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compositionComposition:TIGECYCLINE-50MG
prescription
Prescription Medicine
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TIGEPLUG 50MG INJECTION is used to treat bacterial infections. It contains Tigecycline which works by killing the infection-causing bacteria. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TIGECYCLINE-50MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TIGEPLUG 50MG INJECTION

TIGEPLUG 50MG INJECTION is an injection used to treat serious bacterial infections, such as complicated skin infections, severe abdominal infections, and community-acquired pneumonia. It belongs to a group of medicines that work by stopping the growth and spread of bacteria in the body. Because it targets a wide variety of bacteria, it is typically reserved for severe cases where other treatments may not be suitable.

This medication is given directly into a vein as an intravenous infusion, usually once every 12 hours. Since it is given directly into the bloodstream, food intake does not affect how the medicine is absorbed, but staying well-hydrated and eating balanced meals can help support your recovery. It is important to receive this medicine consistently at the times scheduled by your healthcare team to ensure the infection is completely cleared.

While taking TIGEPLUG 50MG INJECTION, you may experience some common side effects such as nausea, vomiting, or diarrhoea. Most of these are mild, but you must contact your doctor immediately if you experience serious symptoms like severe stomach pain, watery or bloody diarrhoea, or yellowing of your skin or eyes. Your healthcare team will monitor you closely during your treatment to ensure your safety.

Talk to your doctor before starting this medicine if you have a history of liver problems or swelling of the pancreas. Do not take this medicine if you are allergic to this medication or other similar antibiotics. In certain cases, it may be prescribed for children aged 8 years and older to treat serious bacterial infections. It is generally not recommended for children younger than 8 years of age because it may cause permanent tooth discolouration and affect bone development.

This medicine may interact with blood thinners and can make birth control pills less effective. It is also important to tell your doctor if you are pregnant, think you may be pregnant, are planning to become pregnant, or are breastfeeding, as this treatment can cause harm to an unborn baby. Talk to your doctor or pharmacist to understand how your other medicines or health conditions might interact with this treatment.

Being told you need an intravenous (IV) antibiotic in a hospital or healthcare setting can feel overwhelming. Rest assured that your healthcare team will be with you throughout your treatment, monitoring your progress, managing any side effects, and answering any questions you may have to help ensure your care is as safe and comfortable as possible. 

Uses of TIGEPLUG 50MG INJECTION

TIGEPLUG 50MG INJECTION is an antibiotic used to treat a range of serious bacterial infections by eliminating the bacteria responsible for the infection and helping the body recover.

  • Complicated skin and skin structure infections: Helps by clearing deep-seated skin infections, preventing the bacteria from spreading further into body tissues.
  • Complicated intra-abdominal infections: Treats complex infections inside the stomach area, such as deep abscesses or appendicitis, by destroying the bacteria causing the swelling.
  • Community-acquired bacterial pneumonia: Helps clear severe lung infections that are caught outside of a hospital, helping to restore normal breathing.
  • Kidney disease: No formal dose adjustment is generally required for people with kidney disease. However, if you have severe kidney impairment or are receiving dialysis, discuss your treatment with your doctor to ensure TIGEPLUG 50MG INJECTION is appropriate for you. 

Key Benefits

In addition to treating infections, TIGEPLUG 50MG INJECTION provides the following therapeutic benefits that support the body's recovery process. 

  • Broad-spectrum antibacterial action: TIGEPLUG 50MG INJECTION provides vital support when standard antibiotics may not be strong enough to fight off certain resistant bacteria. Because it targets a broad spectrum of bacteria, it is highly effective at resolving severe and complex infections, helping your body start the recovery process quickly.
  • Rapid intravenous action: Since this medication is given directly into a vein, it goes to work in your bloodstream immediately. This rapid action helps to reduce symptoms like fever, pain, and inflammation as the infection starts to improve.
Side effects of Tigeplug 50mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • TIGEPLUG 50MG INJECTION will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How TIGEPLUG 50MG INJECTION Works

