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  3. Tretiva 40 Capsule 10's

Tretiva 40 Capsule 10's, Pack of 10 CAPSULES
Tretiva 40 Capsule 10's, Pack of 10 CAPSULES
Tretiva 40 Capsule 10's, Pack of 10 CAPSULES
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tretiva 40 Capsule is used to treat a severe form of acne known as nodular acne that any other treatments, including antibiotics cannot clear. It contains Isotretinoin, a form of vitamin A, which works by reducing sebum (skin's natural oil) production on the skin's surface by decreasing the activity and size of sebaceous glands. Thereby, unblocks pores and kills acne-causing bacteria. Some people may experience chapped lips, dryness of skin, eyes, nose, or lips. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ISOTRETINOIN-40MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tretiva 40 Capsule

Tretiva 40 Capsule belongs to a class of drugs called retinoids (a synthetic form of vitamin A) primarily used to treat a severe form of acne known as nodular acne that no other treatments, including antibiotics, can clear. Nodular acne is severe acne that occurs due to excessive oil production in the skin cells, causing swollen, red and tender lumps in the skin. Acne nodules are larger in size than typical pimples. 

Tretiva 40 Capsule contains 'isotretinoin', a form of vitamin A that works by reducing sebum (skin's natural oil) production on the skin's surface by decreasing the activity and size of sebaceous glands. Thereby, it unblocks pores and kills acne-causing bacteria.

Take Tretiva 40 Capsule as prescribed. Your doctor will advise you on how often you must take Tretiva 40 Capsule based on your medical condition. Some people may experience chapped lips, dry skin, eyes, or nose. Most of these side effects of Tretiva 40 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Tretiva 40 Capsule or any other medicines, please tell your doctor. Do not take Tretiva 40 Capsule if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. If you have depression or any suicidal thoughts while taking Tretiva 40 Capsule or after stopping treatment with Tretiva 40 Capsule , please consult a doctor. Avoid sun exposure while using Tretiva 40 Capsule as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.

Uses of Tretiva 40 Capsule

Tretiva 40 Capsule used in the treatment of nodular acne. The detailed uses of Tretiva 40 Capsule are as follows:
• Treatment for nodular acne: Tretiva 40 Capsule reduces acne lesions and promotes clear skin to treat severe nodular acne that is not responding to other treatments.
• Sebaceous Gland Reduction: Tretiva 40 Capsule prevents acne by reducing oil production, avoiding the growth of acne, and shrinking sebaceous glands.
• Rosacea management: Tretiva 40 Capsule lessens the appearance of acne-like pimples and face redness.
• Enhancement of Skin Texture: By encouraging the removal of dead skin cells and avoiding clogged pores, Tretiva 40 Capsule helps to improve skin texture.
• Treatment for Psoriasis: Tretiva 40 Capsule is sometimes utilized off-label to treat severe psoriasis by lowering inflammation and skin cell turnover.

Directions for Use

Take Tretiva 40 Capsule with food or as advised by the doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

Tretiva 40 Capsule is a synthetic form of vitamin A used to treat severe acne. Tretiva 40 Capsule reduces sebum (skin's natural oil) production on the skin's surface by decreasing the activity and size of sebaceous glands. Thereby unblocking pores and killing acne-causing bacteria. Also, Tretiva 40 Capsule reduces swelling in the skin.

How Tretiva 40 Capsule Works

Tretiva 40 Capsule contains 'isotretinoin', a form of vitamin A that works by reducing sebum (skin's natural oil) production on the skin's surface by decreasing the activity and size of sebaceous glands. Thereby unblocks pores and kills acne-causing bacteria.

