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  3. Thioprinz 50mg Tablet

Thioprinz 50mg Tablet, Pack of 1 Tablet
Thioprinz 50mg Tablet, Pack of 1 Tablet
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Thioprinz 50mg Tablet helps to reduce the pain/inflammation in rheumatoid arthritis conditions and keep the immune system from attacking new transplant organs like kidneys. Besides this, it also treats pain and inflammation in gastrointestinal issues like Crohn's disease, and ulcerative colitis, for patients who have undergone a kidney transplant. It contains Azathioprine, which works by reducing the function of the cells, causing inflammation, especially in the joint tissues thereby decreasing pain, inflammation, and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. This medicine helps stop your body from rejecting a new organ by suppressing your immune system. In some cases, you may experience certain common side effects such as nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat.
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Composition :

AZATHIOPRINE-50MG

Manufacturer/Marketer :

Rockmed Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Thioprinz 50mg Tablet

Thioprinz 50mg Tablet is used to reduce the pain/inflammation in rheumatoid arthritis conditions and keep the immune system from attacking new transplant organs like kidneys. Besides this, it also treats pain and inflammation in gastrointestinal issues like Crohn's disease and ulcerative colitis for patients who have undergone a kidney transplant. 

Thioprinz 50mg Tablet contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Thioprinz 50mg Tablet helps stop your body from rejecting a new organ by suppressing your immune system. 

Take Thioprinz 50mg Tablet as prescribed. Your doctor will advise you on how often you take Thioprinz 50mg Tablet based on your medical condition. In some cases, you may experience certain common side-effects such as nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Thioprinz 50mg Tablet for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Thioprinz 50mg Tablet if you are pregnant or planning for pregnancy. Thioprinz 50mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Thioprinz 50mg Tablet should not be given to children as safety and efficacy have not been established. Thioprinz 50mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Thioprinz 50mg Tablet. While taking Thioprinz 50mg Tablet, do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person who has them, please inform your doctor immediately, as special treatment is required if you have not had these illnesses. Your doctor may advise you to undergo regular blood tests and kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of Thioprinz 50mg Tablet

Treatment of Rheumatoid arthritis, Immunosuppressant therapy after kidney transplant.

Directions for Use

Swallow Thioprinz 50mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Thioprinz 50mg Tablet contains 'Azathioprine', which is an immunosuppressant that works by reducing the function of the cells and causing inflammation in the joint tissues. It reduces pain and inflammation and slows joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Thioprinz 50mg Tablet helps stop your body from rejecting a new organ by suppressing your immune system. Thioprinz 50mg Tablet is also used to treat severe inflammatory diseases of the skin, Crohn's disease, ulcerative colitis, and some blood disorders.

How Thioprinz 50mg Tablet Works

Thioprinz 50mg Tablet contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Thioprinz 50mg Tablet helps stop your body from rejecting a new organ by suppressing your immune system.

Storage

Store in a cool and dry place away from sunlight
Side effects of Thioprinz 50mg Tablet
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • If you suspect cervical cancer, get tested with: A pap smear or HPV test.
  • Get vaccinated against HPV to prevent cervical cancer.
  • Use condoms during sex to reduce the risk of HPV infection that can lead to cervical cancer.
  • To lower your risk of developing cervical cancer do not smoke.
  • Eat nutritious food and stay healthy to boost your immune system and fight against cancer.

What if I have taken an overdose of Thioprinz 50mg Tablet

Do not take more than the prescribed dose of Thioprinz 50mg Tablet as it may cause overdose. The symptoms of overdose include diarrhoea, nausea, vomiting, fever, sore throat, chills and other signs of infection. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Thioprinz 50mg Tablet if you are allergic to any immunosuppressant medicines or Azathioprine. Let your doctor know before using Thioprinz 50mg Tablet if you have liver or kidney problems, serious blood disorders, immune system problems, bone marrow problems, serious infections, immunodeficiency syndrome, or if you have a condition where your body produces too little of a natural chemical called thiopurine methyltransferase (TPMT), received any vaccinations. Do not take Thioprinz 50mg Tablet if you are pregnant or planning for pregnancy as Thioprinz 50mg Tablet is a Pregnancy category risk D medicines which can cause serious congenital disabilities to the unborn baby. Thioprinz 50mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk. While taking Thioprinz 50mg Tablet, do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person having them, please inform your doctor immediately as it requires special treatment if you have not had these illnesses. Thioprinz 50mg Tablet causes dizziness and drowsiness, so drive with caution. Thioprinz 50mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with Thioprinz 50mg Tablet as it could lead to increased dizziness. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Using Thioprinz 50mg Tablet for a long time can increase your chance of getting certain types of cancer, such as lymphoma (cancer of the spleen, thymus gland, and bone marrow), leukemia (blood cancer), and skin cancer. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Thioprinz 50mg Tablet.

Drug-Drug Interactions

verifiedApollotooltip
AzathioprineFebuxostat
Critical
AzathioprineCladribine
Severe

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
How does the drug interact with Thioprinz 50mg Tablet:
Taking Thioprinz 50mg Tablet and Febuxostat together can increase the blood levels of Thioprinz 50mg Tablet

How to manage the interaction:
Taking Thioprinz 50mg Tablet with Febuxostat is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AzathioprineCladribine
Severe
How does the drug interact with Thioprinz 50mg Tablet:
The use of cladribine with Thioprinz 50mg Tablet can increase the risk of serious infections.

