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compositionComposition:THALIDOMIDE-100MG
prescription
Prescription Medicine
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Thalix-100 Capsule is used to treat multiple myeloma (a type of cancer) and erythema nodosum leprosum (an inflammatory complication). It helps slow the growth of cancer cells and supports the body’s immune response. It also helps reduce inflammation and related symptoms.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

THALIDOMIDE-100MG

Manufacturer/Marketer :

Fresenius Kabi India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Thalix-100 Capsule

Thalix-100 Capsule is a prescription medicine used to treat specific types of cancer, such as multiple myeloma, and painful skin conditions associated with leprosy complications. It works by targeting abnormal cell growth and reducing severe swelling and inflammation in the body. This medication is always prescribed under strict medical supervision due to its powerful effects on the immune system.

To get the best results, you must take Thalix-100 Capsule consistently and exactly at the same time each day, usually at bedtime to manage drowsiness. It can be taken with or without food, but taking it with a glass of water is recommended. Staying well-hydrated and incorporating gentle daily movement can also help support your body during this treatment.

While taking Thalix-100 Capsule , you may experience some mild side effects like drowsiness, dry skin, or constipation. However, if you notice serious signs such as severe tingling in your hands or feet, or sudden chest pain, you must contact your doctor immediately. Early detection of serious side effects is key to managing your treatment safely.

Do not take this if you are pregnant, planning to become pregnant, or if there is any chance you could become pregnant during treatment. Before starting, tell your doctor if you have a history of nerve problems, blood clots, or heart conditions. This medicine has very strict safety requirements because it can cause severe, life-threatening birth defects.

This medicine can interact with alcohol, smoking, and other sedative drugs, which can make you extremely sleepy. Pregnant and breastfeeding women must never take this medicine, and elderly individuals should use it with caution under close medical supervision, as they may be more sensitive to its side effects.
 

Uses of Thalix-100 Capsule

Your doctor may prescribe this medicine to treat several conditions, including:

  • Multiple myeloma: In combination with other therapies, Thalix-100 Capsule helps slow down the growth of cancerous plasma cells in the bone marrow, helping to keep the disease under control.
  • Erythema nodosum leprosum (ENL): It treats and prevents painful, inflamed skin lumps caused by moderate to severe leprosy complications by reducing the body’s inflammatory response.
     

Key Benefits

Thalix-100 Capsule provides the following benefits when used as prescribed:

  • Targets Underlying Disease: Thalix-100 Capsule offers significant relief by directly targeting the underlying causes of severe inflammatory and cancerous conditions.
  • Reduces Leprosy Symptoms: For patients managing skin complications from leprosy, it helps clear painful lesions and reduces systemic symptoms like fever and physical discomfort, allowing for more comfortable daily movement.
  • Controls Disease Progression: For patients with multiple myeloma, Thalix-100 Capsule helps manage disease progression. By keeping abnormal cell growth in check, it supports longer periods of disease control, helping you maintain your physical function and overall quality of life during your treatment plan.
     
Side effects of Thalix-100 Capsule
Managing Medication-Triggered Hypocalcemia (Calcium deficiency or Low Calcium Levels In Blood): A Step-by-Step Guide:
  • Consult Your Doctor: If you experience symptoms such as muscle cramps, tingling, numbness, weakness, or spasms, which may indicate low calcium levels (hypocalcemia), consult your doctor to determine if your medication is the cause.
  • Your doctor will assess your medication regimen and adjust it if necessary to minimize the risk of hypocalcemia.
  • Your doctor may order blood tests to check your calcium levels and monitor for any changes.
  • To manage hypocalcemia, your doctor recommends dietary and lifestyle modifications. This may include increasing your intake of calcium-rich foods to support bone health and calcium levels. If necessary, your doctor may also prescribe calcium and vitamin D supplements to help stabilize your calcium levels.
  • If your condition does not improve or worsens, consult your doctor immediately for further evaluation and treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Muscle weakness can be due to tiredness, which can be managed by eating often.
  • Observe your movements and understand why the muscle is weakening.
  • Regularly do strengthening exercises to improve blood flow throughout the body and reduce weakness.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet, quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.

Directions for Use

  • Thalix-100 Capsule should be taken at least one hour after meals.
  • It is usually taken once daily, preferably at bedtime, or as prescribed by your doctor.
  • Swallow Thalix-100 Capsule as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Thalix-100 Capsule Works

Thalix-100 Capsule belongs to a group of medicines that modify or regulate the immune system. It works in three distinct ways to fight disease and reduce symptoms. First, it helps your body's immune system identify and destroy abnormal or cancerous cells more effectively. Second, it stops the formation of new blood vessels that cancer cells need to grow and spread. Without a dedicated blood supply, abnormal cells cannot survive. Finally, it blocks the production of certain natural chemicals in your body that cause severe swelling, pain, and tissue inflammation.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Thalix-100 Capsule as it might cause increased sleepiness.

