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compositionComposition:TEMOZOLOMIDE-20MG
prescription
Prescription Medicine
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TEMONAT 20MG CAPSULE is an anti-cancer medicine used in the treatment of brain tumours such as glioblastoma multiforme (a type of tumour that grows and spreads rapidly) in adults and malignant glioma, including glioblastoma multiforme or anaplastic astrocytoma. This medicine works by inhibiting the production of DNA (deoxyribonucleic acid-genetic material of the cell), thereby affecting cell growth and division. Common side effects include loss of appetite, anxiety, confusion, headache, vomiting, nausea, diarrhoea, constipation, muscle weakness, muscle aches, and fever.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

TEMOZOLOMIDE-20MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About TEMONAT 20MG CAPSULE

TEMONAT 20MG CAPSULE is a prescription medicine used to treat specific types of brain cancers in adults. It is primarily prescribed to manage newly diagnosed glioblastoma multiforme, a severe form of brain tumour, as well as anaplastic astrocytoma when other treatments stop working. Its main medical purpose is to target and slow down the replication of cancer cells inside the brain.

You must take TEMONAT 20MG CAPSULE consistently at the same time each day exactly as your doctor directs, typically during specific treatment cycles. To reduce stomach upset and prevent vomiting, you should take this medicine on an empty stomach, either one hour before a meal or two hours after eating, or right before bedtime. Adopting a diet of small, frequent meals and drinking plenty of fluids can help manage nausea and support your body during this treatment.

Common side effects of this medication include nausea, vomiting, fatigue, headache, constipation, and loss of appetite. It is crucial to consult your doctor immediately if you experience serious side effects like signs of an infection (such as a fever or chills), unusual bleeding, persistent bruising, or signs of liver damage like yellowing of the skin or eyes.

Before starting this treatment, talk to your doctor if you have a history of kidney disease, liver disease, or low blood cell counts. Do not take this if you have had a severe allergic reaction to this medication or to dacarbazine, or if you are allergic to any of its ingredients.

This medicine can interact with other drugs such as valproic acid, which can increase the levels of the medicine in your body and raise the risk of severe side effects. Avoid alcohol and smoking while taking this medication as they can put extra strain on your liver and worsen feelings of nausea or fatigue. Pregnant women, breastfeeding mothers, and elderly individuals must consult their doctor before using this medicine due to the high risk of serious complications.
 

Uses of TEMONAT 20MG CAPSULE

Your doctor may prescribe TEMONAT 20MG CAPSULE to help manage the following conditions:

  • Glioblastoma multiforme: TEMONAT 20MG CAPSULE is used to treat newly diagnosed glioblastoma multiforme in adults, typically alongside radiation therapy first and then continued as a maintenance therapy on its own.
  • Anaplastic astrocytoma: TEMONAT 20MG CAPSULE is prescribed to treat anaplastic astrocytoma in patients whose tumours have returned or have stopped responding to standard chemotherapy treatments.
     

Key Benefits

TEMONAT 20MG CAPSULE is an anticancer medicine used to treat certain types of brain tumours. It works by slowing or stopping the growth of cancer cells, helping control disease progression and supporting treatment outcomes.

  • Helps Control Brain Tumours: Slows the growth and spread of cancer cells, helping manage certain malignant brain tumours.
  • Reaches Brain Tissue Effectively: Crosses the blood-brain barrier, allowing the medicine to act directly on tumour cells within the brain.
  • Supports Cancer Treatment: May be used alone or in combination with radiotherapy to improve treatment effectiveness, as recommended by your doctor.
  • Convenient Oral Therapy: Available as an oral capsule, allowing treatment to be taken at home according to the prescribed chemotherapy schedule.
  • Supports Long-Term Disease Management: By helping control tumour growth, it may improve treatment outcomes, relieve disease-related symptoms, and support quality of life.
Side effects of Temonat 20mg Capsule
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Directions for Use

  • TEMONAT 20MG CAPSULE can be taken with or without food, or as directed by your doctor. To minimize potential side effects like nausea and vomiting, it is recommended to take TEMONAT 20MG CAPSULE consistently either on an empty stomach or with meals.
  • TEMONAT 20MG CAPSULE is usually taken once daily; however, follow your doctor's instructions regarding dosage and timing to ensure optimal effectiveness.
  • Swallow TEMONAT 20MG CAPSULE as a whole with a glass of water.
  • Do not crush, chew, or break TEMONAT 20MG CAPSULE, as this may impact absorption.

How TEMONAT 20MG CAPSULE Works

TEMONAT 20MG CAPSULE contains temozolomide. It belongs to a group of medicines known as alkylating agents. Once you swallow the capsule, the active drug enters your bloodstream and travels directly to the brain. In the brain, the medicine breaks down into an active compound that binds directly to the DNA of rapidly dividing cancer cells. By attaching to the DNA, this compound damages the genetic structure of the cancer cells, preventing them from replicating and dividing. Because the damaged cancer cells can no longer reproduce, they naturally die off. This action helps slow down or stop the progression of the brain tumour.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking TEMONAT 20MG CAPSULE. It could lead to unpleasant side effects.

