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compositionComposition:TOLVAPTAN-15MG
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Prescription Medicine
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Tolvahike-15 Tablet 10's is used to treat low sodium levels and autosomal dominant polycystic kidney disease. It contains Tolvaptan which works by increasing the amount of water released from the body via urine. In some cases, this medicine may cause side effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TOLVAPTAN-15MG

Manufacturer/Marketer :

La Renon Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Tolvahike-15 Tablet 10's

Tolvahike-15 Tablet 10's is a prescription oral tablet used to treat low levels of sodium in the blood, a condition known as hyponatremia. It is prescribed for individuals with heart failure, syndrome of inappropriate antidiuretic hormone (SIADH), or certain kidney conditions where sodium levels drop too low. This medication helps raise sodium concentrations to a safer, healthier range.

This medicine is typically taken once daily, and it is crucial to take it consistently at the same time each day. You can take it with or without food, but you must have access to water and drink when you feel thirsty. Avoid restricting your fluid intake while taking this medication unless specifically instructed otherwise by your doctor.

While taking Tolvahike-15 Tablet 10's, you may experience common side effects such as dry mouth, increased thirst, or frequent urination. However, if you notice signs of liver damage—such as unusual fatigue, loss of appetite, right upper abdominal pain, or yellowing of your skin or eyes—you must contact your healthcare provider immediately.

Before starting this treatment, talk to your doctor if you have kidney disease, liver problems, or are unable to feel or respond to thirst. Do not take this if you cannot drink water, have very low blood volume, or are taking certain medications that interact with it.

This medication can interact with alcohol, which may worsen dehydration, and certain prescription medicines that affect how your body breaks down the drug. If you are pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss whether this treatment is safe for you.

Uses of Tolvahike-15 Tablet 10's

Your doctor may prescribe this medicine to treat several conditions, including:

  • Low blood sodium levels (hyponatremia): Tolvahike-15 Tablet 10's helps increase sodium concentrations in the blood by helping the body remove excess water through urine without losing essential electrolytes.
  • Syndrome of Inappropriate Antidiuretic Hormone (SIADH): In this condition, the body retains too much water, diluting sodium; Tolvahike-15 Tablet 10's blocks the hormone responsible for water retention, restoring a proper chemical balance.
  • Autosomal dominant polycystic kidney disease (ADPKD): In specific cases, it is prescribed to help slow down the decline of kidney function and reduce the growth of kidney cysts.

Key Benefits

Tolvahike-15 Tablet 10's helps manage conditions associated with low sodium levels and excess fluid retention by increasing the removal of free water while preserving sodium. It is also used to slow kidney function decline in certain patients with polycystic kidney disease. Key benefits include:

  • Corrects Low Sodium Levels: By increasing the excretion of excess water, Tolvahike-15 Tablet 10's helps raise sodium levels in the blood, relieving symptoms such as confusion, weakness, and swelling associated with low sodium.
  • Reduces Fluid Retention: Tolvahike-15 Tablet 10's helps remove excess water from the body without significant sodium loss, improving symptoms of fluid overload and reducing the need for strict fluid restriction.
  • Supports Kidney Health: In people with certain forms of polycystic kidney disease, Tolvahike-15 Tablet 10's helps slow the decline in kidney function, supporting long-term kidney health and disease management.

Directions for Use

  • Tolvahike-15 Tablet 10's can be taken with or without food. However, avoid taking it with grapefruit or its juice, as this may increase the effects of the medication.
  • It is usually taken once daily; however, your doctor may adjust the dosage based on your serum sodium and fluid levels.
  • Swallow Tolvahike-15 Tablet 10's as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Tolvahike-15 Tablet 10's Works

Tolvahike-15 Tablet 10's contains tolvaptan, which works by targeting a specific hormone in the body called vasopressin, which is also known as the antidiuretic hormone. This hormone controls how much water your kidneys reabsorb back into your bloodstream. By blocking the action of vasopressin at the V2-receptors in the kidneys, Tolvahike-15 Tablet 10's prevents the kidneys from holding onto excess water. Instead, this water is released from the body through urine. Because the medicine selectively removes water while leaving sodium behind, the concentration of sodium in your blood naturally rises back to a healthy level.
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Alcohol

Unsafe

Avoid consuming alcohol while taking Tolvahike-15 Tablet 10's as it may cause increased dizziness.

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Pregnancy

Unsafe

Tolvahike-15 Tablet 10's belongs to pregnancy category C. Tolvahike-15 Tablet 10's is not recommended for use in pregnant women as it may cause foetal harm. Women of childbearing age must use effective contraception while taking Tolvahike-15 Tablet 10's.

