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compositionComposition:TRIPTORELIN-11.25MG
prescription
Prescription Medicine
info
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Tmoate 11.25 Depot Injection Combipack 1's is used to treat prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. It contains Triptorelin which works by inhibiting the synthesis of testosterone in men and oestrogen in women. In some cases, this medicine may cause side effects such as hot flashes, dizziness, headache, flu symptoms, nausea, vomiting, diarrhoea, upset stomach and swelling in the legs. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRIPTORELIN-11.25MG

Manufacturer/Marketer :

Shilpa Medicare Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Tmoate 11.25 Depot Injection Combipack 1's

Tmoate 11.25 Depot Injection Combipack 1's is a prescription injection used primarily to treat advanced prostate cancer in men. It is also prescribed to manage conditions in women, such as endometriosis and uterine fibroids, and to treat early-onset puberty in children. This medication works by safely reducing the body's production of certain sex hormones.

Because this medication is usually prescribed as a long-acting injection given once every few weeks or months, keeping your medical appointments consistently is vital to its success. Since it is injected, it does not interact with food and can be taken without regard to meals. To support your treatment, incorporating bone-strengthening lifestyle habits like regular light exercise is highly recommended.

While using Tmoate 11.25 Depot Injection Combipack 1's, you may experience common, mild side effects such as hot flashes, temporary headache, or mild pain at the injection site. However, if you experience rare but serious symptoms like severe muscle weakness, trouble urinating, or severe bone pain, please consult your doctor immediately.

Before starting this treatment, you must tell your healthcare provider if you have a history of diabetes, heart rhythm disorders, or bone-thinning conditions. Do not take this medication if you are pregnant, planning to become pregnant, or have unexplained vaginal bleeding.

This medication can interact with other drugs that affect your heart rhythm, making a complete review of your current prescriptions essential. It is also important to consult your healthcare provider if you are breastfeeding or are an elderly patient, as specific monitoring may be needed.

Uses of Tmoate 11.25 Depot Injection Combipack 1's

Tmoate 11.25 Depot Injection Combipack 1's is used to manage hormone-dependent conditions by regulating the production of sex hormones in the body. Its uses include:

  • Advanced prostate cancer: It helps lower testosterone levels in the body, which can slow down or stop the growth of hormone-sensitive cancer cells in the prostate.
  • Endometriosis: It temporarily stops the production of oestrogen, which helps shrink abnormal tissue growing outside the uterus and relieves painful symptoms.
  • Uterine fibroids: It reduces hormone levels to shrink non-cancerous uterine growths, helping to decrease heavy menstrual bleeding and pelvic pain before surgery.
  • Early-onset puberty: It helps delay early sexual development in children by temporarily pausing the release of puberty-inducing hormones.

Key Benefits

Tmoate 11.25 Depot Injection Combipack 1's is a gonadotropin-releasing hormone agonist that regulates the production of sex hormones. Depending on the condition being treated, it may help manage advanced prostate cancer, endometriosis, uterine fibroids, or central precocious puberty.

  • Helps Manage Advanced Prostate Cancer: Lowers testosterone levels, which may slow the growth and progression of hormone-sensitive prostate cancer.
  • Relieves Prostate Cancer-Related Symptoms: By controlling disease activity, it may help reduce symptoms such as bone pain and urinary discomfort in some patients.
  • Reduces Endometriosis Symptoms: Lowers oestrogen levels, helping relieve pelvic pain and other symptoms associated with endometriosis.
  • Helps Manage Uterine Fibroids: May reduce heavy menstrual bleeding and shrink fibroids temporarily, improving symptoms and supporting pre-operative management when prescribed for this purpose.
  • Controls Early Puberty: In children with central precocious puberty, it suppresses premature sex hormone production, helping delay further pubertal development until a more appropriate age.
Side effects of Tmoate 11.25 Depot Injection Combipack
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.
  • Rest well; get enough sleep. This helps the body fight infection.
  • Keep yourself hydrated by drinking enough water and other fluids.
  • Wash your hands often and avoid touching your eyes, mouth or nose.
  • Wear a mask whilst going out.
  • Warm steam or a hot shower may help with nose secretions.
  • Avoid contact with others to prevent contamination.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Boost immunity with vitamins by including foods rich in vitamins C (citrus fruits, bell peppers) and D (fortified milk, fatty fish).
  • Eat omega-3 rich foods like fatty fish like salmon, tuna, and sardines to reduce inflammation.
  • Stay hydrated by drinking plenty of fluids to thin mucus and aid drainage.
  • Consider probiotic-rich foods like yogurt to potentially help prevent future ear infections.
  • Limit dairy and sugar intake to manage mucus production.
  • Sleep with head elevated by using extra pillows to facilitate fluid drainage.
  • Apply warm compress for temporary pain relief.
  • Wash hands frequently to prevent spreading germs.
  • Use a humidifier to add moisture to the air to help with congestion and ear pressure.
  • Avoid secondhand smoke to reduce risk of ear infections.
  • Consult your doctor before making significant dietary or lifestyle changes, especially if taking medication for ear infection.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Tmoate 11.25 Depot Injection Combipack 1's will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Tmoate 11.25 Depot Injection Combipack 1's Works