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Pregnancy

Unsafe

Thalix-100 Capsule belongs to pregnancy category X. Thalix-100 Capsule should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of child-bearing age. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Thalix-100 Capsule as it is unknown if Thalix-100 Capsule passes into breastmilk.

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Driving

Unsafe

Thalix-100 Capsule may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

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Liver

Caution

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Thalix-100 Capsule is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Thalix-100 Capsule should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Thalix-100 Capsule .

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Geriatrics

Caution

Thalix-100 Capsule should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Thalix-100 Capsule .

What if I have taken an overdose of Thalix-100 Capsule

If you suspect an overdose, seek immediate medical attention. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Manage constipation: Eat a high-fiber diet rich in fruits, vegetables, and whole grains, and drink plenty of water throughout the day.
  • Prevent dizziness: Rise slowly from sitting or lying positions to give your body time to adjust, especially when waking up.
  • Protect your skin: Wear sunscreen and protective clothing when outdoors, as this medicine can make your skin more sensitive to sunlight.
  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can dangerously increase sleepiness and dizziness.
     
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How Soon It Starts Working

  • The time required for Thalix-100 Capsule to start to work: The time required for Thalix-100 Capsule to show its action is unknown.
  • The time for which the effects of Thalix-100 Capsule last: The duration of action for Thalix-100 Capsule is clinically unknown.

What if you forget to take Thalix-100 Capsule

If you miss a dose and it is less than 12 hours late, take it as soon as you remember. If it has been more than 12 hours since your scheduled time, skip the missed dose completely and take your next dose at the regular bedtime. Do not take a double dose to make up for a missed one.

Storage

•Store Thalix-100 Capsule capsules at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Do Not Share Medicine: Never share this medicine with anyone else, even if they have the same symptoms as you.
  • Use Effective Contraception: Women who can become pregnant must use two reliable methods of contraception before, during, and for the recommended period after treatment, unless they completely avoid sexual activity. Men taking Thalix-100 Capsule should use condoms during sexual activity with women who can become pregnant, even if they have had a vasectomy, and continue for the recommended period after treatment. Your healthcare provider will explain exactly how long contraception is required after your last dose.
  • Avoid Blood and Sperm Donation: Do not donate blood or sperm while taking this medicine and for the required safety period after stopping.
  • Inspect Before Use: Always inspect the blister pack before taking a capsule; do not use any capsules that are broken, cracked, or leaking.
  • Avoid Driving if Drowsy: Avoid driving or operating machinery until you know exactly how this medicine affects your alertness.
     

Drug-Drug Interactions

verifiedApollotooltip

Some medicines may affect how Thalix-100 Capsule works or increase the risk of side effects:

  • Sedative medicines: May cause extreme, dangerous drowsiness when taken with sleeping pills, strong pain relievers, anxiety medications, or muscle relaxants.
  • Nerve-damaging drugs: May increase your risk of severe tingling and numbness when combined with other medicines known to cause nerve damage.
  • Blood thinners or hormonal therapies: May increase the risk of developing dangerous blood clots in your lungs or veins.

     
ThalidomideAtezolizumab
Severe
ThalidomideIrinotecan
Severe

Drug-Drug Interactions

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ThalidomideAtezolizumab
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule with atezolizumab may increase the risk of serious side effects.

How to manage the interaction:
Taking Thalix-100 Capsule with Atezolizumab together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual symptoms, you should consult a doctor immediately. Do not stop using any medications without consulting your doctor.
ThalidomideIrinotecan
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule together with irinotecan may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalix-100 Capsule and irinotecan together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideConjugated Estrogens
Severe
How does the drug interact with Thalix-100 Capsule:
Coadministration of Thalix-100 Capsule with conjugated estrogens may increase the risk of developing blood clots.

How to manage the interaction:
Although taking Thalix-100 Capsule and conjugated estrogens can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience chest pain, shortness of breath, coughing up blood, swelling in an arm, or weakness. Do not discontinue any medications without consulting a doctor.
ThalidomideBevacizumab
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule together with bevacizumab may increase the risk of blood clots.

How to manage the interaction:
Although taking Thalix-100 Capsule and bevacizumab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideCladribine
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule together with cladribine may increase the risk of blood clots.

How to manage the interaction:
Although taking Thalix-100 Capsule and cladribine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideTofacitinib
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule with Tofacitinib may increase the risk of infection.

How to manage the interaction:
Although taking Thalix-100 Capsule and tofacitinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
ThalidomideDarbepoetin alfa
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule together with darbepoetin alfa may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Thalix-100 Capsule and Darbepoetin alfa, but it can be taken if your doctor has advised it. However, if you experience chest pain shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
ThalidomideAnastrozole
Severe
How does the drug interact with Thalix-100 Capsule:
Using Thalix-100 Capsule together with anastrozole can increase the risk of dangerous blood clots.

