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  3. Tolvat 15 Tablet 4's

Tolvat 15 Tablet 4's, Pack of 4 TABLETS
Tolvat 15 Tablet 4's, Pack of 4 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Tolvat 15 Tablet is used to treat low sodium levels and autosomal dominant polycystic kidney disease. It contains Tolvaptan which works by increasing the amount of water released from the body via urine. In some cases, this medicine may cause side effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

TOLVAPTAN-15MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tolvat 15 Tablet

Tolvat 15 Tablet is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, Tolvat 15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
 
Tolvat 15 Tablet contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions; the increase in serum sodium concentration is solely a result of increased urine production.
 
You are advised to take Tolvat 15 Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Do not take Tolvat 15 Tablet if you are pregnant as it may cause foetal harm. Consult your doctor before taking Tolvat 15 Tablet if you are breastfeeding. Tolvat 15 Tablet is not recommended for children below 18 years as the efficacy and safety have not been established. Tolvat 15 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side effects.

Uses of Tolvat 15 Tablet

Treatment of Hyponatremia (low sodium levels) and autosomal dominant polycystic kidney disease (ADPKD).

Directions for Use

Swallow the medicine as a whole with a glass of water, and do not crush, break, or chew it.

Medicinal Benefits

Tolvat 15 Tablet belongs to a group of medicines called vasopressin V2 receptor antagonist. Tolvat 15 Tablet is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Besides this, Tolvat 15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD). Tolvat 15 Tablet works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, Tolvat 15 Tablet slows down the development of cysts in kidneys and reduces the symptoms of the disease. Tolvat 15 Tablet antagonises the effect of vasopressin; this results in an increase in free water clearance and decreases urine osmolality due to increased urinary excretion, thereby increasing serum sodium concentrations.

How Tolvat 15 Tablet Works

Tolvat 15 Tablet contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions; the increase in serum sodium concentration is solely a result of increased urine production.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tolvat 15 Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink six to eight glasses of water per day to be healthy.
  • Healthy urinary habits can help minimize pollakiuria (frequent urinating).
  • Avoid liquids containing caffeine, artificial sweeteners, and soda, as they might cause bladder discomfort.
  • Add bladder-friendly foods such as omega-3 fatty acids, blueberries, and cranberries.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.

What if I have taken an overdose of Tolvat 15 Tablet

Take Tolvat 15 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include excessive urination, excessive thirst, dizziness, and faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Tolvat 15 Tablet if you are allergic to any of its contents, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, if you cannot tell that you are thirsty. Inform your doctor if you have liver disease, difficulty in urination, diabetes, high levels of uric acid, advanced kidney disease or if you have to restrict fluid intake due to certain medical conditions. Do not take Tolvat 15 Tablet if you are pregnant as it may cause foetal harm. Consult your doctor before taking Tolvat 15 Tablet if you are breastfeeding. Tolvat 15 Tablet is not recommended for children below 18 years as efficacy and safety have not been established. Tolvat 15 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. 

Drug-Drug Interactions

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TolvaptanItraconazole
Critical
TolvaptanIndinavir
Critical

Drug-Drug Interactions

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TolvaptanItraconazole
Critical
How does the drug interact with Tolvat 15 Tablet:
Co-administration of Tolvat 15 Tablet and Itraconazole may significantly raise Tolvat 15 Tablet blood levels and effects.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Itraconazole, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanIndinavir
Critical
How does the drug interact with Tolvat 15 Tablet:
When Tolvat 15 Tablet and Indinavir are taken together, may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Indinavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanVoriconazole
Critical
How does the drug interact with Tolvat 15 Tablet:
Co-administration of Tolvat 15 Tablet together with Voriconazole may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Voriconazole, but it can be taken if prescribed by a doctor. If you experience difficulty swallowing, trouble speaking, muscle weakness call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanDelavirdine
Critical
How does the drug interact with Tolvat 15 Tablet:
When Tolvat 15 Tablet and Delavirdine are taken together, may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Delavirdine, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanFosamprenavir
Critical
How does the drug interact with Tolvat 15 Tablet:
When Tolvat 15 Tablet is taken with Fosamprenavir, may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Fosamprenavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanTelithromycin
Critical
How does the drug interact with Tolvat 15 Tablet:
When Tolvat 15 Tablet and Telithromycin are taken together, may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Telithromycin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanTelaprevir
Critical
How does the drug interact with Tolvat 15 Tablet:
When Tolvat 15 Tablet and Telaprevir are taken together, may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Telaprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanMifepristone
Critical
How does the drug interact with Tolvat 15 Tablet:
When Tolvat 15 Tablet is taken with Mifepristone, it may increase the levels of Tolvat 15 Tablet, which may increase the risk of side effects.

How to manage the interaction:
Taking Tolvat 15 Tablet and Mifepristone together is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanBoceprevir
Critical
How does the drug interact with Tolvat 15 Tablet:
Co-administration of Boceprevir and Tolvat 15 Tablet may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Boceprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanAtazanavir
Critical
How does the drug interact with Tolvat 15 Tablet:
When Tolvat 15 Tablet and Atazanavir are taken together, may significantly increase the blood levels and effects of Tolvat 15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tolvat 15 Tablet and Atazanavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOLVAPTAN-15MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOLVAPTAN-15MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit

How to manage the interaction:
Consuming grapefruit juice while taking Tolvat 15 Tablet can increase the effects of Tolvat 15 Tablet. Avoid taking Tolvat 15 Tablet with grapefruit juice.

Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Manage stress with meditation, yoga, and massage.
  • Drink plenty of fluids.
  • Rehydration beverages that contain electrolytes are also helpful.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Tolvat 15 Tablet Substitute

Substitutes safety advice

  • Natrise Tablet 4's

    by Others

    ₹132.07per tablet

  • Hyponat-O 15 Tablet 10's

    by Others

    ₹67.28per tablet

  • Vaptan Tablet 10's

    by AYUR

    ₹90.00per tablet

  • Resodim 15 Tablet 4's

    by Others

    ₹180.68per tablet

  • Tolvasca-15 Tablet 4's

    by Others

    ₹185.40per tablet

Product Substitutes

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Alcohol

Unsafe

Avoid consuming alcohol while taking Tolvat 15 Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Tolvat 15 Tablet belongs to pregnancy category C. Tolvat 15 Tablet is not recommended for use in pregnant women as it may cause foetal harm. Women of childbearing age must use effective contraception while taking Tolvat 15 Tablet.

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Breast Feeding

Unsafe

Tolvat 15 Tablet is not recommended for use in breastfeeding women. Consult your doctor if you are breastfeeding; your doctor will decide whether Tolvat 15 Tablet can be taken by breastfeeding mothers or not.

bannner image

Driving

Caution

Tolvat 15 Tablet may cause dizziness, weakness and tiredness. Do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Caution

Dose adjustment may be needed. Tolvat 15 Tablet should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have liver problems or any concerns regarding this.

bannner image

Kidney

Caution

Tolvat 15 Tablet should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney problems or any concerns regarding this.

bannner image

Children

Unsafe

Tolvat 15 Tablet is not recommended for children below 18 years as efficacy and safety have not been established.

FAQs

Tolvat 15 Tablet is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, Tolvat 15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD).

Tolvat 15 Tablet works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, Tolvat 15 Tablet slows down the development of cysts in the kidneys, reduces the symptoms of the disease, and increases urine production. Thereby increases serum sodium concentrations.

Dry mouth could be a side-effect of Tolvat 15 Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Diarrhoea could be a side-effect of Tolvat 15 Tablet. Drink plenty of fluid to prevent dehydration if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or if you find blood in stools.

Tolvat 15 Tablet may cause the liver to not work properly. Consult your doctor immediately if you experience nausea, vomiting, fever, loss of appetite, abdominal pain, tiredness, dark urine, jaundice, itching and flu-like symptoms.

Tolvat 15 Tablet may cause water loss due to increased urine production. This might result in side-effects such as thirst, dry mouth and kidney problems. To prevent this, drink plenty of water regularly. Drink 1-2 glasses of water before going to bed even though you are not thirsty. Special care must be taken in patients with diseases that might reduce fluid intake.

Consult your doctor before taking Tolvat 15 Tablet if you are diabetic as Tolvat 15 Tablet might increase the blood sugar levels. Regular monitoring of blood glucose levels while taking Tolvat 15 Tablet is advised.

You are advised to take Tolvat 15 Tablet for the duration prescribed by the doctor. Tolvat 15 Tablet should not be taken for more than 30 days.

Tolvat 15 Tablet might increase the blood sugar levels. Consult the doctor if you are diabetic.

Do not take Tolvat 15 Tablet if you are allergic to any of its components, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, or if you cannot tell that you are thirsty.

Avoid consuming grapefruit or its juice while taking Tolvat 15 Tablet as it might increase the effects of the medicine in the body.

Do not exceed the prescribed dose as it might cause an overdose. Taking an excess of Tolvat 15 Tablet may cause excessive thirst, dizziness, excessive urination, or fainting. Consult the doctor if you experience these symptoms.

Tolvat 15 Tablet is not recommended for patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney problems.

If you miss a dose of Tolvat 15 Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

Tolvat 15 Tablet is not recommended for use during pregnancy and breastfeeding.

Common side effects are dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Talk to your doctor if you experience these side effects persistently.

Store Tolvat 15 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Treatment with Tolvat 15 Tablet should be started and re-started in a hospital or in the presence of a healthcare professional to monitor the sodium levels in your blood closely. Too rapid correction of hyponatremia (low sodium levels) may cause osmotic demyelination syndrome (serious nerve damage). Consult the doctor if you notice symptoms of osmotic demyelination syndrome such as difficulty speaking, feeling that food or drinks are getting stuck in your throat, difficulty swallowing, mood changes, drowsiness, confusion, body movements that are difficult to control, weakness of the arms or legs, or seizures.

Country of origin

INDIA

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - TOL0084

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Author Details

Doctor imageDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.6846.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022275s007lbl.pdf
  3. https://www.ema.europa.eu/en/documents/product-information/samsca-epar-product-information_en.pdf
  4. https://www.drugs.com/mtm/tolvaptan.html
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