Storage

Store in a cool and dry place away from sunlight
Side effects of Tretiva 40 Capsule
  • Exercise and a healthy diet can help manage high cholesterol, but consult your doctor about medication if lifestyle changes are not enough.
  • Avoid foods high in cholesterol, saturated fat, and trans fats, such as egg yolks, cheese, fried foods, pastries, ice cream, and red meat.
  • Increase your intake of vegetables, fruits, oats, whole grains, lentils, and beans to boost fibre consumption.
  • Include foods rich in monounsaturated fats, like nuts, avocados, olive oil, and oily fish.
  • Exercise regularly for 30 minutes and maintain a healthy weight.
  • Quit smoking and limit excessive alcohol consumption, as both can negatively impact your cholesterol levels.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
Managing Medication-Triggered Cheilitis (Inflammation of the lips): A Step-by-Step Guide:
  • Consult your doctor if you experience lip inflammation, redness, or irritation after taking medication.
  • Your doctor will assess your condition, investigate possible causes, and design a treatment plan.
  • To soothe and moisturize the lips, use topical creams or ointments like petroleum jelly or lip balm.
  • Practice good lip care by keeping your lips clean, avoiding irritants, and staying hydrated.
  • If your condition worsens or persists, speak with your doctor about further therapy.
  • If you notice increased red blood cell sedimentation rate (ESR) after starting a medication, consult your doctor so that they may advise possible medication adjustments.
  • Regular blood tests are advised to monitor your ESR levels to assess the effectiveness of any treatment plan.
  • Eat a well-balanced diet rich in nutrients and antioxidants to reduce inflammation.
  • Drink lots of water to maintain proper blood viscosity.
  • Do regular physical activity as it helps to manage chronic conditions that may contribute to high ESR.
  • If you a smoker, quit smoking as it can negatively impact ESR levels.
  • Exercise for at least 30 minutes most days of the week.
  • Limit alcohol consumption.
  • Consider a low carbohydrate diet that limits grains, starchy vegetables and fruit. Include foods rich in protein and fat.
  • Avoid excess sugar, fatty foods and carbohydrates.
  • Aim for weight loss as it helps to improve cardiovascular health and minimize the risk of complications related to obesity.
  • Apply a gentle lip balm with ingredients such as castor seed oil or shea butter.
  • Ensure you are hydrated by drinking plenty of water; this helps heal your lips.
  • Avoid licking your lips or picking at them.
  • Use a humidifier at home, particularly at night, to maintain moisture in the air.
  • Protect your lips from sun exposure by using SPF lip balm and avoid using any irritating components.
  • Stay away from metal objects that could irritate your lips.
  • Consume a vitamin-rich diet to enhance the health of your skin overall.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.

What if I have taken an overdose of Tretiva 40 Capsule

Do not take more than the prescribed dose of Tretiva 40 Capsule as it may cause overdose. The symptoms of overdose include vomiting, dizziness, headache, stomach pain, loss of balance or coordination, warmth or tingling in your face and swollen or cracked lips. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Tretiva 40 Capsule if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. If you have depression or any suicidal thoughts while taking Tretiva 40 Capsule or after stopping treatment with Tretiva 40 Capsule , please consult a doctor. Avoid sun exposure while using Tretiva 40 Capsule as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn. Do not undergo any cosmetic procedures while taking Tretiva 40 Capsule and for a minimum of 6 months after stopping treatment with Tretiva 40 Capsule as it may increase the risk of scarring. Inform your doctor if you have asthma, diabetes, hypervitaminosis A (high levels of vitamin A), liver or heart problems, weak bones, osteoporosis (bone loss), anorexia nervosa (an eating disorder where people eat too little), any mental problems such as psychosis (loss of contact with reality) or depression before taking Tretiva 40 Capsule .

Drug-Drug Interactions

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IsotretinoinDemeclocycline
Critical
IsotretinoinOxytetracycline
Critical

Drug-Drug Interactions

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IsotretinoinDemeclocycline
Critical
How does the drug interact with Tretiva 40 Capsule:
Taking Tretiva 40 Capsule with Demeclocycline may increase the risk of a rare and serious condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking Tretiva 40 Capsule and Demeclocycline together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
IsotretinoinOxytetracycline
Critical
How does the drug interact with Tretiva 40 Capsule:
Co-administration of Tretiva 40 Capsule with Oxytetracycline can increase the risk of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Tretiva 40 Capsule and Oxytetracycline together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
IsotretinoinDoxycycline
Critical
How does the drug interact with Tretiva 40 Capsule:
Taking Tretiva 40 Capsule with Doxycycline may increase the risk of a rare condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking Tretiva 40 Capsule and Doxycycline together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting doctor.
IsotretinoinMinocycline
Severe
How does the drug interact with Tretiva 40 Capsule:
Taking Tretiva 40 Capsule with minocycline may increase the risk of a rare and serious condition called pseudotumor cerebri (increased pressure in the brain).

How to manage the interaction:
Although taking Tretiva 40 Capsule and minocycline together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, nausea, vomiting, and visual disturbances, consult a doctor. Do not stop using any medications without consulting a doctor.
IsotretinoinLomitapide
Severe
How does the drug interact with Tretiva 40 Capsule:
Taking Tretiva 40 Capsule with lomitapide may affect liver and cause liver problems.

How to manage the interaction:
Although taking Tretiva 40 Capsule and lomitapide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
IsotretinoinAminolevulinic acid
Severe
How does the drug interact with Tretiva 40 Capsule:
Taking Tretiva 40 Capsule with aminolevulinic acid may increase the risk of a severe sunburn.

How to manage the interaction:
Although taking Tretiva 40 Capsule and aminolevulinic acid together can possibly result in an interaction, it can be taken if your doctor has prescribed it. After taking you should avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours. Incase you experience any unusual symptoms, consult a doctor. Do not stop using any medications without consulting doctor.
IsotretinoinTeriflunomide
Severe
How does the drug interact with Tretiva 40 Capsule:
Taking Tretiva 40 Capsule with teriflunomide may affect liver and causes liver problems.

