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compositionComposition:TIGECYCLINE-50MG
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Prescription Medicine
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Tigeline 50 mg Combipack Injection 1's is used to treat bacterial infections. It contains Tigecycline which works by killing the infection-causing bacteria. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TIGECYCLINE-50MG

Manufacturer/Marketer :

Human Pharmacia

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Tigeline 50 mg Combipack Injection 1's

Tigeline 50 mg Combipack Injection 1's is an injection used to treat serious bacterial infections, such as complicated skin infections, severe abdominal infections, and community-acquired pneumonia. It belongs to a group of medicines that work by stopping the growth and spread of bacteria in the body. Because it targets a wide variety of bacteria, it is typically reserved for severe cases where other treatments may not be suitable.

This medication is given directly into a vein as an intravenous infusion, usually once every 12 hours. Since it is given directly into the bloodstream, food intake does not affect how the medicine is absorbed, but staying well-hydrated and eating balanced meals can help support your recovery. It is important to receive this medicine consistently at the times scheduled by your healthcare team to ensure the infection is completely cleared.

While taking Tigeline 50 mg Combipack Injection 1's, you may experience some common side effects such as nausea, vomiting, or diarrhoea. Most of these are mild, but you must contact your doctor immediately if you experience serious symptoms like severe stomach pain, watery or bloody diarrhoea, or yellowing of your skin or eyes. Your healthcare team will monitor you closely during your treatment to ensure your safety.

Talk to your doctor before starting this medicine if you have a history of liver problems or swelling of the pancreas. Do not take this medicine if you are allergic to this medication or other similar antibiotics. In certain cases, it may be prescribed for children aged 8 years and older to treat serious bacterial infections. It is generally not recommended for children younger than 8 years of age because it may cause permanent tooth discolouration and affect bone development.

This medicine may interact with blood thinners and can make birth control pills less effective. It is also important to tell your doctor if you are pregnant, think you may be pregnant, are planning to become pregnant, or are breastfeeding, as this treatment can cause harm to an unborn baby. Talk to your doctor or pharmacist to understand how your other medicines or health conditions might interact with this treatment.

Being told you need an intravenous (IV) antibiotic in a hospital or healthcare setting can feel overwhelming. Rest assured that your healthcare team will be with you throughout your treatment, monitoring your progress, managing any side effects, and answering any questions you may have to help ensure your care is as safe and comfortable as possible. 

Uses of Tigeline 50 mg Combipack Injection 1's

Tigeline 50 mg Combipack Injection 1's is an antibiotic used to treat a range of serious bacterial infections by eliminating the bacteria responsible for the infection and helping the body recover.

  • Complicated skin and skin structure infections: Helps by clearing deep-seated skin infections, preventing the bacteria from spreading further into body tissues.
  • Complicated intra-abdominal infections: Treats complex infections inside the stomach area, such as deep abscesses or appendicitis, by destroying the bacteria causing the swelling.
  • Community-acquired bacterial pneumonia: Helps clear severe lung infections that are caught outside of a hospital, helping to restore normal breathing.
  • Kidney disease: No formal dose adjustment is generally required for people with kidney disease. However, if you have severe kidney impairment or are receiving dialysis, discuss your treatment with your doctor to ensure Tigeline 50 mg Combipack Injection 1's is appropriate for you. 

Key Benefits

In addition to treating infections, Tigeline 50 mg Combipack Injection 1's provides the following therapeutic benefits that support the body's recovery process. 

  • Broad-spectrum antibacterial action: Tigeline 50 mg Combipack Injection 1's provides vital support when standard antibiotics may not be strong enough to fight off certain resistant bacteria. Because it targets a broad spectrum of bacteria, it is highly effective at resolving severe and complex infections, helping your body start the recovery process quickly.
  • Rapid intravenous action: Since this medication is given directly into a vein, it goes to work in your bloodstream immediately. This rapid action helps to reduce symptoms like fever, pain, and inflammation as the infection starts to improve.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Tigeline 50 mg Combipack Injection 1's will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Tigeline 50 mg Combipack Injection 1's Works

