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Thiokem-D Injection is used to treat acute musculoskeletal pain and muscle spasms. It contains Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) with analgesic properties. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the spinal cord and brain centres. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Thiokem-D Injection

Thiokem-D Injection is a prescription medicine given as an injection to treat painful muscle spasms associated with various bone, joint, and spinal conditions. It helps relieve intense localised pain, swelling, and muscle stiffness, allowing patients to regain basic mobility. This injection is typically prescribed for acute, short-term relief when rapid action is needed or when oral medicines are not suitable.

Because this medication is administered as an injection, your doctor will determine the frequency and consistency of your treatment schedule. The injection bypasses the digestive system, meaning it can be given with or without food, though staying well-hydrated is highly recommended during your therapy. Making simple daily adjustments, such as resting the affected muscle group and performing very gentle, doctor-approved movements, can significantly improve your recovery outcomes.

While using Thiokem-D Injection, you may experience mild, temporary side effects like pain or redness at the injection site, mild nausea, or drowsiness. However, you must contact your doctor immediately if you experience serious symptoms, such as severe abdominal pain, dark or tarry stools, or signs of an allergic reaction. Your healthcare team is trained to monitor and manage these responses safely.

Do not take this if you have active stomach ulcers, a history of asthma attacks triggered by painkillers, severe liver or kidney disease, or certain serious heart or blood vessel conditions unless your doctor specifically advises otherwise. Diclofenac-containing medicines may increase the risk of heart attack or stroke, particularly with prolonged use or in people with pre-existing cardiovascular disease. It is also not suitable for individuals with a history of seizures or those who are pregnant or breastfeeding. Always share your complete medical history with your healthcare provider before starting this treatment to ensure it is safe for you.

This injection can interact with blood thinners, other anti-inflammatory pain medicines, and certain blood pressure medications, which may increase the risk of stomach bleeding or kidney strain. You should strictly avoid alcohol while on this medication as it can worsen drowsiness and increase the risk of stomach irritation. Elderly patients should be monitored closely, as they may be more sensitive to the side effects of this medicine.

Uses of Thiokem-D Injection

Thiokem-D Injection is used in the treatment of painful muscle spasms associated with various bone, joint, and spinal conditions. The detailed uses of Thiokem-D Injection are as follows:

  • Acute lower back pain: Thiokem-D Injection helps by rapidly reducing severe muscle spasms and the localised inflammation that causes your lower back to lock up.
  • Muscle spasms from spinal disorders: It targets painful, involuntary muscle contractions associated with conditions like degenerative disc disease or cervical spondylosis.
  • Post-operative muscle pain: It provides effective relief from acute muscle tightness and pain following orthopaedic surgeries, helping you start your rehabilitation sooner.
  • Injury-related muscle spasms: It treats severe muscle tightness and spasm caused by sudden sprains, strains, or direct muscle injuries.

Key Benefits

Thiokem-D Injection helps relieve painful muscle spasms, improving comfort and mobility. The following are the benefits of this medication:

  • Provides rapid relief from pain and muscle spasms, especially when administered by injection.
  • Helps reduce inflammation and swelling associated with muscle or joint injuries.
  • Relaxes tight muscles, making movement easier and more comfortable.
  • Restores mobility by improving flexibility and range of motion.
  • Supports recovery by making everyday activities and physical therapy or rehabilitation exercises easier to perform.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • Thiokem-D Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Thiokem-D Injection Works

Thiokem-D Injection works through the combined action of two distinct components that target pain and muscle stiffness through different pathways in the body. Diclofenac: It is a non-steroidal anti-inflammatory drug (NSAID) that blocks the action of specific chemical messengers called prostaglandins. These messengers are responsible for causing pain, heat, and swelling at the site of injury or muscle strain. By reducing prostaglandin production, this component quickly calms inflammation and relieves pain. Thiocolchicoside: It is a muscle-relaxing agent that acts through both the central and peripheral nervous systems. It primarily interacts with certain receptors (GABA-A and glycine) in the brain and spinal cord that are involved in regulating muscle tone, helping reduce excessive muscle contractions and relieve painful spasms. Its actions on the brain, spinal cord, and peripheral tissues help relax tight muscles without significantly reducing normal muscle strength. Together, these two components offer a highly effective dual-action approach to pain relief and improved movement.
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Alcohol

Caution

Please seek medical advice if you have a regular alcohol intake habit before taking Thiokem-D Injection

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Pregnancy

Unsafe

Thiokem-D Injection is not recommended during pregnancy as it may harm your developing baby. Please consult your doctor for more information.

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Breast Feeding

Unsafe

Thiokem-D Injection is not recommended during breastfeeding as it may be excreted in breast milk. Please consult your doctor for more information.

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Driving

Caution

Thiokem-D Injection may make you feel dizzy and sleepy. Do not drive or operate machinery if you experience dizziness or drowsiness after taking Thiokem-D Injection.

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Liver

Caution

Thiokem-D Injection should be used cautiously in patients with liver impairment/liver disease. If you have liver disease, please inform your doctor before receiving this medicine.

