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compositionComposition:EPHEDRINE-30MG
prescription
Prescription Medicine
info
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Themidrine 30 mg Injection 1 ml is used to treat low blood pressure. It contains Ephedrine which works by temporarily reducing the blood supply to small blood vessels. This medicine may sometimes cause side effects such as nausea, vomiting, headache, weakness, restlessness, and confusion. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EPHEDRINE-30MG

Manufacturer/Marketer :

Themis Pharmaceutical Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Themidrine 30 mg Injection 1 ml

Themidrine 30 mg Injection 1 ml is a prescription injection used to treat low blood pressure (hypotension), especially during surgery or after spinal or general anesthesia. It works by narrowing blood vessels and increasing the force and rate of the heartbeat, helping restore blood pressure and maintain adequate blood flow to vital organs. Themidrine 30 mg Injection 1 ml is given only by trained healthcare professionals in hospitals or emergency settings.

Because Themidrine 30 mg Injection 1 ml is used during surgical procedures or medical emergencies, it is administered as an injection by a healthcare provider and is not intended for self-use. The dose is carefully adjusted according to your blood pressure and clinical condition. Before surgery, follow your doctor's instructions regarding fasting and other preparations to help ensure a safe procedure and recovery.

Common side effects of Themidrine 30 mg Injection 1 ml include a fast heartbeat, headache, nervousness, anxiety, nausea, or increased blood pressure. These effects are usually temporary, but seek immediate medical attention if you experience severe chest pain, difficulty breathing, irregular heartbeat, severe headache, or signs of an allergic reaction.

Before receiving Themidrine 30 mg Injection 1 ml, tell your doctor if you have heart disease, high blood pressure, thyroid disorders, diabetes, glaucoma, or a history of irregular heart rhythms. Do not receive Themidrine 30 mg Injection 1 ml if you are allergic to Themidrine 30 mg Injection 1 ml or if your doctor determines that certain serious heart conditions make its use unsafe. Your healthcare team will evaluate your medical history to ensure Themidrine 30 mg Injection 1 ml is appropriate for you.

Themidrine 30 mg Injection 1 ml may interact with certain antidepressants, including monoamine oxidase inhibitors (MAOIs), blood pressure medicines, and other stimulant medicines, which may increase the risk of serious side effects. Be sure to inform your doctor about all prescription medicines, over-the-counter medicines, and herbal supplements you are taking. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, your healthcare provider will carefully assess the benefits and risks before administering Themidrine 30 mg Injection 1 ml.

Uses of Themidrine 30 mg Injection 1 ml

Themidrine 30 mg Injection 1 ml is used in the treatment of hypotension (low blood pressure). The detailed uses of Themidrine 30 mg Injection 1 ml are as follows:

  • Low blood pressure during anesthesia (Hypotension): An Themidrine 30 mg Injection 1 ml injection like Themidrine 30 mg Injection 1 ml is highly effective at raising blood pressure back to a safe level when it drops during spinal or general anesthesia.
  • Support for heart rate: In specific clinical situations, it helps support a slow heart rate, ensuring adequate blood circulation throughout the body during medical procedures.
     

Key Benefits

Themidrine 30 mg Injection 1 ml helps rapidly increase blood pressure in situations where it falls dangerously low, supporting blood flow to vital organs. By restoring adequate circulation, it helps maintain stability during surgery and other medical emergencies.

Benefits may include:

  • Helps rapidly increase low blood pressure during surgery or other medical emergencies.
  • Supports blood flow to vital organs such as the brain, heart, and kidneys.
  • Helps reduce symptoms associated with sudden low blood pressure, including dizziness, weakness, and nausea.
  • Promotes stable circulation during anesthesia and surgical procedures.
  • Supports safer management of low blood pressure under close medical supervision.
  • Helps protect vital organs by restoring adequate oxygen-rich blood flow.
     
