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Tremtane Plus Tablet 10's is used to treat schizophrenia. It contains Trifluoperazine and Trihexyphenidyl which work by inhibiting a chemical messenger (dopamine) in the brain that regulates mood. In some cases, this medicine may cause side effects such as nausea, constipation, dryness in the mouth, sedation, weight gain, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Matias Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Tremtane Plus Tablet 10's

Tremtane Plus Tablet 10's is a combination prescription medication used primarily to treat schizophrenia and other psychotic disorders. It is also highly effective in managing abnormal, involuntary muscle movements that can occur as side effects of other psychiatric medications. By targeting chemical imbalances in the brain, this medicine helps restore calmer, more organised thinking.

For the best results, you must take Tremtane Plus Tablet 10's regularly and consistently at the same times each day. You can take this medication with or without food, though taking it with a meal may help prevent mild stomach upset. Making simple daily adjustments, such as drinking plenty of fluids and avoiding extreme heat, can help your body adapt more easily to the treatment.

While taking Tremtane Plus Tablet 10's, you may experience some common side effects, such as dry mouth, blurred vision, or mild drowsiness. These are usually manageable, but you must contact your doctor immediately if you notice more serious signs, such as extreme muscle stiffness, a sudden high fever, or an irregular heart rate.

Before starting this medication, tell your doctor if you have a history of glaucoma, prostate enlargement, heart conditions, or kidney issues. Do not take this if you have severe liver damage, narrow-angle glaucoma, or a history of bone marrow depression. Your doctor will help evaluate if this medication is safe for your specific health history.

Some substances can interact with Tremtane Plus Tablet 10's, so you should avoid drinking alcohol or taking over-the-counter sleeping aids while using this medication, as they can cause extreme drowsiness. If you smoke, let your doctor know, as smoking can change how your body processes this medicine.

Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Speak openly with your doctor, as this medicine may carry risks of extrapyramidal symptoms in newborns or neonatal withdrawal, which is highest in the third trimester. Consult your doctor if managing care for an elderly individual to discuss specific safety precautions.

Uses of Tremtane Plus Tablet 10's

Tremtane Plus Tablet 10's is used to treat schizophrenia and other psychotic disorders on a long-term basis. The detailed uses of Tremtane Plus Tablet 10's are as follows:

  • Schizophrenia and psychotic disorders: Tremtane Plus Tablet 10's helps relieve symptoms such as hearing voices, seeing things that are not there, and experiencing deep suspicion or disorganised thinking.
  • Drug-induced movement disorders (extrapyramidal symptoms): Tremtane Plus Tablet 10's helps treat and prevent physical side effects like tremors, muscle spasms, and severe muscle stiffness caused by other psychiatric medications.

Key Benefits

Managing schizophrenia can be emotionally challenging, and this medicine is here to help make that journey easier. Tremtane Plus Tablet 10's offers comprehensive relief by addressing both mental and physical symptoms simultaneously. By restoring chemical balance in the brain, this medicine brings several key health benefits:

  • Reduce distracting thoughts: It helps reduce distressing thoughts and hallucinations, allowing you to think more clearly and engage more comfortably in daily social and professional activities.
  • Relaxes muscles: This medication helps relax stiff, tense muscles and reduces involuntary shaking or restlessness.
  • Improves movement: This physical relief makes daily movements smoother and pain-free, helping you maintain your independence and overall physical comfort.
Side effects of Tremtane Plus Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Do pelvic floor exercises (Kegel exercises) to gain more control over urinary sphincters (muscles used to control flow of urine out of the bladder).
  • Drink fluids only at certain times to control when you will urinate.
  • If you feel frequent urge to urinate or have problems starting to urinate or if your urine stream is weak or starts and stops, or feel pain in your genitals, lower abdomen or lower back, consult your doctor.

Directions for Use

  • Take Tremtane Plus Tablet 10's, preferably with food to avoid stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Tremtane Plus Tablet 10's Works

Tremtane Plus Tablet 10's combines two active ingredients that work together to balance brain chemistry and muscle control: Trifluoperazine belongs to a class of medicines called typical antipsychotics. It works by blocking dopamine receptors in the brain, which helps control overactive nerve pathways that lead to hallucinations, delusions, and severe anxiety. Trihexyphenidyl is an anticholinergic medicine. It balances another chemical messenger called acetylcholine, which often becomes overactive when dopamine is blocked. This action helps relieve the muscle stiffness, shaking, and spasms that can occur during antipsychotic treatment.
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Alcohol

Unsafe

Avoid consumption of alcohol with Tremtane Plus Tablet 10's as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

Tremtane Plus Tablet 10's is not recommended for use during pregnancy, especially in the third trimesters as it may cause adverse effects in the baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Tremtane Plus Tablet 10's may be unsafe to use during breastfeeding. Please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Tremtane Plus Tablet 10's may cause dizziness, double vision or drowsiness in some people. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking Tremtane Plus Tablet 10's.

