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  3. Topotec 2.5Mg Inj

Topotec 2.5Mg Inj, Pack of 1 Tablet
Topotec 2.5Mg Inj, Pack of 1 Tablet
Topotec 2.5Mg Inj, Pack of 1 Tablet
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Topotec 2.5Mg Inj contains topotecan which is used in the treatment of ovarian and small cell lung cancer. It is an anticancer medicine which works by binding to the cell's DNA, and stops it from naturally dividing and functioning, ultimately destroying it. This medicine can sometimes be used for treating other cancer conditions aswell. Common side effects inculde nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy and electrolyte disturbance.
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Composition :

TOPOTECAN-2.5MG

Manufacturer/Marketer :

Unitech Health Care Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Topotec 2.5Mg Inj

Topotec 2.5Mg Inj belongs to a group of medicines called 'anti-cancer/anti-neoplastic agents', used to treat ovarian and small cell lung cancer. On the other hand, it may use to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. It may sometimes be used to treat other cancers. Ovarian cancer begins in the ovaries (a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues.

Topotec 2.5Mg Inj contains 'Topotecan'. It works by penetrating into the cell wall and binding to the cell's DNA, stopping it from naturally dividing and functioning, ultimately destroying it. These medicines target cancer cells because they often affect rapidly dividing cells.

The amount of medicine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule. Topotec 2.5Mg Inj is prescribed by a doctor experienced in the use of medications to treat cancer. You may sometimes experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses, and electrolyte disturbances. Most of these side effects of Topotec 2.5Mg Inj do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Topotec 2.5Mg Inj for as long as your doctor has prescribed. Do not stop using the Topotec 2.5Mg Inj midway. Talk to your doctor before taking Topotec 2.5Mg Inj if you have severe allergic reactions to Topotec 2.5Mg Inj or other medicines or suffer from severe lung problems, Infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Topotec 2.5Mg Inj if you are pregnant or breastfeeding because this Topotec 2.5Mg Inj can cause harmful effects on the unborn baby. Both women and men using this Topotec 2.5Mg Inj should use birth control to avoid pregnancy.

Uses of Topotec 2.5Mg Inj

Topotec 2.5Mg Inj is used in the treatment of ovarian cancer and small-cell lung cancer. The detailed uses of Topotec 2.5Mg Inj are as follows:<br/>• Ovarian cancer: Topotec 2.5Mg Inj is effective in treating advanced ovarian cancer that has recurred or is resistant to other treatments, helping to slow tumor growth and manage symptoms.<br/>• Small cell lung cancer: Topotec 2.5Mg Inj manages recurrent or chemotherapy-sensitive small cell lung cancer, potentially extending survival and improving quality of life.<br/>• Cervical cancer: In certain cases, such as recurrent or metastatic disease, Topotec 2.5Mg Inj can also be used to control tumor growth and alleviate symptoms.<br/>

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Directions for Use

• Topotec 2.5Mg Inj is prescribed and administered based on your medical condition and treatment plan as determined by your doctor.• This injection is given only by qualified healthcare professionals experienced in administering cancer therapies.• It must not be self-administered, as it requires careful handling and monitoring during and after administration.• You will be closely monitored during treatment to ensure your safety and treatment effectiveness.

Medicinal Benefits

Topotec 2.5Mg Inj contains 'Topotecan', which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or together with other chemotherapy drugs depending on the type of cancer you have.

How Topotec 2.5Mg Inj Works

Topotec 2.5Mg Inj contains 'Topotecan'. It works by penetrating into the cell wall and binding to the cell's DNA, stopping it from naturally dividing and functioning, ultimately destroying it. These medicines target cancer cells because they often affect rapidly dividing cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Topotec 2.5Mg Inj out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC
Side effects of Topotec 2.5Mg Inj
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Topotec 2.5Mg Inj

Topotec 2.5Mg Inj is a parenteral formulation, hence the chance of overdose may be less. However, keep track of your medicine as an overdose of Topotec 2.5Mg Inj may cause serious side effects such as myelosuppression, increased hepatic enzymes, etc. Seek immediate medical attention if you observe any of these side effects. If an overdose is suspected, observe the patient.

