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compositionComposition:TERLIPRESSIN-1MG
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Prescription Medicine
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Tresil 1mg Injection is used to treat Bleeding oesophageal varices. It contains Terlipressin, a synthetic pituitary hormone that breaks down in the body to release a substance called lysine vasopressin that is used to stop bleeding from leaking varicose veins in the food pipe. It works by narrowing the affected blood vessels and restricting their flow. Thus, it helps to control bleeding.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TERLIPRESSIN-1MG

Manufacturer/Marketer :

Serum Institute Of India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Tresil 1mg Injection

Tresil 1mg Injection is a prescription injection primarily used to treat life-threatening bleeding in the food pipe (oesophageal varices) and a severe type of kidney failure linked to advanced liver disease. It works by narrowing the blood vessels in the stomach area, which reduces pressure in the liver and helps control dangerous bleeding.

Because this medicine is given as an injection directly into a vein, it is strictly managed by healthcare professionals in a hospital setting. It is given at regular intervals based on your clinical condition, and you do not need to worry about taking it with food. While receiving this treatment, staying hydrated under medical supervision and adhering to a low-sodium diet can help support your liver and kidneys.

Common side effects of Tresil 1mg Injection include abdominal cramps, pale skin, headaches, and a temporary increase in blood pressure. However, you must inform your healthcare team immediately if you experience severe chest pain, difficulty breathing, or bluish discolouration of your fingers or toes.

Before receiving Tresil 1mg Injection, it is vital to tell your doctor if you have a history of heart disease, irregular heartbeats, high blood pressure, or breathing problems like asthma. Do not take this if you are pregnant, as it can cause harm to the unborn baby, or if you have severe, uncontrolled heart conditions.

This medicine can interact with other drugs that affect your heart rhythm or blood pressure, so a complete list of your current medications must be reviewed by your medical team. Additionally, because it is used for severe liver-related emergencies, avoiding alcohol and smoking is absolutely critical for your recovery. Pregnant or breastfeeding women, as well as elderly individuals with heart conditions, must discuss the risks and benefits thoroughly with their doctor before receiving this treatment.

Uses of Tresil 1mg Injection

Tresil 1mg Injection may be prescribed to help manage the following conditions:

  • Bleeding food pipe veins (Oesophageal Varices): Tresil 1mg Injection helps stop dangerous, acute bleeding in the swollen veins of the food pipe, which often occurs in people with severe liver disease.
  • Kidney failure related to liver disease (Hepatorenal Syndrome): Tresil 1mg Injection helps improve kidney function in people with advanced liver cirrhosis by redirecting blood flow to the kidneys, helping them filter waste properly again.

Key Benefits

Tresil 1mg Injection is used to control bleeding from oesophageal varices and to treat hepatorenal syndrome in patients with advanced liver disease. It works by narrowing specific blood vessels, reducing portal vein pressure, and improving blood flow to vital organs.

  • Controls Variceal Bleeding: Helps rapidly reduce pressure in the portal vein, controlling bleeding from enlarged veins in the oesophagus.
  • Supports Kidney Function: Improves blood flow to the kidneys in patients with hepatorenal syndrome, helping restore kidney function and urine production.
  • Stabilises Medical Emergencies: Helps stabilise patients with severe liver-related complications, allowing time for additional treatments such as endoscopic procedures.
  • Reduces Portal Hypertension: Lowers increased pressure within the portal venous system, helping reduce the risk of further bleeding episodes.
  • Improves Treatment Outcomes: When used as part of standard medical care, it helps improve the management of serious complications associated with advanced liver disease.
Side effects of Tresil 1mg Injection
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Consult a doctor when you have signs such as pain, numbness, or discoloration in order to establish the cause and get the proper treatment.
  • Medications may be prescribed by your doctor to promote blood flow and prevent further complications.
  • Exercise often, such as walking or swimming, to increase cardiovascular health and circulation.
  • Keep yourself at an ideal weight because excess weight creates strain on the blood vessels, and improves the circulation.
  • Stop smoking since it damages the blood vessels and impairs circulation.
  • Relieve stress through techniques such as meditation or deep breathing.
  • Avoid very cold temperatures as they can constrict blood vessels and reduce the flow of circulation.
  • Drink sufficient water to allow good blood circulation.
  • Monitor blood pressure regularly and ensure that it is within the healthy range.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Tresil 1mg Injection will be administered intravenously by the doctor or healthcare professional in a medical setting.
  • Do not self-administer.

