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compositionComposition:NORFLOXACIN-400MG+TINIDAZOLE-600MG
prescription
Prescription Medicine
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Tizflox 400 mg/600 mg Tablet is used to treat diarrhoea, dysentery and stomach infections. It contains Norfloxacin and Tinidazole, which kill bacteria and parasites that cause infections. It may cause side effects, such as nausea, dryness of mouth, stomach upset, or headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

NORFLOXACIN-400MG+TINIDAZOLE-600MG

Manufacturer/Marketer :

Galpha Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Tizflox 400 mg/600 mg Tablet

Tizflox 400 mg/600 mg Tablet is a prescription oral medicine used to treat mixed stomach and intestinal infections, such as infectious diarrhoea and dysentery. It works by targeting both bacterial and parasitic organisms that cause gut infections, helping to clear the infection and relieve symptoms. Doctors prescribe this medicine to stop the growth of these harmful micro-organisms.

To get the best results, you should take Tizflox 400 mg/600 mg Tablet regularly at evenly spaced intervals exactly as your doctor has directed. It is best taken with food to prevent an upset stomach, and you should complete the entire course even if you start feeling better. Drinking plenty of fluids and eating simple, easily digestible foods can help support your recovery during treatment.

While taking this medicine, you may experience mild side effects like nausea, a metallic taste in your mouth, or a temporary loss of appetite. However, if you experience serious side effects such as severe skin rashes, muscle weakness, tingling sensations, or tendon pain, you must contact your doctor immediately.

Talk to your doctor before starting Tizflox 400 mg/600 mg Tablet if you have a history of nerve disorders, kidney problems, or tendon issues. Do not take this medicine if you have had an allergic reaction to similar antibacterial medicines in the past, or if you have a history of tendon swelling or rupture.

Avoid drinking alcohol while taking Tizflox 400 mg/600 mg Tablet and for at least three days after finishing the course, as it can cause severe nausea, rapid heartbeat, and headache. Let your doctor know about all other medicines you are taking, especially blood thinners or antacids, and consult them first if you are pregnant, breastfeeding, or elderly.

Uses of Tizflox 400 mg/600 mg Tablet

Tizflox 400 mg/600 mg Tablet is used to treat the following bacterial and parasitic infections of the gastrointestinal tract:

  • Bacterial diarrhoea: It clears harmful bacteria in the digestive tract, reducing frequent loose stools and stomach cramping.
  • Amoebic dysentery: It targets and destroys the parasites responsible for severe gut infections, helping to stop bloody stools and abdominal pain.
  • Mixed abdominal infections: It works against both bacteria and amoebas simultaneously to treat complex gastrointestinal infections effectively.
     

Key Benefits

The following benefits may be experienced when Tizflox 400 mg/600 mg Tablet effectively treats the underlying infection: 

  • Targets Multiple Infection-Causing Organisms: It works against both bacteria and certain parasites, providing comprehensive treatment for mixed infections.
  • Promotes Faster Recovery: Helps eliminate the underlying infection more effectively, which may shorten the duration of illness and speed up recovery.
  • Relieves Digestive Symptoms: Reduces diarrhoea, abdominal cramps, bloating, and discomfort associated with gastrointestinal infections.
  • Improves Daily Comfort and Function: By controlling infection-related symptoms, it helps you return to normal eating habits and daily activities more comfortably.
  • Helps Prevent Recurrence: Completing the full prescribed course helps ensure the infection is fully cleared and reduces the risk of recurrence or antimicrobial resistance.
     

Directions for Use

Follow these step-by-step instructions to take Tizflox 400 mg/600 mg Tablet safely and effectively:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed and may cause a bitter taste.
  • Take this medicine with food or immediately after a meal to reduce the risk of stomach irritation.
  • Always follow your doctor's exact instructions regarding the timing and duration of your treatment. Do not stop taking the medicine early, even if your symptoms improve.
     

