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compositionComposition:TERLIPRESSIN-0.1MG/ML
prescription
Prescription Medicine
info
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Terlivista Injection is used to treat Bleeding oesophageal varices. It contains Terlipressin, a synthetic pituitary hormone that breaks down in the body to release a substance called lysine vasopressin that is used to stop bleeding from leaking varicose veins in the food pipe. It works by narrowing the affected blood vessels and restricting their flow. Thus, it helps to control bleeding.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TERLIPRESSIN-0.1MG/ML

Manufacturer/Marketer :

Protech Telelinks

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Terlivista Injection

Terlivista Injection is a prescription injection primarily used to treat life-threatening bleeding in the food pipe (oesophageal varices) and a severe type of kidney failure linked to advanced liver disease. It works by narrowing the blood vessels in the stomach area, which reduces pressure in the liver and helps control dangerous bleeding.

Because this medicine is given as an injection directly into a vein, it is strictly managed by healthcare professionals in a hospital setting. It is given at regular intervals based on your clinical condition, and you do not need to worry about taking it with food. While receiving this treatment, staying hydrated under medical supervision and adhering to a low-sodium diet can help support your liver and kidneys.

Common side effects of Terlivista Injection include abdominal cramps, pale skin, headaches, and a temporary increase in blood pressure. However, you must inform your healthcare team immediately if you experience severe chest pain, difficulty breathing, or bluish discolouration of your fingers or toes.

Before receiving Terlivista Injection, it is vital to tell your doctor if you have a history of heart disease, irregular heartbeats, high blood pressure, or breathing problems like asthma. Do not take this if you are pregnant, as it can cause harm to the unborn baby, or if you have severe, uncontrolled heart conditions.

This medicine can interact with other drugs that affect your heart rhythm or blood pressure, so a complete list of your current medications must be reviewed by your medical team. Additionally, because it is used for severe liver-related emergencies, avoiding alcohol and smoking is absolutely critical for your recovery. Pregnant or breastfeeding women, as well as elderly individuals with heart conditions, must discuss the risks and benefits thoroughly with their doctor before receiving this treatment.

Uses of Terlivista Injection

Terlivista Injection may be prescribed to help manage the following conditions:

  • Bleeding food pipe veins (Oesophageal Varices): Terlivista Injection helps stop dangerous, acute bleeding in the swollen veins of the food pipe, which often occurs in people with severe liver disease.
  • Kidney failure related to liver disease (Hepatorenal Syndrome): Terlivista Injection helps improve kidney function in people with advanced liver cirrhosis by redirecting blood flow to the kidneys, helping them filter waste properly again.

Key Benefits

Terlivista Injection is used to control bleeding from oesophageal varices and to treat hepatorenal syndrome in patients with advanced liver disease. It works by narrowing specific blood vessels, reducing portal vein pressure, and improving blood flow to vital organs.

  • Controls Variceal Bleeding: Helps rapidly reduce pressure in the portal vein, controlling bleeding from enlarged veins in the oesophagus.
  • Supports Kidney Function: Improves blood flow to the kidneys in patients with hepatorenal syndrome, helping restore kidney function and urine production.
  • Stabilises Medical Emergencies: Helps stabilise patients with severe liver-related complications, allowing time for additional treatments such as endoscopic procedures.
  • Reduces Portal Hypertension: Lowers increased pressure within the portal venous system, helping reduce the risk of further bleeding episodes.
  • Improves Treatment Outcomes: When used as part of standard medical care, it helps improve the management of serious complications associated with advanced liver disease.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Terlivista Injection will be administered intravenously by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Terlivista Injection Works

Terlivista Injection contains terlipressin. It mimics a natural hormone in the body that regulates blood vessel constriction. When injected, it targets the blood vessels in your abdominal organs, causing them to narrow. By narrowing these abdominal blood vessels, Terlivista Injection reduces the volume of blood flowing back into the liver. This dramatically lowers the pressure in the portal vein (the main vein leading to the liver), which helps stop bleeding from fragile, swollen veins in your food pipe. At the same time, this constriction helps redirect blood flow back into the main circulatory system. This increases blood pressure and improves blood flow to the kidneys, helping reverse the sudden kidney failure associated with severe liver damage.
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Alcohol

Consult your doctor

The interaction of Terlivista Injection with alcohol is unknown. Therefore, if you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

Limited data available on the effect of Terlivista Injection on pregnant women. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Terlivista Injection. Your doctor may give this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Terlipressin is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Terlivista Injection. Your doctor may give this medicine if the benefits outweigh the risks.

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Driving

Caution

Limited information is available. However, if you are unwell after receiving Terlivista Injection, avoid driving or operating machinery.

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Liver

Consult your doctor

If you have any liver problems, inform your doctor before receiving Terlivista Injection.

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Kidney

Caution

Terlivista Injection should be used with caution in patients with long-standing kidney failure. Also, inform your doctor if you have impaired kidney function.

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Children

Unsafe

Terlivista Injection is not recommended for children and adolescents as the safety and effectiveness were not established.

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Heart

Caution

Terlivista Injection should be avoided in patients with heart problems, as it may cause serious ischemic events like cardiac or cerebrovascular complications. Use only if absolutely necessary and under strict medical supervision.

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Geriatrics

Caution

Terlivista Injection should be avoided in geriatric patients unless absolutely necessary, as it may increase the risk of cardiovascular and renal complications. Use only if clearly indicated and under strict medical supervision.

