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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tizidal D 50mg/2mg Tablet is used to treat spasticity (muscle stiffness and spasms) associated with pain. It contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac blocks prostaglandins (PGs) that cause pain and swelling. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. As a result, it helps to reduce muscle stiffness, spasms, and pain.

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Manufacturer/Marketer :

Adley Formulations

Consume Type :

ORAL

Return Policy :

Not Returnable

About Tizidal D 50mg/2mg Tablet

Tizidal D 50mg/2mg Tablet is a combination medicine that contains pain relievers and muscle relaxants. It is used to treat spasticity (muscle stiffness and spasms) associated with pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. A muscle spasm occurs due to involuntary contractions of a muscle. A spasm may be a muscle cramp or feel tight or stiff, like a knot.

Tizidal D 50mg/2mg Tablet contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac blocks prostaglandins (PGs) that cause pain and swelling. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. As a result, Tizidal D 50mg/2mg Tablet helps to reduce muscle stiffness, spasms, and pain.

Tizidal D 50mg/2mg Tablet is prescribed medication, and it should be taken as directed by the doctor. In some cases, you may experience common side effects such as feeling or being sick (vomiting), diarrhoea, headaches, drowsiness and ringing in your ears (tinnitus), fluctuations in blood pressure, dry mouth, stomach upsets, and decrease or increase in heart rate. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before prescribing Tizidal D 50mg/2mg Tablet, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Also, tell your doctor about your medical history and other medications you are currently taking to rule out any potential adverse effects. Do not take Tizidal D 50mg/2mg Tablet unless recommended by the doctor if you are pregnant or planning pregnancy or breastfeeding. Tizidal D 50mg/2mg Tablet may cause dizziness, so drive only if you are alert and focused. Tizidal D 50mg/2mg Tablet should not be given to children as safety has not been established. Avoid consuming alcohol while on treatment with Tizidal D 50mg/2mg Tablet as it could lead to liver damage.

Uses of Tizidal D 50mg/2mg Tablet

Tizidal D 50mg/2mg Tablet is used in the treatment of spasticity and associated musculoskeletal pain. The detailed uses of Tizidal D 50mg/2mg Tablet are as follows:<br/>• Relieves muscle stiffness and spasms: Tizanidine in Tizidal D 50mg/2mg Tablet acts as a muscle relaxant to reduce involuntary muscle tightness and improve mobility.<br/>• Reduces pain and inflammation: Tizidal D 50mg/2mg Tablet helps alleviate pain, swelling, and inflammation in muscles and joints associated with spasticity.<br/>• Improves functional movement: Tizidal D 50mg/2mg Tablet enhances comfort and physical activity in patients with painful muscle spasms.<br/>

Directions for Use

• Take Tizidal D 50mg/2mg Tablet with food to avoid stomach upset.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Tizidal D 50mg/2mg Tablet contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac inhibits the production of prostaglandins (PGs), which induce pain and swelling. Tizanidine modulates the spinal cord and brain centres. This aids in the relief of muscle stiffness and the improvement of muscle movements. As a result, Tizidal D 50mg/2mg Tablet aids in relieving muscle stiffness, spasms, and pain.

How Tizidal D 50mg/2mg Tablet Works

Tizidal D 50mg/2mg Tablet contains Tizanidine and Diclofenac. Muscle relaxation: Tizanidine, a muscle relaxant, operates in the brain and spinal cord to reduce muscular stiffness and spasms by decreasing the release of excitatory amino acids. Reducing Pain and Inflammation: Diclofenac, a non-steroidal anti-inflammatory medication (NSAID), effectively lowers pain and inflammation by inhibiting the formation of prostaglandins.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Tizidal D 50mg/2mg Tablet out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Tizidal D 50mg/2mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Tizidal D 50mg/2mg Tablet may include nausea, vomiting, low blood pressure, a slow or abnormal heartbeat, dizziness, small pupils, difficulty breathing, coma, restlessness or sleepiness, and ulcer in your stomach or gut. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Tizidal D 50mg/2mg Tablet if you are allergic to its components. Inform your doctor about all your medical conditions, especially if you have/ had hepatotoxicity, hypotension, renal dysfunction or renal toxicities, asthma, fluid retention, GI toxicity, rash, or thrombosis (blood clots). It is not recommended to take Tizidal D 50mg/2mg Tablet during pregnancy or whilst breastfeeding. Tizidal D 50mg/2mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Tizidal D 50mg/2mg Tablet is not recommended for children as safety and effectiveness have not been established. Do not stop taking Tizidal D 50mg/2mg Tablet unless your doctor tells you to. Treatment with Tizidal D 50mg/2mg Tablet should be stopped gradually. Stopping treatment suddenly may cause effects such as an increase in heart rate and high blood pressure.

Drug-Drug Interactions

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TizanidineSaquinavir
Critical

Drug-Drug Interactions

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TizanidineSaquinavir
Critical
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Combining Tizidal D 50mg/2mg Tablet with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Tizidal D 50mg/2mg Tablet with Saquinavir is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Taking Fluvoxamine with Tizidal D 50mg/2mg Tablet it can increases the risk of side effects.