How Tresil 1mg Injection Works

Tresil 1mg Injection contains terlipressin. It mimics a natural hormone in the body that regulates blood vessel constriction. When injected, it targets the blood vessels in your abdominal organs, causing them to narrow. By narrowing these abdominal blood vessels, Tresil 1mg Injection reduces the volume of blood flowing back into the liver. This dramatically lowers the pressure in the portal vein (the main vein leading to the liver), which helps stop bleeding from fragile, swollen veins in your food pipe. At the same time, this constriction helps redirect blood flow back into the main circulatory system. This increases blood pressure and improves blood flow to the kidneys, helping reverse the sudden kidney failure associated with severe liver damage.
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Alcohol

Consult your doctor

The interaction of Tresil 1mg Injection with alcohol is unknown. Therefore, if you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

Limited data available on the effect of Tresil 1mg Injection on pregnant women. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Tresil 1mg Injection. Your doctor may give this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Terlipressin is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Tresil 1mg Injection. Your doctor may give this medicine if the benefits outweigh the risks.

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Driving

Caution

Limited information is available. However, if you are unwell after receiving Tresil 1mg Injection, avoid driving or operating machinery.

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Liver

Consult your doctor

If you have any liver problems, inform your doctor before receiving Tresil 1mg Injection.

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Kidney

Caution

Tresil 1mg Injection should be used with caution in patients with long-standing kidney failure. Also, inform your doctor if you have impaired kidney function.

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Children

Unsafe

Tresil 1mg Injection is not recommended for children and adolescents as the safety and effectiveness were not established.

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Heart

Caution

Tresil 1mg Injection should be avoided in patients with heart problems, as it may cause serious ischemic events like cardiac or cerebrovascular complications. Use only if absolutely necessary and under strict medical supervision.

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Geriatrics

Caution

Tresil 1mg Injection should be avoided in geriatric patients unless absolutely necessary, as it may increase the risk of cardiovascular and renal complications. Use only if clearly indicated and under strict medical supervision.

What if I have taken an overdose of Tresil 1mg Injection

Because this medication is injected under close medical supervision, an overdose is rare. However, if too much of the medicine is given, it can cause severe high blood pressure or a dangerously slow heart rate. The medical team will monitor you closely and treat any symptoms of overdose immediately.

Diet & Lifestyle Advise

  • Follow a strict low-sodium diet: Reducing your salt intake is crucial to prevent your body from holding onto excess fluid, which can worsen liver and kidney complications.
  • Limit or restrict fluid intake: If recommended by your doctor, monitor and limit the amount of fluids you drink to avoid fluid overload, which can put extra strain on your heart and lungs.
  • Avoid alcohol completely: Alcohol causes direct liver damage and can worsen bleeding in your food pipe. Completely avoiding alcohol is essential for your recovery and long-term health.
  • Rest and limit physical strain: Avoid heavy lifting or intense physical exertion, as sudden strain can increase pressure in your abdominal veins and raise the risk of bleeding.
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Have a query?

How Soon It Starts Working

The time required for Tresil 1mg Injection to start to work: Tresil 1mg Injection ideally shows its action within five minutes after administration. The time for which the effects of Tresil 1mg Injection last: The effect of Tresil 1mg Injection lasts for 6 hours.

What if you forget to take Tresil 1mg Injection

Since Tresil 1mg Injection is given in a hospital or clinical setting by a healthcare professional, it is highly unlikely that you will miss a dose. If you suspect a dose was missed, inform your nurse or doctor immediately.

Storage

•In a hospital setting, Tresil 1mg Injection is typically stored in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F). It must not be frozen.