What if I have taken an overdose of Terlivista Injection

Because this medication is injected under close medical supervision, an overdose is rare. However, if too much of the medicine is given, it can cause severe high blood pressure or a dangerously slow heart rate. The medical team will monitor you closely and treat any symptoms of overdose immediately.

Diet & Lifestyle Advise

  • Follow a strict low-sodium diet: Reducing your salt intake is crucial to prevent your body from holding onto excess fluid, which can worsen liver and kidney complications.
  • Limit or restrict fluid intake: If recommended by your doctor, monitor and limit the amount of fluids you drink to avoid fluid overload, which can put extra strain on your heart and lungs.
  • Avoid alcohol completely: Alcohol causes direct liver damage and can worsen bleeding in your food pipe. Completely avoiding alcohol is essential for your recovery and long-term health.
  • Rest and limit physical strain: Avoid heavy lifting or intense physical exertion, as sudden strain can increase pressure in your abdominal veins and raise the risk of bleeding.
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How Soon It Starts Working

The time required for Terlivista Injection to start to work: Terlivista Injection ideally shows its action within five minutes after administration. The time for which the effects of Terlivista Injection last: The effect of Terlivista Injection lasts for 6 hours.

What if you forget to take Terlivista Injection

Since Terlivista Injection is given in a hospital or clinical setting by a healthcare professional, it is highly unlikely that you will miss a dose. If you suspect a dose was missed, inform your nurse or doctor immediately.

Storage

•In a hospital setting, Terlivista Injection is typically stored in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F). It must not be frozen.

Drug Warnings

  • Monitor injection sites: If you feel pain, burning, redness, or swelling where the injection is being given, tell your healthcare provider immediately to prevent skin damage.
  • Check the solution: Before use, the medical provider should visually inspect the solution to ensure it is clear, colourless, and free of any visible particles.
  • Keep a close eye on breathing: Alert your doctor immediately if you feel short of breath, as this medicine can sometimes cause fluid to build up in your lungs.
  • Avoid sudden movements: Gently change positions (such as sitting up or standing up slowly) as your blood pressure can fluctuate during treatment.

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines before receiving Terlivista Injection:

  • Heart rhythm medications (like beta-blockers): Combined use may cause your heart rate to drop to dangerously slow levels.
  • Blood pressure medications: Taking these alongside Terlivista Injection can cause unpredictable fluctuations in your blood pressure.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Terlivista Injection when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[VASOACTIVE DRUG]

FAQs

Terlivista Injection is used to treat Bleeding oesophageal varices.
Terlivista Injection contains Terlipressin, a synthetic pituitary hormone that works by narrowing the affected blood vessels and restricting the blood flow through them. Thus, it helps to control bleeding.
You are recommended to consult a doctor before taking quinidine while on treatment with Terlivista Injection as it may increase the risk or severity of QT prolongation (a heart rhythm disorder). Therefore, please consult a doctor before taking other medicines with Terlivista Injection.
Terlivista Injection may cause headaches as a common side effect. However, if the condition persists or worsens, please inform your doctor.
The side effects of Terlivista Injection include abdominal cramps, diarrhoea, high or low blood pressure, slow heart rate, headache, pale skin, and insufficient blood circulation in arms, legs and skin. Consult the doctor if any of these symptoms persist or worsen.
Terlivista Injection should not be taken if you are allergic to any of its ingredients, experiencing hypoxia (low levels of oxygen) or worsening respiratory symptoms, or have ongoing coronary, peripheral, or mesenteric ischemia (conditions affecting blood flow).
Before taking Terlivista Injection, let your doctor know if you have severe bleeding in the oesophagus (food pipe). If you have a severe infection like septic shock, breathing issues such as asthma, uncontrolled high blood pressure, heart problems (angina, arrhythmias, or a history of heart attack), poor blood circulation (to the brain or limbs), kidney impairment, electrolyte imbalances, significant fluid or blood loss, if you are pregnant, or are over 70 years old.
Terlivista Injection will be given as a continuous intravenous infusion by the doctor or nurse. Do not self-administer.
Terlivista Injection is not recommended for children as its safety and effectiveness were not established.
No, Terlivista Injection must be given in a hospital or specialised clinic setting by a trained healthcare professional because it requires continuous monitoring of your heart, blood pressure, and kidneys. Talk to your doctor if you have questions about your treatment setting.
This medicine works by narrowing your blood vessels, which temporarily reduces blood flow to the surface of your skin, making you look pale. This is a common effect and usually resolves after the treatment ends. Talk to your doctor if you are concerned.
No, you should not receive Terlivista Injection if you are pregnant. It can cause the muscles of the uterus to contract, which can harm the pregnancy or cause early labour. Talk to your doctor about alternative options.
No, Terlivista Injection does not cure liver disease. It is an emergency treatment used to manage severe complications of liver disease, such as bleeding veins in the food pipe or temporary kidney failure. Talk to your doctor about long-term management for your liver condition.
A slow heart rate is a known side effect of this medicine. Your healthcare team will continuously monitor your heart rate during the injection and will take action if it drops too low. Talk to your doctor or nurse if you feel dizzy or lightheaded.
It is not fully known if Terlivista Injection passes into breast milk. If you are breastfeeding, you must discuss the risks and benefits with your healthcare team before receiving this medication. Talk to your doctor or pharmacist for guidance.
Yes, in some cases, Terlivista Injection can cause fluid to build up in the body, which can lead to shortness of breath or fluid in the lungs. Your doctor will monitor your fluid levels and breathing closely during treatment. Talk to your doctor if you have a history of asthma or breathing issues.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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