TIGEPLUG 50MG INJECTION contains tigecycline, an antibiotic belonging to the glycylcycline class, which is derived from tetracycline antibiotics (specifically minocycline). It works by entering bacterial cells and blocking their ability to produce essential proteins needed for growth and multiplication. Without these proteins, the bacteria cannot grow or spread, allowing your body's natural immune system to help clear the infection. Before or during treatment, your doctor may order a culture and sensitivity test to identify the bacteria causing the infection and confirm that this antibiotic is appropriate. If you have ever had an allergic reaction to TIGEPLUG 50MG INJECTION, tetracyclines, or related antibiotics, inform your doctor before starting treatment. If your symptoms do not improve, worsen, or new symptoms develop during treatment, contact your doctor promptly, as your treatment may need to be reassessed.
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Alcohol

Caution

Avoid taking alcohol while using TIGEPLUG 50MG INJECTION since it may worsen the side effects.

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Pregnancy

Unsafe

TIGEPLUG 50MG INJECTION is not recommended during pregnancy due to its harmful effects on the baby, including toxic effects on skeletal formation. Please consult your doctor before taking TIGEPLUG 50MG INJECTION if you are pregnant or planning to conceive.

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Breast Feeding

Caution

It is not known if TIGEPLUG 50MG INJECTION is excreted into breast milk. Please consult your doctor before taking TIGEPLUG 50MG INJECTION if you are breastfeeding.

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Driving

Caution

You may experience dizziness as one of the side effects of TIGEPLUG 50MG INJECTION. In such cases, do not drive or operate machinery until you feel better.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking TIGEPLUG 50MG INJECTION. TIGEPLUG 50MG INJECTION should be used caution in cases of severe liver disease.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before taking TIGEPLUG 50MG INJECTION. Dose adjustment may be required.

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Children

Caution

TIGEPLUG 50MG INJECTION is not recommended for children younger than eight years old.

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Heart

Caution

Limited data is available regarding the use of TIGEPLUG 50MG INJECTION in patients with heart problems. Please consult your doctor if you have any concerns regarding this.

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Geriatrics

Caution

TIGEPLUG 50MG INJECTION should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of TIGEPLUG 50MG INJECTION

Because this medicine is given under medical supervision, an overdose is highly unlikely. If you suspect you have received too much or experience unusual symptoms during or after your infusion, tell your healthcare provider or seek emergency medical help right away.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear fluids to help your body process the medication and support recovery.
  • Eat a balanced diet: Choose foods rich in vitamins, minerals, and other nutrients to strengthen your immune system and aid healing.
  • Avoid alcohol: Do not consume alcohol while receiving this medication, as it may put additional strain on your liver.
  • Get adequate rest: Ensure you get enough sleep and rest so your body can focus its energy on fighting the infection and recovering.
  • Consider probiotics after treatment: Speak with your doctor about taking a probiotic after completing your treatment to help restore healthy bacteria in your digestive system.
health query

Have a query?

How Soon It Starts Working

The time required for TIGEPLUG 50MG INJECTION to start to work: The time required for TIGEPLUG 50MG INJECTION to show its action is unknown. The time for which the effects of TIGEPLUG 50MG INJECTION last: The duration of action for TIGEPLUG 50MG INJECTION is clinically unknown.

What if you forget to take TIGEPLUG 50MG INJECTION

Since this medication is given by a healthcare professional, it is unlikely that you will miss a dose. However, if you miss an appointment or suspect a dose was missed, contact your doctor or clinic immediately to get back on schedule.

Storage

• Store the unmixed dry powder at room temperature between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: Always ensure the solution is yellow to orange in colour and free from floating particles before it is injected.
  • Report infusion site reactions: Tell your healthcare team immediately if you experience pain, burning, coldness, or swelling around the vein during the infusion.
  • Protect your skin from sunlight: This medication may increase your skin's sensitivity to the sun. Wear protective clothing and apply sunscreen when outdoors.
  • Inform your doctor about blood thinners: If you are taking blood-thinning medications, let your doctor know before starting treatment, as closer monitoring of your blood clotting levels may be required.
  • Complete the full course: Never skip doses or stop treatment early, even if you feel better, to help prevent antibiotic resistance.
  • Severe diarrhoea: If you develop severe, watery, or bloody diarrhoea, do not take any over-the-counter anti-diarrhoea medicines. Contact your doctor immediately, as this may be a sign of a serious bowel infection that requires prompt medical attention.
  • Use during pregnancy: Inform your doctor if you are pregnant or planning to become pregnant before starting treatment. TIGEPLUG 50MG INJECTION can cause harm to an unborn baby and should only be used if clearly needed. 

