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compositionComposition:TREOSULFAN-5GM
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Prescription Medicine
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₹16574 with coupons & bank offers*

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Treoall 5 gm Injection 1's is used to treat advanced ovarian cancer. It contains Treosulfan, which works by inhibiting tumour growth. It prevents the cancer cells from multiplying. This helps reduce the number of cancer cells and helps treat ovarian cancer. In some cases, Treoall 5 gm Injection 1's may cause side effects such as nausea, vomiting, mild hair loss, and bronze discolouration of the skin.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TREOSULFAN-5GM

Manufacturer/Marketer :

Hetero Healthcare Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Treoall 5 gm Injection 1's

Treoall 5 gm Injection 1's is a medicine used as conditioning treatment before an allogeneic blood stem cell transplant, a procedure in which healthy stem cells from a donor are given to replace the patient's blood-forming cells. It helps prepare the bone marrow and immune system so the donor stem cells can settle and begin producing healthy blood cells.

This medicine is given as an intravenous (IV) infusion into a vein in a hospital or specialised transplant centre. As part of a transplant conditioning plan, treosulfan is commonly given once daily for three consecutive days before the stem cell transplant. It is usually combined with another conditioning medicine, such as fludarabine. The exact treatment schedule is planned and closely managed by the transplant team.

Treatment can cause low blood cell counts, nausea, vomiting, mouth sores, tiredness, and temporary hair loss. Low blood cell counts can increase the risk of infection, bleeding, and anaemia. Serious complications can also occur, so you will be monitored closely before, during, and after treatment.

Before starting this medicine, tell your doctor about all your medical conditions, especially liver, kidney, lung, or heart problems and any active infection. Tell your healthcare team about all medicines, supplements, and vaccines you use.

Treosulfan can harm an unborn baby and may affect fertility. Tell your doctor if you are pregnant, planning a pregnancy, breastfeeding, or planning to have children in the future. Your doctor can discuss contraception and fertility preservation before treatment begins.

Uses of Treoall 5 gm Injection 1's

Your doctor may prescribe Treoall 5 gm Injection 1's as part of a conditioning treatment before an allogeneic blood stem cell transplant:

  • Preparation for blood stem cell transplantation: Treoall 5 gm Injection 1's helps remove or suppress existing blood-forming cells and prepares the bone marrow for healthy donor stem cells.
  • Suppression of the immune system before transplantation: It reduces immune activity to help the donor stem cells settle and grow after the transplant.

Key Benefits

Treoall 5 gm Injection 1's helps prepare the body for a donor stem cell transplant and supports successful establishment of the transplanted cells.

  • Prepares the bone marrow: It reduces existing blood-forming cells, creating space for donor stem cells to settle and grow.
  • Reduces immune activity: It suppresses the immune system before transplantation, reducing the body's ability to reject donor cells.
  • Supports donor cell growth: Proper conditioning helps transplanted stem cells establish themselves and begin producing new blood cells.
  • Provides a planned conditioning option: Treosulfan can be combined with other conditioning medicines as part of a carefully designed transplant regimen.
Side effects of Treoall 5 gm Injection
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Focus on consuming whole, nutrient-dense foods to promote healthy, radiant skin.
  • Eat a variety of colourful fruits and vegetables, including citrus fruits, bell peppers, and broccoli.
  • Wear protective clothing, such as long-sleeved shirts and pants, during peak sun hours.
  • Drink plenty of water throughout the day to keep your skin moisturized and plump.
  • Practice mindfulness techniques, such as meditation, deep breathing, or yoga, to reduce stress and promote skin health.
  • Use gentle, fragrance-free skincare products that nourish and protect your skin.
  • Avoid prolonged sun exposure, especially during peak hours, to prevent skin damage and premature aging.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Treoall 5 gm Injection 1's is administered by the doctor or nurse.
  • Do not self-administer.

How Treoall 5 gm Injection 1's Works

Treoall 5 gm Injection 1's contains treosulfan, a medicine that damages the DNA (genetic material) of rapidly dividing cells. This prevents these cells from multiplying and causes them to die. Before a stem cell transplant, this action helps reduce existing blood-forming cells in the bone marrow and suppresses the immune system. This prepares the body to receive healthy donor stem cells, which can then settle in the bone marrow and begin making new blood cells.
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Alcohol

Consult your doctor

It is not known if alcohol affects Treoall 5 gm Injection 1's. Please consult your doctor.