How to manage the interaction:
Although taking Tretiva 40 Capsule and teriflunomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting doctor.
IsotretinoinTretinoin
Severe
How does the drug interact with Tretiva 40 Capsule:
Taking Tretiva 40 Capsule together with tretinoin may increase the risk of hypervitaminosis A (excessive vitamin A-related effects).

How to manage the interaction:
Although taking Tretiva 40 Capsule and tretinoin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as increased pressure in the brain (headache, nausea, vomiting, visual disturbances) or liver damage (fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, yellowing of the skin or eyes). Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Regular exercise can improve your mood and self-esteem, though it doesn't clear acne. Take a shower immediately after finishing exercise as sweat may irritate acne.
  • Avoid sun exposure while using Tretiva 40 Capsule as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.
  • Regular hair washing is also recommended, and hair contact with the face should be avoided.
  • Remove the makeup completely before going to bed.

Habit Forming

No

Therapeutic Class

RETINOIDS
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Alcohol

Unsafe

Avoid consumption of alcohol with Tretiva 40 Capsule as it may increase the risk of liver damage and cause a rise in cholesterol levels.

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Pregnancy

Unsafe

Tretiva 40 Capsule is a Category X pregnancy drug and is considered unsafe for pregnant women as it may cause severe birth defects. Please consult a doctor if you are pregnant or planning to become pregnant.

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Breast Feeding

Unsafe

Tretiva 40 Capsule may be excreted in breast milk and cause adverse effects in the baby. Please consult a doctor before using Tretiva 40 Capsule while breastfeeding.

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Driving

Caution

Tretiva 40 Capsule may reduce night vision in some patients. Therefore, drive only if you are alert after taking Tretiva 40 Capsule .

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Liver

Unsafe

Tretiva 40 Capsule is usually not recommended for patients with impaired liver function. If you have any concerns regarding the use of Tretiva 40 Capsule in patients with liver problems, please consult a doctor.

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Kidney

Caution

If you have any concerns regarding the use of Tretiva 40 Capsule in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Tretiva 40 Capsule is not recommended for children below 12 years of age.

Have a query?

FAQs

Tretiva 40 Capsule is used to treat a severe form of acne known as nodular acne that cannot be cleared by any other treatments, including antibiotics.

Tretiva 40 Capsule may cause decreased night vision temporarily or permanently in some patients. It is not necessary for everyone taking Tretiva 40 Capsule to experience this side effect. Avoid driving after taking Tretiva 40 Capsule if you are unable to see in the dark and consult a doctor if you notice any changes in vision or have painful or persistent dry eyes.

Tretiva 40 Capsule may increase the skin sensitivity to sunlight. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen and wear protective clothing while going out to prevent sunburn.

No, you are not recommended to undergo any cosmetic procedures to smoothen your skin including waxing, laser procedures or dermabrasion (an exfoliating technique to remove outer layers of skin with a rotating instrument) while taking Tretiva 40 Capsule and for minimum 6 months after stopping treatment with Tretiva 40 Capsule as it may increase the risk of scarring.

You are not recommended to take vitamin A supplements with Tretiva 40 Capsule as it may cause hypervitaminosis A (excessive levels of vitamin A in the body) leading to an increased risk of adverse effects. However, please consult a doctor before taking other medicines or supplements with Tretiva 40 Capsule .

No, Tretiva 40 Capsule is not recommended for use during pregnancy as it may cause severe birth defects. Also, it is advised to use effective contraceptive measures before, while taking Tretiva 40 Capsule and after 1 month of stopping treatment with Tretiva 40 Capsule . However, please inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before taking Tretiva 40 Capsule .

Tretiva 40 Capsule is safe to use if prescribed by the doctor. Use Tretiva 40 Capsule exactly as advised by the doctor as it is associated with adverse effects.

Tretiva 40 Capsule is not a steroid. It is a retinoid used to treat severe nodular acne.

Pregnancy tests, lipid profile tests, liver function tests, blood glucose tests, and creatine phosphokinase (CPK) tests are recommended tests during Tretiva 40 Capsule treatment.

In most cases the effect of Tretiva 40 Capsule is permanent. Isotretinoin is clinically effective anti-acne therapy that shows significant improvement in many patients.

Tretiva 40 Capsule does not cause cancer. In fact, isotretinoin slows the growth of cancer cells by activating protein receptors in cells, including cancer cells.

Long-term use of Tretiva 40 Capsule , even in low doses, has not been studied and is not recommended. Hence, long-term side effects of Tretiva 40 Capsule have not been established.

Tretiva 40 Capsule is not known to affect male fertility.

Tretiva 40 Capsule might elevate liver enzymes. Therefore, regular liver function tests are advised.

Side effects of Tretiva 40 Capsule include chapped lips and dry skin, eyes, nose, or lips. These side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - TRE0055

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

May 2, 2025 | 12:08 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/18662s051lbl.pdf
  2. https://www.drugs.com/mtm/isotretinoin.html
  3. https://www.nhs.uk/medicines/isotretinoin-capsules/
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