Tofacitinib-5 Tablet 10's
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About Tofacitinib-5 Tablet 10's
Tofacitinib-5 Tablet 10's is a prescription medicine used to manage moderate to severe autoimmune inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It is also prescribed to treat moderate to severe ulcerative colitis, an inflammatory bowel disease. By targeting key inflammatory pathways in the body, this medicine helps reduce painful swelling and prevents further damage to your joints and tissues.
To achieve the best results, you must take Tofacitinib-5 Tablet 10's consistently every day exactly as prescribed by your doctor. It is typically taken once or twice daily, and you can take it either with or without food. Along with taking your medicine regularly, adopting a balanced, anti-inflammatory diet and incorporating gentle physical exercise can significantly improve your mobility and overall treatment outcomes.
While taking Tofacitinib-5 Tablet 10's, you may experience some common, mild side effects such as headaches, diarrhoea, or cold-like symptoms. However, because this medicine affects your immune system, it is crucial to consult your doctor immediately if you develop any signs of serious infections, unusual bruising, high fever, or shingles.
Talk to your doctor before starting this medicine if you have a history of tuberculosis, chronic infections, liver damage, kidney issues, or heart problems. Do not take this if you currently have a severe active infection, severe liver problems, or if you are allergic to any of its ingredients.
This medicine can interact with other drugs that suppress your immune system or certain medications processed by your liver, which can increase the risk of severe side effects or reduce how well the treatment works. You should avoid drinking excess alcohol, stop smoking, and consult your doctor before starting treatment if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult.
Uses of Tofacitinib-5 Tablet 10's
The following are the common conditions for which Tofacitinib-5 Tablet 10's may be prescribed:
- Rheumatoid Arthritis: Helps reduce joint pain, stiffness, and swelling in adults when other standard therapies have not worked well.
- Psoriatic Arthritis: Lowers active joint inflammation and helps improve physical function in daily activities.
- Ankylosing Spondylitis: Targets inflammation in the spine to reduce chronic back pain and stiffness.
- Ulcerative Colitis: Reduces chronic inflammation in the lining of the large intestine to help achieve and maintain symptom-free periods.
Key Benefits
Tofacitinib-5 Tablet 10's helps control excessive immune system activity that causes inflammation in autoimmune conditions. By reducing ongoing inflammation, it helps relieve symptoms, improve daily function, and lower the risk of long-term damage associated with these diseases.
Key benefits include:
- Easier Daily Movement: By reducing inflammation in the joints, Tofacitinib-5 Tablet 10's helps restore flexibility, making daily tasks like walking, bending, and reaching much more comfortable.
- Long-Term Control Over Flares: Regular use helps keep your immune system from overreacting, which reduces the frequency and severity of painful symptom flare-ups.
- Improved Bowel Comfort: For those managing ulcerative colitis, this medicine helps calm gut inflammation, leading to fewer urgent bathroom trips, less cramping, and healthier digestion.
Directions for Use
- Tofacitinib-5 Tablet 10's can be taken with or without food.
- It is recommended to take Tofacitinib-5 Tablet 10's 1-2 times a day, depending on your medical condition, or as prescribed by your doctor.
- Swallow Tofacitinib-5 Tablet 10's as a whole with a glass of water.
- Do not crush, chew, or break it.
How Tofacitinib-5 Tablet 10's Works
Alcohol
Caution
It is not known if alcohol interacts with Tofacitinib-5 Tablet 10's, so please consult a doctor.
Pregnancy
Unsafe
Tofacitinib-5 Tablet 10's must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofacitinib-5 Tablet 10's and for 4 weeks after discontinuation.
Breast Feeding
Unsafe
Avoid breastfeeding while taking Tofacitinib-5 Tablet 10's. Please consult a doctor if you have any concerns.
Driving
Safe
Tofacitinib-5 Tablet 10's generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.
Liver
Caution
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofacitinib-5 Tablet 10's is not recommended for patients with severe liver problems.
Kidney
Caution
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
Unsafe
Tofacitinib-5 Tablet 10's is not recommended for children below 18 years as safety and effectiveness were not established.
