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  3. TREND SPRINKLE 250MG CAPSULE

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TREND SPRINKLE 250MG CAPSULE, Pack of 10 CAPSULES
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

TREND SPRINKLE 250MG CAPSULE is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

DIVALPROEX-250MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About TREND SPRINKLE 250MG CAPSULE

TREND SPRINKLE 250MG CAPSULE is used to treat epilepsy/seizures/fits. Additionally, TREND SPRINKLE 250MG CAPSULE is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain.

TREND SPRINKLE 250MG CAPSULE contains 'Divalproex', which reduces excessive, abnormal nerve activity in the brain. Thereby helping in controlling seizures.

TREND SPRINKLE 250MG CAPSULE increases the levels of the chemical substance GABA; this helps block nerve transmission in the brain and produces a calming effect. Thereby helping treat bipolar disorder.

In some cases, you may experience side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Talk to your doctor if you experience these side effects persistently.

Do not take TREND SPRINKLE 250MG CAPSULE if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking TREND SPRINKLE 250MG CAPSULE. Consult your doctor if you are breastfeeding. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of TREND SPRINKLE 250MG CAPSULE

TREND SPRINKLE 250MG CAPSULE is used in the treatment of epilepsy, bipolar disorder, and migraine. The detailed uses of TREND SPRINKLE 250MG CAPSULE are as follows:

  • Seizure Management: TREND SPRINKLE 250MG CAPSULE is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.
  • Bipolar Disorder Treatment: TREND SPRINKLE 250MG CAPSULE can be utilised in the treatment of bipolar disorder, aiding in mood stabilisation and reducing the frequency of mood swings.
  • Migraine Prevention: TREND SPRINKLE 250MG CAPSULE may also be prescribed to prevent migraines, providing relief from recurrent headaches.

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Directions for Use

  • TREND SPRINKLE 250MG CAPSULE can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow TREND SPRINKLE 250MG CAPSULE as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • TREND SPRINKLE 250MG CAPSULE is used to treat and prevent epilepsy, seizures, or fits by controlling abnormal electrical activity in the brain.
  • It helps manage various types of seizures, including simple partial, complex partial, and absence seizures.
  • TREND SPRINKLE 250MG CAPSULE may be used alone or in combination with other anti-epileptic medicines for better seizure control.
  • It is also prescribed to treat mood disorders, such as bipolar disorder, by enhancing GABA (gamma-aminobutyric acid) activity in the brain, which produces a calming and stabilising effect.
  • TREND SPRINKLE 250MG CAPSULE helps prevent migraine headaches by reducing abnormal nerve transmission and limiting the spread of pain signals.
  • By decreasing excessive nerve activity, TREND SPRINKLE 250MG CAPSULE restores normal brain function and helps maintain emotional balance.
  • TREND SPRINKLE 250MG CAPSULE provides broad neurological benefits by controlling seizures, stabilising mood, and reducing migraine frequency.

How TREND SPRINKLE 250MG CAPSULE Works

TREND SPRINKLE 250MG CAPSULE contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. TREND SPRINKLE 250MG CAPSULE increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of TREND SPRINKLE 250MG CAPSULE

Do not take more than the prescribed dose of TREND SPRINKLE 250MG CAPSULE as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take TREND SPRINKLE 250MG CAPSULE if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders.
  • Inform your doctor before taking TREND SPRINKLE 250MG CAPSULE if you have pancreatitis, blood problems or multi-organ hypersensitivity.
  • Consult your doctor immediately if you experience suicidal tendencies while taking TREND SPRINKLE 250MG CAPSULE.
  • TREND SPRINKLE 250MG CAPSULE may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems.
  • Please do not stop taking TREND SPRINKLE 250MG CAPSULE without consulting your doctor to avoid worsening of seizures.
  • Do not take TREND SPRINKLE 250MG CAPSULE if you are pregnant, as it could cause serious birth defects.
  • If you are of childbearing age, use effective contraception while taking TREND SPRINKLE 250MG CAPSULE.
  • Consult your doctor before taking TREND SPRINKLE 250MG CAPSULE if you are breastfeeding.
  • Avoid driving or operating machinery as TREND SPRINKLE 250MG CAPSULE causes dizziness and may affect thinking and motor skills.
  • Avoid consuming alcohol along with TREND SPRINKLE 250MG CAPSULE as it could lead to increased dizziness.
  • Care should be taken while giving TREND SPRINKLE 250MG CAPSULE to children below 2 years, as there is a higher risk of liver intoxication during the first six months of treatment.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateBuprenorphine
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Trend Sprinkle 250mg Capsule:
Combining Sodium phenylbutyrate and Trend Sprinkle 250mg Capsule can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Trend Sprinkle 250mg Capsule is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Using buprenorphine together with Trend Sprinkle 250mg Capsule may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Trend Sprinkle 250mg Capsule can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Co-administration of Teriflunomide and Trend Sprinkle 250mg Capsule can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Trend Sprinkle 250mg Capsule can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
The combined use of Ertapenem and Trend Sprinkle 250mg Capsule can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Trend Sprinkle 250mg Capsule can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Co-administration of Lithium with Trend Sprinkle 250mg Capsule can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Trend Sprinkle 250mg Capsule can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Co-administration of Ketamine and Trend Sprinkle 250mg Capsule can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Trend Sprinkle 250mg Capsule can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Co-administration of Meropenam and Trend Sprinkle 250mg Capsule together can reduce the effect of Trend Sprinkle 250mg Capsule.