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Liver

Unsafe

Tremtane Plus Tablet 10's is not recommended for patients suffering from Liver diseases/conditions. Please consult a doctor if you have any concerns regarding this.

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Kidney

Caution

Take Tremtane Plus Tablet 10's with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Please consult your paediatrician. Your child's doctor may weigh the benefits and risks before prescribing this medicine to your child.

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Heart

Caution

Tremtane Plus Tablet 10's should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Tremtane Plus Tablet 10's.

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Geriatrics

Caution

Tremtane Plus Tablet 10's should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

What if I have taken an overdose of Tremtane Plus Tablet 10's

In case of an accidental overdose, seek emergency medical attention immediately. Symptoms of an overdose can include severe dry mouth, extreme sleepiness, a rapid heart rate, confusion, or difficulty breathing.

Diet & Lifestyle Advise

  • Stay hydrated: Drink regular sips of water, chew sugar-free gum, or suck on ice chips to help relieve dry mouth.
  • Eat more fibre: Eat a fibre-rich diet with plenty of whole grains, fruits, and vegetables to help prevent constipation.
  • Stand up slowly: Rise from sitting or lying down to prevent dizziness or lightheadedness caused by sudden changes in blood pressure.
  • Avoid overheating: Avoid prolonged exposure to hot weather and stay well hydrated, as this medicine can reduce your body's ability to sweat, increasing your risk of heatstroke.
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How Soon It Starts Working

The time required for Tremtane Plus Tablet 10's to start to work: Tremtane Plus Tablet 10's ideally shows its action within 1 hour after administration. The time for which the effects of Tremtane Plus Tablet 10's last: The effect of Tremtane Plus Tablet 10's lasts for 6 to 12 hours.

What if you forget to take Tremtane Plus Tablet 10's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Tremtane Plus Tablet 10's at room temperature, ideally between 20°C and 25°C (68°F to 77°F).• Keep the tablets in their original packaging to protect them from direct light and moisture, and avoid storing them in damp areas, such as bathroom cabinets.

Drug Warnings

  • Do not stop suddenly: Do not stop taking medicine suddenly, as doing so can cause your symptoms to return or lead to uncomfortable withdrawal effects.
  • Dose reduction: To avoid withdrawal effects, dose reduction over weeks is preferred under supervision.
  • Take care while driving: Avoid driving, riding a bicycle, or operating heavy machinery until you are certain how this medication affects your vision and alertness.
  • Protect your skin: Wear sunscreen and protective clothing when outdoors, as this medication can make your skin more sensitive to sunburn.
  • Tell your doctor: Inform your dentist, surgeon, or any medical specialist that you are taking Tremtane Plus Tablet 10's before undergoing any scheduled procedures or starting new treatments.
  • Regular checkups: Attend regular check-ups for metabolic effects (weight changes, blood sugar), liver function, eye pressure, blood count monitoring and the risk of blood disorders and movement assessment during long-term use.
  • Impaired memory: Trihexyphenidyl may impair memory or concentration, especially in elderly patients, and should be used at the lowest effective dose. 

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Central nervous system depressants: For example, sleeping pills, strong pain relievers, or muscle relaxants can cause extreme drowsiness and slow breathing.
  • Anticholinergic medications or certain allergy remedies: They can increase the risk of dry mouth, severe constipation, and difficulty urinating.
  • Other medications: For example, certain antihistamines and antiarrhythmics have a risk of QT prolongation. Consult your doctor.
Critical

Drug-Drug Interactions

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How does the drug interact with Tremtane Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Quinidine increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Quinidine possibly results in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
Critical
How does the drug interact with Tremtane Plus Tablet:
Co-administration of Trifluoperazine and Trihexyphenidyl with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with potassium citrate is not recommended as it can result in an interaction, but it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tremtane Plus Tablet:
Co-administration of Trifluoperazine and Trihexyphenidyl with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with Ziprasidone can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tremtane Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Terfenadine increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Terfenadine can result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Tremtane Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Astemizole increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Astemizole can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Tremtane Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Ibutilide increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Although taking Trifluoperazine and Trihexyphenidyl with Ibutilidee can result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Tremtane Plus Tablet:
Co-administration of Trifluoperazine and Trihexyphenidyl with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with potassium chloride is not recommended as it can result in an interaction, but it can be taken if a doctor prescribes it. However, contact a doctor immediately if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tremtane Plus Tablet:
Coadministration of Trifluoperazine and Trihexyphenidyl with Cisapride increases the risk of irregular heart rhythms. The risk is higher if you have a previous history of heart problems and electrolyte disturbances.

