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Thiole D 2mg/37.5mg Injection is used to treat acute musculoskeletal pain and muscle spasms. It contains Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) with analgesic properties. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the spinal cord and brain centres. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Zodley Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Thiole D 2mg/37.5mg Injection

Thiole D 2mg/37.5mg Injection is a combination medication primarily used to treat acute musculoskeletal pain and muscle spasms. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Thiole D 2mg/37.5mg Injection is a combination of Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) with analgesic properties. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.

A healthcare professional will administer this medicine. Common side effects of Thiole D 2mg/37.5mg Injection include headache, stomach upset, constipation, dizziness, drowsiness, diarrhoea, pain, swelling, and redness at the injection site. These side effects are not familiar to everyone and vary individually. However, if the side effects are persistent, please consult your doctor.

Before starting Thiole D 2mg/37.5mg Injection, inform your doctor if you have any liver, heart or kidney diseases, high blood pressure, diabetes, stomach ulcers, asthma, and auto-immune conditions like systemic lupus erythematosus. Pregnant and breastfeeding women should consult their doctor before using Thiole D 2mg/37.5mg Injection. Avoid consuming alcohol while undergoing treatment with Thiole D 2mg/37.5mg Injection. This medicine is not recommended for children and adolescents below 18 years of age as safety has not been established. However, please seek medical advice.

Uses of Thiole D 2mg/37.5mg Injection

Thiole D 2mg/37.5mg Injection is used in the treatment of Acute musculoskeletal pain and muscle spasms. The detailed uses of Thiole D 2mg/37.5mg Injection are as follows:

  • Relieve acute musculoskeletal pain and inflammation: Thiole D 2mg/37.5mg Injection combines Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), with Thiocolchicoside, a muscle relaxant. Together, they reduce pain, swelling, and stiffness in conditions like low back pain, neck pain, and sprains.
  • Treat painful muscle spasms: Thiole D 2mg/37.5mg Injection acts on the central nervous system to relax muscles and ease spasms, while Diclofenac targets the underlying inflammation.

Key Benefits

Thiole D 2mg/37.5mg Injection treats acute musculoskeletal pain and muscle spasms. It contains Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and relieves pain. It inhibits cyclo-oxygenase (COX) enzymes that further prevent the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • Thiole D 2mg/37.5mg Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Thiole D 2mg/37.5mg Injection Works

Thiole D 2mg/37.5mg Injection is a combination of Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) with analgesic properties. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This process helps reduce muscle stiffness and improves muscle movements, thus relieving pain due to muscle spasms.
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Alcohol

Caution

Please seek medical advice if you have a regular alcohol intake habit before taking Thiole D 2mg/37.5mg Injection

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Pregnancy

Unsafe

Thiole D 2mg/37.5mg Injection is not recommended during pregnancy as it may harm your developing baby. Please consult your doctor for more information.

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Breast Feeding

Unsafe

Thiole D 2mg/37.5mg Injection is not recommended during breastfeeding as it may be excreted in breast milk. Please consult your doctor for more information.

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Driving

Caution

Thiole D 2mg/37.5mg Injection may make you feel dizzy and sleepy. Do not drive or operate machinery if you experience dizziness or drowsiness after taking Thiole D 2mg/37.5mg Injection.

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Liver

Caution

Thiole D 2mg/37.5mg Injection should be used cautiously in patients with liver impairment/liver disease. If you have liver disease, please inform your doctor before receiving this medicine.

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Kidney

Caution

Thiole D 2mg/37.5mg Injection should be used cautiously in patients with kidney impairment/liver disease. If you have kidney disease, please inform your doctor before receiving this medicine.

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Children

Unsafe

Thiole D 2mg/37.5mg Injection is not recommended for use in children as the safety and efficacy data are not established. Please seek medical advice for more information.

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Heart

Caution

Thiole D 2mg/37.5mg Injection should be used cautiously in heart patients due to risks like increased blood pressure and fluid retention. Always consult your doctor before use to avoid cardiovascular complications.