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Pregnancy

Caution

Please consult your doctor if you have any concerns about this. TEMONAT 20MG CAPSULE should not be used during pregnancy unless prescribed by your doctor. Women of childbearing potential must use effective contraception during the treatment and for 6months after completion of the treatment.

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Breast Feeding

Unsafe

TEMONAT 20MG CAPSULE should not be taken during breastfeeding as it passes into the breastmilk and may harm the baby.

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Driving

Caution

TEMONAT 20MG CAPSULE may make you feel tired or sleepy. Drive and/or operate machines only if you are alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before using TEMONAT 20MG CAPSULE. Your doctor will weigh the benefits and potential risks before prescribing TEMONAT 20MG CAPSULE.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before using TEMONAT 20MG CAPSULE. Your doctor will weigh the benefits and potential risks before prescribing TEMONAT 20MG CAPSULE.

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Children

Caution

Safety and effectiveness of TEMONAT 20MG CAPSULE in paediatric patients under the age of three have not been established.

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Heart

Caution

TEMONAT 20MG CAPSULE should be taken with caution in patients with heart problems. Therefore, please talk to your doctor before using TEMONAT 20MG CAPSULE.

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Geriatrics

Caution

TEMONAT 20MG CAPSULE should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform a healthcare professional before use.

What if I have taken an overdose of TEMONAT 20MG CAPSULE

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. An overdose can cause severe and dangerous drops in your blood cell counts, increasing your risk of life-threatening infections or bleeding.

Diet & Lifestyle Advise

  • Eat small, frequent meals: To help manage nausea, try eating five or six small, bland meals throughout the day instead of three large ones. Avoid greasy, spicy, or very sweet foods.
  • Stay well-hydrated: Drink plenty of water, clear broths, or electrolyte solutions to stay hydrated, especially on days when you feel nauseous or have a poor appetite.
  • Practice strict infection prevention: Wash your hands frequently with soap and water, avoid crowded places, and stay away from people who are currently sick or have colds.
  • Use a soft toothbrush: To prevent bleeding gums, use an extra-soft toothbrush and avoid using toothpicks. Use an electric razor instead of a manual blade to prevent skin cuts.
     
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How Soon It Starts Working

The time required for TEMONAT 20MG CAPSULE to start to work: The exact onset time of TEMONAT 20MG CAPSULE has not been clinically established. The time for which the effects of TEMONAT 20MG CAPSULE last: The duration of TEMONAT 20MG CAPSULE’s effect is clinically not established.

What if you forget to take TEMONAT 20MG CAPSULE

If you miss a dose of TEMONAT 20MG CAPSULE, do not take a double dose to make up for the missed one. Contact your doctor or pharmacist immediately to find out when you should take your next dose based on your treatment schedule.

Storage

• Store TEMONAT 20MG CAPSULE capsules at room temperature, between 68°F and 77°F (20°C and 25°C).

Drug Warnings

  • Do not touch damaged capsules: Always handle capsules with dry hands. If a capsule is cracked or leaking, caregivers should wear disposable gloves to handle it and discard it according to chemotherapy safety protocols.
  • Get regular blood tests: You must undergo regular blood tests before and during each treatment cycle to ensure your white blood cells, red blood cells, and platelets are at safe levels.
  • Use reliable birth control: Both men and women must use highly effective birth control during treatment and for several months after the final dose, as TEMONAT 20MG CAPSULE can cause severe birth defects.
  • Do not drive if fatigued: This medicine can make you feel extremely tired or dizzy. Do not drive or operate machinery until you know how this medication affects you.
  • Avoid live vaccinations: Talk to your doctor before getting any vaccines. Avoid receiving live vaccines during your treatment, as your immune system is temporarily weakened.
     

Drug-Drug Interactions

verifiedApollotooltip

TEMONAT 20MG CAPSULE may interact with certain medicines, affecting its effectiveness or increasing the risk of side effects.

  • Valproic acid: Taking this seizure medication alongside TEMONAT 20MG CAPSULE can reduce how quickly your body clears this drug, which may increase the risk of severe side effects.
  • Bone marrow-suppressing drugs: Taking other medicines that weaken your immune system or lower your blood counts can dangerously increase your risk of severe infections and bleeding.
     
TemozolomideAdalimumab
Severe
TemozolomideClozapine
Severe

Drug-Drug Interactions

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TemozolomideAdalimumab
Severe
How does the drug interact with Temonat 20mg Capsule:
Using adalimumab together with Temonat 20mg Capsule may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 20mg Capsule and adalimumab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideClozapine
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking Temonat 20mg Capsule with clozapine may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 20mg Capsule and clozapine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideVoclosporin
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking voclosporin with Temonat 20mg Capsule, may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 20mg Capsule and voclosporin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideFingolimod
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking Temonat 20mg Capsule with Fingolimod can increase the risk of infection.

