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compositionComposition:DICLOFENAC-100MG+TOLPERISONE-450MG
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Prescription Medicine
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TOLPERITAS-DSR TABLETS is used to reduce and relieve pain due to the muscle spasms (excessive tension in the muscles). It contains Diclofenac and Tolperisone, which work on the brain and spinal cord centres to relieve muscle stiffness or spasm and relieve pain and improve muscle's movement. Also, it reduces mild to moderate pain and inflammation. It may cause side effects such as nausea, diarrhoea, vomiting, heartburn, weakness, stomach pain/epigastric pain, sleepiness, dizziness, and appetite loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DICLOFENAC-100MG+TOLPERISONE-450MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About TOLPERITAS-DSR TABLETS

TOLPERITAS-DSR TABLETS is an oral prescription medication used to treat painful muscle spasms and acute musculoskeletal conditions. It helps relieve localised pain, reduce muscle stiffness, and improve overall physical mobility. This medication is typically prescribed for short-term relief during recovery from muscle strains, back pain, or joint issues.

For best results, it is important to take TOLPERITAS-DSR TABLETS consistently at the intervals recommended by your healthcare provider. You should take this tablet with or immediately after a meal to help protect your stomach from potential irritation. Incorporating daily habits such as staying hydrated and performing light, doctor-approved stretches can also support your physical recovery while taking this medication.

While taking TOLPERITAS-DSR TABLETS, some people may experience mild side effects, such as a mild upset stomach or light dizziness. If you notice any serious issues, such as severe abdominal pain, dark stools, or a skin rash, stop taking the medication and consult your doctor immediately.

Before starting TOLPERITAS-DSR TABLETS, talk to your doctor if you have a history of stomach ulcers, asthma, or liver or kidney disease. Do not take this if you have active bleeding in your stomach, severe heart failure, or a known allergy to any of its components.

This medicine can interact with alcohol, which may increase your risk of stomach irritation and drowsiness. If you are pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist before using this medicine to ensure it is safe for your specific situation.

Uses of TOLPERITAS-DSR TABLETS

TOLPERITAS-DSR TABLETS is used for painful muscle spasms and acute musculoskeletal conditions. The detailed uses of TOLPERITAS-DSR TABLETS are as follows:

  • Painful muscle spasms: TOLPERITAS-DSR TABLETS helps relieve intense, involuntary muscle contractions that cause localised pain and discomfort.
  • Acute lower back pain: It targets both the muscle tightness and underlying inflammation in the lower back, helping to ease movement.
  • Musculoskeletal pain: It helps manage pain associated with spasms in the neck, shoulders, or joints, allowing for easier rehabilitation.

Key Benefits

TOLPERITAS-DSR TABLETS helps relieve musculoskeletal pain by reducing inflammation and relaxing painful muscle spasms. By addressing both pain and muscle stiffness, it supports faster recovery and improves mobility.

  • Helps Relieve Pain and Muscle Spasms: By reducing inflammation and relaxing tight muscles, TOLPERITAS-DSR TABLETS helps relieve pain, muscle spasms, and stiffness associated with injuries and musculoskeletal conditions.
  • Improves Movement and Flexibility: As pain and muscle tension decrease, TOLPERITAS-DSR TABLETS helps improve your range of motion, making everyday activities such as walking, bending, and reaching more comfortable.
  • Supports Faster Recovery: By breaking the cycle of pain, inflammation, and muscle spasm, TOLPERITAS-DSR TABLETS helps promote recovery from acute muscle injuries and strains, allowing you to return to your normal daily routine sooner.
Side effects of Tolperitas-DSR Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Limit processed foods and eat more vegetables and fruits.
  • Exercise at least 30 minutes every day.
  • Maintain a healthy weight.
  • Quit smoking as it can worsen kidney damage.
  • Control your blood pressure and blood glucose.
  • Limit salt intake and alcohol consumption.
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost Vitamin K with leafy greens (spinach, kale), broccoli, cauliflower, and cabbage.
  • Include iron-rich foods like lean red meat, legumes, fortified cereals, and dark leafy greens.
  • Stay hydrated by drinking plenty of water.
  • Add Vitamin C-rich foods (citrus fruits, bell peppers) to enhance iron absorption.
  • Limit excessive alcohol and blood-thinning foods like garlic and certain herbs.
  • Engage in gentle exercise like walking, swimming, or yoga.
  • Monitor injuries and apply pressure to wounds promptly.
  • Schedule regular medical checkups for routine blood tests.