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Breast Feeding

Unsafe

Tolvahike-15 Tablet 10's is not recommended for use in breastfeeding women. Consult your doctor if you are breastfeeding; your doctor will decide whether Tolvahike-15 Tablet 10's can be taken by breastfeeding mothers or not.

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Driving

Caution

Tolvahike-15 Tablet 10's may cause dizziness, weakness and tiredness. Do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Tolvahike-15 Tablet 10's should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Tolvahike-15 Tablet 10's should be used with caution in patients with kidney disease. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Tolvahike-15 Tablet 10's is not recommended for children below 18 years as efficacy and safety have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Tolvahike-15 Tablet 10's. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Tolvahike-15 Tablet 10's can be given in elderly patients with extreme caution, if prescribed by the physician.

What if I have taken an overdose of Tolvahike-15 Tablet 10's

In case of an overdose, seek immediate emergency medical attention or contact a poison control centre right away. An overdose can cause severe dehydration and dangerous chemical imbalances in your blood.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink water whenever you feel thirsty and do not ignore your body's natural thirst signals, as this medicine increases fluid loss and may lead to dehydration.
  • Follow your healthcare provider's fluid advice: Do not restrict your fluid intake unless your doctor specifically instructs you to do so while taking Tolvahike-15 Tablet 10's.
  • Avoid grapefruit products: Do not consume grapefruit or grapefruit juice, as they can interfere with how your body processes Tolvahike-15 Tablet 10's and increase the risk of side effects.
  • Avoid alcohol: Do not drink alcohol while taking Tolvahike-15 Tablet 10's, as it can worsen dehydration and place additional strain on your liver.
  • Attend regular monitoring appointments: Keep all scheduled blood test appointments so your doctor can monitor your sodium levels, liver function, and your response to treatment.
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Have a query?

How Soon It Starts Working

The time required for Tolvahike-15 Tablet 10's to start to work: Tolvahike-15 Tablet 10's ideally shows its action within 2 to 4 hours after administration. 

The time for which the effects of Tolvahike-15 Tablet 10's last: The effect of Tolvahike-15 Tablet 10's lasts for 12 hours.

What if you forget to take Tolvahike-15 Tablet 10's

If you miss a dose, take it as soon as you remember on the same day. If you do not remember until the next day, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store Tolvahike-15 Tablet 10's tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medication in its original packaging to protect it from light and moisture.

Drug Warnings

  • Begin treatment under medical supervision: Your first doses of Tolvahike-15 Tablet 10's should be taken in a hospital or healthcare setting so your blood sodium levels can be monitored closely to ensure they do not rise too quickly.
  • Do not use for longer than prescribed: Do not take Tolvahike-15 Tablet 10's for more than 30 days unless your doctor specifically advises you to, as prolonged use may increase the risk of serious liver damage.
  • Watch for signs of bleeding: Contact your doctor promptly if you notice unusual bruising, prolonged bleeding, nosebleeds, or blood in your urine or stools.
  • Stay hydrated: Drink water regularly and keep a bottle of water with you, especially during hot weather or when travelling, to help prevent dehydration unless your doctor has advised you to restrict your fluid intake.
  • Check before taking new medicines: Consult your doctor or pharmacist before starting any over-the-counter medicines, herbal supplements, or vitamins, as they may interact with Tolvahike-15 Tablet 10's.

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Tolvahike-15 Tablet 10's.

  • Strong CYP3A Inhibitors: Medicines such as ketoconazole or clarithromycin can greatly increase the level of Tolvahike-15 Tablet 10's in your body, raising the risk of serious side effects.
  • Other Diuretics (Water Pills): Taking Tolvahike-15 Tablet 10's with other diuretics may significantly increase fluid loss, leading to severe dehydration and low blood pressure.
  • Potassium-Raising Medicines and Blood Pressure Medicines: Use with caution, as combining these medicines with Tolvahike-15 Tablet 10's may increase the risk of high potassium levels or excessive lowering of blood pressure. Your doctor may recommend regular monitoring.