Heart
Caution
No serious side effects were observed. But it requires careful consideration and monitoring due to increased risks of heart-related problems, particularly in patients with existing cardiovascular risk factors.
Geriatrics
Caution
No serious adverse effects were observed; however, it requires careful consideration and caution due to the increased risk of certain adverse events, particularly infections.
What if I have taken an overdose of Tofacitinib-5 Tablet 10's
Diet & Lifestyle Advise
- Anti-inflammatory diet: Focus on eating a diet rich in anti-inflammatory foods, such as olive oil, leafy green vegetables, and fish rich in omega-3 fatty acids, to support your joints and gut health.
- Protect your joints: Keep active with low-impact physical activities like swimming, walking, or stationary cycling. This helps maintain joint flexibility and muscle strength without putting too much strain on your joints.
- Manage gut triggers: If you are taking this medicine for ulcerative colitis, keep a food journal to identify and avoid foods that trigger your symptoms (such as highly spiced, greasy, or high-fibre foods during active flares).
- Practise strict hand hygiene: Since Tofacitinib-5 Tablet 10's dampens your immune system, wash your hands frequently with soap and water, and avoid close contact with people who have contagious illnesses like the cold or flu.
- Schedule non-live vaccinations: Talk to your doctor about keeping your vaccinations up to date, such as the flu or pneumonia vaccines, ensuring you only receive non-live versions while on this treatment.

Have a query?
How Soon It Starts Working
- The time required for Tofacitinib-5 Tablet 10's to start to work: The time required for Tofacitinib-5 Tablet 10's to show its action is unknown.
- The time for which the effects of Tofacitinib-5 Tablet 10's last: The duration of action for Tofacitinib-5 Tablet 10's is clinically unknown.
What if you forget to take Tofacitinib-5 Tablet 10's
Storage
Drug Warnings
- Complete recommended screening tests: Your doctor should screen you for tuberculosis (TB) and perform blood tests before you start Tofacitinib-5 Tablet 10's.
- Avoid live vaccines during treatment: Do not receive live vaccines, such as certain shingles vaccines or the nasal spray influenza vaccine, unless your doctor advises otherwise, as your immune system may be weakened.
- Attend regular monitoring appointments: Keep all scheduled blood tests so your doctor can monitor your blood cell counts, liver function, kidney function, and cholesterol levels throughout treatment.
- Watch for signs of infection or shingles: Contact your doctor immediately if you develop fever, persistent cough, unexplained skin rashes, or painful blisters on one side of your body.
- Seek emergency medical care for serious symptoms: Stop taking Tofacitinib-5 Tablet 10's and get immediate medical attention if you experience sudden chest pain, difficulty breathing, swelling or pain in one leg, or symptoms suggestive of a blood clot.
Drug-Drug Interaction Summary:
- Other immunosuppressants: Taking Tofacitinib-5 Tablet 10's with medicines such as cyclosporine, azathioprine, tacrolimus, or biologic therapies can greatly increase the risk of serious infections and is generally not recommended.
- Medicines affecting liver enzymes: Strong CYP3A4 inhibitors (such as ketoconazole) may increase Tofacitinib-5 Tablet 10's levels, while strong CYP3A4 inducers (such as rifampicin) may reduce its effectiveness. Your doctor may adjust your dose if necessary.
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Drug-Food Interaction Summary:
- Alcohol: Tofacitinib-5 Tablet 10's can be taken with or without food. However, excessive alcohol intake may increase the risk of liver problems, so discuss alcohol consumption with your doctor.
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Reference
- Electronic Medicines Compendium (EMC). Pil.2500 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
- U.S. Food and Drug Administration (FDA). 203214S018Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
- Drugs.com Clinical Review Team. Tofacitinib Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
- Tofacitinib Tofacitinib. 2012. [Accessed on 02 Apr. 2019]Check here
- Tofacitinib [Prescribing Information]. 2025. [Accessed on 07 Aug. 2023]Check here
- XELJANZ 5mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 28 Aug 2025]Check here
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