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Kidney

Caution

Thiokem-D Injection should be used cautiously in patients with kidney impairment/liver disease. If you have kidney disease, please inform your doctor before receiving this medicine.

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Children

Unsafe

Thiokem-D Injection is not recommended for use in children as the safety and efficacy data are not established. Please seek medical advice for more information.

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Heart

Caution

Thiokem-D Injection should be used cautiously in heart patients due to risks like increased blood pressure and fluid retention. Always consult your doctor before use to avoid cardiovascular complications.

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Geriatrics

Caution

Geriatric patients may receive Thiokem-D Injection, but only with caution due to higher risk of gastrointestinal, kidney, and heart side effects. Close medical supervision is essential to ensure safe use.

What if I have taken an overdose of Thiokem-D Injection

If you suspect an overdose, or if you experience severe symptoms such as extreme drowsiness, shallow breathing, severe vomiting, or fainting after an injection, seek emergency medical help immediately. Bring the medicine packaging with you to show the medical team.

Diet & Lifestyle Advise

  • Drink plenty of water: Proper hydration is essential for muscle health and helps prevent dehydration-induced muscle cramps and spasms.
  • Apply heat or cold: Use an ice pack for the first 48 hours to reduce swelling, then switch to a warm compress to relax tight muscle fibres.
  • Incorporate magnesium-rich foods: Eat foods like spinach, almonds, pumpkin seeds, and avocados, which naturally support healthy muscle relaxation and nerve function.
  • Practice gentle stretching: Once the acute pain begins to subside, perform light, doctor-approved stretches to maintain flexibility and prevent the muscles from shortening or tightening again.
  • Mind your posture: Maintain proper spinal alignment when sitting, standing, or lifting heavy objects to avoid placing unnecessary stress on recovering muscles.
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How Soon It Starts Working

The time required for Thiokem-D Injection to start to work: The time required for Thiokem-D Injection to show its action is unknown. The time for which the effects of Thiokem-D Injection last: The duration of action for Thiokem-D Injection is unknown.

What if you forget to take Thiokem-D Injection

If you miss a scheduled injection at a clinic, contact your healthcare provider immediately to reschedule. If you are administering the medication at home and miss a dose, inject it as soon as you remember. However, if it is almost time for your next scheduled injection, skip the missed dose and return to your regular schedule. Do not double the dose to catch up.

Storage

• Store Thiokem-D Injection ampoules or vials at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect before injecting: Always check the liquid inside the vial or ampoule before use. If you see cloudiness, floating particles, or a change in colour, discard it immediately.
  • Practice safe needle hygiene: Always use a sterile syringe and needle for every injection, and discard them immediately after use in a puncture-proof sharps container.
  • Do not drive: This medicine can make you feel dizzy or sleepy. Avoid driving, operating machinery, or performing tasks that require mental alertness until you know how this injection affects you.
  • Monitor your skin: If you notice any sudden skin rashes, peeling, or blisters developing after the injection, stop the medication and seek medical care immediately.
  • Keep treatment short: This medication is meant for short-term relief. Prolonged use can increase your risk of stomach ulcers, bleeding, or heart complications.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (e.g., warfarin): Combining these medicines can significantly increase your risk of stomach bleeding and bruising.
  • Other pain relievers (e.g., ibuprofen, naproxen): Taking this medicine alongside other oral painkillers can increase the risk of stomach ulcers and kidney damage.
  • Blood pressure medicines (e.g., enalapril, furosemide): This injection may reduce their ability to lower blood pressure and increase the risk of kidney strain.
  • Medicines that lower the seizure threshold (e.g., tramadol, bupropion): Combining these medicines can increase the risk of experiencing seizures.

Drug-Drug Interactions

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How does the drug interact with Thiokem-D Injection:
Co-administration of Meloxicam with Thiokem-D Injection can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Thiokem-D Injection is avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult your doctor immediately if you experience dizziness, tarry stools, coughing up or vomiting blood, headache, or weakness. Do not stop any medication without a doctor's advice.
How does the drug interact with Thiokem-D Injection:
Co-administration use of Flurbiprofen with Thiokem-D Injection may increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
There is a possibility of interaction of Flurbiprofen with Thiokem-D Injection but they can be taken if your doctor has prescribed them. Consult your doctor immediately if you experience tarry stools, coughing or vomiting blood, acidity, severe headache, or weakness. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Thiokem-D Injection:
Coadministration of Cidofovir with Thiokem-D Injection may increase the risk of developing kidney problems.

How to manage the interaction:
Although taking Cidofovir with Thiokem-D Injection can possibly result in an interaction, it can be taken when your doctor has suggested it. If you experience vomiting, increased or decreased urination, sudden weight gain or loss, swelling, muscle cramps, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Thiokem-D Injection:
Taking Panobinostat with Thiokem-D Injection can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction of Panobinostat with Thiokem-D Injection, but they can be taken if your doctor has prescribed them. Consult your doctor immediately if you experience any tarry stools, coughing or vomiting blood, or weakness. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Thiokem-D Injection:
Coadministration of Fondaparinux with Thiokem-D Injection may increase the risk of bleeding.