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Geriatrics

Caution

Geriatric patients may receive Thiole D 2mg/37.5mg Injection, but only with caution due to higher risk of gastrointestinal, kidney, and heart side effects. Close medical supervision is essential to ensure safe use.

What if I have taken an overdose of Thiole D 2mg/37.5mg Injection

As Thiole D 2mg/37.5mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching, reducing spasm, tear and sprain incidence. Mild exercises, such as jogging and walking, are helpful for muscle stretching.
  • Massages can also be helpful to ease the pain.
  • Avoid wearing tight-fitting clothes; wear loose garments for proper blood circulation.
  • Rest well and get plenty of sleep.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice or hot pack on the muscle for 15-20 minutes.
  • Stay hydrated; drink plenty of water.

Have a query?

How Soon It Starts Working

The time required for Thiole D 2mg/37.5mg Injection to start to work: The time required for Thiole D 2mg/37.5mg Injection to show its action is unknown. The time for which the effects of Thiole D 2mg/37.5mg Injection last: The duration of action for Thiole D 2mg/37.5mg Injection is unknown.

What if you forget to take Thiole D 2mg/37.5mg Injection

As this medicine will be administered by a healthcare professional, the chances of missing a dose are less. However, consult your doctor if you have any concerns.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Inform your doctor if you have any liver, heart or kidney diseases, high blood pressure, diabetes, stomach ulcers, gastrointestinal diseases, asthma, and autoimmune diseases (systemic lupus erythematosus) before being treated with Thiole D 2mg/37.5mg Injection. Please consult your doctor before starting Thiole D 2mg/37.5mg Injection if you have high cholesterol, chickenpox, porphyria (rare inherited disorder), hereditary disorders like Lapp lactase deficiency (lactose intolerance), galactose intolerance, glucose-galactose malabsorption (small intestines not being able to absorb and use glucose and galactose), fits, and blood clotting disorders. Do not take any other NSAIDs for pain relief along with Thiole D 2mg/37.5mg Injection unless prescribed. Stop using Thiole D 2mg/37.5mg Injection and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Thiole D 2mg/37.5mg Injection is not recommended for pregnant and breastfeeding women; hence, please seek medical advice. This medicine may cause dizziness and drowsiness, so drive only if you are alert and focused. Thiole D 2mg/37.5mg Injection is not recommended in children and adolescents below 18 years as safety and efficacy are not established.

Drug-Drug Interactions

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Drug-Drug Interaction: Thiole D 2mg/37.5mg Injection may interact with anti-diabetics, water pills, blood thinners (warfarin), anti-depressants (lithium), anti-cancer drugs (methotrexate), immunosuppressants (ciclosporin, tacrolimus), medicines used for abortion (mifepristone), pain killers (aspirin), heart-related drugs (digoxin), antibiotics (voriconazole), fits medicines (phenytoin), cholesterol-lowering drugs (cholestyramine, colestipol), and antiretrovirals (zidovudine).

Drug-Food Interaction: Avoid alcohol consumption while using this medicine to avoid the risk of adverse effects.

Drug-Disease Interaction: Before starting Thiole D 2mg/37.5mg Injection, inform your doctor if you have stomach ulcers, galactose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, fits, asthma, porphyria, diabetes, high blood pressure, autoimmune diseases, heart, kidney, and liver problems.

Drug-Drug Interactions

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How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Meloxicam with Thiole D 2mg/37.5mg Injection can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Thiole D 2mg/37.5mg Injection is avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult your doctor immediately if you experience dizziness, tarry stools, coughing up or vomiting blood, headache, or weakness. Do not stop any medication without a doctor's advice.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Taking Enoxaparin with Thiole D 2mg/37.5mg Injection can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction of Enoxaparin with Thiole D 2mg/37.5mg Injection, but they can be taken if your doctor has prescribed them. Consult your doctor immediately if you experience unusual bleeding, swelling, vomiting blood, headache, or weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Coadministration of Ketorolac and Thiole D 2mg/37.5mg Injection can increase the risk of stomach inflammation, bleeding, or ulceration.

