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compositionComposition:TOBRAMYCIN-80MG
prescription
Prescription Medicine
info
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Tobomac 80 Injection is used to treat bacterial infections of the brain and spinal cord (meningitis), stomach or intestines, bladder or kidney (urinary tract infection), lungs (pneumonia), and bone, skin or soft tissue, including burns. It contains Tobramycin, which works by inhibiting protein synthesis in bacterial cells and kills bacteria. It may cause some side effects such as pain, redness or swelling at the injection site, passing more urine than usual, headache, nausea or vomiting.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOBRAMYCIN-80MG

Manufacturer/Marketer :

Asterisk Laboratories India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Tobomac 80 Injection

Tobomac 80 Injection is an injectable antibiotic used to treat severe, life-threatening bacterial infections in various parts of the body. It belongs to a class of medicines that specifically target and kill harmful bacteria, helping to clear serious infections of the lungs, blood, abdomen, skin, and urinary tract.

Since this medicine is given as an injection or infusion, healthcare professionals typically give it at regular intervals throughout the day to keep a steady level of the medicine in your body. It is injected directly into a vein or muscle, meaning its absorption does not depend on food. Staying well-hydrated by drinking plenty of water during treatment is crucial to help protect your kidneys and support your recovery.

While highly effective, this medicine can sometimes cause side effects, including changes in urination, dizziness, or ringing in your ears. It is important to talk to your doctor immediately if you experience any changes in your hearing, balance, or kidney function during treatment.

Do not take this medicine if you have a history of severe allergic reactions to similar antibiotics. Before starting treatment, tell your doctor if you have kidney disease, hearing problems, or muscle disorders. This medicine is generally not suitable for patients with pre-existing nerve or inner ear issues unless deemed absolutely necessary by a specialist.

This medicine can interact with other drugs that affect your kidneys or hearing, such as certain water pills or other strong antibiotics. If you are pregnant, breastfeeding, or planning a pregnancy, consult your doctor immediately, as this medicine may carry risks to the developing baby.

Uses of Tobomac 80 Injection

Tobomac 80 Injection is used to treat severe, life-threatening bacterial infections. The detailed uses of Tobomac 80 Injection are as follows:

  • Serious lung infections: It helps clear severe bacterial pneumonia and other deep chest infections by destroying the bacteria causing the illness.
  • Blood infections: It targets and eliminates bacteria circulating in the bloodstream, preventing life-threatening systemic complications.
  • Severe urinary tract infections: It treats complicated infections of the kidneys and urinary bladder when standard oral antibiotics are not suitable.
  • Abdominal infections: It helps treat complex infections inside the stomach and abdomen, working alongside other treatments to clear the infection.
  • Skin and bone infections: It reaches deep tissues to stop bacterial growth in severe wound, skin, joint, or bone infections.

Key Benefits

Tobomac 80 Injection helps treat serious bacterial infections by delivering the antibiotic directly into the bloodstream or muscle, allowing it to reach therapeutic levels quickly. This targeted approach helps control infection effectively and supports a faster recovery. This medicine offers several key benefits:

  • Provides Rapid Infection Control: By bypassing the digestive system and entering the body directly, Tobomac 80 Injection can quickly reach the right amount needed to fight the infection. This helps limit the spread of infection and supports early symptom improvement.
  • Effective for Severe and Complex Infections: Tobomac 80 Injection is often used when infections are severe or when oral antibiotics may not be suitable. Its injectable formulation provides reliable treatment for a wide range of bacterial infections that require prompt medical attention.
  • Supports Faster Recovery and Reduced Complications: By helping eliminate the infection-causing bacteria, Tobomac 80 Injection can reduce symptoms such as fever, inflammation, and discomfort. Effective treatment may also help lower the risk of the infection spreading to other parts of the body, supporting a safer and smoother recovery process.
Side effects of Tobomac 80 Injection
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

To get the full benefit of Tobomac 80 Injection, it is essential to use it exactly as your healthcare provider has directed. Follow these simple steps for safe use:

  • This medicine is administered as an injection into a muscle or as an infusion (drip) into a vein, depending on your medical condition and your doctor's recommendation.
  • A doctor, nurse, or other trained healthcare professional will usually prepare and administer this medicine in a hospital, clinic, or healthcare setting.
  • If you have been instructed to use this medicine at home, carefully follow all preparation, storage, and administration instructions provided by your healthcare team.
  • Before use, inspect the solution carefully. Do not use it if it appears cloudy, discoloured, or contains visible particles.
  • Never reuse needles, syringes, or infusion equipment. Dispose of all used medical supplies safely according to the instructions provided by your healthcare provider.
  • Complete the full course of treatment exactly as prescribed, even if your symptoms begin to improve, unless your doctor advises otherwise.