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with TIGEPLUG 50MG INJECTION:

  • Blood thinners (such as warfarin): May increase the risk of bleeding, requiring your doctor to monitor your blood clotting times more closely.
  • Birth control pills: May decrease the effectiveness of hormonal contraceptives, so you should use an additional barrier method of birth control while receiving this medicine.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with TIGEPLUG 50MG INJECTION when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

TIGEPLUG 50MG INJECTION is used to treat bacterial infections like abdominal infections, community-acquired pneumonia (lung infection), and complicated skin and skin structure infections.
TIGEPLUG 50MG INJECTION contains Tigecycline, a broad-spectrum antibiotic that treats various bacterial infections. It works by inhibiting bacterial protein synthesis, which further inhibits bacterial growth.
TIGEPLUG 50MG INJECTION can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start TIGEPLUG 50MG INJECTION if you are undergoing any vaccinations.
TIGEPLUG 50MG INJECTION can make your skin more sensitive to the harmful effects of sunlight. Hence it is advised to use sunscreen and wear protective clothing while using TIGEPLUG 50MG INJECTION. It is also recommended to avoid tanning booths and sunlamps.
Diarrhoea can be a side-effect of TIGEPLUG 50MG INJECTION. Drink enough fluids and eat fibre rich food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.
TIGEPLUG 50MG INJECTION will be administered by a healthcare professional; do not self-administer.
Yes, TIGEPLUG 50MG INJECTION contains Tigecycline which belongs to the glycylcycline class of antibiotics.
TIGEPLUG 50MG INJECTION starts working within 30-60 minutes. However, it might take a few days to notice its full effects.
TIGEPLUG 50MG INJECTION may cause side effects like nausea, vomiting, diarrhoea, headache, and abnormal liver function tests. If any of these effects persist or worsen, seek medical advice promptly.
Yes, in some cases, a trained home healthcare nurse can inject this medication at your home. However, your first dose is usually given in a clinic or hospital setting so you can be monitored closely. Talk to your doctor to see if home treatment is appropriate for you.
If you develop severe, watery, or bloody diarrhoea, do not take any over-the-counter anti-diarrhoea medicines. Contact your doctor immediately, as this can be a sign of a serious bowel infection that requires different treatment.
TIGEPLUG 50MG INJECTION is generally not recommended during pregnancy because it may cause harm to the unborn baby and may affect fetal bone development. If you are pregnant, think you may be pregnant, or are planning to become pregnant, discuss the potential risks and alternative treatment options with your doctor before using this medicine.
It is best to avoid alcohol during your treatment. Both alcohol and this medicine can strain your liver, and drinking alcohol may make side effects like nausea or dizziness worse. Talk to your doctor or pharmacist for personalised advice.
The length of treatment depends entirely on the type and severity of your infection. It typically lasts between 5 to 14 days, but your doctor will decide the exact length based on how your body responds.
No, this medicine is an antibiotic and only works against bacterial infections. It will not cure viral infections like the common cold, flu, or Covid-19.
TIGEPLUG 50MG INJECTION may be used in adults and, in certain cases, in children aged 8 years and older for the treatment of serious bacterial infections when prescribed by a doctor. It is generally not recommended for children younger than 8 years of age because of the risk of permanent tooth discolouration and effects on bone development.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Tigecycline Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  3. U.S. Food and Drug Administration (FDA). 021821S026S031Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  4. ScienceDirect ScienceDirect. [Accessed on 29 Mar. 2019]Check here
  5. Nickie D. Greer. Tigecycline (Tygacil): the first in the glycylcycline class of antibiotics. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. April 2006. [Accessed on 25th November 2022].Check here
  6. Pharmadox Healthcare, Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 25th November 2022].Check here

Country of origin

INDIA

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - TIG0058
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