How to manage the interaction:
Co-administration of Ketorolac and Thiole D 2mg/37.5mg Injection can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any unusual bleeding or bruising, tarry stools, coughing or vomiting blood, headache, or weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Sirolimus with Thiole D 2mg/37.5mg Injection may increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Sirolimus with Thiole D 2mg/37.5mg Injection can lead to an interaction, it can be taken when advised by a doctor. Consult a doctor if you experience vomiting, loss of appetite, increased or decreased urination, swelling, muscle cramps, or weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Apixaban with Thiole D 2mg/37.5mg Injection may increase the risk of stomach bleeding.

How to manage the interaction:
Although there is an interaction of Apixaban with Thiole D 2mg/37.5mg Injection, it can be taken if your doctor has advised it. Consult a doctor if you experience black stools, severe bruising, weakness, headache, vomiting or coughing up blood, or heavy menstrual bleeding (in women). Do not discontinue any medication without consulting a doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Coadministration of Dabigatran etexilate with Thiole D 2mg/37.5mg Injection may increase the risk of stomach bleeding.

How to manage the interaction:
Taking Dabigatran etexilate with Thiole D 2mg/37.5mg Injection can possibly results in an interaction, it can be taken if your doctor has advised it. You should consult a doctor immediately if you experience unusual bleeding or bruising, tarry stools, coughing up or vomiting blood, and weakness. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Tacrolimus with Thiole D 2mg/37.5mg Injection may increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Tacrolimus with Thiole D 2mg/37.5mg Injection can lead to an interaction, it can be taken when advised by your doctor. Consult your doctor if you experience nausea, vomiting, increased or decreased urination, swelling, shortness of breath, muscle cramps, or weakness. Do not stop using any medications without a doctor's advice.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Taking Ibrutinib with Thiole D 2mg/37.5mg Injection can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction of Ibrutinib with Thiole D 2mg/37.5mg Injection, they can be taken when a doctor has prescribed them. Consult a doctor immediately if you experience any unusual bleeding, tarry stools, coughing or vomiting blood, or headaches. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Mipomersen with Thiole D 2mg/37.5mg Injection may cause liver problems.

How to manage the interaction:
Co-administration of Mipomersen with Thiole D 2mg/37.5mg Injection can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any fever, chills, joint pain, unusual bleeding, loss of hunger, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor
How does the drug interact with Thiole D 2mg/37.5mg Injection:
Co-administration of Indometacin and Thiole D 2mg/37.5mg Injection can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Indometacin and Thiole D 2mg/37.5mg Injection can lead to an interaction, it can be taken if advised by your doctor. If you experience any unusual bleeding or bruising, tarry stools, coughing or vomiting blood, headache, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MUSCLE RELAXANTS, ANTI- INFLAMMATORY AGENTS]

FAQs

Thiole D 2mg/37.5mg Injection is used to treat Acute musculoskeletal pain and muscle spasms.

Thiole D 2mg/37.5mg Injection contains Diclofenac and Thiocolchicoside. Diclofenac works by blocking the action of certain chemical messengers that cause pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant which relieves muscle stiffness due to muscle spasms and improves muscle movements.

Diarrhoea can be a side-effect of Thiole D 2mg/37.5mg Injection. Drink enough fluids and eat fibre-rich food if you experience diarrhoea. If you find blood in the stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.

Using other NSAIDs or painkillers is not advised while using Thiole D 2mg/37.5mg Injection. Please seek medical advice for further information.

You are not recommended to take Thiole D 2mg/37.5mg Injection with warfarin as simultaneous use of these two medicines may increase the effect of anti-coagulants/blood thinners and cause bleeding risk. Please seek medical advice for more information.

Disclaimer

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Country of origin

India
Other Info - TH57752
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