How Tizflox 400 mg/600 mg Tablet Works

Tizflox 400 mg/600 mg Tablet contains two active medicines that work together to treat gastrointestinal infections caused by bacteria and parasites. Norfloxacin is an antibiotic that works by interfering with the ability of bacteria to repair and copy their genetic material. This prevents the bacteria from multiplying and helps eliminate the infection from the digestive tract. Tinidazole is an antiprotozoal and antibacterial medicine that targets parasites and certain types of bacteria that thrive in low-oxygen environments, such as the intestines. It works by damaging the DNA of these microorganisms, preventing them from surviving and spreading. Together, these medicines help clear mixed bacterial and parasitic infections of the stomach and intestines, reducing symptoms such as diarrhoea, abdominal discomfort, and dysentery while promoting recovery from the infection.
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Alcohol

Unsafe

Tizflox 400 mg/600 mg Tablet should not be taken along with alcohol as it is known to cause stomach irritation.

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Pregnancy

Consult your doctor

Caution should be exercised, it is advisable to consult a doctor before using it.

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Breast Feeding

Consult your doctor

Tizflox 400 mg/600 mg Tablet does not pass on to the child significantly via breast milk, it is advisable to consult a doctor before using it.

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Driving

Caution

Tizflox 400 mg/600 mg Tablet may cause dizziness and vision problems. So, drive only if you are alert.

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Liver

Caution

Tizflox 400 mg/600 mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Tizflox 400 mg/600 mg Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Tizflox 400 mg/600 mg Tablet is not recommended for children below 12 years of age without a doctor's consent. For children above 12 years, the dose to be adjusted and recommended by a child specialist only.

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Heart

Caution

Tizflox 400 mg/600 mg Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Tizflox 400 mg/600 mg Tablet.

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Geriatrics

Caution

Tizflox 400 mg/600 mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Tizflox 400 mg/600 mg Tablet.

What if I have taken an overdose of Tizflox 400 mg/600 mg Tablet

If you suspect an overdose or experience severe symptoms like extreme dizziness, confusion, or fits, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Stay Well Hydrated: Stay hydrated by drinking plenty of clean water, oral rehydration solutions (ORS), clear broths, or coconut water to replace lost fluids and electrolytes.
  • Choose Easy-to-Digest Foods: Eat bland, easy-to-digest foods such as bananas, rice, applesauce, and toast while recovering.
  • Avoid Foods That May Worsen Symptoms: Avoid dairy products, high-fibre foods, spicy dishes, fatty foods, caffeine, and artificial sweeteners, as these can irritate your gut and worsen diarrhoea.
  • Maintain Good Hand Hygiene: Practise strict hand hygiene by washing your hands thoroughly with soap and water before eating and after using the bathroom to prevent reinfection.
     
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How Soon It Starts Working

  • The time required for Tizflox 400 mg/600 mg Tablet to start to work: The time required for Tizflox 400 mg/600 mg Tablet to start to work is 1 to 2 hours after administration.
  • The time for which the effects of Tizflox 400 mg/600 mg Tablet last: The effect of Tizflox 400 mg/600 mg Tablet lasts for 24 hours.

What if you forget to take Tizflox 400 mg/600 mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Tizflox 400 mg/600 mg Tablet at room temperature, between 15°C and 30°C (59°F to 86°F). •Keep the tablets in their original packaging to protect them from direct light and moisture.

Drug Warnings

  • Complete the Full Course: Finish the entire course prescribed by your doctor, even if you feel completely recovered after a few doses, to prevent the infection from returning.
  • Use Caution When Driving or Operating Machinery: Avoid driving or operating machinery if you experience dizziness or lightheadedness while taking this medicine.
  • Protect Yourself from Sun Exposure: Wear sunscreen and protective clothing when outdoors, as this medicine can make your skin more sensitive to sunlight.
  • Report Tendon or Joint Problems Immediately: Stop taking the medicine and contact your doctor immediately if you experience sudden pain, snapping, or swelling in any of your joints.
  • Inform Laboratory Personnel About Your Medication: Inform your laboratory staff that you are taking this medicine, as it can affect the results of certain urine and blood tests.