Drug Warnings

Topotec 2.5Mg Inj will be administered by a healthcare professional. To treat your condition effectually, continue taking Topotec 2.5Mg Inj for as long as your doctor has prescribed. Do not stop Topotec 2.5Mg Inj midway. Talk to your doctor before taking Topotec 2.5Mg Inj if you have severe allergic reactions to Topotec 2.5Mg Inj or other medicines or suffer from severe lung problems, Infections, renal dysfunction, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), hepatic disorders. Topotec 2.5Mg Inj should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Topotec 2.5Mg Inj if you are pregnant or breastfeeding because this Topotec 2.5Mg Inj can cause harmful effects on the unborn baby. Both women and men using this Topotec 2.5Mg Inj should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Topotec 2.5Mg Inj treatment and appropriate until recovery is achieved. Do not receive any kind of immunization or vaccination without your doctor's approval while taking the Topotec 2.5Mg Inj.

Drug-Drug Interactions

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TopotecanCarboplatin
Severe
TopotecanEtanercept
Severe

Drug-Drug Interactions

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TopotecanCarboplatin
Severe
How does the drug interact with Topotec 2.5Mg Inj:
When carboplatin is used with Topotec 2.5Mg Inj, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of carboplatin with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
TopotecanEtanercept
Severe
How does the drug interact with Topotec 2.5Mg Inj:
When Etanercept is used with Topotec 2.5Mg Inj, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Topotec 2.5Mg Inj and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TopotecanTofacitinib
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Taking Tofacitinib with Topotec 2.5Mg Inj may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Topotec 2.5Mg Inj, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TopotecanInfliximab
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Combining Infliximab with Topotec 2.5Mg Inj can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Topotec 2.5Mg Inj with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TopotecanThalidomide
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Taking thalidomide together with Topotec 2.5Mg Inj may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Topotec 2.5Mg Inj together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
TopotecanBaricitinib
Severe
How does the drug interact with Topotec 2.5Mg Inj:
Coadministration of baricitinib and Topotec 2.5Mg Inj can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Topotec 2.5Mg Inj if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
TopotecanClozapine
Severe
How does the drug interact with Topotec 2.5Mg Inj:
When Clozapine is taken with Topotec 2.5Mg Inj, the effect of Clozapine in the blood can go up.

How to manage the interaction:
Although there is a possible interaction between Topotec 2.5Mg Inj and Clozapine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, weight loss, pain or burning during urination - it's important to contact your doctor right away. They may be able to recommend other options that won't cause any problems with your current medications. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Topotec 2.5Mg Inj Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Topotec 2.5Mg Inj.

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Pregnancy

Unsafe

Topotec 2.5Mg Inj should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Topotec 2.5Mg Inj and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Topotec 2.5Mg Inj should not be used during breastfeeding as it passes into the breastmilk and may harm your baby. Hence, if you are breastfeeding, inform your doctor before receiving this medicine.

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Driving

Caution

Topotec 2.5Mg Inj may affect your reactions and your ability to drive.Note: Possible side effects of chemotherapy with Topotec 2.5Mg Inj may occur, such as nausea and vomiting. If you are affected by these side effects, do not drive and/or operate machines that require your alertness.

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Liver

Caution

If you have had a history or evidence of liver impairment, please inform your doctor before taking the Topotec 2.5Mg Inj. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Kidney

Caution

If you have had a history or evidence of kidney diseases, please inform your doctor before taking the Topotec 2.5Mg Inj. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Children

Unsafe

The safety and effectiveness of Topotec 2.5Mg Inj in pediatric patients have not been established. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing this medicine.

FAQs

Topotec 2.5Mg Inj belongs to a group of medicines called anti-cancer drugs used in the treatment of ovarian cancer and small cell lung cancer. It is also used to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible.

Topotec 2.5Mg Inj contains &#039;Topotecan&#039;. Topotecan works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.

If you are allergic to topotecan or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Topotec 2.5Mg Inj.

Yes, Topotec 2.5Mg Inj can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.

Avoid taking Topotec 2.5Mg Inj if you are pregnant because Topotec 2.5Mg Inj can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Topotec 2.5Mg Inj.

The live vaccine may not work while on treatment with Topotec 2.5Mg Inj. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Topotec 2.5Mg Inj is used to treat ovarian or small cell lung cancer that has come back after chemotherapy. On the other hand, it can also treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. When treating cervical cancer, Topotec 2.5Mg Inj is used with another medication called cisplatin.

Country of origin

INDIA

Manufacturer/Marketer address

28, Shiv Shakti Nagar, Near Indo Bharat School,, Gautam Marg, Nirman Nagarm, Jaipur, Rajasthan 302019
Other Info - TOP0233

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:02 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.4159.pdf
  2. https://www.drugs.com/drug-interactions/topotecan.htmlhttp://chemocare.com/chemotherapy/drug-info/Topotecan.aspx#:~:text=What%20Topotecan%20Is%20Used%20For,(small%20cell%20lung%20cancer).

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