Side effects of Themidrine 30 mg Injection 1 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Themidrine 30 mg Injection 1 ml will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Themidrine 30 mg Injection 1 ml Works

Themidrine 30 mg Injection 1 ml works by increasing the activity of natural stress chemicals (mainly norepinephrine) in your body and by stimulating alpha and beta receptors in your heart and blood vessels. This helps tighten blood vessels and strengthen the heart's pumping action, allowing blood pressure to rise quickly when it drops during anesthesia. In some parts of the body, beta receptor stimulation may slightly relax certain blood vessels, but the overall effect is an increase in blood pressure and improved blood flow to vital organs. Repeated doses may become less effective over time (tachyphylaxis), so your healthcare team may adjust treatment if needed.
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Alcohol

Caution

The interaction of Themidrine 30 mg Injection 1 ml with alcohol is unknown. Please consult a doctor before consuming alcohol while using Themidrine 30 mg Injection 1 ml.

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Pregnancy

Caution

Themidrine 30 mg Injection 1 ml is a category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

Themidrine 30 mg Injection 1 ml is given to breastfeeding women only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Drive only if you are alert after taking Themidrine 30 mg Injection 1 ml. However, Themidrine 30 mg Injection 1 ml is generally given for hospitalised patients.

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Liver

Caution

Themidrine 30 mg Injection 1 ml should be given with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Themidrine 30 mg Injection 1 ml should be given with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Themidrine 30 mg Injection 1 ml is not recommended for children as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Themidrine 30 mg Injection 1 ml. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Themidrine 30 mg Injection 1 ml in elderly patients. Please consult your doctor.

What if I have taken an overdose of Themidrine 30 mg Injection 1 ml

Themidrine 30 mg Injection 1 ml is carefully measured and injected under strict medical supervision, making an overdose highly unlikely. In the rare event of an overdose, your medical team is fully equipped to recognize the symptoms immediately and provide the necessary supportive care.

Diet & Lifestyle Advise

  • Follow fasting guidelines: Adhere strictly to the fasting instructions given by your surgical team before your procedure to prevent stomach complications during anesthesia.
  • Stay hydrated post-surgery: Once your doctor confirms it is safe to drink fluids, ensure you hydrate well to help maintain steady blood pressure during your recovery.
  • Change positions slowly: When allowed to get out of bed, sit up and stand up slowly to avoid temporary dizziness or lightheadedness as your body adapts.
  • Prioritize rest: Allow your body ample time to rest and recover in the days following anesthesia to let your cardiovascular system stabilize fully.
     
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How Soon It Starts Working

The time required for Themidrine 30 mg Injection 1 ml to start to work: Themidrine 30 mg Injection 1 ml ideally shows its action within 10 to 20 minutes after administration. The time for which the effects of Themidrine 30 mg Injection 1 ml last: The effect of Themidrine 30 mg Injection 1 ml lasts for 60 minutes.

What if you forget to take Themidrine 30 mg Injection 1 ml

Since Themidrine 30 mg Injection 1 ml is injected by a healthcare professional in a hospital setting during a surgical procedure, it is not possible for you to miss a dose.

Storage

• Themidrine 30 mg Injection 1 ml should be kept at a controlled room temperature between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution before administration: Your healthcare provider should ensure the solution is completely clear and colorless before use. Do not use it if it appears cloudy, discolored, or contains visible particles.
  • Report injection site discomfort immediately: Tell your medical team at once if you experience burning, coldness, pain, or swelling around the injection site during administration.
  • Expect close monitoring during treatment: Your heart rate, blood pressure, and oxygen levels will be monitored continuously while you receive Themidrine 30 mg Injection 1 ml to ensure it is administered safely.
  • Discuss your medical history with your doctor: Inform your healthcare provider if you have a history of glaucoma before receiving Themidrine 30 mg Injection 1 ml, as it may temporarily increase pressure inside the eye.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine oxidase inhibitors (MAOIs): Do not use Themidrine 30 mg Injection 1 ml if you have taken an MAOI within the past 14 days, as this combination may cause a sudden and dangerous increase in blood pressure.
  • Beta-blockers: These medicines may reduce the blood pressure-raising effects of Themidrine 30 mg Injection 1 ml and may affect your heart rate.
  • Inhaled anesthetics: Certain anesthetic gases used during surgery may increase the risk of irregular heartbeats when used with Themidrine 30 mg Injection 1 ml.
     