 

Drug-Drug Interactions

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Drug-Drug Interactions

Tizflox 400 mg/600 mg Tablet may interact with the following medicines, potentially affecting treatment effectiveness or increasing the risk of side effects: 

  • Blood Thinners: May increase the risk of bleeding when combined with blood thinners like warfarin.
    Antacids Containing Magnesium or Aluminium: Antacids containing magnesium or aluminum can reduce the absorption of this medicine; take them at least two hours apart.
  • Caffeine and Theophylline-Containing Medicines: May increase the levels of caffeine or theophylline in your body, leading to restlessness or rapid heartbeat.

Drug-Food Interactions

The following foods and beverages may affect how Tizflox 400 mg/600 mg Tablet works or increase the risk of side effects:

  • Dairy Products: Avoid dairy products like milk or yogurt at the same time as taking this medicine, as calcium can reduce its absorption.
  • Alcohol: Avoid alcohol during and for at least 72 hours after completing the treatment to prevent a severe reaction.

Drug-Disease Interactions

Special caution may be required if you have any of the following medical conditions before taking Tizflox 400 mg/600 mg Tablet:

  • Nerve Disorders, Seizure Disorders, or Muscle Weakness: May worsen symptoms in individuals with pre-existing nerve disorders, seizures, or muscle weakness.
  • History of Tendon Problems: Use with caution if you have a history of tendon problems, as it may increase the risk of tendon inflammation or rupture.
     
Tinidazole + NorfloxacinCisapride
Critical
Tinidazole + NorfloxacinAmprenavir
Critical

Drug-Drug Interactions

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Tinidazole + NorfloxacinCisapride
Critical
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Coadministration of Norfloxacin and Tinidazole with Cisapride can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin and Tinidazole with Cisapride together can result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
Tinidazole + NorfloxacinAmprenavir
Critical
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Co-administration of Amprenavir with Norfloxacin and Tinidazole can increase the risk or severity of developing serious side effects.

How to manage the interaction:
Co-administration of Amprenavir with Norfloxacin and Tinidazole is generally avoided, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like flushing, severe headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, excessive sweating, dizziness, lightheadedness, or blurred vision, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
Tinidazole + NorfloxacinDisopyramide
Critical
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Coadministration of Norfloxacin and Tinidazole with Disopyramide can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin and Tinidazole with Disopyramide together can result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
Tinidazole + NorfloxacinSotalol
Critical
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Coadministration of Norfloxacin and Tinidazole with Sotalol can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin and Tinidazole with Sotalol is generally avoided as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
Tinidazole + NorfloxacinAmiodarone
Critical
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
The combination of Amiodarone and Norfloxacin may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Amiodarone with Norfloxacin and Tinidazole results in an interaction, but it can be taken if a doctor prescribes it. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
Tinidazole + NorfloxacinMesoridazine
Critical
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Using Mesoridazine together with norfloxacin and Tinidazole can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Norfloxacin and Tinidazole results in an interaction, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
Tinidazole + NorfloxacinBepridil
Critical
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Using bepridil together with norfloxacin and Tinidazole can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin and Tinidazole with Bepridil results in an interaction, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or a fast or pounding heartbeat. Do not stop using any medications without talking to a doctor.
Tinidazole + NorfloxacinSaquinavir
Severe
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Coadministration of Norfloxacin and Tinidazole with Saquinavir can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin and Tinidazole with Saquinavir together can result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
Tinidazole + NorfloxacinOsimertinib
Severe
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Coadministration of Norfloxacin and Tinidazole with Osimertinib can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin and Tinidazole with Osimertinib together can result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
Tinidazole + NorfloxacinBupropion
Severe
How does the drug interact with Tizflox 400 mg/600 mg Tablet:
Coadministration of Bupropion with norfloxacin and tinidazole may enhance the risk or severity of seizure.