How to manage the interaction:
Although taking Temonat 20mg Capsule and fingolimod together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideEtanercept
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking Temonat 20mg Capsule with Etanercept can increase the risk of infections.

How to manage the interaction:
Although taking Temonat 20mg Capsule and etanercept together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideThalidomide
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking thalidomide with Temonat 20mg Capsule can increase the risk of blood clots.

How to manage the interaction:
Although taking Temonat 20mg Capsule and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg. Do not stop using any medications without consulting doctor.
TemozolomideBaricitinib
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking baricitinib and Temonat 20mg Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Temonat 20mg Capsule if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
TemozolomideCladribine
Severe
How does the drug interact with Temonat 20mg Capsule:
Using cladribine together with Temonat 20mg Capsule may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 20mg Capsule and cladribine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideLeflunomide
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking Temonat 20mg Capsule with Leflunomide can increase the risk of infections.

How to manage the interaction:
Although taking Temonat 20mg Capsule and leflunomide together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
TemozolomideInfliximab
Severe
How does the drug interact with Temonat 20mg Capsule:
Taking Temonat 20mg Capsule with Infliximab can increase the risk of infections.

How to manage the interaction:
Although taking Temonat 20mg Capsule and infliximab together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and beverages may influence the absorption and effectiveness of TEMONAT 20MG CAPSULE during treatment.

  • Food: Taking TEMONAT 20MG CAPSULE with food significantly decreases how much medicine your body absorbs and increases your risk of severe nausea and vomiting. Always take it on an empty stomach.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

TEMONAT 20MG CAPSULE belongs to a class of medicines called anti-cancer agents, used to treat specific forms of brain tumours such as glioblastoma multiforme (a type of tumour that grows and spreads rapidly) in adults and malignant glioma, including glioblastoma multiforme or anaplastic astrocytoma (a rare malignant brain tumour) in patients older than 3years.
TEMONAT 20MG CAPSULE works by binding to the DNA (deoxyribonucleic acid-genetic material of the cell) and interfering with cell growth and division. Thus, TEMONAT 20MG CAPSULE prevents tumours from growing.
TEMONAT 20MG CAPSULE may cause permanent infertility. Male patients should use effective contraception and refrain from fathering a child for up to three months after treatment is completed. Prior to treatment, it is recommended to seek sperm conservation advice from your doctor.
Yes, TEMONAT 20MG CAPSULE can cause neutropenia (low white blood cells count), lymphopenia (low lymphocytes count), thrombocytopenia (low platelet count). As a part of therapy, your doctor may monitor your blood profile.
TEMONAT 20MG CAPSULE may lead to hyperglycemia (Increased blood sugar). Consult your doctor if you are diabetic. Regularly monitor your blood sugar levels while taking TEMONAT 20MG CAPSULE.
The live vaccine may interact with TEMONAT 20MG CAPSULE. Do not have vaccinations or immunisations without talking to your doctor first.
No. You must swallow the capsules whole. Opening or chewing the capsules can expose you or your caregivers to harmful chemical powder, which can cause severe skin or respiratory irritation. Talk to your doctor if you have difficulty swallowing capsules.
If you vomit after taking your dose, do not take another capsule to replace it. Contact your doctor or pharmacist immediately for specific instructions on how to handle your schedule. Talk to your doctor about anti-nausea medications you can take before your next dose.
This medicine temporarily lowers the number of blood cells made in your bone marrow. Regular blood tests are essential to ensure your white blood cells, red blood cells, and platelets do not drop to dangerously low levels, which could cause severe infections or bleeding.
Your treatment schedule is divided into cycles, often lasting several months. The exact duration depends on the type of brain tumour, how well the tumour responds, and how your body tolerates the medicine. Talk to your doctor for your specific timeline.
It is highly recommended to avoid alcohol. Alcohol can worsen common side effects like nausea, dizziness, and fatigue, and it can place unnecessary extra strain on your liver during chemotherapy. Talk to your doctor if you have concerns.
Yes. While temporary hair thinning or hair loss is a common side effect of TEMONAT 20MG CAPSULE, your hair will typically begin to grow back once you have completed your full course of treatment.
No. This medicine can cause severe harm to an unborn baby or lead to birth defects. Both men and women must use highly effective birth control during treatment and for several months after stopping. Talk to your doctor immediately if a pregnancy occurs.
You should consult your healthcare provider before taking any over-the-counter pain relievers. Some pain medicines can increase your risk of bleeding, which is dangerous if your blood platelet counts are low. Talk to your doctor or pharmacist for a safe recommendation.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 021029S031Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Temozolomide 150 - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Temozolomide Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Temozolomide Temozolomide. 1999Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 18 Feb. 2020]Check here
  7. Temozolomide Temozolomide. 2024. [Accessed on 08 Nov. 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - TEM0005
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