How to manage the interaction:
There may be a possible interaction of Fondaparinux with Thiokem-D Injection, but they can be taken if your doctor has prescribed them. Contact a doctor if you experience unusual bleeding, black or red stools, weakness, headache, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Thiokem-D Injection:
Co-administration of Celecoxib with Thiokem-D Injection may increase the risk of stomach bleeding and developing ulcers.

How to manage the interaction:
Although there is an interaction of Celecoxib with Thiokem-D Injection, it can be taken if your doctor has advised it. Consult a doctor if you experience black stools, severe bruising, prolonged nosebleeds, vomiting or coughing up blood, heavy menstrual bleeding (in women), weakness, or headache. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Thiokem-D Injection:
Co-administration of Apixaban with Thiokem-D Injection may increase the risk of stomach bleeding.

How to manage the interaction:
Although there is an interaction of Apixaban with Thiokem-D Injection, it can be taken if your doctor has advised it. Consult a doctor if you experience black stools, severe bruising, weakness, headache, vomiting or coughing up blood, or heavy menstrual bleeding (in women). Do not discontinue any medication without consulting a doctor.
How does the drug interact with Thiokem-D Injection:
Taking Dasatinib with Thiokem-D Injection may increase the risk of unusual bleeding.

How to manage the interaction:
There may be a possible interaction of Dasatinib with Thiokem-D Injection and can be taken if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding, tarry stools, coughing up or vomiting blood, or weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Thiokem-D Injection:
Taking Ponatinib with Thiokem-D Injection can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction of Ponatinib with Thiokem-D Injection, but they can be taken if a doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding, tarry stools, coughing or vomiting blood, or severe headaches. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Thiokem-D Injection:
Co-administration of Mipomersen with Thiokem-D Injection may cause liver problems.

How to manage the interaction:
Co-administration of Mipomersen with Thiokem-D Injection can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any fever, chills, joint pain, unusual bleeding, loss of hunger, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol during your treatment, as it can worsen drowsiness, increase coordination issues, and greatly elevate the risk of stomach bleeding.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MUSCLE RELAXANTS, ANTI- INFLAMMATORY AGENTS]

FAQs

Thiokem-D Injection is used to treat Acute musculoskeletal pain and muscle spasms.
Thiokem-D Injection contains Diclofenac and Thiocolchicoside. Diclofenac works by blocking the action of certain chemical messengers that cause pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant which relieves muscle stiffness due to muscle spasms and improves muscle movements.
Diarrhoea can be a side-effect of Thiokem-D Injection. Drink enough fluids and eat fibre-rich food if you experience diarrhoea. If you find blood in the stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.
You are not recommended to take Thiokem-D Injection with warfarin as simultaneous use of these two medicines may increase the effect of anti-coagulants/blood thinners and cause bleeding risk. Please seek medical advice for more information.
Yes. Since Thiokem-D Injection is given as an injection, food does not affect how the medicine is absorbed. However, if you tend to experience nausea or stomach discomfort, your doctor may advise having a light meal beforehand. Follow your doctor's advice based on your condition.
Thiokem-D Injection is designed for short-term, acute relief and is typically used for only a few consecutive days. Prolonged use is not recommended due to an increased risk of side effects like stomach irritation, bleeding, or kidney issues. Talk to your doctor about the appropriate duration of your treatment.
It is safest to avoid driving or operating machinery immediately after receiving this injection. Thiokem-D Injection can cause drowsiness, dizziness, or lightheadedness in some individuals, which can impair your reaction times. Talk to your doctor to understand how this medicine affects you before attempting to drive.
No. Thiokem-D Injection is generally not recommended during pregnancy, especially during the third trimester, as it may harm the developing baby or cause complications during delivery. If you are pregnant or planning to become pregnant, talk to your doctor before using this medicine. Your doctor can recommend a safer alternative if needed.
Drinking alcohol while receiving Thiokem-D Injection can cause severe drowsiness, dizziness, and coordination problems. It also significantly increases the risk of developing serious stomach ulcers or internal bleeding. Talk to your doctor if you have concerns about avoiding alcohol during your therapy.
Mild pain, redness, or swelling at the injection site is common and usually resolves within a couple of days. Applying a cold pack wrapped in a cloth to the area for 10-15 minutes can help. However, if the pain worsens, or if you notice warmth, pus, or run a fever, seek medical attention immediately. Talk to your doctor if symptoms persist.
You should avoid taking any other over-the-counter or prescription painkillers, especially other non-steroidal anti-inflammatory drugs (NSAIDs), while receiving Thiokem-D Injection unless your doctor advises otherwise. Taking multiple NSAIDs together can significantly increase the risk of stomach irritation, ulcers, bleeding, and kidney problems. If you need additional pain relief or are already taking another painkiller, talk to your doctor before combining medications.

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Country of origin

India
Other Info - TH97722
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