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  3. THEMIBUTOL PLUS 800MG TABLET

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THEMIBUTOL PLUS 800MG TABLET, Pack of 10 TABLETS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
THEMIBUTOL PLUS 800MG TABLET is used to treat tuberculosis (TB). It contains Isoniazid and Ethambutol which work by inhibiting the growth of tuberculosis-causing bacteria. In some cases, this medicine may cause side effects such as weakness, general discomfort, fatigue, loss of appetite, nausea or vomiting, dark urine, and vision problems. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ETHAMBUTOL-800MG + ISONIAZID-300MG

Manufacturer/Marketer :

Themis Chemicals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About THEMIBUTOL PLUS 800MG TABLET

THEMIBUTOL PLUS 800MG TABLET belongs to the group of medications called ‘antituberculosis agents’ primarily used in the treatment of tuberculosis (TB). Tuberculosis is an infectious bacterial disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. THEMIBUTOL PLUS 800MG TABLET does not work against infections caused by the virus.

THEMIBUTOL PLUS 800MG TABLET contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating). Thereby, bacteria get killed without a cell wall and burst due to disruption in their metabolism.

Take THEMIBUTOL PLUS 800MG TABLET exactly as prescribed by the doctor. THEMIBUTOL PLUS 800MG TABLET may cause side effects such as weakness, malaise (general discomfort), fatigue (feeling tired), loss of appetite, nausea or vomiting, dark urine, pale stools, jaundice (yellowing of the skin or whites of the eyes) and vision problems. Inform your doctor immediately if any of these side effects persist or get worse.

It is not recommended to take THEMIBUTOL PLUS 800MG TABLET if you are allergic to any contents of it. THEMIBUTOL PLUS 800MG TABLET is not recommended for patients with severe liver problems and sight problems. Before taking THEMIBUTOL PLUS 800MG TABLET, inform your doctor if you have kidney problems, epilepsy (fits), diabetes, alcohol abuse, psychosis, malnourishment, HIV infection, and extra-pulmonary TB (TB infection outside the lungs). THEMIBUTOL PLUS 800MG TABLET should be used with caution in pregnant and breastfeeding women. Dose adjustments may be required in children and elderly people. THEMIBUTOL PLUS 800MG TABLET may interact with alcohol and increase the risk of liver damage. THEMIBUTOL PLUS 800MG TABLET may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of THEMIBUTOL PLUS 800MG TABLET

Treatment of Tuberculosis

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Directions for Use

• Take THEMIBUTOL PLUS 800MG TABLET on an empty stomach, preferably at least one hour before breakfast or a snack, or two hours after a meal, or as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow THEMIBUTOL PLUS 800MG TABLET as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

THEMIBUTOL PLUS 800MG TABLET contains Isoniazid and Ethambutol, which is a fixed-dose combination used to treat tuberculosis (TB). Combination therapy reduces the development of drug resistance (reduction in the effectiveness of medication) as the bacteria causing TB develops drug resistance easily when monotherapy is given even for shorter periods. THEMIBUTOL PLUS 800MG TABLET helps to reduce the symptoms and control the disease effectively.

How THEMIBUTOL PLUS 800MG TABLET Works

THEMIBUTOL PLUS 800MG TABLET contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating). Thereby, bacteria get killed without a cell wall and burst due to disruption in their metabolism.

Storage

Keep this medicine out of the sight and reach of children.

What if I have taken an overdose of THEMIBUTOL PLUS 800MG TABLET

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

It is advised to get your eyesight checked before taking THEMIBUTOL PLUS 800MG TABLET. If you notice any changes in your vision while using this medicine, stop taking this medicine and immediately inform your doctor. In most cases, the vision change is temporary and sight returns to normal. However, it might take a longer time for eyesight to recover in some cases or the change might be permanent. If you develop jaundice (yellowing of the skin and whites of the eyes), loss of appetite, nausea, vomiting, or malaise, inform your doctor immediately, as these effects may be a sign of hepatitis (liver disease). In these cases, the doctor may advise you to undergo liver function tests and provide the necessary treatment.

Drug-Drug Interactions

verifiedApollotooltip
IsoniazidRegorafenib
Critical
IsoniazidLomitapide
Critical

Drug-Drug Interactions

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IsoniazidRegorafenib
Critical
How does the drug interact with Themibutol Plus 800mg Tablet:
When Themibutol Plus 800mg Tablet is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Themibutol Plus 800mg Tablet is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLomitapide
Critical
How does the drug interact with Themibutol Plus 800mg Tablet:
When Lomitapide is taken with Themibutol Plus 800mg Tablet, Themibutol Plus 800mg Tablet may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Themibutol Plus 800mg Tablet with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidLovastatin
Critical
How does the drug interact with Themibutol Plus 800mg Tablet:
When Lovastatin is taken with Themibutol Plus 800mg Tablet, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Themibutol Plus 800mg Tablet with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
EthambutolMipomersen
Severe
How does the drug interact with Themibutol Plus 800mg Tablet:
Coadministration of mipomersen with Themibutol Plus 800mg Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Themibutol Plus 800mg Tablet and Mipomersen together can cause an interaction, it can be taken if your doctor has suggested it. However, contact your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting your doctor.
EthambutolTeriflunomide
Severe
How does the drug interact with Themibutol Plus 800mg Tablet:
Coadministration of Themibutol Plus 800mg Tablet with teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Themibutol Plus 800mg Tablet with Teriflunomide can result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting your doctor.
EthambutolLomitapide
Severe
How does the drug interact with Themibutol Plus 800mg Tablet:
Taking Lomitapide and Themibutol Plus 800mg Tablet together can increase the risk of liver problems.