Drug Warnings

  • Monitor injection sites: If you feel pain, burning, redness, or swelling where the injection is being given, tell your healthcare provider immediately to prevent skin damage.
  • Check the solution: Before use, the medical provider should visually inspect the solution to ensure it is clear, colourless, and free of any visible particles.
  • Keep a close eye on breathing: Alert your doctor immediately if you feel short of breath, as this medicine can sometimes cause fluid to build up in your lungs.
  • Avoid sudden movements: Gently change positions (such as sitting up or standing up slowly) as your blood pressure can fluctuate during treatment.

Drug-Drug Interactions

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Inform your doctor if you are taking any of the following medicines before receiving Tresil 1mg Injection:

  • Heart rhythm medications (like beta-blockers): Combined use may cause your heart rate to drop to dangerously slow levels.
  • Blood pressure medications: Taking these alongside Tresil 1mg Injection can cause unpredictable fluctuations in your blood pressure.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • No clinically significant food interactions are known with Tresil 1mg Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[VASOACTIVE DRUG]

FAQs

Tresil 1mg Injection is used to treat Bleeding oesophageal varices.
Tresil 1mg Injection contains Terlipressin, a synthetic pituitary hormone that works by narrowing the affected blood vessels and restricting the blood flow through them. Thus, it helps to control bleeding.
You are recommended to consult a doctor before taking quinidine while on treatment with Tresil 1mg Injection as it may increase the risk or severity of QT prolongation (a heart rhythm disorder). Therefore, please consult a doctor before taking other medicines with Tresil 1mg Injection.
Tresil 1mg Injection may cause headaches as a common side effect. However, if the condition persists or worsens, please inform your doctor.
The side effects of Tresil 1mg Injection include abdominal cramps, diarrhoea, high or low blood pressure, slow heart rate, headache, pale skin, and insufficient blood circulation in arms, legs and skin. Consult the doctor if any of these symptoms persist or worsen.
Tresil 1mg Injection should not be taken if you are allergic to any of its ingredients, experiencing hypoxia (low levels of oxygen) or worsening respiratory symptoms, or have ongoing coronary, peripheral, or mesenteric ischemia (conditions affecting blood flow).
Before taking Tresil 1mg Injection, let your doctor know if you have severe bleeding in the oesophagus (food pipe). If you have a severe infection like septic shock, breathing issues such as asthma, uncontrolled high blood pressure, heart problems (angina, arrhythmias, or a history of heart attack), poor blood circulation (to the brain or limbs), kidney impairment, electrolyte imbalances, significant fluid or blood loss, if you are pregnant, or are over 70 years old.
Tresil 1mg Injection will be given as a continuous intravenous infusion by the doctor or nurse. Do not self-administer.
Tresil 1mg Injection is not recommended for children as its safety and effectiveness were not established.
No, Tresil 1mg Injection must be given in a hospital or specialised clinic setting by a trained healthcare professional because it requires continuous monitoring of your heart, blood pressure, and kidneys. Talk to your doctor if you have questions about your treatment setting.
This medicine works by narrowing your blood vessels, which temporarily reduces blood flow to the surface of your skin, making you look pale. This is a common effect and usually resolves after the treatment ends. Talk to your doctor if you are concerned.
No, you should not receive Tresil 1mg Injection if you are pregnant. It can cause the muscles of the uterus to contract, which can harm the pregnancy or cause early labour. Talk to your doctor about alternative options.
No, Tresil 1mg Injection does not cure liver disease. It is an emergency treatment used to manage severe complications of liver disease, such as bleeding veins in the food pipe or temporary kidney failure. Talk to your doctor about long-term management for your liver condition.
A slow heart rate is a known side effect of this medicine. Your healthcare team will continuously monitor your heart rate during the injection and will take action if it drops too low. Talk to your doctor or nurse if you feel dizzy or lightheaded.
It is not fully known if Tresil 1mg Injection passes into breast milk. If you are breastfeeding, you must discuss the risks and benefits with your healthcare team before receiving this medication. Talk to your doctor or pharmacist for guidance.
Yes, in some cases, Tresil 1mg Injection can cause fluid to build up in the body, which can lead to shortness of breath or fluid in the lungs. Your doctor will monitor your fluid levels and breathing closely during treatment. Talk to your doctor if you have a history of asthma or breathing issues.

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Country of origin

India
Other Info - TRES209
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