How to manage the interaction:
Although Fluvoxamine with Tizidal D 50mg/2mg Tablet is not recommended, but can be taken together if prescribed by a doctor. However, if you experience drowsiness, dizziness, low blood pressure, slurred speech, confusion, or severe weakness, contact your doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Coadministration of Ciprofloxacin and Tizidal D 50mg/2mg Tablet together can increase the risk of side effects.

How to manage the interaction:
Using Ciprofloxacin and Tizidal D 50mg/2mg Tablet together is avoided, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Co-administration of Tizidal D 50mg/2mg Tablet with Ziprasidone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Tizidal D 50mg/2mg Tablet with Ziprasidone is not recommended, as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Coadministration of Tizidal D 50mg/2mg Tablet with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tizidal D 50mg/2mg Tablet with Cisapride is avoided as it can result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or vomiting. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Coadministration of Tizidal D 50mg/2mg Tablet with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Tizidal D 50mg/2mg Tablet with Dronedarone is generally avoided as it can result in an interaction, it can be taken when prescribed by a doctor. If you experience sudden dizziness, shortness of breath, palpitations, or chest pain, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Co-administration of Tizidal D 50mg/2mg Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Tizidal D 50mg/2mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Coadministration of Metoprolol and Tizidal D 50mg/2mg Tablet may reduce the efficiency of metoprolol.

How to manage the interaction:
Taking Metoprolol and Tizidal D 50mg/2mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience blurry vision, confusion, dizziness, fainting, lightheadedness, nausea or vomiting, contact your doctor immediately. do not discontinue any medications without talking to your doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Co-administration of Tizidal D 50mg/2mg Tablet and Amlodipine can increase the risk or severity of developing side effects like low blood pressure.

How to manage the interaction:
Although co-administration of amlodipine with Tizidal D 50mg/2mg Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience headache, dizziness, palpitations, or irregular heart rate while taking these drugs, contact the doctor immediately. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not discontinue any medications without consulting the doctor.
How does the drug interact with Tizidal D 50mg/2mg Tablet:
Taking Nimodipine and Tizidal D 50mg/2mg Tablet when taken together may lower the blood pressure which may lead to side effects.

How to manage the interaction:
Although taking Nimodipine and Tizidal D 50mg/2mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience lightheadedness, dizziness, headaches, fainting, or irregular heart rate, consult a doctor. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Regular exercise helps muscle stretch, making them less likely to spasm, tear, and sprain. Mild activities such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Rest well, and get plenty of sleep.
  • Change your position at least every two hours to avoid developing pressure sores.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Tizidal D 50mg/2mg Tablet as it may cause increased drowsiness. It may also increase the risk of stomach bleeding.

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Pregnancy

Caution

Tizidal D 50mg/2mg Tablet is not recommended for use in pregnant women. If you are pregnant or planning pregnancy, inform your doctor before taking Tizidal D 50mg/2mg Tablet.

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Breast Feeding

Caution

Tizidal D 50mg/2mg Tablet is not recommended for use in breastfeeding mothers. If you are breastfeeding, consult your doctor before taking Tizidal D 50mg/2mg Tablet.

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Driving

Caution

Tizidal D 50mg/2mg Tablet may cause dizziness or drowsiness. So, do not drive or operate machinery unless you are alert.

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Liver

Caution

Inform your doctor before receiving Tizidal D 50mg/2mg Tablet if you have a liver impairment/disorder history. Tizidal D 50mg/2mg Tablet is not recommended for use in severely impaired liver function patients.

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Kidney

Caution

Inform your doctor before receiving Tizidal D 50mg/2mg Tablet if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Tizidal D 50mg/2mg Tablet is not recommended for children as safety and effectiveness are not established.

Have a query?

FAQs

Tizidal D 50mg/2mg Tablet is used to treat Spasticity (muscle stiffness and spasms) associated with pain.

Tizidal D 50mg/2mg Tablet contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac inhibits the production of prostaglandins (PGs), which induce pain and swelling. Tizanidine modulates the spinal cord and brain centres. This aids in the relief of muscle stiffness and the improvement of muscle movements. As a result, Tizidal D 50mg/2mg Tablet aids in relieving muscle stiffness, spasms, and pain.

Diarrhoea might be a side-effect of Tizidal D 50mg/2mg Tablet. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Dry mouth could be a side-effect of Tizidal D 50mg/2mg Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent mouth drying.

Taking Tizidal D 50mg/2mg Tablet can elevate symptoms of gastric ulcer and bleeding. So, talk to your doctor before taking Tizidal D 50mg/2mg Tablet if you have gastrointestinal bleeding or other bleeding problems before using Tizidal D 50mg/2mg Tablet.

It is not advisable to take Tizidal D 50mg/2mg Tablet and ciprofloxacin simultaneously. Inform your doctor if you are now using or have recently used ciprofloxacin. Your doctor may advise you to take these two medications at different times.

Country of origin

India

Manufacturer/Marketer address

first floor, 15-6-108 afzal gunj, hyderabad, telangana 500012
Other Info - TI18254

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