How to manage the interaction:
Although taking Thalix-100 Capsule with Anastrozole together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience shortness of breath, difficulty breathing, chest pain, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, contact a doctor immediately. Do not stop taking any medication without doctors advise.
ThalidomideGemcitabine
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule together with gemcitabine may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalix-100 Capsule and gemcitabine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ThalidomideAsparaginase
Severe
How does the drug interact with Thalix-100 Capsule:
Taking Thalix-100 Capsule together with asparaginase may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Thalix-100 Capsule and asparaginase together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

The following foods and drinks may affect how Thalix-100 Capsule works or increase the risk of side effects:

  • Alcohol: Avoid entirely, as it severely amplifies sleepiness, dizziness, and coordination problems.
  • High-fat meals: Taking this medicine with very high-fat food may delay how quickly your body absorbs it.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTILEPROTICS]

FAQs

Thalix-100 Capsule belongs to the group of medicines called immunomodulatory agents used to treat multiple myeloma. Thalix-100 Capsule is also used to treat and prevent symptoms of erythema nodosum leprosum (ENL) and as maintenance therapy for the prevention and suppression of erythema nodosum leprosum recurrence.
Thalix-100 Capsule stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Thereby, Thalix-100 Capsule helps treat multiple myeloma.
Do not stop taking Thalix-100 Capsule on your own. You are advised to take Thalix-100 Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. Do not hesitate to speak with your doctor if you experience any difficulties while taking Thalix-100 Capsule .
Orthostatic hypotension could be a side-effect of Thalix-100 Capsule . Orthostatic hypotension is a sudden lowering of blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.
No, it is not safe to father a child while taking Thalix-100 Capsule . Thalidomide is present in the semen of male patients taking Thalix-100 Capsule ; it could cause severe birth defects or death of the unborn baby. During sexual activity with females of reproductive potential, always use effective contraception such as latex or synthetic condom while taking Thalix-100 Capsule and for at least 4weeks after discontinuing Thalix-100 Capsule , even if you have undergone a successful vasectomy. Male patients taking Thalix-100 Capsule must not donate semen.
Patients taking Thalix-100 Capsule must not donate blood during the treatment with Thalix-100 Capsule and for 4weeks after discontinuation of Thalix-100 Capsule as the donated blood might be given to pregnant women whose foetus should not be exposed to thalidomide since it causes severe birth defects or death of the unborn baby.
People with multiple myeloma taking Thalix-100 Capsule may have an increased risk for blood clots in veins, arteries, and lungs. The risk is higher if you take dexamethasone with Thalix-100 Capsule for treating multiple myeloma. Consult your doctor immediately if you notice symptoms such as shortness of breath, chest pain, and swelling in the legs or arm.
Thalix-100 Capsule may cause side effects such as nausea, vomiting, indigestion, dizziness, heartburn, constipation, tiredness, tremor or swelling of hands and feet. If these side effects persist or worsen, please consult your doctor.
If you forget to take a dose of Thalix-100 Capsule , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one, as this may increase the risk of side effects.
No. You must not take this medicine if you are pregnant or planning a pregnancy. It causes severe, life-threatening birth defects. Talk to your doctor.
Thalix-100 Capsule commonly causes drowsiness and sleepiness. Taking it at bedtime helps you sleep through these effects and keeps you safer during the day. Talk to your doctor.
Contact your doctor immediately. Tingling or numbness can be an early sign of nerve damage, which may become permanent if not addressed quickly. Talk to your doctor.
No. You must not donate blood while taking this medicine and for some time after stopping, to prevent the drug from being given to a pregnant woman. Talk to your doctor.
No. You must swallow the capsule whole. Opening or crushing the capsule is dangerous because the powder inside can harm anyone who touches or inhales it. Talk to your doctor.
If it has been less than 12 hours, take it right away. If it has been more than 12 hours, skip it and take your next scheduled dose at bedtime. Talk to your doctor.
Men taking this medicine must use condoms during sex with women of childbearing age, as the drug can pass into semen and cause birth defects. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.6317 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A699032 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Thalidomide Pregnancy and Lactation Reference Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Thalidomide Thalidomide. 2008. [Accessed on 27 Mar. 2019]Check here
  5. Thalidomide [Prescribing Information]. 2014. [Accessed on 28 Mar. 2023]Check here
  6. Thalidomide BMS 50 mg Hard Capsules - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 10 June 2022]Check here
  7. Irene M. Ghobrial, S. Vincent Rajkumar. Management of Thalidomide Toxicity. NIH National Library of Medicine, National center for biotechnology information. Pubmedcentral. October 2003. [Accessed on 21st June 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Fresenius Kabi AG? , Else-Kröner-Straße 1 ? , 61352 Bad Homburg , Germany
Other Info - THA0004
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