How to manage the interaction:
Taking Trifluoperazine and Trihexyphenidyl with Cisapride together will result in an interaction, but they can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, shortness of breath, or heart palpitations. Do not discontinue using any medications without consulting a doctor.
How does the drug interact with Tremtane Plus Tablet:
Taking trihexyphenidyl with esketamine can increase the risk of CNS side effects.

How to manage the interaction:
Although there is an interaction between Tremtane Plus Tablet and esketamine, it can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impaired thinking, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Tremtane Plus Tablet:
Using Morphine with Trifluoperazine and Trihexyphenidyl can increase the risk of central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Trifluoperazine and Trihexyphenidyl can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, or impaired judgment, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: It is best to avoid alcohol, which can severely increase drowsiness, dizziness, and coordination issues, elevating your risk of accidents.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Tremtane Plus Tablet 10's is used to prevent and treat schizophrenia (a mental illness). Additionally, it may be used for anxiety and depression over a short period.
Tremtane Plus Tablet 10's contains Trifluoperazine and Trihexyphenidyl. Trifluoperazine is a typical antipsychotic which works by blocking the action of a chemical messenger (dopamine) in the brain that affects thoughts and mood. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms). Trihexyphenidyl is used to treat and prevent side effects such as involuntary movements (shaking of hands, muscle spasms) caused by Trifluoperazine.
Dry mouth could be a side-effect of Tremtane Plus Tablet 10's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Antidepressants should be avoided while taking Tremtane Plus Tablet 10's as it might increase sedative effects. Consult your doctor before taking Tremtane Plus Tablet 10's if you are using depressants.
Tremtane Plus Tablet 10's can cause decreased sweating which results in rising in body temperature (hyperthermia). This serious side effect is greater in hot weather so it is advisable to drink plenty of water fluids, especially in summer. However, kidney patients should consult a doctor before drinking any fluid.
Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, feel unusually suspicious or confused. Trihexyphenidyl in Tremtane Plus Tablet 10's may cause hallucination in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Tremtane Plus Tablet 10's, please talk to your doctor immediately.
Tremtane Plus Tablet 10's should be avoided by dementia (decline in memory, behaviour, thinking and ability to do daily activities) patients as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you are suffering from dementia before taking Tremtane Plus Tablet 10's.
Though Tremtane Plus Tablet 10's starts working within a few hours, it might take 2-3 weeks to notice the full benefits. Keep taking Tremtane Plus Tablet 10's for the prescribed duration for effective treatment.
No, you should not stop taking Tremtane Plus Tablet 10's even though you feel better as it may cause withdrawal symptoms. Consult the doctor if you experience any difficulties while taking Tremtane Plus Tablet 10's; the doctor might lower the dose gradually.
Tremtane Plus Tablet 10's does not cause sleepiness. However, it may cause sleepiness if you take alcohol with Tremtane Plus Tablet 10's. Therefore, avoid consuming alcohol while taking Tremtane Plus Tablet 10's. Tremtane Plus Tablet 10's might cause dizziness and drowsiness in some people. Avoid driving or operating machinery if you experience these symptoms.
Tremtane Plus Tablet 10's can be stored in a cool and dry place away from sunlight. Keep it out of sight and reach of children.
The side effects of Tremtane Plus Tablet 10's include dizziness, nausea, abdominal pain, blurred vision, constipation, decreased blood pressure, urine retention, dry mouth, weight gain, and excessive sweating. Consult the doctor if any of these side effects persist or worsen.
It is highly recommended to avoid alcohol while taking Tremtane Plus Tablet 10's. Alcohol can increase side effects like dizziness, confusion, and extreme sleepiness, which can be dangerous. Talk to your doctor if you have concerns.
Some people may experience dizziness or lightheadedness when rising from a sitting or lying position. To prevent this, try to stand up slowly and hold onto a stable surface. Talk to your doctor if this dizziness continues.
Do not take Tremtane Plus Tablet 10's if you have narrow-angle glaucoma, as it can increase the pressure inside your eyes and worsen your condition. If you have any other type of eye condition, talk to your doctor before starting this medicine.
Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at once, and talk to your doctor or pharmacist if you are unsure.
Yes, this medication can make your skin more sensitive to direct sunlight, increasing the risk of sunburn. Wear sunscreen, protective clothing, and sunglasses when spending time outdoors, and talk to your doctor if you experience severe skin reactions.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

101-104 Gcp Business Centre Opp. Memnagar Fire Station Vijay Cross Road Memnagar Ahmedabad-380014 India
Other Info - TRE0409
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