How to manage the interaction:
Co-administration of bupropion along with norfloxacin and tinidazole can lead to an interaction, but it can be taken if recommended by a doctor. While taking these medications, you should avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORFLOXACIN-400MG+TINIDAZOLE-600MGCalcium rich foods

Drug-Food Interactions

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NORFLOXACIN-400MG+TINIDAZOLE-600MGCalcium rich foods
Common Foods to Avoid:
Tofu Set With Calcium, Ragi, Seasame Seeds, Kale, Milk, Almonds, Bok Choy, Calcium-Fortified Soy Milk, Cheese, Yogurt

How to manage the interaction:
Consumption of food containing minerals like magnesium, zinc, and calcium reduces the absorption of Tinidazole and Norfloxacin, resulting in reduced medication efficacy in treating infections. It is advised to take Tinidazole and Norfloxacin on an empty stomach and to avoid consuming food or products containing minerals one hour before and 2 hours after consuming Tinidazole and Norfloxacin.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Tizflox 400 mg/600 mg Tablet is used to treat diarrhoea, dysentery‚ and stomach infections.
Tizflox 400 mg/600 mg Tablet is a combination of two antibiotics, Norfloxacin, and Tinidazole,‚ primarily taken to treat diarrhoea, dysentery, and severe stomach infections. Norfloxacin helps by preventing the bacterial cells from dividing, thereby killing the bacteria. Tinidazole kills parasites that cause infections by damaging their DNA. Both of them effectively treat the infection by killing the bacteria, as they are bactericidal in nature.
Yes, Tizflox 400 mg/600 mg Tablet may cause minor skin rashes or reactions. If you are experiencing skin rashes or any allergic reactions, consult a doctor and stop taking Tizflox 400 mg/600 mg Tablet.
No, Tizflox 400 mg/600 mg Tablet is a combination of two antibiotic drugs that help resolve moderate to severe infections of the stomach. This medicine is not a painkiller. However, completing a full course of Tizflox 400 mg/600 mg Tablet may bring relief to discomfort and stomach pain caused by infections.
The use of Tizflox 400 mg/600 mg Tablet is considered to be harmful to patients with known allergy to norfloxacin or tinidazole, or any other excipient present in the medicine. It should preferably be avoided in patients with a history of tendinitis (inflammation of the tendons) or tendon rupture. It is also avoided in patients with some neurological disorders.
No. Do not stop taking Tizflox 400 mg/600 mg Tablet early, even if your diarrhoea or other symptoms improve. Stopping treatment prematurely may allow the infection to return and may contribute to antibiotic resistance. Complete the full course prescribed by your doctor.
It is recommended not to take dairy products such as milk, yoghurt, and Tizflox 400 mg/600 mg Tablet as they might decrease the effectiveness of Tizflox 400 mg/600 mg Tablet. Please maintain a gap of at least 2 hours between them.
Tizflox 400 mg/600 mg Tablet can be taken with or without food, as directed by your doctor.
Tizflox 400 mg/600 mg Tablet is antibiotic medication contains Norfloxacin and Tinidazole, primarily used to treat diarrhoea, dysentery, and severe stomach infections.
Yes. In rare cases, Tizflox 400 mg/600 mg Tablet may cause tendon inflammation (tendinitis), tendon pain, or even tendon rupture, particularly in the Achilles tendon. If you experience sudden tendon or joint pain, swelling, stiffness, or difficulty moving, stop taking the medicine and contact your doctor immediately. The risk may be higher in people with a history of tendon disorders.
Yes, a metallic or bitter taste in the mouth is a common side effect of Tizflox 400 mg/600 mg Tablet, particularly due to tinidazole. This effect is usually mild and temporary and generally disappears after completing treatment. Consult your doctor if it becomes troublesome or persists.
No, you should avoid alcohol while taking Tizflox 400 mg/600 mg Tablet and for at least 3 days after your last dose. Drinking alcohol may cause unpleasant reactions such as flushing, headache, nausea, vomiting, rapid heartbeat, dizziness, and stomach irritation. Consult your doctor if you have concerns.