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Pregnancy

Caution

Treoall 5 gm Injection 1's should not be used during pregnancy unless prescribed by the doctor. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Treoall 5 gm Injection 1's.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Treoall 5 gm Injection 1's.

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Driving

Caution

Treoall 5 gm Injection 1's may cause nausea or vomiting. Drive or operate heavy machinery only if you are alert.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Treoall 5 gm Injection 1's.

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Kidney

Caution

If you have a history of kidney diseases, inform your doctor before receiving Treoall 5 gm Injection 1's. Dose adjustment may be needed in patients with impaired kidney function.

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Children

Unsafe

Treoall 5 gm Injection 1's is not recommended for children due to a lack of data on the safety and effectiveness.

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Heart

Consult your doctor

If you have a history of heart disease, please inform the doctor before receiving Treoall 5 gm Injection 1's.

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Geriatrics

Caution

Elderly patients may require caution and dose adjustments, as Treoall 5 gm Injection 1's may increase the risk of side effects.

What if I have taken an overdose of Treoall 5 gm Injection 1's

An overdose is unlikely because this medicine is prepared and given by trained healthcare professionals. If too much medicine is given, your healthcare team will closely monitor you and provide appropriate supportive treatment.

Diet & Lifestyle Advise

  • Stay hydrated: Drink fluids as recommended by your healthcare team to help prevent dehydration during treatment.
  • Choose easy-to-eat foods: Small, frequent meals and soft foods may be easier to manage if you have nausea or mouth soreness.
  • Follow food-safety precautions: Your immune defences may become very low during conditioning and transplantation. Follow your transplant team's advice about safely preparing and storing food.
  • Take care of your mouth: Use a soft toothbrush and follow the mouth-care routine recommended by your healthcare team.
  • Reduce exposure to infections: Wash your hands regularly and follow your transplant team's advice about avoiding people who are unwell and crowded places.
health query

Have a query?

How Soon It Starts Working

The time required for Treoall 5 gm Injection 1's to start to work: The time required for Treoall 5 gm Injection 1's to show its action is not clinically established. The time for which the effects of Treoall 5 gm Injection 1's last: The duration of action for Treoall 5 gm Injection 1's is not clinically established.

What if you forget to take Treoall 5 gm Injection 1's

Because Treoall 5 gm Injection 1's is given according to a carefully planned transplant schedule in a hospital or transplant centre, a missed dose is unlikely. If an infusion is delayed or cannot be given as planned, your transplant team will decide how to adjust the conditioning and transplant schedule safely.

Storage

• Treoall 5 gm Injection 1's is stored and handled in a controlled clinical environment by healthcare professionals.

