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compositionComposition:TOFACITINIB-11MG
prescription
Prescription Medicine
info
Tofanta XR 11 Tablet 10's
Tofanta XR 11 Tablet 10's

Tofanta XR 11 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Ajanta Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tofanta XR 11 Tablet

Tofanta XR 11 Tablet is used to treat rheumatoid arthritis (an autoimmune disease which leads to joint pain and damage), psoriatic arthritis (an inflammatory condition of the joints), and ulcerative colitis (an inflammatory disease of the large intestine).

Tofanta XR 11 Tablet contains Tofacitinib, which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 

Not everyone who is taking Tofanta XR 11 Tablet will get these side effects. In some cases, you may experience common side effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

You can take Tofanta XR 11 Tablet with or without food. It should be swallowed as a whole with a glass of water. Do not chew, bite, crush, or break it. Your doctor will advise you on how often you should take your tablets based on your medical condition. It is always important to complete your treatment course for better results.

Avoid taking Tofanta XR 11 Tablet if you are allergic to it. Inform your doctor if you have an active infection, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofanta XR 11 Tablet if you are pregnant or breastfeeding. Tofanta XR 11 Tablet is not recommended for use in children below 18 years as safety and effectiveness have not been established. 

Uses of Tofanta XR 11 Tablet

Tofanta XR 11 Tablet is used in the treatment of Rheumatoid arthritis, Psoriatic arthritis, and Ulcerative colitis. The detailed uses of Tofanta XR 11 Tablet are as follows:

  • Treatment of Rheumatoid Arthritis: Tofanta XR 11 Tablet helps to manage moderate to severe rheumatoid arthritis by reducing joint pain, inflammation, and slowing disease progression.
  • Management of Psoriatic Arthritis: Tofanta XR 11 Tablet treats active psoriatic arthritis by reducing joint pain, swelling, stiffness, and improving overall joint function.
  • Treatment of Ulcerative Colitis: Tofanta XR 11 Tablet helps to induce and maintain remission in moderate to severe ulcerative colitis.

Key Benefits

  • Tofanta XR 11 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
  • Tofanta XR 11 Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).
  • This medicine helps lower inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
Side effects of Tofanta XR 11 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Tofanta XR 11 Tablet can be taken with or without food.
  • It is recommended to take Tofanta XR 11 Tablet 1-2 times a day, depending on your medical condition, or as prescribed by your doctor.
  • Swallow Tofanta XR 11 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Tofanta XR 11 Tablet Works

Tofanta XR 11 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
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Alcohol

Caution

It is not known if alcohol interacts with Tofanta XR 11 Tablet , so please consult a doctor.

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Pregnancy

Unsafe

Tofanta XR 11 Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofanta XR 11 Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofanta XR 11 Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

Tofanta XR 11 Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofanta XR 11 Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofanta XR 11 Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

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Heart

Caution

No serious side effects were observed. But it requires careful consideration and monitoring due to increased risks of heart-related problems, particularly in patients with existing cardiovascular risk factors.

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Geriatrics

Caution

No serious adverse effects were observed; however, it requires careful consideration and caution due to the increased risk of certain adverse events, particularly infections.

What if I have taken an overdose of Tofanta XR 11 Tablet

Take Tofanta XR 11 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause unwanted side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Have a query?

How Soon It Starts Working

  • The time required for Tofanta XR 11 Tablet to start to work: The time required for Tofanta XR 11 Tablet to show its action is unknown. 
  • The time for which the effects of Tofanta XR 11 Tablet last: The duration of action for Tofanta XR 11 Tablet is clinically unknown.

