrial Complex, Barl-Brahmana, Jammu - 181133, India.
Other Info - TAZ0087
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