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verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Avoid consuming grapefruit or grapefruit juice while taking Tolvahike-15 Tablet 10's, as they can significantly increase the concentration of the medicine in your blood and make side effects more likely.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CARDIOVASCULAR AGENTS]

FAQs

Tolvahike-15 Tablet 10's is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, Tolvahike-15 Tablet 10's is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
Tolvahike-15 Tablet 10's works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, Tolvahike-15 Tablet 10's slows down the development of cysts in the kidneys, reduces the symptoms of the disease, and increases urine production. Thereby increases serum sodium concentrations.
Dry mouth could be a side-effect of Tolvahike-15 Tablet 10's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Diarrhoea could be a side-effect of Tolvahike-15 Tablet 10's. Drink plenty of fluid to prevent dehydration if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or if you find blood in stools.
Tolvahike-15 Tablet 10's may cause the liver to not work properly. Consult your doctor immediately if you experience nausea, vomiting, fever, loss of appetite, abdominal pain, tiredness, dark urine, jaundice, itching and flu-like symptoms.
Tolvahike-15 Tablet 10's may cause water loss due to increased urine production. This might result in side-effects such as thirst, dry mouth and kidney problems. To prevent this, drink plenty of water regularly. Drink 1-2 glasses of water before going to bed even though you are not thirsty. Special care must be taken in patients with diseases that might reduce fluid intake.
Consult your doctor before taking Tolvahike-15 Tablet 10's if you are diabetic as Tolvahike-15 Tablet 10's might increase the blood sugar levels. Regular monitoring of blood glucose levels while taking Tolvahike-15 Tablet 10's is advised.
You are advised to take Tolvahike-15 Tablet 10's for the duration prescribed by the doctor. Tolvahike-15 Tablet 10's should not be taken for more than 30 days.
Tolvahike-15 Tablet 10's might increase the blood sugar levels. Consult the doctor if you are diabetic.
Do not take Tolvahike-15 Tablet 10's if you are allergic to any of its components, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, or if you cannot tell that you are thirsty.
Avoid consuming grapefruit or its juice while taking Tolvahike-15 Tablet 10's as it might increase the effects of the medicine in the body.
Do not exceed the prescribed dose as it might cause an overdose. Taking an excess of Tolvahike-15 Tablet 10's may cause excessive thirst, dizziness, excessive urination, or fainting. Consult the doctor if you experience these symptoms.
Tolvahike-15 Tablet 10's is not recommended for patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney problems.
If you miss a dose of Tolvahike-15 Tablet 10's take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Tolvahike-15 Tablet 10's is not recommended for use during pregnancy and breastfeeding.
Common side effects are dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Talk to your doctor if you experience these side effects persistently.
Store Tolvahike-15 Tablet 10's at room temperature, in a dry place. Keep out of sight and reach of children.
Treatment with Tolvahike-15 Tablet 10's should be started and re-started in a hospital or in the presence of a healthcare professional to monitor the sodium levels in your blood closely. Too rapid correction of hyponatremia (low sodium levels) may cause osmotic demyelination syndrome (serious nerve damage). Consult the doctor if you notice symptoms of osmotic demyelination syndrome such as difficulty speaking, feeling that food or drinks are getting stuck in your throat, difficulty swallowing, mood changes, drowsiness, confusion, body movements that are difficult to control, weakness of the arms or legs, or seizures.
This medication must be started in a hospital to allow doctors to closely monitor your blood sodium levels. If sodium levels rise too rapidly, it can cause a serious and irreversible brain condition. Talk to your doctor if you have concerns about your hospital stay.
Watch for yellowing of your skin or eyes, dark urine, pale stools, severe fatigue, loss of appetite, or pain in the upper right side of your stomach. If you experience any of these symptoms, stop taking the medicine and call your doctor right away.
Generally, you should not restrict your fluid intake while taking this medication. You must drink water whenever you feel thirsty to avoid severe dehydration. Talk to your doctor for specific fluid guidelines tailored to your health condition.
You must not take Tolvahike-15 Tablet 10's if you are unable to sense thirst or cannot drink water. Doing so can lead to life-threatening dehydration and rapid changes in blood chemistry. Talk to your doctor immediately if your ability to drink fluids changes.
This medication is generally not recommended during pregnancy unless the benefits clearly outweigh the potential risks to the unborn baby. If you are pregnant or planning to become pregnant, talk to your doctor to discuss safer alternatives.
If sodium levels rise too fast, it can cause osmotic demyelination syndrome, a severe neurological condition that affects speaking, swallowing, and movement. This is why close medical supervision and blood tests are mandatory during initial treatment. Talk to your doctor for more information.

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Country of origin

India

Manufacturer/Marketer address

Behind Rajpath Club, Kensville Road, Opp. Infostretch Building, Off S.G. Highway, Ahmedabad- 380059, Gujarat- India
Other Info - TOL0369
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