Directions for Use

  • Take TOLPERITAS-DSR TABLETS with food to avoid stomach upset or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How TOLPERITAS-DSR TABLETS Works

TOLPERITAS-DSR TABLETS contains two active components that work together to relieve pain and muscle tightness. The first component, diclofenac, is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking certain chemical messengers in the body, known as prostaglandins, which are responsible for causing pain, swelling, and inflammation at the site of injury. The second component, tolperisone, is a muscle relaxant. It acts on the central nervous system to reduce muscle tone and stiffness without causing significant drowsiness or muscle weakness. Together, these ingredients help ease muscle spasms and relieve pain effectively.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking TOLPERITAS-DSR TABLETS as it may increase dizziness. It can also increase the risk of stomach bleeding.

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Pregnancy

Caution

Avoid taking TOLPERITAS-DSR TABLETS if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

TOLPERITAS-DSR TABLETS must not be used during breastfeeding.

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Driving

Caution

TOLPERITAS-DSR TABLETS may cause sleepiness or dizziness. Do not drive or do anything needing concentration until you know how it affects you.

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Liver

Unsafe

Those who have severe liver problems should not take this TOLPERITAS-DSR TABLETS because TOLPERITAS-DSR TABLETS contains Tolperisone, which causes the most dangerous adverse in patients with liver disease.

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Kidney

Unsafe

Those who have severe kidney problems should not take this TOLPERITAS-DSR TABLETS because TOLPERITAS-DSR TABLETS contains Tolperisone, which causes the most dangerous adverse in patients with kidney disease.

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Children

Unsafe

TOLPERITAS-DSR TABLETS should not be given to children as the safety and effectiveness were not established.

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Heart

Unsafe

This medicine is contraindicated in cardiac patients due to its adverse effects.

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Geriatrics

Caution

TOLPERITAS-DSR TABLETS can be given in elderly patients with caution due to the serious adverse effects.

What if I have taken an overdose of TOLPERITAS-DSR TABLETS

If you accidentally take more than the prescribed amount, seek immediate medical attention or contact a local poison control centre. Overdose can lead to severe stomach pain, vomiting, or extreme dizziness.

Diet & Lifestyle Advise

  • Stay hydrated: Drinking plenty of water helps maintain proper muscle function and prevents dehydration-related cramping.
  • Apply gentle heat or cold: Using a warm compress or an ice pack on the affected muscle for 15–20 minutes can help ease stiffness and reduce inflammation.
  • Practice light stretching: Engage in gentle, low-impact movements or doctor-approved stretches to maintain flexibility without straining the muscle.
  • Avoid heavy lifting: Protect your muscles from further injury by avoiding heavy lifting, sudden twists, or strenuous exercise while you are recovering.
  • Eat stomach-friendly foods: If you experience mild stomach irritation, eat bland, small meals and avoid spicy or highly acidic foods while taking this medicine.
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How Soon It Starts Working

The time required for TOLPERITAS-DSR TABLETS to start to work: TOLPERITAS-DSR TABLETS ideally shows its action within 30 minutes after administration. The time for which the effects of TOLPERITAS-DSR TABLETS last: The duration of action for TOLPERITAS-DSR TABLETS is not clinically established.

What if you forget to take TOLPERITAS-DSR TABLETS

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store TOLPERITAS-DSR TABLETS at room temperature, ideally below 30°C (86°F), in a cool, dry place.  •Keep the tablets in their original packaging to protect them from direct light and moisture.