Tmoate 11.25 Depot Injection Combipack 1's contains triptorelin, which belongs to a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It targets the pituitary gland in the brain, which controls hormone production. Initially, the injection causes a short-term increase in the hormones that stimulate the ovaries or testicles. After a short period of continuous use, Tmoate 11.25 Depot Injection Combipack 1's desensitises the pituitary gland. This action leads to a significant and sustained drop in the production of sex hormones, specifically testosterone in men and oestrogen in women. By keeping these hormone levels very low, the medicine reduces hormonal stimulation of hormone-dependent conditions, slowing their growth and relieving related symptoms.
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Alcohol

Caution

It is advised to avoid alcohol consumption to minimize the unwanted effects of Tmoate 11.25 Depot Injection Combipack 1's. Please consult your doctor for more information.

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Pregnancy

Unsafe

Tmoate 11.25 Depot Injection Combipack 1's is a pregnancy category X drug. It is unsafe to use Tmoate 11.25 Depot Injection Combipack 1's in pregnancy and can have harmful effects on the unborn baby. Use reliable forms of contraception to prevent pregnancy while using Tmoate 11.25 Depot Injection Combipack 1's.

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Breast Feeding

Unsafe

Tmoate 11.25 Depot Injection Combipack 1's is unsafe to use during breastfeeding. Consult your doctor for further information.

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Driving

Unsafe

Tmoate 11.25 Depot Injection Combipack 1's causes dizziness and affects your ability to drive. Do not drive or operate machinery if you experience any unmanageable side effects with Tmoate 11.25 Depot Injection Combipack 1's.

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Liver

Caution

Please let your doctor know if you have any history of liver diseases or hepatic impairment before starting Tmoate 11.25 Depot Injection Combipack 1's.

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Kidney

Caution

Please let your doctor know if you have any history of kidney diseases before starting Tmoate 11.25 Depot Injection Combipack 1's.

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Children

Caution

Tmoate 11.25 Depot Injection Combipack 1's is not recommended in children younger than two years of age.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Tmoate 11.25 Depot Injection Combipack 1's. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Your doctor will administer Tmoate 11.25 Depot Injection Combipack 1's if needed in the hospital setting.

What if I have taken an overdose of Tmoate 11.25 Depot Injection Combipack 1's

Because this medication is typically administered by a healthcare professional, an accidental overdose is highly unlikely. However, if you suspect you have received too much or experience severe symptoms, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Support your bones: Since lowered hormone levels can cause bone thinning, eat a diet rich in calcium and vitamin D. Foods like yoghurt, leafy greens, and fortified cereals are excellent choices.
  • Incorporate weight-bearing exercise: Engage in low-impact activities like walking or light strength training to help keep your bones and muscles strong.
  • Manage hot flashes naturally: Wear light, layered clothing, keep your bedroom cool, and limit triggers like hot drinks, spicy foods, and caffeine.
  • Monitor your blood sugar: This medication can occasionally affect your body's sugar processing. Eat balanced meals focused on whole grains, vegetables, and lean proteins to support healthy blood sugar levels.
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How Soon It Starts Working

The time required for Tmoate 11.25 Depot Injection Combipack 1's to start to work: The time required for Tmoate 11.25 Depot Injection Combipack 1's to show its action is unknown. The time for which the effects of Tmoate 11.25 Depot Injection Combipack 1's last: The duration of action for Tmoate 11.25 Depot Injection Combipack 1's is clinically unknown.

What if you forget to take Tmoate 11.25 Depot Injection Combipack 1's

If you miss an appointment for your injection, contact your healthcare provider or clinic immediately to reschedule. Keeping a consistent schedule is very important to maintain stable hormone levels. Do not double the dose to make up for a missed one.

Storage

• Store Tmoate 11.25 Depot Injection Combipack 1's according to the package instructions, typically at room temperature below 25°C (77°F).• Do not freeze this medication, and keep it in its original packaging to protect it from light and moisture.