How to manage the interaction:
Although taking Themibutol Plus 800mg Tablet and Lomitapide together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
EthambutolKetoconazole
Severe
How does the drug interact with Themibutol Plus 800mg Tablet:
Taking Ketoconazole with Themibutol Plus 800mg Tablet can increase the risk of liver problems

How to manage the interaction:
Although there is an interaction, Ketoconazole can be taken with Themibutol Plus 800mg Tablet if prescribed by the doctor. However, consult the doctor if you experience symptoms such as fever, joint pain or swelling, unusual bleeding or bruising, skin rash, nausea, vomiting, dark urine, skin or eye yellowing. Do not stop using any medications without talking to the doctor.
EthambutolLeflunomide
Severe
How does the drug interact with Themibutol Plus 800mg Tablet:
Coadministration of Themibutol Plus 800mg Tablet with Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although taking Themibutol Plus 800mg Tablet with Leflunomide can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
EthambutolVigabatrin
Severe
How does the drug interact with Themibutol Plus 800mg Tablet:
Co-administration of Vigabatrin with Themibutol Plus 800mg Tablet may increase the risk of serious side effects associated with vision loss, especially if used together for prolonged periods.

How to manage the interaction:
Co-administration of Themibutol Plus 800mg Tablet with Vigabatrin can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
IsoniazidTizanidine
Severe
How does the drug interact with Themibutol Plus 800mg Tablet:
Co-administration of Themibutol Plus 800mg Tablet may considerably enhance the blood levels of Tizanidine, which may result in side effects.

How to manage the interaction:
There may be a possibility of interaction between Tizanidine and Themibutol Plus 800mg Tablet, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience excessive drowsiness, dizziness, lightheadedness, fainting, and irregular heart rhythm. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Vitamin C-rich foods such as kiwi, broccoli, and bell pepper help improve the immune system.
  • Avoid processed and fried foods.
  • Stay hydrated. Drink plenty of fluids.
  • Warm ginger tea or warm soup can help in providing relief from cough.
  • Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, and fish such as tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

THEMIBUTOL PLUS 800MG TABLET Substitute

Substitutes safety advice
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Alcohol

Caution

Consumption of alcohol may increase the risk of side-effects and worsen the condition.

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Pregnancy

Caution

THEMIBUTOL PLUS 800MG TABLET should be used with caution in pregnant women. It is given to pregnant women only if clinically needed when the benefits outweigh the risks.

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Breast Feeding

Caution

THEMIBUTOL PLUS 800MG TABLET should be used with caution in breastfeeding mothers. It is given to breastfeeding mothers only when the benefits outweigh the risks.

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Driving

Caution

THEMIBUTOL PLUS 800MG TABLET may cause dizziness in some people. So, do not drive or operate heavy machinery if you are not fully alert.

bannner image

Liver

Caution

THEMIBUTOL PLUS 800MG TABLET is not recommended for patients with severe liver problems. In mild to moderate liver diseases, the dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

THEMIBUTOL PLUS 800MG TABLET should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

bannner image

Children

Caution

THEMIBUTOL PLUS 800MG TABLET should be used with caution in children. The dose may have to be adjusted based on age, body weight and healthy history of the child.

FAQs

THEMIBUTOL PLUS 800MG TABLET is used in the treatment of tuberculosis (TB).

THEMIBUTOL PLUS 800MG TABLET contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating, which is necessary for bacteria's survival).

It is advised to take THEMIBUTOL PLUS 800MG TABLET on an empty stomach. So, you should take this medicine at least 30 minutes before a meal or after 2 hours of taking a meal for better absorption.

You are recommended to avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, fish such as tuna, salmon and mackerel, wine and beer as they may interact with THEMIBUTOL PLUS 800MG TABLET and cause adverse effects such as sweating, headache, dizziness, flushing (reddening of the skin) and uneven heartbeat.

THEMIBUTOL PLUS 800MG TABLET may cause side-effects such as weakness, malaise (general discomfort), fatigue (feeling tired), loss of appetite, nausea or vomiting, dark urine, pale stools, jaundice (yellowing of the skin or whites of the eyes) and vision problems. Inform your doctor immediately if any of these side-effects persist or get worse.

THEMIBUTOL PLUS 800MG TABLET may affect liver function, so it is not prescribed in patients with severe liver problems and alcohol abuse unless clinically needed. Also, do not consume excessive amounts of alcohol while using THEMIBUTOL PLUS 800MG TABLET as it may increase the risk of liver damage.

Yes, ethambutol in THEMIBUTOL PLUS 800MG TABLET may rarely cause vision problems like blurred/decreased vision, color blindness. Consult your doctor immediately if there is a problem in vision.

Yes, THEMIBUTOL PLUS 800MG TABLET can affect the action of birth control pills. THEMIBUTOL PLUS 800MG TABLET contains isoniazid and ethambutol, which can increase the breakdown of hormones in birth control pills, making them less effective. This could potentially result in an unwanted pregnancy. Please discuss with your doctor if you have any concerns.

No, do not stop taking THEMIBUTOL PLUS 800MG TABLET even if you feel better as it can result in the infection not being fully treated and potentially developing drug resistance. Therefore, complete the full course of treatment as prescribed by your doctor.

Yes, THEMIBUTOL PLUS 800MG TABLET can cause urine discolouration. As THEMIBUTOL PLUS 800MG TABLET contains isoniazid and ethambutol, which can lead to dark-coloured urine as a common but non-harmful side effect. If the discolouration persists, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.
Other Info - THE0006

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 18, 2025 | 6:48 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.9139.pdf
  2. https://www.medicines.org.uk/emc/files/pil.5310.pdf

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