How to manage the interaction:
Although taking Thioprinz 50mg Tablet and Cladribine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain during urination, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineFingolimod
Severe
How does the drug interact with Thioprinz 50mg Tablet:
The use of fingolimod with Thioprinz 50mg Tablet may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Thioprinz 50mg Tablet with Fingolimod can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
AzathioprineInfliximab
Severe
How does the drug interact with Thioprinz 50mg Tablet:
Coadministration of Thioprinz 50mg Tablet and Infliximab can increase the risk or severity of developing infections.

How to manage the interaction:
Although taking Infliximab and Thioprinz 50mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. If you have any symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineAdalimumab
Severe
How does the drug interact with Thioprinz 50mg Tablet:
When Thioprinz 50mg Tablet and Adalimumab are taken together, they may raise the risk of severe infections.

How to manage the interaction:
Although there is a possible interaction between Thioprinz 50mg Tablet and Adalimumab, you can take these medicines together if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineEtanercept
Severe
How does the drug interact with Thioprinz 50mg Tablet:
When Etanercept is used with Thioprinz 50mg Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Thioprinz 50mg Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AzathioprineClozapine
Severe
How does the drug interact with Thioprinz 50mg Tablet:
When Thioprinz 50mg Tablet and Clozapine are taken together can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Thioprinz 50mg Tablet with Clozapine can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
AzathioprineBaricitinib
Severe
How does the drug interact with Thioprinz 50mg Tablet:
Coadministration of baricitinib and Thioprinz 50mg Tablet can raise the risk of developing harmful infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Thioprinz 50mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
AzathioprineTeriflunomide
Severe
How does the drug interact with Thioprinz 50mg Tablet:
When Thioprinz 50mg Tablet is taken with Teriflunomide, may raise the risk of side effects affecting bone marrow function, resulting in low levels of different types of blood cells. This can increase your chances of developing anemia, bleeding issues, or infections.

How to manage the interaction:
Taking Thioprinz 50mg Tablet with Teriflunomide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience paleness, exhaustion, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineBCG vaccine
Severe
How does the drug interact with Thioprinz 50mg Tablet:
Taking the BCG vaccine with Thioprinz 50mg Tablet can increase the risk of infection.

How to manage the interaction:
Co-administration of Thioprinz 50mg Tablet with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.

  • Acupuncture, massage, and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Avoid smoking and alcohol consumption.

 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Thioprinz 50mg Tablet Substitute

Substitutes safety advice

  • Azoran 50 mg Tablet 20's

    by Others

    ₹10.62per tablet

  • AZR Tablet 10's

    by AYUR

    ₹10.62per tablet

  • Innomune Tablet 10's

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    ₹10.62per tablet

  • Azapure 50mg Tablet 10's

    by AYUR

    ₹10.62per tablet

  • Zymurine Tablet 10's

    by Others

    ₹9.99per tablet

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Thioprinz 50mg Tablet. It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

Thioprinz 50mg Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only when strictly guidance of the doctor as there is no clinical data available on use in pregnant women.

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Breast Feeding

Caution

It is not recommended to take Thioprinz 50mg Tablet while you are breastfeeding. Thioprinz 50mg Tablet passes into breast milk.

bannner image

Driving

Caution

Thioprinz 50mg Tablet may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Take Thioprinz 50mg Tablet only after the doctor's prescription, especially if you are dealing with Liver diseases/conditions as your doctor may adjust the dose as required.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Thioprinz 50mg Tablet.

bannner image

Children

Unsafe

Thioprinz 50mg Tablet should not be used by children below 18 years of age, as the efficacy and safety have not been established.

Have a query?

FAQs

Thioprinz 50mg Tablet is used in treating Rheumatoid arthritis and immunosuppressant therapy after kidney transplant.

Thioprinz 50mg Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.

Thioprinz 50mg Tablet acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.

If you miss a dose of Thioprinz 50mg Tablet, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Diarrhoea might be a side-effect of Thioprinz 50mg Tablet. Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Thioprinz 50mg Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only when strictly guidance of the doctor as there is no clinical data available on use in pregnant women.

Thioprinz 50mg Tablet starts to work gradually. it can take up to 12 weeks of taking the right adjusted dose before you notice any benefits.

If you miss a prescription dose, take it as soon as you recall and resume your regular routine. If you are near the next dose, skip the missing dose and resume your regular schedule. Do not take a double dose to make up for a forgotten dose.

It depends on your individual medical condition and response to the medication. Your doctor will determine the appropriate duration of treatment based on your specific needs.

Taking Thioprinz 50mg Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. As a result, avoid direct sunlight, apply sunscreen (SPF 30 or higher), and wear in clothes that shield your arms and legs.

You'll have regular blood tests while taking azathioprine. These tests will ensure that any concerns or problems are found quickly.

Thioprinz 50mg Tablet may have an effect on your liver, kidneys, or bone marrow. Before you begin taking this medication, you will undergo blood tests to assess your liver function, renal function, and blood count. From week one to week eight of your treatment, you will undergo at least one blood test every week.

Yes, taking Thioprinz 50mg Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. Seek medical attention if you experience any changes in your body.

Using Cyclosporine together with Thioprinz 50mg Tablet may decrease the effects of cyclosporine. Caution is advised if Cyclosporine must be taken with Thioprinz 50mg Tablet. You may need a dose adjustment or special test if you use both medications.

Alcohol does not affect the way azathioprine works. However, both azathioprine and alcohol can affect your liver. For this reason, limit or avoid the consumption of alcohol is recommended.

Common side effects of Thioprinz 50mg Tablet may include nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India
Other Info - TH63570

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.3301.pdf
  2. https://www.nhs.uk/medicines/azathioprine/
  3. https://www.drugs.com/mtm/azathioprine.html
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