Tigeline 50 mg Combipack Injection 1's contains tigecycline, an antibiotic belonging to the glycylcycline class, which is derived from tetracycline antibiotics (specifically minocycline). It works by entering bacterial cells and blocking their ability to produce essential proteins needed for growth and multiplication. Without these proteins, the bacteria cannot grow or spread, allowing your body's natural immune system to help clear the infection. Before or during treatment, your doctor may order a culture and sensitivity test to identify the bacteria causing the infection and confirm that this antibiotic is appropriate. If you have ever had an allergic reaction to Tigeline 50 mg Combipack Injection 1's, tetracyclines, or related antibiotics, inform your doctor before starting treatment. If your symptoms do not improve, worsen, or new symptoms develop during treatment, contact your doctor promptly, as your treatment may need to be reassessed.
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Alcohol

Caution

Avoid taking alcohol while using Tigeline 50 mg Combipack Injection 1's since it may worsen the side effects.

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Pregnancy

Unsafe

Tigeline 50 mg Combipack Injection 1's is not recommended during pregnancy due to its harmful effects on the baby, including toxic effects on skeletal formation. Please consult your doctor before taking Tigeline 50 mg Combipack Injection 1's if you are pregnant or planning to conceive.

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Breast Feeding

Caution

It is not known if Tigeline 50 mg Combipack Injection 1's is excreted into breast milk. Please consult your doctor before taking Tigeline 50 mg Combipack Injection 1's if you are breastfeeding.

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Driving

Caution

You may experience dizziness as one of the side effects of Tigeline 50 mg Combipack Injection 1's. In such cases, do not drive or operate machinery until you feel better.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Tigeline 50 mg Combipack Injection 1's. Tigeline 50 mg Combipack Injection 1's should be used caution in cases of severe liver disease.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before taking Tigeline 50 mg Combipack Injection 1's. Dose adjustment may be required.

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Children

Caution

Tigeline 50 mg Combipack Injection 1's is not recommended for children younger than eight years old.

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Heart

Caution

Limited data is available regarding the use of Tigeline 50 mg Combipack Injection 1's in patients with heart problems. Please consult your doctor if you have any concerns regarding this.

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Geriatrics

Caution

Tigeline 50 mg Combipack Injection 1's should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Tigeline 50 mg Combipack Injection 1's

Because this medicine is given under medical supervision, an overdose is highly unlikely. If you suspect you have received too much or experience unusual symptoms during or after your infusion, tell your healthcare provider or seek emergency medical help right away.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear fluids to help your body process the medication and support recovery.
  • Eat a balanced diet: Choose foods rich in vitamins, minerals, and other nutrients to strengthen your immune system and aid healing.
  • Avoid alcohol: Do not consume alcohol while receiving this medication, as it may put additional strain on your liver.
  • Get adequate rest: Ensure you get enough sleep and rest so your body can focus its energy on fighting the infection and recovering.
  • Consider probiotics after treatment: Speak with your doctor about taking a probiotic after completing your treatment to help restore healthy bacteria in your digestive system.
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Have a query?

How Soon It Starts Working

The time required for Tigeline 50 mg Combipack Injection 1's to start to work: The time required for Tigeline 50 mg Combipack Injection 1's to show its action is unknown. The time for which the effects of Tigeline 50 mg Combipack Injection 1's last: The duration of action for Tigeline 50 mg Combipack Injection 1's is clinically unknown.

What if you forget to take Tigeline 50 mg Combipack Injection 1's

Since this medication is given by a healthcare professional, it is unlikely that you will miss a dose. However, if you miss an appointment or suspect a dose was missed, contact your doctor or clinic immediately to get back on schedule.