Drug Warnings

  • Always inspect the blister pack before use; do not take the tablet if the packaging is torn or the tablet appears damaged.
  • Avoid driving or operating machinery if you experience dizziness or drowsiness after taking this medication.
  • Do not take other pain relievers, such as ibuprofen, naproxen, or aspirin, alongside TOLPERITAS-DSR TABLETS unless specifically advised by your doctor, as this increases the risk of stomach bleeding.
  • Inform your dentist or surgeon that you are taking TOLPERITAS-DSR TABLETS before undergoing any medical or dental procedures.
  • Limit or avoid alcohol consumption during treatment, as it can worsen stomach irritation and increase drowsiness.

Drug-Drug Interactions

verifiedApollotooltip
  • Other NSAIDs (e.g., ibuprofen), blood thinners (e.g., warfarin), and oral corticosteroids: Taking TOLPERITAS-DSR TABLETS with these medicines may significantly increase the risk of stomach irritation, ulcers, gastrointestinal bleeding, and bruising. Your doctor may recommend closer monitoring or alternative treatment.
  • Blood pressure medicines: TOLPERITAS-DSR TABLETS may reduce the effectiveness of certain antihypertensive medicines, potentially making blood pressure more difficult to control. Regular blood pressure monitoring may be advised.
  • Certain antibiotics and muscle relaxants: Some antibiotics and other muscle relaxants may interact with TOLPERITAS-DSR TABLETS, potentially increasing side effects such as dizziness, drowsiness, or muscle weakness. Inform your doctor about all medicines you are taking before starting treatment.
Tolperisone + DiclofenacMeloxicam
Critical
Tolperisone + DiclofenacPrasugrel
Severe

Drug-Drug Interactions

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Tolperisone + DiclofenacMeloxicam
Critical
How does the drug interact with Tolperitas-DSR Tablet:
Co-administration of Meloxicam and Tolperitas-DSR Tablet can increase the risk or severity of stomach inflammation.

How to manage the interaction:
Taking Meloxicam and Tolperitas-DSR Tablet is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience dizziness, tarry stools, coughing up or vomiting blood, severe headache, and weakness. Do not stop any medication without a doctor's advise.
Tolperisone + DiclofenacPrasugrel
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Taking Prasugrel and Tolperitas-DSR Tablet may increase the risk of bleeding complications.

How to manage the interaction:
Co-administration of Prasugrel and Tolperitas-DSR Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any unusual bleeding or bruising, tarry stools, coughing up or vomiting blood, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
Tolperisone + DiclofenacCelecoxib
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Co-administration of Celecoxib and Tolperitas-DSR Tablet may increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although there is an interaction between Celecoxib and Tolperitas-DSR Tablet, it can be taken if your doctor has advised it. Consult a doctor if you experience black stool, severe bruising, vomiting or coughing up blood, heavy menstrual bleeding (in women), or dizziness. Do not discontinue any medication without consulting a doctor.
Tolperisone + DiclofenacFlurbiprofen
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Co-administration of Flurbiprofen with Tolperitas-DSR Tablet may increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
There is a possibility of interaction of Flurbiprofen with Tolperitas-DSR Tablet, it can be taken if your doctor has prescribed them. Consult your doctor immediately if you experience tarry stools, coughing up or vomiting blood, burning in the stomach, and weakness. Do not stop using any medications without first talking to your doctor.
Tolperisone + DiclofenacMipomersen
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Co-administration of Mipomersen with Tolperitas-DSR Tablet can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Mipomersen with Tolperitas-DSR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain or swelling, unusual bleeding or bruising, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
Tolperisone + DiclofenacCidofovir
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Coadministration of Cidofovir and Tolperitas-DSR Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Cidofovir and Tolperitas-DSR Tablet can result in an interaction, it can be taken if your doctor has suggested it. However, if you experience increased or decreased urination, sudden weight gain or loss, swelling, muscle cramps, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
Tolperisone + DiclofenacKetoconazole
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Coadministration of Ketoconazole and Tolperitas-DSR Tablet may increase the risk of liver problems.

How to manage the interaction:
There may be a possible interaction of Ketoconazole and Tolperitas-DSR Tablet, it can be taken if a doctor has prescribed them. Consult a doctor immediately if you have unusual bleeding or bruising, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
Tolperisone + DiclofenacKetorolac
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Coadministration of Ketorolac and Tolperitas-DSR Tablet can increase the risk of stomach inflammation, bleeding, and ulceration.