How to manage the interaction:
Co-administration of Meropenam and Trend Sprinkle 250mg Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Co-administration of Vorinostat with Trend Sprinkle 250mg Capsule can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Trend Sprinkle 250mg Capsule can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Co-administration of Leflunomide and Trend Sprinkle 250mg Capsule can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Trend Sprinkle 250mg Capsule can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Trend Sprinkle 250mg Capsule:
Co-administration of Trend Sprinkle 250mg Capsule with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Trend Sprinkle 250mg Capsule can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.
  • The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, help those around you know what to do.
  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

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Alcohol

Unsafe

Avoid consumption of alcohol while taking TREND SPRINKLE 250MG CAPSULE as it may cause increased dizziness.

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Pregnancy

Unsafe

TREND SPRINKLE 250MG CAPSULE belongs to pregnancy category D. Avoid taking TREND SPRINKLE 250MG CAPSULE if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

TREND SPRINKLE 250MG CAPSULE may pass into breastmilk. Consult your doctor before taking TREND SPRINKLE 250MG CAPSULE if you are breastfeeding.

bannner image

Driving

Unsafe

TREND SPRINKLE 250MG CAPSULE causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

TREND SPRINKLE 250MG CAPSULE should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

TREND SPRINKLE 250MG CAPSULE can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years, as they are at a higher risk of liver toxicity.

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Heart

TREND SPRINKLE 250MG CAPSULE can be used in cardiac patients, but requires careful monitoring.

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Geriatrics

Caution

TREND SPRINKLE 250MG CAPSULE should be used under caution in geriatric patients for conditions like bipolar mania and seizures. Please consult your physician.

FAQs

TREND SPRINKLE 250MG CAPSULE is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.

TREND SPRINKLE 250MG CAPSULE decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

TREND SPRINKLE 250MG CAPSULE helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

TREND SPRINKLE 250MG CAPSULE limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

TREND SPRINKLE 250MG CAPSULE may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with TREND SPRINKLE 250MG CAPSULE only after consulting a doctor.

TREND SPRINKLE 250MG CAPSULE may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue TREND SPRINKLE 250MG CAPSULE without consulting your doctor. To treat your condition effectually, continue taking TREND SPRINKLE 250MG CAPSULE for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking TREND SPRINKLE 250MG CAPSULE; your doctor will gradually reduce the dose to avoid worsening seizures.

Before taking TREND SPRINKLE 250MG CAPSULE, certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.

TREND SPRINKLE 250MG CAPSULE may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking TREND SPRINKLE 250MG CAPSULE.

Topiramate (anticonvulsant) should not be taken along with TREND SPRINKLE 250MG CAPSULE as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

It's crucial to consult with your doctor before discontinuing TREND SPRINKLE 250MG CAPSULE. Abruptly stopping this medication can lead to severe consequences, especially if it's prescribed to treat conditions like epilepsy.

TREND SPRINKLE 250MG CAPSULE is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

TREND SPRINKLE 250MG CAPSULE can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.

Yes, TREND SPRINKLE 250MG CAPSULE can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking TREND SPRINKLE 250MG CAPSULE, it's essential to consult with your doctor.

Yes, TREND SPRINKLE 250MG CAPSULE can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking TREND SPRINKLE 250MG CAPSULE, seeking medical attention is crucial.

Avoid consumption of alcohol while taking TREND SPRINKLE 250MG CAPSULE as it may cause increased dizziness.

If you experience abdominal pain, nausea, and anorexia while taking TREND SPRINKLE 250MG CAPSULE, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

An overdose of TREND SPRINKLE 250MG CAPSULE can be a severe medical emergency. If you or someone you know has taken an overdose of TREND SPRINKLE 250MG CAPSULE, it's crucial to seek immediate medical attention.

TREND SPRINKLE 250MG CAPSULE can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - TRE0113

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Nov 18, 2025 | 7:31 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018723s037lbl.pdf
  2. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e26005ef-77f0-4393-a2dc-b5fe460cead8&type=display
  3. https://www.drugs.com/mtm/divalproex-sodium.html
  4. https://www.depakote.com/depakote-formulations

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