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compositionComposition:TOFACITINIB-11MG
prescription
Prescription Medicine
info
Tofadoz-11 XR Tablet 10's
Tofadoz-11 XR Tablet 10's

Tofadoz 11 XR Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tofadoz 11 XR Tablet

Tofadoz 11 XR Tablet is used to treat rheumatoid arthritis (an autoimmune disease which leads to joint pain and damage), psoriatic arthritis (an inflammatory condition of the joints), and ulcerative colitis (an inflammatory disease of the large intestine).

Tofadoz 11 XR Tablet contains Tofacitinib, which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

Not everyone who is taking Tofadoz 11 XR Tablet will get these side effects. In some cases, you may experience common side effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Tofadoz 11 XR Tablet with or without food. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your tablets based on your medical condition. It is always important to complete your treatment course for better results.

Avoid taking Tofadoz 11 XR Tablet if you are allergic to it. Inform your doctor if you have an active infection, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofadoz 11 XR Tablet if you are pregnant or breastfeeding. Tofadoz 11 XR Tablet is not recommended for use in children below 18 years as safety and effectiveness have not been established. 

Uses of Tofadoz 11 XR Tablet

Tofadoz 11 XR Tablet is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Tofadoz 11 XR Tablet are as follows:

  • Treatment of Rheumatoid Arthritis: Tofadoz 11 XR Tablet helps to manage moderate to severe rheumatoid arthritis by reducing joint pain, inflammation, and slowing disease progression.
  • Management of Psoriatic Arthritis: Tofadoz 11 XR Tablet treats active psoriatic arthritis by reducing joint pain, swelling, stiffness, and improving overall joint function.
  • Treatment of Ulcerative Colitis: Tofadoz 11 XR Tablet helps to induce and maintain remission in moderate to severe ulcerative colitis.

Key Benefits

  • Tofadoz 11 XR Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
  • Tofadoz 11 XR Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).
  • This medicine helps lower inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
Side effects of Tofadoz-11 XR Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Tofadoz 11 XR Tablet can be taken with or without food.
  • It is recommended to take Tofadoz 11 XR Tablet 1-2 times a day, depending on your medical condition, or as prescribed by your doctor.
  • Swallow Tofadoz 11 XR Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Tofadoz 11 XR Tablet Works

Tofadoz 11 XR Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
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Alcohol

Caution

It is not known if alcohol interacts with Tofadoz 11 XR Tablet , so please consult a doctor.

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Pregnancy

Unsafe

Tofadoz 11 XR Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofadoz 11 XR Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofadoz 11 XR Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

Tofadoz 11 XR Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofadoz 11 XR Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofadoz 11 XR Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

Caution

No serious side effects were observed. But it requires careful consideration and monitoring due to increased risks of heart-related problems, particularly in patients with existing cardiovascular risk factors.

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Geriatrics

Caution

No serious adverse effects were observed; however, it requires careful consideration and caution due to the increased risk of certain adverse events, particularly infections.

What if I have taken an overdose of Tofadoz 11 XR Tablet

Take Tofadoz 11 XR Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause unwanted side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Have a query?

How Soon It Starts Working

  • The time required for Tofadoz 11 XR Tablet to start to work: The time required for Tofadoz 11 XR Tablet to show its action is unknown. 
  • The time for which the effects of Tofadoz 11 XR Tablet last: The duration of action for Tofadoz 11 XR Tablet is clinically unknown.

What if you forget to take Tofadoz 11 XR Tablet

If you miss a dose of Tofadoz 11 XR Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Tofadoz 11 XR Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Tofadoz 11 XR Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, or if you have severe liver problems such as cirrhosis. 
  • Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, chronic lung disease, liver problems, hepatitis B/C, cancer, inflammation/ulcers of the large intestine, or kidney problems; are planning to get vaccinated; or have heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. 
  • If your white blood cell count or red blood cell count is low, avoid taking Tofadoz 11 XR Tablet .
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties. Inform your doctor about your complete medical and medication history before starting treatment with Tofadoz 11 XR Tablet , which helps the physician decide the best treatment plan.

Drug-Drug Interactions

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Drug-Drug Interactions: Tofadoz 11 XR Tablet may interact with antibiotic (rifampicin), anti-fungal (fluconazole, ketoconazole), immunosuppressant (azathioprine, mercaptopurine, cyclosporine, tacrolimus), corticosteroids (prednisone).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have infections, bloodstream infection, severe liver problems, tuberculosis, blood clot problems, diabetes, high cholesterol, intestinal perforation, or gastrointestinal obstruction.

TofacitinibMethotrexate
Severe
TofacitinibDeflazacort
Severe

Drug-Drug Interactions

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TofacitinibMethotrexate
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Coadministration of methotrexate with Tofadoz-11 XR Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Tofadoz-11 XR Tablet and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting to a doctor.
TofacitinibDeflazacort
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Co-administration of Deflazacort with Tofadoz-11 XR Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Deflazacort and Tofadoz-11 XR Tablet, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
TofacitinibCapecitabine
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Co-administration of Tofadoz-11 XR Tablet with Capecitabine may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capecitabine can be taken with Tofadoz-11 XR Tablet if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
TofacitinibPazopanib
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet with Pazopanib may increase the risk of infection.

How to manage the interaction:
Co-administration of Pazopanib with Tofadoz-11 XR Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibCladribine
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet with Cladribine may increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Tofadoz-11 XR Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TofacitinibTelithromycin
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
When Tofadoz-11 XR Tablet is taken with Telithromycin, it can slow down the way the body breaks down Tofadoz-11 XR Tablet.

How to manage the interaction:
Taking Tofadoz-11 XR Tablet with Telithromycin together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
TofacitinibEtanercept
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Etanercept with Tofadoz-11 XR Tablet can increase the risk of serious infections as well as sometimes may lead to cancers.

How to manage the interaction:
Although there is a possible interaction between Tofadoz-11 XR Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
TofacitinibRuxolitinib
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Using Tofadoz-11 XR Tablet together with ruxolitinib can increase the risk of infections.

How to manage the interaction:
Although taking Tofadoz-11 XR Tablet and Ruxolitinib together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
TofacitinibTopotecan
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet with Topotecan may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofadoz-11 XR Tablet and Topotecan, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibChlorambucil
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet with Chlorambucil may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Tofadoz-11 XR Tablet and Chlorambucil, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blo, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofadoz-11 XR Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofadoz-11 XR Tablet, as it can lead to an interaction.

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Therapeutic Class

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FAQs

Tofadoz 11 XR Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Tofadoz 11 XR Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
Hypertension/high blood pressure could be a side-effect of Tofadoz 11 XR Tablet . Consult your doctor before taking Tofadoz 11 XR Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.
Diarrhoea might be a side-effect of Tofadoz 11 XR Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Tofadoz 11 XR Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofadoz 11 XR Tablet if you are trying to become pregnant or if you have any concerns regarding this.
Tofadoz 11 XR Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.
Tofadoz 11 XR Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.
Tofadoz 11 XR Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.
Tofadoz 11 XR Tablet may begin working within 2-8 weeks after starting the treatment.
Tofadoz 11 XR Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofadoz 11 XR Tablet , inform the doctor if you are taking tocilizumab.
Prior to starting Tofadoz 11 XR Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Msn Laboratories Pvt.Ltd., Msn House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, India
Other Info - TOF0061

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