Drug Warnings

  • Expect a multi-medicine conditioning plan: Treosulfan is usually given as part of a conditioning regimen with another medicine, such as fludarabine, before the stem cell transplant.
  • Discuss fertility before treatment: Treosulfan can damage the ovaries or testes and may cause long-term or permanent infertility. Before treatment begins, discuss fertility preservation options, such as sperm, egg, or embryo preservation, with your doctor if having children in the future is important to you.
  • Report fever immediately: Your infection-fighting blood cells can fall to very low levels after conditioning. Contact your healthcare team immediately if you develop fever, chills, or other signs of infection.
  • Watch for signs of liver complications: Rapid weight gain, abdominal pain or swelling, yellowing of the skin or eyes, or dark urine may indicate hepatic sinusoidal obstruction syndrome (VOD) and require prompt medical assessment.
  • Keep all monitoring appointments: Your healthcare team will regularly check your blood cell counts and liver and kidney function before and after transplantation.
  • Report unusual bleeding: Tell your healthcare team promptly about unexplained bruising, bleeding, or small red or purple spots on the skin.
  • Tell your doctor about all medicines and vaccines: Some medicines or vaccines may not be suitable while your immune system is severely weakened.
  • Follow pregnancy-prevention advice: Treosulfan can harm an unborn baby. Follow your healthcare team's instructions about effective contraception during and after treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Other conditioning medicines: Treosulfan is commonly used with medicines such as fludarabine as part of the planned conditioning regimen. These treatments can further suppress blood cell production and immune function, so close monitoring is required.
  • Other medicines that suppress the bone marrow or immune system: Using several treatments with these effects may increase the risk of low blood cell counts and infection.
  • Live vaccines: Live vaccines are generally avoided when the immune system is severely weakened because they may cause infection. Ask your transplant team before receiving any vaccine.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Food: No specific clinically important food interaction is expected because Treoall 5 gm Injection 1's is given directly into a vein. Food does not affect the absorption of an intravenous dose. Follow the dietary and food-safety instructions provided by your transplant team.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Treoall 5 gm Injection 1's works by inhibiting tumour growth. Thereby, it helps treat ovarian cancer.
Treoall 5 gm Injection 1's may cause mild hair loss. The hair may grow back after the treatment with Treoall 5 gm Injection 1's. However, consult your doctor if you have any concerns.
The risk of generalised infection may be increased after some vaccinations. Therefore, do not receive any live vaccinations during therapy.
There are no specific foods or drinks you need to avoid while taking Treoall 5 gm Injection 1's. However, it is important to follow your doctor’s instructions regarding any dietary or lifestyle considerations. Consult the doctor if you have any concerns.
Bleeding gums after brushing your teeth while taking Treoall 5 gm Injection 1's might be a side effect. It may affect your immune system and blood clotting, making your gums more susceptible to bleeding. It is important to maintain proper oral hygiene but avoid brushing too hard. Consult the doctor, if the bleeding persists or worsens.
To cope with tiredness and weakness after starting treatment with Treoall 5 gm Injection 1's, ensure you get plenty of rest, eat a nutritious diet rich in iron, protein, and complex carbohydrates, stay hydrated by drinking water, and consider light physical activity like walking to boost energy. Consult the doctor, if tiredness and weakness persist or worsen.
If you have noticed changes in your skin after taking Treoall 5 gm Injection 1's, it is important to consult the doctor. Skin changes might be a side effect of this medication, and the doctor can help determine the cause and may recommend adjusting your treatment or providing advice on how to manage the skin changes. Meanwhile, avoid using harsh skincare products and protect your skin from prolonged sun exposure.
Avoid smoking, consumption of alcohol, fried food, fast food, processed meats, refined carbs and added sugar during treatment with Treoall 5 gm Injection 1's. Additionally, avoid breastfeeding while treatment with Treoall 5 gm Injection 1's as it may pass into breastmilk.
Treoall 5 gm Injection 1's can be received during pregnancy only if it is administered by the doctor or nurse. The doctor will prescribe this medication only if the potential benefits outweigh the risks.
The doctor may recommend several tests before and during treatment with Treoall 5 gm Injection 1's including blood tests to monitor liver and kidney function, blood cell counts, and signs of infection. Additionally, your doctor may perform regular heart function assessments and monitor your overall response to the treatment. However, specific tests may depend on your health condition and the doctor's recommendations.
The side effects of Treoall 5 gm Injection 1's include mild hair loss, nausea, vomiting, and bronze discolouration of the skin. Consult the doctor if any of these side effects persist or worsen.
This medicine is used as conditioning treatment before an allogeneic blood stem cell transplant. It prepares the bone marrow and suppresses the immune system so healthy donor stem cells can settle and grow.
It is given as an intravenous infusion into a vein by trained healthcare professionals in a hospital or transplant centre.
Treosulfan is commonly given once daily for three consecutive days before the stem cell transplant as part of a planned conditioning regimen. Your transplant team will determine your exact schedule.
Conditioning usually involves more than one medicine. Treosulfan is commonly combined with another conditioning medicine, such as fludarabine, because the medicines work together to prepare your body for the donor stem cells.
Yes. Treosulfan can affect the ovaries or testes and may cause long-term or permanent infertility. Discuss fertility preservation with your doctor before treatment if you may want to have children in the future.
It is a serious condition in which blood flow through small vessels in the liver becomes blocked. Warning signs can include rapid weight gain, abdominal pain or swelling, yellowing of the skin or eyes, and dark urine. Consult your doctor right away if these symptoms occur.
Contact your healthcare team immediately. Conditioning treatment can greatly reduce your infection-fighting white blood cells, so fever may be a sign of a serious infection that requires prompt treatment.
Your immune system will be severely weakened during conditioning and after transplantation. Ask your transplant team before receiving any vaccine. Live vaccines are generally avoided during periods of significant immune suppression.
Hair loss can occur with treosulfan and other medicines used during conditioning. Hair may grow back after treatment, although the timing varies from person to person.
Treosulfan can harm an unborn baby and should not be used during pregnancy. Tell your doctor if you are pregnant, think you may be pregnant, or are planning a pregnancy, and follow the contraception advice provided by your healthcare team.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sy.no: 80-84, Melange Towers, Patrika Nagar, Madhapur, Hyderabad, Telangana - 500 081
Other Info - TRE0371
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