Drug Warnings

  • Inspect the Medicine Before Use: Before administration, the healthcare professional should check the prepared injection and avoid using it if there is unexpected discolouration, cloudiness, or visible particles inconsistent with the product instructions.
  • Follow Injection-Site Instructions: Tmoate 11.25 Depot Injection Combipack 1's is administered by a healthcare professional. Follow the recommended injection schedule and site instructions for the specific formulation prescribed.
  • Use Non-Hormonal Contraception if Advised: Women who could become pregnant should use an effective non-hormonal contraceptive method during treatment and follow their doctor's advice regarding how long contraception is needed.
  • Monitor Blood Sugar and Blood Pressure: Regular monitoring may be recommended, particularly if you have diabetes, high blood pressure, or other cardiovascular risk factors.
  • Attend Regular Follow-Ups: Keep all scheduled appointments and complete recommended blood tests so your doctor can monitor hormone levels, treatment response, and overall health.

Drug-Drug Interactions

verifiedApollotooltip

Certain medicines may interact with Tmoate 11.25 Depot Injection Combipack 1's and alter its effects or increase the risk of side effects. Important interactions include:

  • Heart rhythm medications: Using Tmoate 11.25 Depot Injection Combipack 1's with drugs that change the electrical activity of your heart (such as certain antiarrhythmics, antipsychotics, or some antibiotics) may increase the risk of heart rhythm problems.
  • Prolactin-elevating medicines: Medications that increase prolactin levels in your blood may reduce the overall effectiveness of this treatment.
TriptorelinClozapine
Severe
TriptorelinCeritinib
Severe

Drug-Drug Interactions

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TriptorelinClozapine
Severe
How does the drug interact with Tmoate 11.25 Depot Injection Combipack:
Combining Tmoate 11.25 Depot Injection Combipack with Clozapine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Tmoate 11.25 Depot Injection Combipack and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like an irregular heart rhythm, dizziness, shortness of breath, or heart palpitations, it's important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
TriptorelinCeritinib
Severe
How does the drug interact with Tmoate 11.25 Depot Injection Combipack:
Coadministration of Tmoate 11.25 Depot Injection Combipack with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Ceritinib with Tmoate 11.25 Depot Injection Combipack can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms like irregular heart rhythm, dizziness, fainting, or shortness of breath, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
TriptorelinMoxifloxacin
Severe
How does the drug interact with Tmoate 11.25 Depot Injection Combipack:
Using moxifloxacin together with Tmoate 11.25 Depot Injection Combipack can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Tmoate 11.25 Depot Injection Combipack together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any symptoms like an irregular heart rhythm, prolonged diarrhea or vomiting, complications, sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, you should contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Tmoate 11.25 Depot Injection Combipack 1's when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[GONADOTROPHIN-RELEASING HORMONE AGONIST]

FAQs

Yes. Tmoate 11.25 Depot Injection Combipack 1's may cause mood changes such as anxiety, mood swings, or depression because it lowers hormone levels. If you already have depression or another mental health condition, use this medicine only under close medical supervision, as your symptoms may worsen. Contact your doctor promptly if you experience persistent sadness, loss of interest, mood changes, or thoughts of self-harm.
No, Tmoate 11.25 Depot Injection Combipack 1's is not a chemotherapy drug. It is a hormone therapy that works by lowering hormone levels in your body to help control hormone-sensitive conditions. Talk to your doctor if you want to understand more about how this differs from chemotherapy.
While there is no direct chemical interaction, drinking alcohol can worsen some of the side effects of this medication, such as hot flashes and the risk of bone thinning. Talk to your doctor or pharmacist about safe alcohol consumption during treatment.
Yes, some patients may experience mild weight gain or changes in body fat distribution due to the lowered levels of sex hormones in the body. Talk to your doctor for advice on managing your weight through diet and exercise.
Yes, most women will stop having regular periods during treatment because oestrogen levels are significantly reduced. Your periods should return a few months after your treatment is finished. Talk to your doctor if you experience unexpected or heavy bleeding.
No, this medication must not be used during pregnancy as it can cause harm to an unborn baby. Women of childbearing age must use an effective non-hormonal birth control method while on this medication. Talk to your doctor immediately if you think you might be pregnant.
In most cases, this medication is administered by a qualified healthcare provider in a clinic or doctor's office. Talk to your doctor to see if home administration by a trained caregiver is an option for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.780 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Triptorelin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Triptorelin pamoate. 2010. [Accessed on 23 Jan. 2019]Check here
  5. Triptorelin pamoate. 2000. [Accessed on Jul. 2014]Check here
  6. Ema. Triptorelin. [[Accessed on 15.Sept].2019] :Check here
  7. Bethesda (MD). Triptorelin. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. March 2022. [Accessed on 11th June 2022]Check here

Country of origin

India

Manufacturer/Marketer address

709, 7Th Floor, Palm Spring Center, Link Road, Malad West, Mumbai- 400064
Other Info - TMO0001
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