How Tobomac 80 Injection Works

Tobomac 80 Injection works by stopping bacteria from growing and multiplying. It does this by binding to specific parts of the bacterial cells that are responsible for making essential proteins. Tobramycin binds to the 30S ribosomal subunit within susceptible bacteria, disrupting normal protein synthesis and causing misreading of bacterial messenger RNA (mRNA). This results in the production of abnormal proteins and ultimately leads to bacterial cell death. By eliminating the bacteria responsible for the infection, the medicine helps your body's immune system clear the remaining infection. In simple terms, the medicine confuses the bacteria so they cannot make the proteins they need to survive, and they die as a result.
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Alcohol

Consult your doctor

The interaction of Tobomac 80 Injection with alcohol is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Unsafe

Tobomac 80 Injection is not recommended for use during pregnancy due to the risk of birth defects. Hence, if you are pregnant or planning for pregnancy, inform your doctor before receiving Tobomac 80 Injection. Your doctor may prescribe this medicine only if the benefits clearly outweigh the risks.

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Breast Feeding

Unsafe

Tobomac 80 Injection in not recommended for use during breastfeeding as it passes into breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Tobomac 80 Injection.

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Driving

Caution

Drive only if you are alert after receiving Tobomac 80 Injection. If you experience dizziness, tiredness or drowsiness, avoid driving or operating heavy machinery.

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Liver

Consult your doctor

If you have any liver problems, inform your doctor before receiving Tobomac 80 Injection.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Tobomac 80 Injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

Special care is needed if Tobomac 80 Injection is to be given to babies or infants less than 6 weeks of age.

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Heart

Consult your doctor

Please consult your doctor if you have any concerns regarding the usage of Tobomac 80 Injection in heart patients.

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Geriatrics

Consult your doctor

Tobomac 80 Injection should be used with caution in elderly patients as it can cause increased risk of adverse effects.

What if I have taken an overdose of Tobomac 80 Injection

The overdose of Tobomac 80 Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Tobomac 80 Injection, please inform your doctor immediately.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Ensure you drink at least 8 to 10 glasses of water daily (unless your doctor tells you otherwise) to keep your kidneys flushed and reduce the risk of kidney damage.
  • Avoid loud environments: Because this medicine can affect your hearing, try to avoid exposure to loud noises during your treatment course to protect your ears.
  • Rest and recover: Allow your body ample time to rest so your immune system can work effectively alongside the medicine to fight off the infection.
  • Monitor your output: Keep track of how often you urinate and any changes in the color of your urine, reporting any sudden drops in volume to your doctor.
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Have a query?

How Soon It Starts Working

The time required for Tobomac 80 Injection to start to work: Tobomac 80 Injection ideally shows its action within 10 minutes after administration. The time for which the effects of Tobomac 80 Injection last: The effect of Tobomac 80 Injection lasts for 6 to 8 hours.

What if you forget to take Tobomac 80 Injection

As this medicine is administered in a hospital by a healthcare professional, the chances of missing a dose are less. However, if you have any concerns, please consult a doctor.

Storage

•Store unused vials or infusion bags of Tobomac 80 Injection at controlled room temperature, typically between 20°C to 25°C (68°F to 77°F). •Keep the medicine in its original packaging to protect it from direct light. Do not freeze this medication.

Drug Warnings

  • Check the liquid carefully: Before injecting, inspect the solution. It should be clear and colourless to pale yellow. Do not use it if it is cloudy, discoloured, or contains floating particles.
  • Rotate injection sites: If you are receiving intramuscular injections, rotate the injection site each time to prevent muscle soreness and tissue damage.
  • Keep up with blood tests: Attend all scheduled appointments for blood tests and hearing checks, as these are critical to ensure the drug remains at a safe and effective level.
  • Report hearing changes instantly: Tell your doctor immediately if you notice even mild ringing in your ears, hearing muffled sounds, or feeling off-balance.
  • Do not mix medications: Never mix Tobomac 80 Injection in the same syringe or infusion bag with other medications unless specifically directed by your doctor.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Strong water pills (loop diuretics like furosemide): Taking these together can greatly increase the risk of hearing damage and kidney issues.
  • Other kidney-damaging medications (like certain other antibiotics or chemotherapy drugs): Combining these can compound the strain on your kidneys.
  • Muscle relaxants: Tobomac 80 Injection may increase the effects of these medicines, leading to very severe muscle weakness, including trouble moving or breathing.

Drug-Disease Interactions

  • Kidney disease: The body may struggle to clear the medicine, increasing the risk of severe side effects. Dose adjustments and close monitoring are required.
  • Hearing or balance disorders: Existing nerve damage in the ears can be worsened by this medication.
  • Neuromuscular disorders (like myasthenia gravis): This medicine can worsen muscle weakness, so it must be used with extreme caution.
TobramycinCidofovir
Critical
TobramycinAtracurium
Severe

Drug-Drug Interactions

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TobramycinCidofovir
Critical
How does the drug interact with Tobomac 80 Injection:
Coadministration of cidofovir with Tobomac 80 Injection can cause kidney problems.