What if you forget to take Tofanta XR 11 Tablet

If you miss a dose of Tofanta XR 11 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Tofanta XR 11 Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Tofanta XR 11 Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, or if you have severe liver problems such as cirrhosis. 
  • Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, chronic lung disease, liver problems, hepatitis B/C, cancer, inflammation/ulcers of the large intestine, or kidney problems; are planning to get vaccinated; or have heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. 
  • If your white blood cell count or red blood cell count is low, avoid taking Tofanta XR 11 Tablet .
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties. Inform your doctor about your complete medical and medication history before starting treatment with Tofanta XR 11 Tablet , which helps the physician decide the best treatment plan.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Tofanta XR 11 Tablet may interact with antibiotic (rifampicin), anti-fungal (fluconazole, ketoconazole), immunosuppressant (azathioprine, mercaptopurine, cyclosporine, tacrolimus), corticosteroids (prednisone).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have infections, bloodstream infection, severe liver problems, tuberculosis, blood clot problems, diabetes, high cholesterol, intestinal perforation, or gastrointestinal obstruction.

TofacitinibVedolizumab
Severe
TofacitinibStreptozocin
Severe

Drug-Drug Interactions

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TofacitinibVedolizumab
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Taking Vedolizumab with Tofanta XR 11 Tablet may increase the risk of infection.

How to manage the interaction:
Taking Tofanta XR 11 Tablet with Vedolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.Do not stop using any medications without a doctor's advice.
TofacitinibStreptozocin
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Taking Tofanta XR 11 Tablet with Streptozocin may increase the risk of infection.

How to manage the interaction:
Although taking Streptozocin and Tofanta XR 11 Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibTelithromycin
Severe
How does the drug interact with Tofanta XR 11 Tablet:
When Tofanta XR 11 Tablet is taken with Telithromycin, it can slow down the way the body breaks down Tofanta XR 11 Tablet.

How to manage the interaction:
Taking Tofanta XR 11 Tablet with Telithromycin together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
TofacitinibKetoconazole
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Coadministration of Ketoconazole and Tofanta XR 11 Tablet may increase the blood levels and effects of Tofanta XR 11 Tablet which may lead to side effects (low blood cell counts, anemia, serious infections, and elevated blood lipid levels).

How to manage the interaction:
Although taking Ketoconazole and Tofanta XR 11 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms like paleness, exhaustion, dizziness, fainting, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating, consult a doctor. Do not stop using any medications without a doctor's advice.
TofacitinibMelphalan
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Taking Tofanta XR 11 Tablet with Melphalan may increase the risk of serious infection.

How to manage the interaction:
Although taking Tofanta XR 11 Tablet and Melphalan together can cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibAmprenavir
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Taking Tofanta XR 11 Tablet with amprenavir may increase the blood levels of Tofanta XR 11 Tablet and may increase the risk of infections

How to manage the interaction:
There may be a possibility of interaction between Tofanta XR 11 Tablet and Amprenavir, but it can be taken if prescribed by a doctor. However consult your doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibDocetaxel
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Taking Tofanta XR 11 Tablet with Docetaxel may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofanta XR 11 Tablet and Docetaxel, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibTemsirolimus
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Taking Tofanta XR 11 Tablet with Temsirolimus may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofanta XR 11 Tablet and Temsirolimus, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibIdarubicin
Severe
How does the drug interact with Tofanta XR 11 Tablet:
Taking Idarubicin and Tofanta XR 11 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Tofanta XR 11 Tablet, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
TofacitinibLevamisole
Severe
How does the drug interact with Tofanta XR 11 Tablet:
When Tofanta XR 11 Tablet and levamisole are used together, there is a higher chance of getting serious infections.

How to manage the interaction:
Although taking Levamisole and Tofanta XR 11 Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

[ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)]

FAQs

Tofanta XR 11 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Tofanta XR 11 Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
Hypertension/high blood pressure could be a side-effect of Tofanta XR 11 Tablet . Consult your doctor before taking Tofanta XR 11 Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.
Diarrhoea might be a side-effect of Tofanta XR 11 Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Tofanta XR 11 Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofanta XR 11 Tablet if you are trying to become pregnant or if you have any concerns regarding this.
Tofanta XR 11 Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.
Tofanta XR 11 Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.
Tofanta XR 11 Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.
Tofanta XR 11 Tablet may begin working within 2-8 weeks after starting the treatment.
Tofanta XR 11 Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofanta XR 11 Tablet , inform the doctor if you are taking tocilizumab.
Prior to starting Tofanta XR 11 Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India.
Other Info - TOF0069

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