Storage

• Store the unmixed dry powder at room temperature between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: Always ensure the solution is yellow to orange in colour and free from floating particles before it is injected.
  • Report infusion site reactions: Tell your healthcare team immediately if you experience pain, burning, coldness, or swelling around the vein during the infusion.
  • Protect your skin from sunlight: This medication may increase your skin's sensitivity to the sun. Wear protective clothing and apply sunscreen when outdoors.
  • Inform your doctor about blood thinners: If you are taking blood-thinning medications, let your doctor know before starting treatment, as closer monitoring of your blood clotting levels may be required.
  • Complete the full course: Never skip doses or stop treatment early, even if you feel better, to help prevent antibiotic resistance.
  • Severe diarrhoea: If you develop severe, watery, or bloody diarrhoea, do not take any over-the-counter anti-diarrhoea medicines. Contact your doctor immediately, as this may be a sign of a serious bowel infection that requires prompt medical attention.
  • Use during pregnancy: Inform your doctor if you are pregnant or planning to become pregnant before starting treatment. Tigeline 50 mg Combipack Injection 1's can cause harm to an unborn baby and should only be used if clearly needed. 

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Tigeline 50 mg Combipack Injection 1's:

  • Blood thinners (such as warfarin): May increase the risk of bleeding, requiring your doctor to monitor your blood clotting times more closely.
  • Birth control pills: May decrease the effectiveness of hormonal contraceptives, so you should use an additional barrier method of birth control while receiving this medicine.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Tigeline 50 mg Combipack Injection 1's when used as directed.

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Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Tigeline 50 mg Combipack Injection 1's is used to treat bacterial infections like abdominal infections, community-acquired pneumonia (lung infection), and complicated skin and skin structure infections.
Tigeline 50 mg Combipack Injection 1's contains Tigecycline, a broad-spectrum antibiotic that treats various bacterial infections. It works by inhibiting bacterial protein synthesis, which further inhibits bacterial growth.
Tigeline 50 mg Combipack Injection 1's can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Tigeline 50 mg Combipack Injection 1's if you are undergoing any vaccinations.
Tigeline 50 mg Combipack Injection 1's can make your skin more sensitive to the harmful effects of sunlight. Hence it is advised to use sunscreen and wear protective clothing while using Tigeline 50 mg Combipack Injection 1's. It is also recommended to avoid tanning booths and sunlamps.
Diarrhoea can be a side-effect of Tigeline 50 mg Combipack Injection 1's. Drink enough fluids and eat fibre rich food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.
Tigeline 50 mg Combipack Injection 1's will be administered by a healthcare professional; do not self-administer.
Yes, Tigeline 50 mg Combipack Injection 1's contains Tigecycline which belongs to the glycylcycline class of antibiotics.
Tigeline 50 mg Combipack Injection 1's starts working within 30-60 minutes. However, it might take a few days to notice its full effects.
Tigeline 50 mg Combipack Injection 1's may cause side effects like nausea, vomiting, diarrhoea, headache, and abnormal liver function tests. If any of these effects persist or worsen, seek medical advice promptly.
Yes, in some cases, a trained home healthcare nurse can inject this medication at your home. However, your first dose is usually given in a clinic or hospital setting so you can be monitored closely. Talk to your doctor to see if home treatment is appropriate for you.
If you develop severe, watery, or bloody diarrhoea, do not take any over-the-counter anti-diarrhoea medicines. Contact your doctor immediately, as this can be a sign of a serious bowel infection that requires different treatment.
Tigeline 50 mg Combipack Injection 1's is generally not recommended during pregnancy because it may cause harm to the unborn baby and may affect fetal bone development. If you are pregnant, think you may be pregnant, or are planning to become pregnant, discuss the potential risks and alternative treatment options with your doctor before using this medicine.
It is best to avoid alcohol during your treatment. Both alcohol and this medicine can strain your liver, and drinking alcohol may make side effects like nausea or dizziness worse. Talk to your doctor or pharmacist for personalised advice.
The length of treatment depends entirely on the type and severity of your infection. It typically lasts between 5 to 14 days, but your doctor will decide the exact length based on how your body responds.
No, this medicine is an antibiotic and only works against bacterial infections. It will not cure viral infections like the common cold, flu, or Covid-19.
Tigeline 50 mg Combipack Injection 1's may be used in adults and, in certain cases, in children aged 8 years and older for the treatment of serious bacterial infections when prescribed by a doctor. It is generally not recommended for children younger than 8 years of age because of the risk of permanent tooth discolouration and effects on bone development.

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Country of origin

India

Manufacturer/Marketer address

Vill. Singhawala, Near Nagar Khera, Ambala City-134003.
Other Info - TIG0154
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