You can take an ORS (Oral Rehydration Solution) with Tizflox 400 mg/600 mg Tablet. Your doctor may recommend an Oral Rehydration Solution (ORS) to prevent dehydration, especially with diarrhoea. This combination helps replace lost fluids and electrolytes. Always follow your doctor's guidance on dosage and timing for the medication and ORS.
Take only the recommended dose of Tizflox 400 mg/600 mg Tablet. Exceeding the prescribed amount can lead to severe side effects. Always follow your doctor's dosage instructions. If you think the current dose isn't working, consult your doctor. They may adjust the dosage or suggest alternative treatments.
The recommended storage condition for Tizflox 400 mg/600 mg Tablet is below 30°C (86°F). Keep it in a cool, dry place, protected from direct sunlight, moisture, and heat. Keep it out of the sight and reach of children and pets.
If your symptoms do not improve within a few days of starting Tizflox 400 mg/600 mg Tablet, or if they worsen, contact your doctor. Seek immediate medical attention if you develop severe watery diarrhoea, fever, blood in the stool, or signs of dehydration. Do not take additional medicines without consulting your doctor.
If you forget a dose of Tizflox 400 mg/600 mg Tablet, take it immediately when you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.
If you have constipation or have blood in stools, do not take Tizflox 400 mg/600 mg Tablet. It is not suitable for treating constipation. It is an antimicrobial medication used to treat infections like diarrhoea, dysentery, and stomach infections by killing bacteria and parasites. It's best to consult your doctor for appropriate treatments and remedies for constipation.
The recommended dosage of Tizflox 400 mg/600 mg Tablet is typically two tablets per day, taken 12 hours apart. However, the exact dosage and frequency may vary depending on your circumstances. Your doctor will determine the best dosage schedule for you based on the type and severity of your infection and your overall health. Be sure to follow their instructions carefully to ensure effective treatment.
Tizflox 400 mg/600 mg Tablet effectively treats loose motion (diarrhoea) caused by bacterial and protozoal infections. It helps relieve symptoms of loose motion, but it's crucial to consult a doctor before taking this medication. They will diagnose the underlying cause of loose motion and prescribe the appropriate treatment. Only a doctor can determine if Tizflox 400 mg/600 mg Tablet is the proper treatment for your case.
Tizflox 400 mg/600 mg Tablet is not suitable for children under 12, as it may harm developing bones and joints. Exceptions may be made for children over 12 or those with severe infections, but only under a paediatrician's guidance. Always consult a doctor before administering this medication to children.
Some side effects may occur while taking Tizflox 400 mg/600 mg Tablet, but they usually do not cause complications and are eliminated over time as the body adapts to the medication. They are nausea, dryness of the mouth, stomach upset, headache, metallic taste or change in taste, loss of appetite, weakness, skin rash, or itching. If any of these effects continue, please inform your doctor and get guidance to manage them.
Tizflox 400 mg/600 mg Tablet is generally not recommended during pregnancy unless your doctor considers it absolutely necessary. Your doctor will assess the potential benefits and risks before prescribing this medicine. If you are pregnant or planning to become pregnant, consult your doctor before taking Tizflox 400 mg/600 mg Tablet.
You should avoid taking antacids containing calcium, magnesium, or aluminum at the same time as this medicine. Antacids can bind to the medication and prevent your body from absorbing it properly. Take your antacid at least two hours before or two hours after taking this medicine, or talk to your doctor.
The dosage of Tizflox 400 mg/600 mg Tablet depends on the type and severity of the infection and your overall health. Many patients are prescribed one tablet twice daily (12 hours apart), but your doctor will determine the most appropriate dose for you. Always follow your doctor's instructions and do not exceed the prescribed dose.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

84 Changodar Industrial Estate, Changodar, Sanand - 382220, Taluka Sanand
Other Info - TI87233
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