How to manage the interaction:
Taking Tobomac 80 Injection with Cidofovir is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without consulting a doctor.
TobramycinAtracurium
Severe
How does the drug interact with Tobomac 80 Injection:
Using Atracurium with Tobomac 80 Injection can increase the risk of respiratory depression (breathing disorder).

How to manage the interaction:
Although there is a interaction between Tobomac 80 Injection and Atracurium, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
TobramycinDoxacurium chloride
Severe
How does the drug interact with Tobomac 80 Injection:
Taking Tobomac 80 Injection with doxacurium chloride can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
Although there is a possible interaction between Tobomac 80 Injection and Doxacurium chloride, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
TobramycinTenofovir disoproxil
Severe
How does the drug interact with Tobomac 80 Injection:
Coadministration of Tobomac 80 Injection with Tenofovir disoproxil can increase the risk of kidney problems.

How to manage the interaction:
Taking Tenofovir disoproxil with Tobomac 80 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TobramycinColistin
Severe
How does the drug interact with Tobomac 80 Injection:
Coadministration of Tobomac 80 Injection with Colistin can increase the blood levels and risk of Colistin side effects.

How to manage the interaction:
Although there is a possible interaction between Colistin and Tobomac 80 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience, shortness of breath, muscle pain, dizziness, or palpitations, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TobramycinDeferasirox
Severe
How does the drug interact with Tobomac 80 Injection:
Taking deferasirox with Tobomac 80 Injection may increase the risk of kidney problems.

How to manage the interaction:
Taking Tobomac 80 Injection with Deferasirox together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not stop using any medications without talking to your doctor.
TobramycinPancuronium
Severe
How does the drug interact with Tobomac 80 Injection:
Using pancuronium with Tobomac 80 Injection can increase the risk of respiratory depression(hypoventilation).

How to manage the interaction:
Although taking Pancuronium and Tobomac 80 Injection together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.
TobramycinPolymyxin b
Severe
How does the drug interact with Tobomac 80 Injection:
Taking Tobomac 80 Injection with Polymyxin B can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Tobomac 80 Injection and Polymyxin b, you can take these medicines together if prescribed by a doctor. However, if you experience hearing loss, ringing in the ears, difficulty breathing, nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TobramycinFoscarnet
Severe
How does the drug interact with Tobomac 80 Injection:
Combining Tobomac 80 Injection with Foscarnet can increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Tobomac 80 Injection and foscarnet, but it can be taken if prescribed by a doctor. However, if you experience nausea, swelling, sudden weight gain or weight loss, severe pain in your upper stomach spreading to your back, seizures, pounding heart beats, dizziness or chest pain contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
TobramycinMagnesium sulfate
Severe
How does the drug interact with Tobomac 80 Injection:
Taking magnesium sulfate with Tobomac 80 Injection can increase the risk of muscle weakness.

How to manage the interaction:
Although taking Magnesium sulfate and Tobomac 80 Injection together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience symptoms such as muscle weakness and breathing difficulties consult your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Tobomac 80 Injection is used to treat bacterial infections of the brain and spinal cord (meningitis), stomach or intestines, bladder or kidney (urinary tract infection), lungs (pneumonia), and bone, skin or soft tissue, including burns.
Tobomac 80 Injection contains Tobramycin, an antibiotic that inhibits protein synthesis in bacterial cells. This stops the growth of bacteria and kills them.
You are recommended to use Tobomac 80 Injection for as long as it is advised by your doctor. However, avoid taking for more than 10 days as it may increase the risk of severe side effects.
No, Tobomac 80 Injection is not absorbed well by the stomach, so it must be given as an injection or infusion to treat infections throughout the body. Talk to your doctor for more details.
It is injected directly into a muscle or given slowly through a drip into a vein, usually by a healthcare professional in a clinic or hospital. Talk to your doctor if you have questions about your therapy.
Blood tests help your doctor monitor the amount of medicine in your body. This ensures the dose is high enough to kill the bacteria but low enough to protect your kidneys and hearing. Talk to your doctor about your monitoring schedule.
You should contact your doctor immediately. Ringing in the ears can be an early sign of hearing damage, and your medical team may need to adjust your therapy. Talk to your doctor right away if you experience this.
This medicine is generally not recommended during pregnancy as it can harm the hearing development of an unborn baby. Talk to your doctor to discuss safer alternatives.
While alcohol does not directly interact with this medicine, it can cause dehydration, which increases the strain on your kidneys. It is best to avoid alcohol and stay well-hydrated. Talk to your doctor for advice.
It can be used, but with extreme caution. Your doctor will need to adjust the dose and monitor your kidney function very closely to prevent complications. Talk to your doctor if you have pre-existing kidney conditions.

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Country of origin

India
Other Info - TO60913
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