EphedrineMethylene blue
Critical
EphedrineTranylcypromine
Critical

Drug-Drug Interactions

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EphedrineMethylene blue
Critical
How does the drug interact with Themidrine 30 mg Injection 1 ml:
When Themidrine 30 mg Injection 1 ml and Methylene blue are combined, there is an increase in the risk or severity of high blood pressure.

How to manage the interaction:
Taking Themidrine 30 mg Injection 1 ml and Methylene blue is not recommended as it can result in an interaction, it can be taken if a doctor has prescribed it. However, if you develop a sudden, severe headache, blurred vision, disorientation, seizures, chest pain, nausea, or vomiting, sudden numbness or weakness (particularly on one side of the body), difficulty speaking, fever, sweating, lightheadedness, or fainting, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
EphedrineTranylcypromine
Critical
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Taking Tranylcypromine with Themidrine 30 mg Injection 1 ml can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine with Themidrine 30 mg Injection 1 ml is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea, or vomiting, sudden numbness or weakness (particularly on one side of the body), trouble speaking, fever, sweating, lightheadedness, and/or fainting, consult the doctor. Do not discontinue any medications without a doctor's advice.
EphedrineDihydroergotamine
Critical
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Co-administration of Dihydroergotamine may increase the high blood pressure and blood vessel narrowing effects of Themidrine 30 mg Injection 1 ml.

How to manage the interaction:
Combining Themidrine 30 mg Injection 1 ml with Dihydroergotamine is not recommended as it can result in an interaction, but it can be taken if a doctor has prescribed it. However, if you experience symptoms like severe stomach pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, breathing difficulty, blurred vision, confusion, slurred speech, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
EphedrineProcarbazine
Critical
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Taking Themidrine 30 mg Injection 1 ml and Procarbazine together can increase the risk of high blood pressure.

How to manage the interaction:
Taking Themidrine 30 mg Injection 1 ml and Procarbazine together is not recommended as it can result in an interaction, it can be taken if a doctor has prescribed it. However, if you develop a sudden, severe headache, blurred vision, disorientation, seizures, chest pain, nausea, or vomiting, sudden numbness or weakness (particularly on one side of the body), difficulty speaking, fever, sweating, lightheadedness, or fainting, you should consult the doctor. Do not discontinue any medications without a doctor's advice.
EphedrinePhenelzine
Critical
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Co-administration of Phenelzine with Themidrine 30 mg Injection 1 ml can increase the risk of high blood pressure.

How to manage the interaction:
Although taking Themidrine 30 mg Injection 1 ml and Phenelzine together is not recommended as it can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience symptoms like very high blood pressure, a sudden and severe headache, blurry vision, confusion, seizures(fits), chest pain, nausea, vomiting, sudden numbness or weakness, trouble speaking, fever, sweating, feeling dizzy, or fainting, consult the doctor. It is important to maintain your blood pressure. Do not discontinue any medications without consulting a doctor.
EphedrineSibutramine
Critical
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Co-administration of Sibutramine can intensify the effects of Themidrine 30 mg Injection 1 ml, and it may also have undesirable effects like anxiety, nervousness, restlessness, and racing thoughts.

How to manage the interaction:
Taking Themidrine 30 mg Injection 1 ml with Sibutramine is not recommended, it can be taken if your doctor has advised it. However, if you experience hallucinations, seizures, abnormal blood pressure changes, a fast heart rate, fever, increased sweating, blurred vision, muscle pain or stiffness, tremors, pain in the stomach, nausea, vomiting, and diarrhoea, consult the doctor. Do not discontinue any medications without a doctor's advice.
EphedrineAmitriptyline
Severe
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Co-administration of Amitriptyline with Themidrine 30 mg Injection 1 ml can increase the levels of Themidrine 30 mg Injection 1 ml which may lead to side effects.