How to manage the interaction:
Co-administration of Ketorolac and Tolperitas-DSR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, tarry stools, coughing up or vomiting blood, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
Tolperisone + DiclofenacWarfarin
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Taking Warfarin and Tolperitas-DSR Tablet can increase the risk of bleeding.

How to manage the interaction:
There may be a possible interaction between Warfarin and Tolperitas-DSR Tablet, it can be taken together if a doctor has prescribed them. However, consult your doctor immediately if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, or weakness, contact a doctor. Do not discontinue any medications without consulting a doctor.
Tolperisone + DiclofenacPiroxicam
Severe
How does the drug interact with Tolperitas-DSR Tablet:
Taking Piroxicam and Tolperitas-DSR Tablet can increase the risk of stomach ulcers, inflammation (redness, swelling), and bleeding.

How to manage the interaction:
Co-administration of Piroxicam and Tolperitas-DSR Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any unusual bleeding or bruising, tarry stools, coughing up or vomiting blood, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol while taking TOLPERITAS-DSR TABLETS. Alcohol may increase the risk of stomach irritation, ulcers, gastrointestinal bleeding, excessive drowsiness, and dizziness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

TOLPERITAS-DSR TABLETS is used to reduce and relieve pain due to the muscle spasms (excessive tension in the muscles).
TOLPERITAS-DSR TABLETS is a combination of two drugs: Diclofenac (Nonsteroidal Anti-Inflammatory Drug) and metaxalone (skeletal muscle relaxant). Diclofenac works by blocking the action of certain chemical messengers that cause pain. Tolperisone works on the spinal cord and centres in the brain to relieve contraction or muscle stiffness without decreasing strength.
TOLPERITAS-DSR TABLETS may impair mental and/or physical abilities required for the performance of heavy tasks like operating machinery or driving a motor vehicle, especially when used with alcohol.
Do not take TOLPERITAS-DSR TABLETS for longer durations as it might increase the risk of heart problems, liver problems and stomach bleeding/ulcer. Please consult a doctor before its use.
There are no recognized reports of any patient getting addicted to TOLPERITAS-DSR TABLETS.
If you are suffering from muscle pain due to overuse or muscle injury, you should take rest. Taking rest will help you to prevent any further injury and help you improve effectively. Make sure that you take enough sleep and try to decrease stress. Applying an ice pack to the altered area may help in reducing inflammation and pain. If your muscle pain is due to some other illness, follow the guidance of your doctor.
Take a missed dose as soon as you remember it. If it is close to the time for your next dose, skip the missed dose and go back to your regular time. Do not take 2 doses at the same time or extra doses.
No, it is highly recommended to take TOLPERITAS-DSR TABLETS with or immediately after a meal. Taking this medicine with food helps protect your stomach lining and reduces the risk of stomach upset or irritation. Talk to your doctor or pharmacist if you have chronic stomach issues.
You should use this medicine with caution if you have high blood pressure, as one of its components can sometimes cause fluid retention or affect blood pressure control. Always inform your healthcare provider about your medical history before starting treatment. Talk to your doctor to see if this medicine is safe for you.
This medicine is generally not recommended during pregnancy, especially in the third trimester, as it may affect the unborn baby or cause complications during delivery. If you are pregnant or planning to become pregnant, talk to your doctor before taking this medication.
It is best to avoid alcohol while taking TOLPERITAS-DSR TABLETS. Combining alcohol with this medication increases the risk of stomach irritation and bleeding and can also make you feel more dizzy or drowsy. Talk to your doctor or pharmacist for personalised advice.
You should avoid taking other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, or aspirin while using TOLPERITAS-DSR TABLETS, as this can increase the risk of stomach ulcers and bleeding. Talk to your doctor or pharmacist before combining any pain medications.
If you develop a skin rash, itching, hives, or any swelling of your face or throat, stop taking TOLPERITAS-DSR TABLETS immediately and seek medical attention. These can be signs of a serious allergic reaction. Talk to your doctor right away if you notice any unusual skin changes.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - TOL0181

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