How to manage the interaction:
Although taking Amitriptyline and Themidrine 30 mg Injection 1 ml simultaneously can interact, you can do so if your doctor has prescribed it. Regular monitoring of blood pressure is advised. Do not discontinue any medications without a doctor's advice.
EphedrineClomipramine
Severe
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Taking Themidrine 30 mg Injection 1 ml with Clomipramine can increase the risk of side effects.

How to manage the interaction:
Although taking clomipramine and Themidrine 30 mg Injection 1 ml together can cause an interaction, it can be taken if a doctor has suggested it. It is important to maintain your blood pressure while using these medications. Do not discontinue any medications without consulting a doctor.
EphedrineAmoxapine
Severe
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Co-administration of Amitriptyline with Themidrine 30 mg Injection 1 ml can enhance the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Themidrine 30 mg Injection 1 ml and Amoxapine, you can take these medicines together if prescribed by a doctor. It's important to maintain your blood pressure. Do not stop using any medications without a doctor's advice.
EphedrineProtriptyline
Severe
How does the drug interact with Themidrine 30 mg Injection 1 ml:
Co-administration of Protriptyline with Themidrine 30 mg Injection 1 ml can increase the risk of side effects.

How to manage the interaction:
Taking Themidrine 30 mg Injection 1 ml with Protriptyline can result in an interaction, but it can be taken if a doctor has advised it. It's important to maintain your blood pressure. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Themidrine 30 mg Injection 1 ml when used as directed.     
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIHYPOTENSIVES]

FAQs

Themidrine 30 mg Injection 1 ml is used to relieve low blood pressure during spinal or epidural anaesthesia.
Themidrine 30 mg Injection 1 ml works by raising blood pressure by temporarily reducing the blood supply to small blood vessels.
Themidrine 30 mg Injection 1 ml should be used with caution in patients suffering from heart rhythm disorders as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you have any heart problems before taking Themidrine 30 mg Injection 1 ml so that the dose may be adjusted appropriately or an alternate medicine may be prescribed.
You are recommended not to take Themidrine 30 mg Injection 1 ml if you have diabetes as it may increase blood sugar levels. Therefore, it is advised to inform your doctor if you have diabetes before taking Themidrine 30 mg Injection 1 ml.
Themidrine 30 mg Injection 1 ml may cause a headache as a temporary side effect. However, if the condition persists or worsens, please consult a doctor.
It is given as an injection directly into a vein by a trained healthcare professional, such as an anesthesiologist, in a hospital or clinic setting. Talk to your doctor for more details.
Yes, a temporary increase in heart rate is a common effect of Themidrine 30 mg Injection 1 ml. Your medical team will monitor your heart rate closely during the procedure. Talk to your doctor if you have a history of heart issues.
Yes. Themidrine 30 mg Injection 1 ml has been used for many years to treat low blood pressure during spinal anesthesia in labor and delivery when needed. Your healthcare team will carefully assess your condition and choose the safest medicine for you and your baby.
Because it is injected directly into a vein, it works almost instantly to raise your blood pressure and stabilize your heart. Talk to your doctor to understand how your vital signs will be monitored.
It is used with caution in individuals with high blood pressure, as it temporarily raises blood pressure further. Your surgical team will evaluate your health before giving it. Talk to your doctor about your complete medical history.
Dizziness can happen as the anesthesia and medications wear off. Let your nurse or doctor know immediately so they can check your blood pressure and ensure you are recovering safely. Talk to your doctor if the dizziness continues.
While Themidrine 30 mg Injection 1 ml itself does not interact directly with food, you will likely need to fast before surgery due to the anesthesia. Always follow the specific fasting instructions given by your medical team. Talk to your doctor for exact pre-surgery guidelines.

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Reference

  1. Drugs.com Clinical Review Team. Ephedrine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 208289S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 18 Mar. 2019]Check here
  4. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Efipres Injection
  5. Westfall TC, WestfallIn DP Adrenergic Agonists and Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011

Country of origin

India

Manufacturer/Marketer address

The-Themis Pharmaceuticals
Other Info - THE0483
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